CDK5 Inhibition Abrogates TNBC Stem‐Cell Property and Enhances Anti‐PD‐1 Therapy

Cancer Stem Cells: The Architects of the Tumor Ecosystem

(2019) Briana C. Prager et al.   Cell Stem Cell

CD44 splice isoform switching determines breast cancer stem cell state

(2019) Honghong Zhang et al.   GENES & DEVELOPMENT

Low CD8+ T Cell Infiltration and High PD-L1 Expression Are Associated with Level of CD44+/CD133+ Cancer Stem Cells and Predict an Unfavorable Prognosis in Pancreatic Cancer

(2019) Ya-Chin Hou et al.   Cancers

Osteoprotegerin Promotes Liver Steatosis by Targeting the ERK-PPARγ-CD36 Pathway

(2019) Cheng Zhang et al.   DIABETES

Differential recruitment of CD44 isoforms by ErbB ligands reveals an involvement of CD44 in breast cancer

(2018) Iris Morath et al.   ONCOGENE

CDK5 Inhibition Resolves PKA/cAMP-Independent Activation of CREB1 Signaling in Glioma Stem Cells

(2018) Subhas Mukherjee et al.   Cell Reports

CDK4/6 inhibition triggers anti-tumour immunity

(2017) Shom Goel et al.   NATURE

Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function

(2017) Naoe T. Nihira et al.   Science Signaling

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1 -mutated breast cancer

(2017) Emma Nolan et al.   Science Translational Medicine

A CD44v+ subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity

(2017) Jing Hu et al.   Cell Death & Disease

Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs

(2017) Zhiyuan Niu et al.   Nature Communications

Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function

(2017) Naoe T. Nihira et al.   Science Signaling

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

(2016) Willy Hugo et al.   CELL

Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: a randomised, phase 2 cohort of the open-label KEYNOTE-021 study

(2016) Corey J Langer et al.   LANCET ONCOLOGY

Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

(2016) Olivier De Henau et al.   NATURE

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

(2016) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma

(2016) Paul T. Nghiem et al.   NEW ENGLAND JOURNAL OF MEDICINE

AC1MMYR2 impairs high dose paclitaxel-induced tumor metastasis by targeting miR-21/CDK5 axis

(2015) Yu Ren et al.   CANCER LETTERS

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients

(2015) Sara Chiker et al.   CELL CYCLE

Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer

(2015) Michael D. Brooks et al.   Cell Stem Cell

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration–proliferation dichotomy

(2015) Deepali Bhandari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Therapies for Triple-Negative Breast Cancer: Combating a Stubborn Disease

(2015) Murugan Kalimutho et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Concise Review: Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic Target

(2015) Yongmin Yan et al.   Stem Cells Translational Medicine

CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis

(2014) Matilde Todaro et al.   Cell Stem Cell

Identification of Prognosis-Relevant Subgroups in Patients with Chemoresistant Triple-Negative Breast Cancer

(2013) K.-D. Yu et al.   CLINICAL CANCER RESEARCH

Immunotherapy Exposes Cancer Stem Cell Resistance and a New Synthetic Lethality

(2013) Laszlo Radvanyi   MOLECULAR THERAPY

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression

(2013) Qian Liang et al.   Scientific Reports

EMT and MET in Metastasis: Where Are the Cancer Stem Cells?

(2012) Thomas Brabletz   CANCER CELL

CD44s Regulates the TGF- -Mediated Mesenchymal Phenotype and Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma

(2012) K. Mima et al.   CANCER RESEARCH

PPARγ is an E3 ligase that induces the degradation of NFκB/p65

(2012) Yongzhong Hou et al.   Nature Communications

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell

(2012) Toshifumi Yae et al.   Nature Communications

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

(2011) Takatsugu Ishimoto et al.   CANCER CELL

Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms

(2011) P de Bie et al.   CELL DEATH AND DIFFERENTIATION

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

(2011) Jang Hyun Choi et al.   NATURE

Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced malignancies

(2010) Christophe Le Tourneau et al.   EUROPEAN JOURNAL OF CANCER

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

A CD44v6 peptide reveals a role of CD44 in VEGFR-2 signaling and angiogenesis

(2009) M. Tremmel et al.   BLOOD

Delivery of CD44 shRNA/Nanoparticles within Cancer Cells

(2009) Suniti Misra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

(2009) C. J. Creighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FireDock: a web server for fast interaction refinement in molecular docking

(2008) E. Mashiach et al.   NUCLEIC ACIDS RESEARCH