Drug metabolism and pharmacokinetics of praziquantel: A review of variable drug exposure during schistosomiasis treatment in human hosts and experimental models

The effect of ketoconazole on praziquantel pharmacokinetics and the role of CYP3A4 in the formation of X-OH-praziquantel and not 4-OH-praziquantel

(2019) Lovejoy Nleya et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Activity and pharmacokinetics of a praziquantel crystalline polymorph in the Schistosoma mansoni mouse model

(2019) Flavio C. Lombardo et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Current trends in drug metabolism and pharmacokinetics

(2019) Yuhua Li et al.   Acta Pharmaceutica Sinica B

Pharmacokinetics of praziquantel in Schistosoma mansoni and Schistosoma haematobium infected school- and preschool- aged children

(2018) Jana Kovač et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evaluation of a novel micro-sampling device, Mitra™, in comparison to dried blood spots, for analysis of praziquantel in Schistosoma haematobium -infected children in rural Côte d’Ivoire

(2018) Jana Kovač et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale

(2018) Peter L. Bonate et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Safety, efficacy and acceptability of praziquantel in the treatment of Schistosoma haematobium in pre-school children of Kwale County, Kenya

(2018) Bridget W. Kimani et al.   PLoS Neglected Tropical Diseases

A quantification method for determination of racemate praziquantel and R-enantiomer in rat plasma for comparison of their pharmacokinetics

(2017) Danlu Zhang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Efficacy of praziquantel on Schistosoma haematobium and re-infection rates among school-going children in the Ndumo area of uMkhanyakude district, KwaZulu-Natal, South Africa

(2017) Muhubiri Kabuyaya et al.   Infectious Diseases of Poverty

Putting the treatment of paediatric schistosomiasis into context

(2017) Takafira Mduluza et al.   Infectious Diseases of Poverty

Efficacy and safety of praziquantel in preschool-aged and school-aged children infected with Schistosoma mansoni: a randomised controlled, parallel-group, dose-ranging, phase 2 trial

(2017) Jean T Coulibaly et al.   Lancet Global Health

Population Pharmacokinetics and Pharmacodynamics of Praziquantel in Ugandan Children with Intestinal Schistosomiasis: Higher Dosages Are Required for Maximal Efficacy

(2016) Amaya L. Bustinduy et al.   mBio

Praziquantel: do we need another antischistosoma treatment?

(2015) Alan Fenwick OBE   Future Medicinal Chemistry

What is the mechanism of action of praziquantel and how might resistance strike?

(2015) Pauline M Cupit et al.   Future Medicinal Chemistry

Monitoring the efficacy of drugs for neglected tropical diseases controlled by preventive chemotherapy

(2015) M. Albonico et al.   Journal of Global Antimicrobial Resistance

Activity of Praziquantel Enantiomers and Main Metabolites against Schistosoma mansoni

(2014) Isabel Meister et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Metabolic profiling of praziquantel enantiomers

(2014) Haina Wang et al.   BIOCHEMICAL PHARMACOLOGY

The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer)

(2014) P. Olliaro et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Pharmacodynamics of mefloquine and praziquantel combination therapy in mice harbouring juvenile and adult Schistosoma mansoni

(2014) Naglaa Mohamed El-Lakkany et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Modulation of expression and activity of cytochrome P450s and alteration of praziquantel kinetics during murine schistosomiasis

(2014) Mara A Gotardo et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Clinical Efficacy and Tolerability of Praziquantel for Intestinal and Urinary Schistosomiasis—A Meta-analysis of Comparative and Non-comparative Clinical Trials

(2014) Julien Zwang et al.   PLoS Neglected Tropical Diseases

Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research

(2014) Tove Tuntland et al.   Frontiers in Pharmacology

Pharmacogenetics: Implications of race and ethnicity on defining genetic profiles for personalized medicine

(2013) Victor E. Ortega et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Transformer database: biotransformation of xenobiotics

(2013) Michael F. Hoffmann et al.   NUCLEIC ACIDS RESEARCH

Interactions of mefloquine with praziquantel in the Schistosoma mansoni mouse model and in vitro

(2011) J. Keiser et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Systematic exploration of synergistic drug pairs

(2011) M. Cokol et al.   Molecular Systems Biology

Praziquantel efficacy in mice infected with PZQ non-susceptible S. mansoni isolate treated with artemether: parasitological, biochemical and immunohistochemical assessment

(2010) Sanaa S. Botros et al.   APMIS

Albendazole-praziquantel interaction in healthy volunteers: kinetic disposition, metabolism and enantioselectivity

(2010) Renata Monteiro Lima et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Comparative efficacy and bioavailability of different praziquantel brands

(2010) Sanaa Botros et al.   EXPERIMENTAL PARASITOLOGY

Activity of antiandrogens against juvenile and adult Schistosoma mansoni in mice

(2010) J. Keiser et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Efficacy of two praziquantel treatments among primary school children in an area of high Schistosoma mansoni endemicity, Nile Delta, Egypt

(2010) RASHIDA BARAKAT et al.   PARASITOLOGY

Enantioselective analysis of praziquantel and trans-4-hydroxypraziquantel in human plasma by chiral LC–MS/MS: Application to pharmacokinetics

(2009) Renata Monteiro Lima et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Association of oxamniquine praziquantel and clonazepam in experimental Schistosomiasis mansoni

(2009) Neusa Araujo et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution

(2009) J. UTZINGER et al.   PARASITOLOGY

The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration

(2009) Alessandro Liberati et al.   PLOS MEDICINE

Taste, A New Incentive to Switch to (R)-Praziquantel in Schistosomiasis Treatment

(2009) Thorsten Meyer et al.   PLoS Neglected Tropical Diseases

Overview of Therapeutic Drug Monitoring

(2009) Ju-Seop Kang et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis

(2008) Michael J Doenhoff et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Efficacy and side effects of praziquantel treatment against Schistosoma haematobium infection among primary school children in Zimbabwe

(2008) N. Midzi et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE