Article
Biochemistry & Molecular Biology
Roberto Rodriguez Madrera, Belen Suarez Valles
Summary: The article describes an analytical method for extraction and quantitative determination of specific compounds in plant material using high-power ultrasound extraction and HPLC-DAD quantification, showing good accuracy and precision. Attention should be paid to the sample/solvent ratio to avoid degradation of the compounds.
Article
Plant Sciences
Congcong Zhang, Dingqi Zhang, Yongli Wang, Linzhang Zhang, Shenglan Qi, Qinqin Fang, Ying Xu, Jiamei Chen, Xuemei Cheng, Ping Liu, Changhong Wang, Wei Liu
Summary: This study investigated the pharmacokinetic characteristics and anti-liver fibrosis effect of Amy and its metabolite Pru. The results showed significant differences in the metabolism of Amy and Pru in rat plasma. In in vitro and in vivo experiments, Amy and Pru exhibited comparable anti-liver fibrosis effects. The deglycosylated activated metabolite Pru of Amy plays an important role in anti-liver fibrosis.
Article
Multidisciplinary Sciences
Matthew S. Bramble, Neerja Vashist, Arthur Ko, Sambhawa Priya, Celeste Musasa, Alban Mathieu, D' Andre Spencer, Michel Lupamba Kasendue, Patrick Mamona Dilufwasayo, Kevin Karume, Joanna Nsibu, Hans Manya, Mary N. A. Uy, Brian Colwell, Michael Boivin, J. P. Banae Mayambu, Daniel Okitundu, Arnaud Droit, Dieudonne Mumba Ngoyi, Ran Blekhman, Desire Tshala-Katumbay, Eric Vilain
Summary: Konzo, a distinct upper motor neuron disease associated with cyanogenic diet and chronic malnutrition, predominantly affects children and women of childbearing age in sub-Saharan Africa. The gut microbiome structure is highly variable depending on region of sampling, and unique enrichments of bacterial species and functional pathways have been identified in prone regions of the Congo that potentially modulate the susceptibility of konzo. Using metagenomic profiling in 180 individuals from the Democratic Republic of the Congo, associations between the gut microbiome and konzo have been found.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Chemical
Mohammed Helmy Faris Shalayel, Ghassab M. M. Al-Mazaideh, Abdulkareem A. A. Alanezi, Afaf F. F. Almuqati, Meshal Alotaibi
Summary: The extract of P. amygdalus var. amara has health benefits, such as lowering diabetes and heart disease risks. It demonstrated potent anti-cancer activity against multiple human tumor cell lines. The treatment significantly decreased cancer cell growth in most cell lines.
Review
Agronomy
Insyirah-Hannah Ruhaizat-Ooi, Rabiatul-Adawiah Zainal-Abidin, Nur Syatila Ab Ghani, Nor Afiqah-Aleng, Hamidun Bunawan, Norfarhan Mohd-Assaad, Zeti-Azura Mohamed-Hussein, Sarahani Harun
Summary: This article discusses the complex interplay of two compounds (GSL and CG) co-occurring in papaya. It also discusses and describes the species-specific pathways in papaya and explores the transcription factors involved in regulating GSL and CG biosynthesis pathways.
Article
Energy & Fuels
Elham Rostami, Nadia Esfandiari, Bizhan Honarvar, Moein Nabipour, Zahra Arab Aboosadi
Summary: In this study, activated carbon was synthesized from bitter orange wood and Amygdalus scoparia Spach using the chemical activation method. Surface modification was conducted to enhance the efficiency of the activated carbon for metal cation removal. The results showed successful surface modification and improved adsorption properties of the activated carbon.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Food Science & Technology
Mohd Aaqib Sheikh, Charanjiv Singh Saini
Summary: The study investigated the effects of microwave heating, hydrothermal treatment, and their combination on the antioxidant potential, anti-nutritional factors, and phenolic compounds of plum kernels. The combined treatments showed the most significant reduction in amygdalin, hydrocyanic acid, phytic acid, and tannins. Microwave treated samples exhibited higher antioxidant activity and phenolic content compared to hydrothermal and combined treatments. HPLC analysis revealed substantial amounts of phenolic compounds in the combined treated samples, including gallic acid, chlorogenic acid, (+)-catechin, syringic acid, rutin, 3,4-dihydroxy benzoic acid, tannic acid, and quercetin.
