Veratrilla baillonii Franch Could Alleviate Lipid Accumulation in LO2 Cells by Regulating Oxidative, Inflammatory, and Lipid Metabolic Signaling Pathways

Hit Dexter 2.0: Machine-Learning Models for the Prediction of Frequent Hitters

(2019) Conrad Stork et al.   Journal of Chemical Information and Modeling

Ursodeoxycholic acid ameliorates hepatic lipid metabolism in LO2 cells by regulating the AKT/mTOR/SREBP-1 signaling pathway

(2019) Jie Hu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Effects of Veratrilla baillonii Extract on Hepatic Gene Expression Profiles in Response to Aconitum brachypodum-Induced Liver Toxicity in Mice

(2019) Jun Li et al.   Frontiers in Pharmacology

A combined molecular biology and network pharmacology approach to investigate the multi-target mechanisms of Chaihu Shugan San on Alzheimer’s disease

(2019) Qiang Zeng et al.   BIOMEDICINE & PHARMACOTHERAPY

Alpinetin improved high fat diet-induced non-alcoholic fatty liver disease (NAFLD) through improving oxidative stress, inflammatory response and lipid metabolism

(2018) Yong Zhou et al.   BIOMEDICINE & PHARMACOTHERAPY

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

(2018) David Højland Ipsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Network Pharmacology: Exploring the Resources and Methodologies

(2018) Junaid Muhammd et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Serum metabonomics study of the hepatoprotective effect of amarogentin on CCl 4 -induced liver fibrosis in mice by GC-TOF-MS analysis

(2018) Ya Zhang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Inhibition of ghrelin o-acyltransferase attenuated lipotoxicity by inducing autophagy via AMPK–mTOR pathway

(2018) Shaoren Zhang et al.   Drug Design Development and Therapy

Hepatoprotective activity of iridoids, seco-iridoids and analog glycosides from Gentianaceae on HepG2 cells via CYP3A4 induction and mitochondrial pathway

(2018) Kang Dai et al.   Food & Function

A nonalcoholic fatty liver disease model in human induced pluripotent stem cell-derived hepatocytes, created by endoplasmic reticulum stress-induced steatosis

(2018) Maddalena Parafati et al.   Disease Models & Mechanisms

Uncovering the mechanism of Maxing Ganshi Decoction on asthma from a systematic perspective: A network pharmacology study

(2018) Wenjie Song et al.   Scientific Reports

Clinical epidemiology and disease burden of nonalcoholic fatty liver disease

(2017) Brandon J Perumpail et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Gentiopicroside and sweroside from Veratrilla baillonii Franch. induce phosphorylation of Akt and suppress Pck1 expression in hepatoma cells

(2016) Xian-Ju Huang et al.   Biochemistry and Cell Biology

Global epidemiology of nonalcoholic fatty liver disease: Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) A. Lonardo et al.   HEPATOLOGY

The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Antitoxic effect of Veratrilla baillonii on the acute toxicity in mice induced by Aconitum brachypodum , one of the genus Aconitum

(2016) Yue-Bin Ge et al.   JOURNAL OF ETHNOPHARMACOLOGY

Lipid phenotypes in patients with nonalcoholic fatty liver disease

(2016) Tingting Du et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The water extract of Veratrilla baillonii could attenuate the subacute toxicity induced by Aconitum brachypodum

(2016) You Yu et al.   PHYTOMEDICINE

Ghrelin Attenuated Lipotoxicity via Autophagy Induction and Nuclear Factor-κB Inhibition

(2015) Yuqing Mao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Systems Pharmacology Dissecting Holistic Medicine for Treatment of Complex Diseases: An Example Using Cardiocerebrovascular Diseases Treated by TCM

(2015) Yonghua Wang et al.   Evidence-based Complementary and Alternative Medicine

The anti-inflammatory secoiridoid glycosides from Gentianae Scabrae Radix: the root and rhizome of Gentiana scabra

(2015) Yu-Min He et al.   Journal of Natural Medicines

Iridoids and Flavonoids of Four Siberian Gentians: Chemical Profile and Gastric Stimulatory Effect

(2015) Daniil Olennikov et al.   MOLECULES

CYP2J2 overexpression ameliorates hyperlipidemia via increased fatty acid oxidation mediated by the AMPK pathway

(2015) Shasha Zhang et al.   Obesity

A Systems Biology-Based Approach to Uncovering the Molecular Mechanisms Underlying the Effects of Dragon's Blood Tablet in Colitis, Involving the Integration of Chemical Analysis, ADME Prediction, and Network Pharmacology

(2014) Haiyu Xu et al.   PLoS One

A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment: Predicting Potential New Drugs and Targets

(2013) Jianling Liu et al.   Evidence-based Complementary and Alternative Medicine

Amelioration by chicory seed extract of diabetes- and oleic acid-induced non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) via modulation of PPARα and SREBP-1

(2013) Nasrin Ziamajidi et al.   FOOD AND CHEMICAL TOXICOLOGY

Multiple Hits, Including Oxidative Stress, as Pathogenesis and Treatment Target in Non-Alcoholic Steatohepatitis (NASH)

(2013) Akinobu Takaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In Vitro and in Vivo Models of Non-Alcoholic Fatty Liver Disease (NAFLD)

(2013) Giridhar Kanuri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comprehensive Analysis of Genes Expressed by Rare Microchimeric Fetal Cells in the Maternal Mouse Lung1

(2012) Stephanie Pritchard et al.   BIOLOGY OF REPRODUCTION

Herbacetin induces apoptosis in HepG2 cells: Involvements of ROS and PI3K/Akt pathway

(2012) Yan Qiao et al.   FOOD AND CHEMICAL TOXICOLOGY

In Vitro Models for the Study of Non-Alcoholic Fatty Liver Disease

(2011) N. C. Chavez-Tapia et al.   CURRENT MEDICINAL CHEMISTRY

Anti-apoptotic activity of gentiopicroside in d-galactosamine/lipopolysaccharide-induced murine fulminant hepatic failure

(2010) Li-Hua Lian et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of nonalcoholic fatty liver disease

(2009) Elango Kathirvel et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats

(2009) Hitesh Vaidya et al.   Journal of Natural Medicines

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology