Inhibition of JNK-Mediated Autophagy Promotes Proscillaridin A- Induced Apoptosis via ROS Generation, Intracellular Ca+2 Oscillation and Inhibiting STAT3 Signaling in Breast Cancer Cells

Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells

(2019) Xihong Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Phytochemicals as potent modulators of autophagy for cancer therapy

(2018) Mohammad Amin Moosavi et al.   CANCER LETTERS

Patulin induced ROS-dependent autophagic cell death in Human Hepatoma G2 cells

(2018) Guang Yang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Proscillaridin A induces apoptosis, inhibits STAT3 activation and augments doxorubicin toxicity in prostate cancer cells

(2018) Yangyang He et al.   International Journal of Medical Sciences

Breast cancer amelioration by Butea monosperma in-vitro and in-vivo

(2018) Prachi Karia et al.   JOURNAL OF ETHNOPHARMACOLOGY

Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells

(2018) Amara Maryam et al.   Oxidative Medicine and Cellular Longevity

Proscillaridin A induces apoptosis and suppresses non-small-cell lung cancer tumor growth via calcium-induced DR4 upregulation

(2018) Run-Ze Li et al.   Cell Death & Disease

3′-epi-12β-hydroxyfroside, a new cardenolide, induces cytoprotective autophagy via blocking the Hsp90/Akt/mTOR axis in lung cancer cells

(2018) Yan Sun et al.   Theranostics

Metformin inhibits human breast cancer cell growth by promoting apoptosis via a ROS-independent pathway involving mitochondrial dysfunction: pivotal role of superoxide dismutase (SOD)

(2018) Prateek Sharma et al.   CELLULAR ONCOLOGY

Ergosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells

(2018) Han-Ying Wu et al.   Scientific Reports

Inhibition of Autophagy Promotes Salinomycin-Induced Apoptosis via Reactive Oxygen Species-Mediated PI3K/AKT/mTOR and ERK/p38 MAPK-Dependent Signaling in Human Prostate Cancer Cells

(2017) Kwang-Youn Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular heterogeneity in breast cancer: State of the science and implications for patient care

(2017) Rachel E. Ellsworth et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells

(2017) Zhen Ren et al.   TOXICOLOGY

Intracellular Ca2+ homeostasis and JAK1/STAT3 pathway are involved in the protective effect of propofol on BV2 microglia against hypoxia-induced inflammation and apoptosis

(2017) Yan Lu et al.   PLoS One

Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress

(2017) Amara Maryam et al.   Scientific Reports

Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model

(2016) Jingwen Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Melatonin promotes ATO-induced apoptosis in MCF-7 cells: Proposing novel therapeutic potential for breast cancer

(2016) Elaheh Nooshinfar et al.   BIOMEDICINE & PHARMACOTHERAPY

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cyclosporine A sensitizes human non-small cell lung cancer cells to gefitinib through inhibition of STAT3

(2016) Jiawei Shou et al.   CANCER LETTERS

Inhibition of mitogen-activated protein kinase signaling pathway sensitizes breast cancer cells to endoplasmic reticulum stress-induced apoptosis

(2016) FEN YANG et al.   ONCOLOGY REPORTS

Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells

(2015) Jaemoo Chun et al.   CANCER LETTERS

Role of p38MAPK in apoptosis and autophagy responses to photodynamic therapy with Chlorin e6

(2015) Qin Xue et al.   Photodiagnosis and Photodynamic Therapy

Outcome disparities in African American women with triple negative breast cancer: a comparison of epidemiological and molecular factors between African American and Caucasian women with triple negative breast cancer

(2014) Lori A Sturtz et al.   BMC CANCER

Evaluating the Cancer Therapeutic Potential of Cardiac Glycosides

(2014) José Manuel Calderón-Montaño et al.   Biomed Research International

Blocking autophagy enhances the apoptosis effect of bufalin on human hepatocellular carcinoma cells through endoplasmic reticulum stress and JNK activation

(2013) Fengli Hu et al.   APOPTOSIS

p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

(2013) Xinbing Sui et al.   CANCER LETTERS

The Role of Calcium Stores in Apoptosis and Autophagy

(2013) S. Smaili et al.   CURRENT MOLECULAR MEDICINE

Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials

(2013) M. Slingerland et al.   INVESTIGATIONAL NEW DRUGS

Syndecan Binding Protein (SDCBP) Is Overexpressed in Estrogen Receptor Negative Breast Cancers, and Is a Potential Promoter for Tumor Proliferation

(2013) Xiao-Long Qian et al.   PLoS One

Cancer treatment and survivorship statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Impact of Breast Cancer Subtypes and Treatment on Survival: An Analysis Spanning Two Decades

(2012) R. Haque et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Cardiac glycosides induce autophagy in human non-small cell lung cancer cells through regulation of dual signaling pathways

(2012) Yan Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Effective Killing of Leukemia Cells by the Natural Product OSW-1 through Disruption of Cellular Calcium Homeostasis

(2012) Celia Garcia-Prieto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperative action of JNK and AKT/mTOR in 1-methyl-4-phenylpyridinium-induced autophagy of neuronal PC12 cells

(2012) Jezabel Rodríguez-Blanco et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis

(2011) Ying-Hong Shi et al.   Autophagy

Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation

(2010) Chew Hooi Wong et al.   PLoS One

Inhibition of MEK sensitizes paclitaxel-induced apoptosis of human colorectal cancer cells by downregulation of GRP78

(2009) Nizar M. Mhaidat et al.   ANTI-CANCER DRUGS

Antiproliferative Activity of Derivatives of Ouabain, Digoxin and Proscillaridin A in Human MCF-7 and MDA-MB-231 Breast Cancer Cells

(2008) Katarzyna Winnicka et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Novel therapeutic applications of cardiac glycosides

(2008) Ioannis Prassas et al.   NATURE REVIEWS DRUG DISCOVERY