Review
Pharmacology & Pharmacy
Yuqi Xin, Anqun Tang, Shuting Pan, Jie Zhang
Summary: This review summarizes research on the endocannabinoid system (ECS) and bone diseases in the past twenty years, revealing the important role cannabinoids play in bone metabolism and highlighting their therapeutic potential in treating bone diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Iswari Davan, Sharida Fakurazi, Ekram Alias, Nurul Izzah Ibrahim, Ng Min Hwei, Haniza Hassan
Summary: In recent years, bone loss and its associated diseases have become a significant public health concern. Oxidative stress, which suppresses osteoblast activity, is correlated with bone loss. Supplementation of antioxidants, such as astaxanthin, could reduce oxidative stress and improve bone health.
Review
Endocrinology & Metabolism
Rui-Jun Bai, Yu-Sheng Li, Fang-Jie Zhang
Summary: This review summarizes the role of osteopontin (OPN) in regulating inflammation activity and bone metabolism in osteoarthritis (OA) and osteoporosis (OP). It also discusses drugs that target OPN for treating OA and OP. However, further research is needed to fully understand the complex mechanism of OPN in regulating these bone diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Yifan Zhang, Jun Ma, Xingfu Bao, Min Hu, Xiaoxi Wei
Summary: This article summarizes the roles and mechanisms of RORs in skeletal diseases, providing evidence for potential therapeutic strategies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Ruobing Zhao, Yan Chen, Dongxue Wang, Chunyu Zhang, Henan Song, Guoxin Ni
Summary: Bone diseases are common and detrimental to the daily activities and quality of life of middle-aged and elderly individuals. It is essential to identify key regulatory factors and potential therapeutic targets for bone diseases. Irisin, a newly discovered myokine, has been found to have beneficial effects on various diseases, especially bone-related disorders. Research has indicated that irisin plays a role in bone diseases such as osteoarthritis and osteoporosis, suggesting its potential as a molecule for the prevention and treatment of bone diseases. This review summarizes the specific regulatory mechanisms of irisin in different bone diseases and provides a theoretical basis for its application in the diagnosis and treatment of these conditions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Zhiyuan Guan, Liying Luo, Shengfu Liu, Zhiqiang Guan, Qinggang Zhang, Xu Li, Kun Tao
Summary: Osteoporosis and osteoarthritis, common diseases in the aging population, are affected by the gut microbiome, which plays a crucial role in regulating bone metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Shenghui Ni, Fengping Shan, Jin Geng
Summary: IL-10 family cytokines play crucial regulatory roles in bone and joint diseases and can provide novel directions for immunotherapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Xiaofeng Lu, Shaoling Yu, Guangjin Chen, Wenhao Zheng, Jinfeng Peng, Xiaofei Huang, Lili Chen
Summary: Bone-related diseases, including fractures, osteoporosis, osteoarthritis, and periodontitis, have a significant impact on patients' quality of life. Melatonin shows potential in preventing and treating these diseases through inducing anti-inflammatory and antioxidative functions, among other physiological effects.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Binghan Yan, Zhichao Li, Hui Su, Haipeng Xue, Daodi Qiu, Zhanwang Xu, Guoqing Tan
Summary: This review investigates the complex mechanisms by which ncRNAs regulate the autophagic pathway to assist in treating bone metabolism disorders, and discusses the roles of autophagy in bone metabolism disorders and the crosstalk between ncRNAs and autophagy.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Zhiqiang Ye, Yuyu Liu, Jintong Song, Yin Gao, Haiping Fang, Zilong Hu, Min Zhang, Wenwei Liao, Liao Cui, Yanzhi Liu
Summary: Salvia miltiorrhiz, known as Danshen in Chinese medicine, has a long history of application in cardiovascular and cerebrovascular diseases. Recent studies have shown its potential positive effects on bone metabolism, making it a promising candidate for the treatment of musculoskeletal disorders.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Microbiology
