Review
Materials Science, Multidisciplinary
Zhuo Li, Shan Lu, Xingjun Li, Zhuo Chen, Xueyuan Chen
Summary: The growing crisis of antibiotic resistance is driving the need for advanced and sustainable antibacterial strategies. Lanthanide-doped upconversion nanoparticles (UCNPs) with unique photophysical properties have been innovatively explored for bacterial detection and therapy, showing promise in addressing challenges in the post-antibiotic era. This review highlights the interface engineering for bacteria-targeted UCNP nanoplatforms, discusses the principles and advantages of various upconversion detection strategies, and summarizes the latest progress in UCNP-based antibacterial applications, particularly in deep-tissue infection imaging and therapy. Concerns and future efforts for practical applications are also addressed in this review.
ADVANCED OPTICAL MATERIALS
(2023)
Review
Optics
Kaimin Du, Jing Feng, Xuan Gao, Hongjie Zhang
Summary: This review summarizes the diverse designs and synthesis strategies of UCNPs-based nanocomposites, and discusses their potential applications and development trends.
LIGHT-SCIENCE & APPLICATIONS
(2022)
Article
Chemistry, Physical
Jincheng Nie, Qiyue Shao, Shijie Yu, Meiling Shi, Yan Dong, Jianqing Jiang
Summary: Comparative studies on temperature-dependent luminescence properties of Yb3+- and Nd3+-sensitized active-core/active-shell UCNCs reveal opposite luminescent thermal behaviors, which are elucidated with the assistance of temperature-dependent spectral analysis. Highly secure anti-counterfeiting patterns are demonstrated using nanohybrids of Yb3+- and Nd3+-sensitized core/shell UCNCs based on their opposite luminescent thermal behaviors. This work provides new insights into luminescent thermal behaviors and energy loss pathways of lanthanide-doped UCNCs.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Applied
Solomon Tiruneh Dibaba, Yao Xie, Wensong Xi, Artur Bednarkiewicz, Wei Ren, Lining Sun
Summary: This study developed a new nanotheranostic agent that enables dual modal imaging and photothermal therapy. By synthesizing core-shell-shell upconversion nanoparticles and coating them with an antimony shell, the researchers achieved good biocompatibility and photothermal therapeutic effect. The nanotheranostic agent showed efficient upconversion luminescence imaging under 808 nm laser irradiation and demonstrated potential for magnetic resonance imaging.
JOURNAL OF RARE EARTHS
(2022)
Article
Chemistry, Multidisciplinary
Yameng Li, Yingjie Ding, Yifan Zhang, Zhiyue Sun, Jiao Liu, Mengxia Dai, Jiayi Feng, Bin Li, Chaozhan Wang, Yinmao Wei, Ji-Wei Shen
Summary: In this study, a novel nanomaterial UCFS@Fe-TA was developed for simultaneous photodynamic therapy (PDT), photothermal therapy (PTT), and chemodynamic therapy (CDT) triggered by single 808 nm laser. The nanomaterial exhibited intense red emission and faster generation of reactive oxygen species at higher temperatures, resulting in efficient tumor suppression.
Article
Nanoscience & Nanotechnology
Zhongzheng Yu, Chang-Keun Lim, Wen Kiat Chan, Yu Chen, Wei Shao, Yan Zhang, Paras N. Prasad, Timothy Thatt Yang Tan
Summary: A novel approach utilizing UCNPs nanoformulation containing ICG to detect water content in organic solvents via turn-on or turn-off fluorescence process with high sensitivity at the ppm level has been reported. This method provides a guide for designing fluorescent nanosensors for water detection in organic solvents and deepens understanding of energy transfer processes in the system.
ACS APPLIED NANO MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Simona Premcheska, Mirijam Lederer, Anna M. Kaczmarek
Summary: Theranostics combines diagnostics and therapy in a single multifunctional system. Multifunctional upconversion luminescent lanthanide-doped nanothermometers offer non-invasive and sensitive multimodal performance in the biomedical field, enabling applications in (bio)imaging, temperature sensing, photodynamic and photothermal therapy, as well as drug delivery.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Jun Du, Jinliang Liu, Ying Chen, Yuefeng Zhao, Yuhao Li, Yuqing Miao
Summary: A fast and facile preparation strategy for bismuth-based upconversion nanomaterials has been reported, which improves the crystallinity and upconversion luminescence intensity. The temperature measurement range has also been extended by optimizing the doping ratio and adjusting the synthetic solvent strategy. This method provides a feasible strategy for the construction of novel fluorescent temperature probes.
