Review
Immunology
Takumi Kawasaki, Moe Ikegawa, Taro Kawai
Summary: The lungs have an immune defense mechanism that uses various cells to eliminate harmful pathogens and activate T cell immune response. In addition to immune cells, other lung cells also participate in antigen presentation and T cell activation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Ryosuke Tashiro, Kuniyasu Niizuma, Jun Kasamatsu, Yuko Okuyama, Sherif Rashad, Atsuo Kikuchi, Miki Fujimura, Shigeo Kure, Naoto Ishii, Teiji Tominaga
Summary: The study found that RNF213 plays a critical role in antigen uptake, processing, and presentation, with Rnf213-KO and Rnf213-KI mice experiments showing that RNF213 deficiency leads to decreased antigen uptake and processing capabilities, resulting in the inability to effectively activate antigen-specific T cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Takuya Sakamoto, Terutsugu Koya, Misa Togi, Kenichi Yoshida, Tomohisa Kato, Yasuhito Ishigaki, Shigetaka Shimodaira
Summary: This study evaluated the function and preclinical validation of human dendritic cell (DC) dexosomes, small DC-secreted vesicles that contain immune signals, for cancer vaccination. The researchers characterized a potential dexosome model using immature and mature DCs derived from a cell line called MUTZ3, and found that one type of MUTZ3-derived DC dexosomes exhibited potential immunogenicity and higher antigen presentation potency, making them potential resources for cancer immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jie Zhang, Biao Fan, Guoliang Cao, Wenping Huang, Fuhao Jia, Guangjun Nie, Hai Wang
Summary: This study developed a personalized DC-mimicking nanovaccine for stimulating TAAs-specific T cell populations. By inducing BMDCs maturation and delivering TAAs through nanostructures, the nanoDCs efficiently generated potent antigen-specific T cell responses, leading to inhibition of tumor growth and metastases formation.
ADVANCED MATERIALS
(2022)
Review
Immunology
Christian Moebs, Martin Salheiser, Fabian Bleise, Marie Witt, Johannes U. Mayer
Summary: This review aims to highlight the role of basophils in antigen presentation and T cell priming, as well as resolving the debate on whether basophils influence antigen presentation through direct or indirect mechanisms. Tissue-specific differences in basophil phenotypes and their interactions with other antigen-presenting cells will be discussed, along with their implications on immunological and clinical outcomes of disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hejin Jiang, Rui Liu, Lu Wang, Xinyue Wang, Mengmeng Zhang, Sisi Lin, Zhenping Cao, Feng Wu, Yingbin Liu, Jinyao Liu
Summary: Chirality plays a critical role in biological systems, and this study demonstrates the potential of using supramolecular chiral polymer micelles (SCPMs) to activate the immune system for disease prevention and treatment.
ADVANCED MATERIALS
(2023)
Review
Immunology
Jiri Brezina, Matous Voboril, Dominik Filipp
Summary: The evolution of the adaptive immune system leads to the generation of self-reactive clones, which must be eliminated to prevent autoimmunity. This process occurs in the thymic medulla, where the interaction between T cell receptor and self-peptide MHC complexes determines the fate of thymocytes. Thymic antigen presenting cells, including medullary thymic epithelial cells and dendritic cells, play a fundamental role in presenting self-antigens in the thymus for the establishment of T cell central tolerance. Recent studies have revealed the heterogeneity of these cell subsets and their roles in T cell selection processes, adding complexity to our understanding. Identification of molecular determinants controlling the presentation of self-antigens would advance our knowledge in this area.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Tim B. Fessenden, Lauren E. Stopfer, Fiona Chatterjee, Julian Zulueta, Josh Mesfin, Therese Cordero Dumit, Irene Reijers, Esmee P. Hoefsmit, Christian Blank, Forest White, Stefani Spranger
Summary: Cytotoxic CD8(+) T cells must recognize tumor-derived antigens to achieve effective tumor elimination. Our study shows that dendritic cells induce cytotoxic CD8(+) T-cell responses by cross-presenting tumor-derived peptides, and the proportion of membrane-derived neoantigens is associated with reduced survival and treatment response.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Mirela Kremenovic, Alfred A. Chan, Bing Feng, Lukas Baeriswyl, Steve Robatel, Thomas Gruber, Li Tang, Delphine J. Lee, Mirjam Schenk