Article
Biotechnology & Applied Microbiology
Wanfu Bai, Qing Liu, Hong Chang, Quanli Liu, Chen Gao, Yingchun Bai, Hongbing Zhou, Songli Shi
Summary: This study revealed and compared the potential mechanisms of the renoprotective effects of BUT and AMY from a metabolomic perspective, showing significant improvements in tubulointerstitial damage, fibrosis, and metabolic perturbations associated with renal fibrosis progression.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jia Wang, Hongbing Zhou, Tong Wu, Peisai Wu, Quanli Liu, Songli Shi
Summary: The research found that amygdalin from Amygdalus mongolica has a significant therapeutic effect on hepatic fibrosis in rats, reducing liver tissue damage, lowering oxidative stress levels, and decreasing collagen fiber deposition.
ACTA PHARMACEUTICA
(2021)
Review
Medicine, Research & Experimental
Ana R. Costa, Ana C. Duarte, Ana R. Costa-Brito, Isabel Goncalves, Cecilia R. A. Santos
Summary: Pharmacoresistance of cancer cells to chemotherapy drugs is a major challenge. ABC transporters are a leading cause of drug resistance as they transport drugs out of the cells. TAS2Rs, regulated by bitter taste receptors, have been found in various cancer types and organs, and their activation has been linked to multiple biological actions. Bitter compounds, such as flavonoids and alkaloids, have shown potential as adjuvants in cancer therapy. This review discusses the therapeutic role of TAS2Rs and bitter compounds in overcoming chemoresistance in different types of cancer.
Article
Food Science & Technology
Xue Huang, Jiayi Xu, Feng Gao, Hongyan Zhang, Ling Guo
Summary: This study uses spectroscopy to rapidly identify sweet and bitter apricot kernels by determining the amygdalin content. A model has been established to classify and differentiate sweet and bitter apricot kernels. The combination of principal component analysis-K-nearest neighbor classification algorithm and multivariate scattering correction pretreatment method can accurately distinguish sweet and bitter apricot kernels in a specific wavelength range, as well as identify apricot kernel species in the full wavelength spectrum. Furthermore, the prediction of amygdalin content using the partial least squares model is superior to the back-propagation neural network model.
FOOD SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Nasrin Valizadeh, Roya Salehi, Marziyeh Aghazadeh, Mahdieh Alipour, Hadi Sadeghzadeh, Mehrdad Mahkam
Summary: This study investigated the effects of bitter almond extract on the osteoblast differentiation of human dental pulp stem cells. The results showed that the addition of bitter almond extract improved the mechanical properties of the scaffolds and promoted cell attachment, proliferation, and osteogenic differentiation. Therefore, bitter almond extract has great potential for bone tissue engineering applications.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Biochemical Research Methods
Guoqin Zhang, Huanhuan Li, Lili Sun, Yi Liu, Ying Cao, Xiaoliang Ren, Yanan Liu
Summary: A simple method was developed to evaluate the compositional quality of bitter almonds based on a combination of chromatographic fingerprinting and chemometrics, using their appearance traits alone. The study found that high-quality bitter almonds were closely correlated with larger, oblong-shaped and heavier kernels.
JOURNAL OF CHROMATOGRAPHIC SCIENCE
(2023)
Review
Food Science & Technology
Jingna Yan, Huarong Tong
Summary: This paper focuses on the importance of bitter compounds in food and beverages. It discusses the relationship between chemical structure and bitterness, and presents methods for screening and evaluating bitter compounds. The activation and transduction mechanisms of bitter taste receptors are also outlined. The paper concludes by highlighting current issues and proposing potential directions for further research.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2023)
Review
Food Science & Technology
Shengyu Liu, Donald Grierson, Wanpeng Xi
Summary: This review provides a comprehensive understanding of the distribution, properties, and environmental response of bitter compounds in fruits and vegetables. It also discusses the potential applications of bitter compounds in breeding, agricultural technologies, and the development of natural pesticides and health-promoting medicines.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Agronomy
Behzad Moshayedi, Mohsen Najarchi, Mohammad Mahdi Najafizadeh, Shahab Khaghani
IRRIGATION AND DRAINAGE
(2020)
Article
Plant Sciences
Hamideh Amin Amlashi, Hamid Madani, Ali Sonboli, Shahab Khaghani, Majid Ramezani
JOURNAL OF ESSENTIAL OIL BEARING PLANTS
(2020)
Article
Chemistry, Physical
Hossein Farahani, Nour Ali Sajedi, Hamid Madani, Mehdi Changizi, Mohammad Reza Naeini
Summary: This field experiment showed that foliar application of silicon can increase the flower yield and modify the essential oil composition of damask rose. Water deficit stress resulted in reduced flower yield but increased concentrations of certain compounds in the essential oil.
Article
Horticulture
F. Mojdehi, M. Taghizadeh, A. H. Baghaie, M. Changizi, S. Khaghani
Summary: The study evaluated the potential of ornamental sunflower to remediate contaminated soil, showing that vermicompost addition increased soil microbial activity and different concentrations of lead and cadmium significantly influenced oxidative enzyme activities.
