Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 40, Issue -, Pages 1-6Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2016.01.010
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Funding
- Australian National University
- Australian Research Council [DP150102883]
- US National Institutes of Health [AI44375]
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Due to the diverse roles T cells play in protection against malaria as well as pathogenesis it is critical to know which cells present antigen and the nature of the antigens they present. During pre-erythrocytic stages of infection, cutting-edge imaging studies have shown how Plasmodium antigens are presented during both the priming and effector phases of the protective CD8+ T cell response. During blood stages, pathology is in part due to the loss of DC function and the action of pathogenic T cells in the brain. Recently endothelial cells presenting malaria antigen to cognate T cells have emerged as critical players in malaria pathogenesis. Manipulating these processes may inform both vaccine design and the development of therapies for cerebral malaria.
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