Summary: In this study, a novel BCG lysate was developed and formulated into a thermosensitive hydrogel. The BCG lysate exhibited enhanced antitumor efficacy and promoted a proinflammatory tumor microenvironment in vivo. The underlying mechanisms of BCG lysate-mediated tumor immunity relied on macrophages (M phi) and dendritic cells (DCs). The BCG hydrogel treatment induced systemic immunity, suppressed lung metastases, and improved survival in melanoma-bearing mice. Furthermore, BCG hydrogel treatment enhanced antigen processing and presentation, and increased the frequency of melanoma-reactive CD8(+) T cells. In human melanoma patients, intralesional-BCG treatment was associated with enhanced M1 M phi, mature DCs, antigen processing and presentation, and increased patient survival.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Ray A. Ohara, Kenneth M. Murphy
Summary: Cross-priming, initially recognized in cytotoxic T lymphocyte (CTL) responses, involves the presentation of minor histocompatibility antigens by antigen presenting cells (APCs) derived from immunizing cells. As understanding of T cell receptor antigen recognition progressed, cross-priming was redefined as cross-presentation and expanded to include different forms of antigens and APCs not involved in in vivo CTL priming. In vitro cell models have been utilized for studying cross-presentation, but recent studies have shown differences between these models and in vivo APCs. Current research focuses on validating in vivo pathways and gene candidates for cross-presentation, and evaluating their contributions to CTL responses across different antigens and immunologic settings.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Jinyu Wang, Michela Manni, Anne Baerenwaldt, Ronja Wieboldt, Nicole Kirchhammer, Robert Ivanek, Michal Stanczak, Alfred Zippelius, David Koenig, Natalia Rodrigues Manutano, Heinz Laeubli
Summary: Interactions between sialylated glycans and Siglec receptors have been identified as a potential new immune checkpoint to improve anticancer immunity. In this study, it was found that cancer-associated dendritic cells (DCs) have a high expression of inhibitory Siglecs, which can impair their maturation states. Furthermore, removing these inhibitory Siglecs from DCs enhances their capability to prime antigen-specific T cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Christophe Macri, Devi Jenika, Cassandra Ouslinis, Justine D. Mintern
Summary: Dendritic cells (DCs) are specialized antigen-presenting cells that play a critical role in adaptive immunity. Targeting antigen directly to DCs is a selective vaccination strategy that takes advantage of the antigen uptake and presentation functions of DC subsets. This review focuses on DC-targeted vaccination strategies aimed at inducing effective cross-presentation for CD8+ T cell immunity. Receptors highly expressed by mouse and human cDCs, such as DEC205, Clec9A, and XCR1, are explored. The outcomes of DC-targeted vaccination in mouse models and human clinical trials are discussed, highlighting its potential for the prevention and treatment of tumors and infectious diseases.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Immunology
Tuo Zhang, Guodong Lian, Wei Fang, Lei Tian, Wenhao Ma, Jicheng Zhang, Zhaoli Meng, Hongna Yang, Chunting Wang, Chengguo Wei, Man Chen
Summary: This study conducted a comprehensive analysis of antigen-presenting cells in human sepsis, revealing novel disease-associated anergic DC subtypes. These findings provide new insights into the cellular mechanisms of immune dysregulation in bacterial sepsis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Payton L. Marshall, Nadine Nagy, Gernot Kaber, Graham L. Barlow, Amrit Ramesh, Bryan J. Xie, Miles H. Linde, Naomi L. Haddock, Colin A. Lester, Quynh-Lam Tran, Christiaan R. de Vries, Aviv Hargil, Andrey V. Malkovskiy, Irina Gurevich, Hunter A. Martinez, Hedwich F. Kuipers, Koshika Yadava, Xiangyue Zhang, Stephen P. Evanko, John A. Gebe, Xi Wang, Robert B. Vernon, Carol de la Motte, Thomas N. Wight, Edgar G. Engleman, Sheri M. Krams, Everett H. Meyer, Paul L. Bollyky
Summary: Treatment with 4-methylumbelliferone (4MU) reduces pericellular hyaluronan, disrupts interactions between DC and T-cells, and inhibits T-cell proliferation. 4MU can delay rejection of allogeneic pancreatic islet and cardiac transplants, as well as suppress allogeneic T-cell activation.
Review
Biochemistry & Molecular Biology
Chunyu Tong, Yimin Liang, Xianle Han, Zhelin Zhang, Xiaohui Zheng, Sen Wang, Bocui Song
Summary: Dendritic cells, as the most effective antigen-presenting cells, have many subsets with different surface receptors. Specific receptors targeting different subsets of dendritic cells will cause different immune responses. Currently, targeted research on dendritic cells plays a crucial role in the treatment and prevention of various diseases in the clinic.
Review
Immunology
Deepyan Chatterjee, Ian Andrew Cockburn
Summary: Recent clinical trials have shown that the RTS,S vaccine's protection is incomplete and short-lived, prompting studies to understand why vaccine-induced protection is limited. Research in systems serology has emphasized the importance of inducing functional antibodies, while in-depth analyses of immune responses to CSP have highlighted challenges in generating and maintaining high-quality antibody responses. Biophysical and structural studies of antibody binding to PfCSP have provided insights for future vaccine design to target a broader range of protective targets within PfCSP.
EXPERT REVIEW OF VACCINES
(2021)
Article
Immunology
Brigette Boast, Lisa A. Miosge, Hye Sun Kuehn, Vicky Cho, Vicki Athanasopoulos, Hayley A. McNamara, Yovina Sontani, Yan Mei, Debbie Howard, Henry J. Sutton, Sofia A. Omari, Zhijia Yu, Mariam Nasreen, T. Daniel Andrews, Ian A. Cockburn, Christopher C. Goodnow, Sergio D. Rosenzweig, Anselm Enders
Summary: IKZF1 is crucial for normal lymphopoiesis, with an L132P mutation leading to B cell-specific phenotype and partial immunodeficiency, shedding light on the development and function of the immune system.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Henry J. Sutton, Racheal Aye, Azza H. Idris, Rachel Vistein, Eunice Nduati, Oscar Kai, Jedida Mwacharo, Xi Li, Xin Gao, T. Daniel Andrews, Marios Koutsakos, Thi H. O. Nguyen, Maxim Nekrasov, Peter Milburn, Auda Eltahla, Andrea A. Berry, K. C. Natasha, Sumana Chakravarty, B. Kim Lee Sim, Adam K. Wheatley, Stephen J. Kent, Stephen L. Hoffman, Kirsten E. Lyke, Philip Bejon, Fabio Luciani, Katherine Kedzierska, Robert A. Seder, Francis M. Ndungu, Ian A. Cockburn
Summary: Using single-cell RNA sequencing, researchers explored the diversity of human B cells in healthy individuals and those exposed to malaria, identifying two distinct lineages with atypical B cells being part of the alternative lineage. Upon malaria vaccination, the alternative lineage cells respond to initial immunization and booster doses, but develop an atypical phenotype with repeated boosts, indicating that atypical cells are a normal component of healthy immune responses.
Article
Cell Biology
Deepyan Chatterjee, Fiona J. Lewis, Henry J. Sutton, Joe A. Kaczmarski, Xin Gao, Yeping Cai, Hayley A. McNamara, Colin J. Jackson, Ian A. Cockburn
Summary: The study demonstrates the role of CSPRepeat in malaria immunity and suggests that truncated CSP molecules could be a potential strategy for malaria vaccination, despite the interference caused by CSPRepeat in immune responses.
Editorial Material
Immunology
Hayley A. McNamara, Ian A. Cockburn
Summary: CD8(+) resident memory T (T-RM) cells from various tissues form a heterogeneous population. CD103(-) T-RM cells in the liver, independent of Transforming growth factor (TGF)-beta, maintain the ability to migrate to barrier tissues or return to secondary lymphoid organs.
Article
Immunology
Harshana Rajakaruna, James H. O'Connor, Ian A. Cockburn, Vitaly V. Ganusov
Summary: This study used intravital microscopy to observe the movement patterns of liver-localized CD8 T cells and found that they crawl on the luminal side of liver sinusoids, providing important insights into the understanding of T cell movement patterns in the body.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Hayley A. McNamara, Mireille H. Lahoud, Yeping Cai, Jessica Durrant-Whyte, James H. O'Connor, Irina Caminschi, Ian A. Cockburn
Summary: This study investigates the mechanisms behind B cell fate determination using a Plasmodium infection model. It finds that the organ environment plays a role in determining B cell fate, with the majority of the response derived from splenic plasmablasts. Furthermore, macrophages and CD11c(+) dendritic cells drive the plasmablast fate of CSP-specific B cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Melisa Gorosito Serran, Facundo Fiocca Vernengo, Laura Almada, Cristian G. Beccaria, Yamila Gazzoni, Pablo F. Canete, Jonathan A. Roco, Jimena Tosello Boari, Maria Cecilia Ramello, Ellen Wehrens, Yeping Cai, Elina I. Zuniga, Carolina L. Montes, Ian A. Cockburn, Eva V. Acosta Rodriguez, Carola G. Vinuesa, Adriana Gruppi
Summary: The study reveals that plasmablasts with high expression of PD-L1 may play a modulatory role in infections, influencing T cell response.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Parasitology
Lara Bardtke, Ian A. Cockburn
Summary: Research shows that protective antibodies against Plasmodium falciparum merozoite antigens can not only inhibit erythrocyte invasion, but also trigger antibody-dependent phagocytosis of infected and uninfected erythrocytes, providing new insights for malaria vaccine design.
TRENDS IN PARASITOLOGY
(2022)
Review
Immunology
Kai Pohl, Ian A. Cockburn
Summary: Malaria causes hundreds of thousands of deaths annually, but these deaths represent only a small fraction of total malaria cases. Immunity to the causative agent, Plasmodium, is incomplete, but immunization with attenuated parasites can provide complete immunity. The innate immune response plays a crucial role in different stages of the parasite lifecycle, balancing strong proinflammatory responses with regulatory mechanisms to protect the host from life-threatening cytokine storms.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Xin Gao, Ian A. Cockburn
Summary: CD11c(+) T-bet(+) atypical B cells (ABCs) are a type of cells identified in the context of vaccination, infections, and autoimmune diseases. However, the origins and functions of ABCs remain unknown. Recent studies using single-cell RNA sequencing have accurately identified these cells and revealed their abundance in healthy individuals. Nonetheless, the normal function of these cells is still elusive.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Xin Gao, Kaiming Luo, Diya Wang, Yunbo Wei, Yin Yao, Jun Deng, Yang Yang, Qunxiong Zeng, Xiaoru Dong, Le Xiong, Dongcheng Gong, Lin Lin, Kai Pohl, Shaoling Liu, Yu Liu, Lu Liu, Thi H. O. Nguyen, Lilith F. Allen, Katherine Kedzierska, Yanliang Jin, Mei-Rong Du, Wanping Chen, Liangjing Lu, Nan Shen, Zheng Liu, Ian A. Cockburn, Wenjing Luo, Di Yu
Summary: A defining feature of successful vaccination is the induction of long-lived antigen-specific memory cells. This study reveals that Tfh17 cells play a key role in maintaining and enhancing humoral immune responses. The results from both mouse and human experiments suggest that Tfh17-induced immunization might be preferable for long-term protection in vaccine development.