EUROPEAN JOURNAL OF HORTICULTURAL SCIENCE
(2021)
Article
Chemistry, Inorganic & Nuclear
A. Ganbarianzade Mahabadi, A. Mirzakhani, A. Azizi, S. Chavoshi, Sh. Khaghani
Summary: The study investigated the phytochemical composition in the aqueous extract of Pelargonium from Iran, and utilized it for an eco-friendly synthesis of cerium oxide nanoparticles with notable catalytic and antioxidant activities. The findings showed high phenolic and flavonoid contents in the extract, and synthesized nanoparticles exhibited excellent physical and chemical properties.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Chemistry, Applied
Azam Bakhtiar, Shahab Khaghani, Abdollah Ghasemi Pirbalouti, Masoud Gomarian, Saeid Chavoshi
Summary: This study analyzed the chemical compositions of the essential oil from eight populations of Ziziphora tenuior L. cultivated in semiarid climate in southwestern Iran, revealing significant variability and identifying three chemotypes. These chemotypes are the result of genetic differences and diversity between populations.
JOURNAL OF ESSENTIAL OIL RESEARCH
(2021)
Article
Biology
S. Farhangian-kashani, A. Azadi, Sh. Khaghani, M. Changizi, M. Gomarian
Summary: This study utilized 105 wheat genotypes to study genetic diversity and identified morpho-physiological traits associated with salinity tolerance. SSR marker analysis revealed high genetic diversity and informative markers, with gpw2181 marker being suggested to play a key role in salt stress tolerance.
Article
Environmental Sciences
Behzad Moshayedi, Mohsen Najarchi, Mohammad Mahdi Najafizadeh, Shahab Khaghani
Summary: This research investigated various drainage parameters for unsteady conditions and compared the results of different equations. The Bouwer & Van Schilfgaarde equation was found to be the best in calculating drainage distance. The study also determined the optimal installation depth and reflection coefficient, and evaluated the changes in water table using different precipitation durations.
Article
Plant Sciences
Alireza Sharifian, Abbas Mirzakhani, Shahab Khaghani, Seyed F. F. Kakhaki
Summary: The effects of potassium silicate and arbuscular mycorrhiza fungus on drought stress in Matthiola incana were investigated. The application of potassium silicate with the fungus increased colonization percentage regardless of the drought stress level. The application of 400 and 200 ppm of potassium silicate elevated the contents of chlorophylls a, b, and total at all drought stress levels. Deficit irrigation increased malondialdehyde content, while potassium silicate treatment reduced proline content.
NOTULAE BOTANICAE HORTI AGROBOTANICI CLUJ-NAPOCA
(2022)
Article
Plant Sciences
Behnaz Moghadasian, Hassanali Naghdi Badi, Ali Mehrafarin, Shahab Khaghani
Summary: This study investigated the oil content and fatty acids composition of caper seeds in Iranian populations. The results showed variation in seed oil content among different caper populations. Caper seed oil has high levels of unsaturated fatty acids and saturated fatty acids, making it a potential alternative for edible oilseed in the future.
JOURNAL OF MEDICINAL PLANTS AND BY-PRODUCTS-JMPB
(2022)
Article
Chemistry, Multidisciplinary
Seyed Saeid Mohammadi, Nahid Ghasemi, Majid Ramezani, Shahab Khaghani
Summary: This study focused on the biosynthesis of silver nanoparticles using the aqueous extract of Alisma Plantago-Aquatica L plant, with optimal conditions determined through various parameters. The nanoparticles synthesized showed characteristics of crystalline silver at a size of 20-58 nm, with involvement of hydroxyl, amine, and carboxyl groups from the plant extract in the synthesis process. The results suggest that the plant extract can serve as a viable and safe alternative in green chemistry practices.
CHEMICAL METHODOLOGIES
(2021)
Article
Engineering, Multidisciplinary
Eshaghali Bayati, Masoud Gomarian, Hossein Mirzaie-Nodoushan, Mehdi Changizi, Shahab Khaghani
Summary: This study aimed to produce a superior genotype from the Agria potato cultivar using somaclonal variation. Results showed that the regenerated genotype had superior traits compared to the parent cultivar in most studied aspects, but the parent cultivar performed better in terms of peel percentage and maturity date. Molecular comparison also indicated differences between the new genotype and the parental cultivar. Overall, somaclonal variation proved to be an effective method for generating new genotypes with superior characteristics.
NEXO REVISTA CIENTIFICA
(2021)
Article
Agriculture, Dairy & Animal Science
N. Ahmadijoo, H. Mansoori-Yarahmadi, J. Fakhraei, M. Changizi
TROPICAL ANIMAL SCIENCE JOURNAL
(2020)