Review
Pharmacology & Pharmacy
Simone N. De Luca, Ross Vlahos
Summary: This review discusses the role of cellular senescence in COPD and its impact on brain conditions, as well as the relationship between cellular senescence and circadian rhythm in COPD. Potential therapies, such as senomorphic and senolytic treatments, are also explored as novel strategies for halting or improving the progression of COPD.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Lorenzo Marinelli, Fabio Lanfranco, Giovanna Motta, Marco Zavattaro
Summary: Erectile dysfunction is a common issue in men with COPD, caused by various factors including hormonal imbalance, smoking, inflammation, endothelial dysfunction, chronic hypoxia, psychiatric disorders, and medications. This can significantly impact the quality of life for COPD patients, but healthcare providers often do not address sexual health concerns due to patients' reluctance to discuss intimate issues.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Respiratory System
Nathaniel M. Hawkins, Sandra Peterson, Allison M. Ezzat, Rohit Vijh, Sean A. Virani, Andrew Gibb, G. B. John Mancini, Sabrina T. Wong
Summary: Cardiovascular risk factors are common in COPD patients, but they are inadequately monitored, treated, and controlled.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Environmental Sciences
Elena Jureviciene, Greta Burneikaite, Laimis Dambrauskas, Vytautas Kasiulevicius, Edita Kazenaite, Rokas Navickas, Roma Puronaite, Giedre Smailyte, Zydrune Visockiene, Edvardas Danila
Summary: Chronic obstructive pulmonary disease (COPD) is often accompanied by other comorbidities, leading to increased burden on healthcare systems and mortality. This study aimed to evaluate the impact of COPD on the occurrence and clustering of comorbidities. Results showed a higher prevalence of cardiovascular diseases, lung cancer, and kidney diseases in patients with COPD, as well as increased odds ratios for lung cancer, heart failure, and cardiovascular diseases. The study also identified different clusters of comorbidities in COPD patients, highlighting the need for adjusted multimorbidity management strategies.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Sang-Jun Lee, Sung-Soo Yoon, Myeong-Hoon Lee, Hye-Jun Kim, Yohwan Lim, Hyewon Park, Sun Jae Park, Seogsong Jeong, Hyun-Wook Han
Summary: This study developed a scoring system for predicting and validating chronic obstructive pulmonary disease (COPD). The scoring system showed significant performance in COPD prediction and had a good effect on the diagnostic ability for cardiovascular disease (CVD) risk.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Respiratory System
Hong Chen, Xiaojia Luo, Yuejun Du, Chenyun He, Yanjun Lu, Zixuan Shi, Jin Zhou
Summary: This study using data from the National Health and Nutrition Examination Survey found that patients with COPD have a higher prevalence of cardiovascular diseases compared with those without COPD. These findings emphasize the importance of cardiovascular disease prevention and management in patients with COPD.
BMC PULMONARY MEDICINE
(2023)
Article
Critical Care Medicine
Katharine M. Lodge, Arlette Vassallo, Bin Liu, Merete Long, Zhen Tong, Paul R. Newby, Danya Agha-Jaffar, Koralia Paschalaki, Clara E. Green, Kylie B. R. Belchamber, Victoria C. Ridger, Robert A. Stockley, Elizabeth Sapey, Charlotte Summers, Andrew S. Cowburn, Edwin R. Chilvers, Wei Li, Alison M. Condliffe
Summary: Patients with chronic obstructive pulmonary disease (COPD) have a high incidence and mortality rate of cardiovascular diseases, and exacerbations further increase the risk. Hypoxia drives the release of neutrophil elastase, leading to tissue injury. This study found that under hypoxic conditions, COPD neutrophils release more elastase and cause damage to pulmonary endothelial cells, as well as increased adherence to endothelial cells. Plasma from COPD patients also showed higher levels of hypoxia-upregulated neutrophil-derived proteins and protease activity, indicating vascular injury.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Nursing
Allison R. Webel, Julie Schexnayder, Patricia A. Cioe, Julie A. Zuniga
Summary: People living with HIV are living longer and facing an increased risk for chronic comorbidities as they age. This review focuses on prevalent chronic conditions and behavioral risk factors common in people living with HIV, providing evidence-based information on epidemiology, prevention, screening, and treatment options across resource settings.
JANAC-JOURNAL OF THE ASSOCIATION OF NURSES IN AIDS CARE
(2021)
Review
Medicine, General & Internal
Tullika Garg, Courtney A. Polenick, Nancy Schoenborn, Jane Jih, Alexandra Hajduk, Melissa Y. Wei, Jaime Hughes
Summary: MCC patients require complex and poorly coordinated care, calling for innovative research methods and strategies. To address their unique needs, research should focus on increasing trial validity, studying MCC epidemiology, engaging clinicians, communities, and patients, and addressing health equity to eliminate disparities.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dermatology
Abdullah Demirbas, Yusuf Yumer, Omer Faruk Elmas, Gozde Ulutas Demirbas, Mustafa Atasoy, Umit Tursen, Recep Dursun, Torello Lotti
Summary: The study showed that patients with rosacea may have impaired respiratory function compared to healthy individuals, with disease severity being associated with worse respiratory functions. Forced expiratory volume in one second (FEV 1%), FEV 1/FVC ratio, and forced expiratory flow at 25-75% of FVC (FEF 25-75%) were found to be more useful in differentiating patients from healthy subjects.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Cell Biology
Shanshan Chen, Yuan Zhan, Jinkun Chen, Jixing Wu, Yiya Gu, Qian Huang, Zhesong Deng, Xiaojie Wu, Yongman Lv, Jungang Xie
Summary: This study identified and validated potential aging-related genes in chronic obstructive pulmonary disease (COPD) through bioinformatics analysis and experimental validation. The results showed that these genes actively participate in COPD-related biological processes and functional pathways, and some of them were up-regulated in the lung tissues of aged COPD patients and associated with decreased lung function.
Review
Medicine, General & Internal
Ianthe Piscaer, Rob Janssen, Frits M. E. Franssen, Leon J. Schurgers, Emiel F. M. Wouters
Summary: Patients with chronic obstructive pulmonary disease (COPD) often have multiple co-occurring conditions and systemic manifestations. Vitamin A, vitamin D, and vitamin K are all potentially involved in COPD pathogenesis. In this review, the potential role of vitamin K in the systemic manifestations of COPD is discussed, including its effects on prevalent co-occurring chronic conditions such as cardiovascular disorders, chronic kidney disease, osteoporosis, and sarcopenia. Recommendations for future clinical studies are also provided.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Fu-Shun Yen, James Cheng-Chung Wei, Lu-Ting Chiu, Chih-Cheng Hsu, Chii-Min Hwu
Summary: In patients with both type 2 diabetes mellitus and chronic obstructive pulmonary disease, the use of metformin is associated with a lower risk of cardiovascular disease, and the longer the duration of metformin use, the lower the risk. Further prospective studies are needed to verify these findings.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Respiratory System
Jamuna K. Krishnan, Mangala Rajan, Samprit Banerjee, Sonal G. Mallya, MeiLan K. Han, David M. Mannino, Fernando J. Martinez, Monika M. Safford
Summary: This study examined mortality differences in patients with chronic obstructive pulmonary disease (COPD) and the impact of race and sex. The results showed that there were no differences in all-cause mortality among different races and sexes. However, black women with COPD had a higher risk of cardiovascular disease-related mortality.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Review
Pharmacology & Pharmacy
Marija Gredic, Isabel Blanco, Gabor Kovacs, Zsuzsanna Helyes, Peter Ferdinandy, Horst Olschewski, Joan Albert Barbera, Norbert Weissmann
Summary: This article summarizes the pathophysiology and treatment options for PH in COPD patients, pointing out that current research still does not fully understand its underlying mechanisms, and some of the treatment methods tested in clinical settings have not been effective. Preclinical studies have proposed some treatment approaches.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)