Article
Immunology
Oriol Fornes, Alicia Jia, Hye Sun Kuehn, Qing Min, Ulrich Pannicke, Nikolai Schleussner, Romane Thouenon, Zhijia Yu, Maria de los Angeles Astbury, Catherine M. Biggs, Miguel Galicchio, Jorge Alberto Garcia-Campos, Silvina Gismondi, Guadalupe Gonzalez Villarreal, Kyla J. Hildebrandt, Manfred Honig, Jia Hou, Despina Moshous, Stefania Pittaluga, Xiaowen Qian, Jacob Rozmus, Ansgar S. Schulz, Aide Tamara Staines-Boone, Bijun Sun, Jinqiao Sun, Schauer Uwe, Edna Venegas-Montoya, Wenjie Wang, Xiaochuan Wang, Wenjing Ying, Xiaowen Zhai, Qinhua Zhou, Altuna Akalin, Isabelle Andre, Thomas F. E. Barth, Bernd Baumann, Anne Brustle, Gaetan Burgio, Jacinta C. Bustamante, Jean-Laurent Casanova, Marco G. Casarotto, Marina Cavazzana, Loic Chentout, Ian A. Cockburn, Mariantonia Costanza, Chaoqun Cui, Oliver Daumke, Kate L. Del Bel, Hermann Eibel, Xiaoqian Feng, Vedran Franke, J. Christof M. Gebhardt, Andrea Goetz, Stephan Grunwald, Benedicte Hoareau, Timothy R. Hughes, Eva-Maria Jacobsens, Martin Janz, Arttu Jalma, Chantal Lagresle-Peyrou, Nannan Lai, Yaxuan Li, Susan Lin, Henry Y. Lu, Saul O. Lugo-Reyes, Xin Meng, Pete Moeller, Nidia Moreno-Corona, Julie E. Niemela, Gherman Novakovsky, Jareb J. Perez-Caraballo, Capucine Picard, Lucie Poggi, Maria-Emilia Puig-Lombardi, Katrina L. Randallr, Anja Reisser, Yohann Schmitt, Sandali Seneviratne, Mehul Sharma, Jennifer Stoddard, Srinivasan Sundararaj, Harry Sutton, Linh Q. Tran, Ying Wang, Wyeth W. Wasserman, Zichao Wen, Wiebke Winkler, Ermeng Xiong, Ally W. H. Yang, Meiping Yu, Lumin Zhang, Hai Zhang, Qian Zhao, Xin Zhen, Anselm Enders, Sven Kracker, Ruben Martinez-Barricarte, Stephan Mathas, Sergio D. Rosenzweig, Klaus Schwarz, Stuart E. Turvey, Ji-Yang Wang
Summary: A recurrent heterozygous mutation in IRF4 has been found to cause autosomal dominant combined immunodeficiency. This mutation leads to severe susceptibility to opportunistic infections, including Pneumocystis jirovecii, and agamma-globulinemia. The pathophysiology of this mutation disrupts normal lymphocyte biology through multimorphic changes in the function of IRF4.
SCIENCE IMMUNOLOGY
(2023)
Article
Immunology
James H. O'Connor, Hayley A. McNamara, Yeping Cai, Lucy A. Coupland, Elizabeth E. Gardiner, Brendan J. McMorran, Christopher R. Parish, Brendan J. McMorran, Vitaly V. Ganusov, Ian A. Cockburn
Summary: Liver-resident CD8(+) T cells have critical roles in pathogen control, but it is also proposed that the liver may be the main site for eliminating these cells. This study suggests that the expression of asialo-glycoproteins (ASGPs) drives the accumulation of effector CD8(+) T cells in the spleen rather than the liver. Platelet interactions do not strongly influence the function of CD8(+) T cells in the liver.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Mathematical & Computational Biology
Viktor S. Zenkov, James H. O'Connor, Ian A. Cockburn, Vitaly V. Ganusov
Summary: Malaria is a deadly disease caused by Plasmodium parasites, and understanding how CD8 T cells search for the parasites in the liver can improve the efficacy of future vaccines. This study found that the search process for malaria liver stages is random, with only a small fraction of T cells displaying attraction to the parasites. The speed and turning angles of T cell movement correlated with attraction, suggesting a potential mechanism to enhance vaccine effectiveness.
FRONTIERS IN BIOINFORMATICS
(2022)