Yu Chen, Xin Wang, Chunlei Zhang, Zhiyong Liu, Chao Li, Zhigang Ren
Summary: Gut microbiota plays a crucial role in human health and disease, and dysbiosis in the gut microbiota has been linked to various bone diseases. Recent studies have contributed to our understanding of the relationship between gut microbiota and bone disorders, and offer potential preventive and therapeutic approaches for these conditions.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Cell Biology
Hang Li, Qiyue Zheng, Xinyan Xie, Jiaojiao Wang, Haihong Zhu, Haoye Hu, Hao He, Qiong Lu
Summary: Exosomal non-coding RNAs play a crucial role in the treatment of bone-related diseases by regulating the development of such diseases through intercellular communication among various cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
M. M. Delsmann, A. Strahl, M. Muhlenfeld, N. M. Jandl, F. T. Beil, C. Ries, T. Rolvien
Summary: The study found a high prevalence of low bone mineral density in elderly patients with end-stage osteoarthritis scheduled for total hip arthroplasty. Routine DXA measurements should be considered in these patients to prevent undiagnosed and untreated osteoporosis, which could impact the success of osseointegration and other clinical outcomes.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Orthopedics
Virginia Veronica Visconti, Chiara Greggi, Simona Fittipaldi, Donato Casamassima, Maria Grazia Tallarico, Francesco Romano, Annalisa Botta, Umberto Tarantino
Summary: The study investigated the role of circulating PTX3 as a marker of bone-related phenotypes in patients with osteoporosis (OP) and osteoarthritis (OA). Serum PTX3 levels were significantly elevated in OP and OA patients, showing excellent sensitivity and specificity for diagnosing the diseases. Furthermore, PTX3 levels were positively associated with ALP and PTH levels in OP patients, suggesting its potential use as a predictor for bone-related phenotypes in OP and OA.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Virginia Veronica Visconti, Ida Cariati, Simona Fittipaldi, Riccardo Iundusi, Elena Gasbarra, Umberto Tarantino, Annalisa Botta
Summary: DNA methylation is a crucial epigenetic mechanism in regulating gene expression, and plays an important role in aging-bone diseases such as osteoporosis and osteoarthritis. Recent studies have shown new discoveries on the involvement of DNA methylation in the pathogenesis of these diseases, highlighting the significance of investigating the specific tissues associated with them.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
N. Li, M. Hiligsmann, A. Boonen, M. M. van Oostwaard, R. T. A. L. de Bot, C. E. Wyers, S. P. G. Bours, J. P. van den Bergh
Summary: This systematic review and meta-analysis found that fracture liaison service (FLS) is associated with a significantly lower probability of subsequent fractures and mortality, especially when comparing outcomes before and after the introduction of FLS. However, there are important methodological issues in the currently available studies.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Avishek Chatterjee, Guangyao Wu, Sergey Primakov, Cary Oberije, Henry Woodruff, Pieter Kubben, Ronald Henry, Marcel J. H. Aries, Martijn Beudel, Peter G. Noordzij, Tom Dormans, Niels C. Gritters van den Oever, Joop P. van den Bergh, Caroline E. Wyers, Suat Simsek, Renee Douma, Auke C. Reidinga, Martijn D. de Kruif, Julien Guiot, Anne-Noelle Frix, Renaud Louis, Michel Moutschen, Pierre Lovinfosse, Philippe Lambin
Summary: The study found that age is an important predictor of mortality risk in COVID-19 patients. Comorbidities such as smoking, male gender, hypertension, diabetes, dementia, cancer, chronic obstructive pulmonary disease, chronic cardiac disease, chronic neurological disease, and chronic kidney disease are associated with an increased risk of death. In the external validation set, the age-only model outperformed all other modeling attempts.