Article
Chemistry, Multidisciplinary
Yaoxuan Chen, Rupeng Zhao, Lele Li, Yuliang Zhao
Summary: This study develops a near-infrared light-controlled DNAzyme delivery platform, which enhances the gene-silencing efficacy by improving the endosomal escape capability. The nanoplatform integrates DNAzyme-based gene therapy with NIR light-triggered photodynamic therapy for combinational tumor treatment.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Mengliang Zhu, Hang Zhang, Guangliu Ran, Daniel N. Mangel, Yuhang Yao, Ruijing Zhang, Jiao Tan, Wenkai Zhang, JianXin Song, Jonathan L. Sessler, Jun-Long Zhang
Summary: The study introduces a metal selection approach for fine-tuning the excited state properties and functional features of phototheranostics. Results suggest that the Yb complex designed in the study shows potential for in vivo use in photoacoustic imaging and photothermal/photodynamic therapy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Gibum Lee, Wonseok Choi, Chulhong Kim, Sei Kwang Hahn, Jung Ho Lee
Summary: Researchers have developed a hyaluronate-BP-upconversion nanoparticle (HA-BP-UCNP) complex for non-invasive multimodal therapy of skin cancer using near-infrared light for photoacoustic imaging, photodynamic therapy, and photothermal therapy.
Article
Chemistry, Multidisciplinary
Minfeng Huo, Peilei Liu, Linlin Zhang, Chenyang Wei, Liying Wang, Yu Chen, Jianlin Shi
Summary: The near infrared-driven PDT platform based on photosynthetic cyanobacterial cells hybridized with photosensitizer rose bengal (RB)-loaded upconversion nanoparticles, named as UR-Cyan cells, offers enhanced and sustainable PDT efficacy against tumor cells/tissues by promoting both oxygen production and singlet oxygen generation. This design provides a practical approach to overcome the hypoxic burden of PDT operations with excellent biocompatibility and clinical promises.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Dandan Zhou, Yun Gao, Zhe Yang, Ning Wang, Jianxian Ge, Xiaoyi Cao, Dandan Kou, Yuan Gu, Cang Li, Mohammad Javad Afshari, Ruru Zhang, Can Chen, Ling Wen, Shuwang Wu, Jianfeng Zeng, Mingyuan Gao
Summary: To overcome the drawbacks of monomodal strategies, a combination therapy using lanthanide-doped upconversion nanoparticles (UCNPs) integrated with chlorin e6 (Ce6)-imbedded RBC membrane vesicles as a near-infrared-induced photodynamic therapy (PDT) agent is developed. The nanoagent not only acts as a light transductor for PDT but also as a radiosensitizer for enhanced low-dose radiotherapy (RT). The combination of PDT and RT shows potential for synergistic tumor growth inhibition and cancer metastasis arrest.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Xinyue Song, Fengyan Li, Feng Tian, Linlin Ren, Qi Wang, Chengfang Jiang, Tao Yan, Shusheng Zhang
Summary: Researchers developed an upconversion nanoparticle-based optogenetic nanosystem for enhanced photodynamic therapy and cascade gene therapy. Genetically-encoded photosensitizers were localized in mitochondria and activated by upconversion nanoprobe to generate reactive oxygen species, controlling the release of siRNA and inducing cancer cell apoptosis.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Electrical & Electronic
P. P. Mokoena, D. O. Oluwole, T. Nyokong, H. C. Swart, O. M. Ntwaeaborwa
Summary: Er3+-Yb3+ co-doped Ba-5(PO4)(3)OH nanoparticle powder phosphors were successfully synthesized by urea combustion method, showing considerable photodynamic therapy activity and upconverted red emission due to non-radiative energy transfer from Yb3+ to Er3+ in the proposed mechanism of upconversion photoluminescence.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)