Article
Endocrinology & Metabolism
Zohreh Safipour, Rogier van Der Zanden, Joop van den Bergh, Paddy Janssen, Peter Vestergaard, Frank de Vries, Johanna H. M. Driessen
Summary: This study found that the use of oral glucocorticoids in patients with myasthenia gravis did not increase the risk of major osteoporotic fractures based on both a case-control study and pooled analysis. Osteoporosis prevention in myasthenia gravis patients according to clinical guidelines is still recommended.
OSTEOPOROSIS INTERNATIONAL
(2022)
Editorial Material
Endocrinology & Metabolism
W. F. Lems, J. P. van den Bergh, P. P. M. M. Geusens
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Veerle van Hulten, Cindy Sarodnik, Johanna H. M. Driessen, Nicolaas C. Schaper, Piet P. M. M. Geusens, Carol A. B. Webers, Geert-Jan Dinant, Ramon P. G. Ottenheijm, Nicklas H. Rasmussen, Rikke Viggers, Coen D. A. Stehouwer, Carla J. H. van der Kallen, Miranda T. Schram, Sandrine P. G. Bours, Pieter C. Dagnelie, Joop P. van den Bergh
Summary: This study investigated the association between prevalent morphometric vertebral fractures (VFs) and glucose metabolism status in individuals with T2D, prediabetes, and normal glucose metabolism. The results showed that women with T2D had a lower probability of having prevalent VFs compared to women with normal glucose metabolism, while there was no significant association for men with T2D and participants with prediabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Annemarijn Weber, Stephanie M. D. Huysmans, Sander M. J. van Kuijk, Silvia M. A. A. Evers, Elisabeth M. C. Jutten, Rachel Senden, Aggie T. G. Paulus, Joop P. W. van den Bergh, Rob A. de Bie, Johannes M. R. Merk, Sandrine P. G. Bours, Mark Hulsbosch, Esther R. C. Janssen, Inez Curfs, Wouter L. W. van Hemert, Martijn G. M. Schotanus, Paul de Baat, Niek C. Schepel, Willem A. den Boer, Johannes G. E. Hendriks, Wai-Yan Liu, Marinus de Kleuver, Martin H. Pouw, Miranda L. van Hooff, Eva Jacobs, Paul C. P. H. Willems
Summary: This article introduces a randomized controlled trial aimed at evaluating the effectiveness and cost-effectiveness of dynamic bracing in improving the quality of life of patients with osteoporotic vertebral compression fractures. The trial will include 98 postmenopausal women and compare the effects of standard care and dynamic bracing, while assessing multiple outcome measures.
Article
Rheumatology
Piet Geusens, Natasha M. Appelman-Dijkstra, M. Carola Zillikens, Hanna Willems, Willem F. Lems, Joop van den Bergh
Summary: In subjects older than 50 years, the presence of clinical risk factors (CRFs) or recent fractures is crucial for identifying cases. Further evaluation including bone mineral density measurement, imaging of the spine, fall risk assessment, and laboratory examination is needed for patients who are at high short and long-term fracture risk. Treatment options include anti-resorptive and anabolic drugs, and a lifelong strategy is necessary to determine the appropriate therapy. Efforts are needed to improve case finding, raise public awareness, and establish national policies on reimbursement for assessment and therapy.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
(2022)
Article
Orthopedics
Anne M. Daniels, Josephine Kranendonk, Caroline E. Wyers, Heinrich M. J. Janzing, Sander Sassen, Bert van Rietbergen, Piet P. M. M. Geusens, Sjoerd Kaarsemaker, Pascal F. W. Hannemann, Martijn Poeze, Joop P. van den Bergh
Summary: This study evaluated the value of conventional radiographs and clinical reassessment in diagnosing clinically suspected scaphoid fractures. The results showed that both conventional radiographs and clinical reassessment had limited accuracy in diagnosing scaphoid fractures and cannot be considered as directive diagnostic methods.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Article
Endocrinology & Metabolism
Lisanne Vranken, Irma J. A. de Bruin, Annemariek H. M. Driessen, Piet P. M. Geusens, John A. Eisman, Jacqueline R. Center, Robert Y. van der Velde, Heinrich M. J. Janzing, Sjoerd Kaarsemaker, Joop P. van den Bergh, Caroline E. Wyers
Summary: Fracture liaison services (FLS) are effective in preventing secondary fractures. This study evaluated whether FLS care is associated with reduced subsequent fracture and mortality risk over a 3-year follow-up period. The results showed that FLS care was associated with a lower mortality risk and lower subsequent major/hip fracture risk in the first year for patients with a major/hip index fracture, but not for patients with a non-major/non-hip fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Economics
Nannan Li, Annelies Boonen, Joop P. van den Bergh, Sander M. J. van Kuijk, Caroline E. Wyers, Marsha van Oostwaard, Lisanne Vranken, Sandrine P. G. Bours, Mickael Hiligsmann
Summary: The EQ-5D-5L and SF-6D are valid instruments for measuring health-related quality of life in patients with fractures attending the Fracture Liaison Service, but they cannot be used interchangeably due to differences in utilities and only moderate agreement between the instruments.
JOURNAL OF MEDICAL ECONOMICS
(2022)
Article
Biotechnology & Applied Microbiology
Piet Geusens, Natasha Appelman-Dijkstra, Willem Lems, Joop van den Bergh
Summary: Romosozumab is a novel osteoanabolic drug that targets sclerostin and has shown to be superior to antiresorptive agents in increasing bone mineral density, repairing bone microarchitecture, and reducing fracture risk.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2023)
Article
Clinical Neurology
J. J. L. Berkvens, C. E. Wyers, D. Hans, S. Mergler, K. Beerhorst, P. Verschuure, I. Y. Tan, H. J. M. Majoie, J. P. van den Bergh
Summary: This longitudinal study aimed to assess trabecular bone scores (TBS) in institutionalized adults with refractory epilepsy and intellectual disability and study the association between TBS and incident fractures during seven years of follow-up. The results showed a high incidence of fractures and a significant decrease in TBS over the follow-up period, but TBS was not associated with incident fractures.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2022)
Article
Critical Care Medicine
Sophie I. J. van Bakel, Hester A. Gietema, Patricia M. Stassen, Harry R. Gosker, Debbie Gach, Joop P. van den Bergh, Frits H. M. van Osch, Annemie M. W. J. Schols, Rosanne J. H. C. G. Beijers
Summary: This study found that CT scan-derived low pectoralis muscle CSA is significantly associated with higher 30-day in-hospital mortality in patients with COVID-19 independently of the 4C Mortality Score.
Article
Endocrinology & Metabolism
Lieke Maas, Nele Raskin, Marloes van Onna, Dennis Cornelissen, Sandrine Bours, Trudy van der Weijden, Joop P. van den Bergh, Marsha van Oostwaard, Caroline E. Wyers, Mickael Hiligsmann, Annelies Boonen
Summary: This study describes the development of a decision aid to help patients decide whether to start anti-osteoporosis medication. The aid was well-received by patients and healthcare professionals, and could facilitate shared decision-making between patients and healthcare providers.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Sanne Treurniet, Melissa S. A. M. Bevers, Caroline E. E. Wyers, Dimitra Micha, Bernd P. P. Teunissen, Mariet W. W. Elting, Joop P. P. van den Bergh, Elisabeth M. W. Eekhoff
Summary: In this report, a 34-year-old woman with severe osteoporosis and multiple vertebral fractures after her first pregnancy was treated with teriparatide and zoledronic acid. Significant improvements in bone mineral density, microarchitecture, and strength were observed at the hip, spine, and distal radius, but remained severely impaired compared to healthy controls at 40 months postpartum.
CALCIFIED TISSUE INTERNATIONAL
(2023)
