The two faces of synaptic failure in AppNL-G-F knock-in mice

Simultaneous Live Imaging of Multiple Endogenous Proteins Reveals a Mechanism for Alzheimer’s-Related Plasticity Impairment

(2019) Sarah G. Cook et al.   Cell Reports

Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second Generation Amyloid-beta Mouse Model

(2019) Christian Sacher et al.   JOURNAL OF NUCLEAR MEDICINE

Reduction in open field activity in the absence of memory deficits in the App NL−G−F knock-in mouse model of Alzheimer’s disease

(2018) Lauren S. Whyte et al.   BEHAVIOURAL BRAIN RESEARCH

Identification of an acute functional cross-talk between amyloid-β and glucocorticoid receptors at hippocampal excitatory synapses

(2018) Scherazad Kootar et al.   NEUROBIOLOGY OF DISEASE

Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APPNL-F/NL-F knock-in mice

(2018) Disha Shah et al.   Scientific Reports

Age-dependent behavioral and biochemical characterization of single APP knock-in mouse (APPNL-G-F/NL-G-F) model of Alzheimer's disease

(2018) Jogender Mehla et al.   NEUROBIOLOGY OF AGING

Prefrontal–hippocampal interactions in episodic memory

(2017) Howard Eichenbaum   NATURE REVIEWS NEUROSCIENCE

Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer’s disease

(2017) Qin Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony

(2017) Stefania Forner et al.   TRENDS IN NEUROSCIENCES

Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL−G−F mice before prominent plaque deposition

(2017) Amira Latif-Hernandez et al.   BEHAVIOURAL BRAIN RESEARCH

Early pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition

(2016) Disha Shah et al.   Alzheimers & Dementia

Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability

(2016) Martijn C. de Wilde et al.   Alzheimers & Dementia

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate

(2016) Ting Yang et al.   JOURNAL OF NEUROSCIENCE

Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression

(2016) T. Saito et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Rodent models for Alzheimer’s disease drug discovery

(2015) Daniela Puzzo et al.   Expert Opinion on Drug Discovery

Rescue of impaired late–phase long-term depression in a tau transgenic mouse model

(2015) Tariq Ahmed et al.   NEUROBIOLOGY OF AGING

New Mouse Model of Alzheimer’s

(2014) Per Nilsson et al.   ACS Chemical Neuroscience

Impairments of long-term depression induction and motor coordination precede Aβ accumulation in the cerebellum of APPswe/PS1dE9 double transgenic mice

(2014) Yuki Kuwabara et al.   JOURNAL OF NEUROCHEMISTRY

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

(2014) Scott J. Webster et al.   Frontiers in Genetics

Anatomical substrates for direct interactions between hippocampus, medial prefrontal cortex, and the thalamic nucleus reuniens

(2013) C. Varela et al.   Brain Structure & Function

Interplay of Hippocampus and Prefrontal Cortex in Memory

(2013) Alison R. Preston et al.   CURRENT BIOLOGY

Improved spatial learning is associated with increased hippocampal but not prefrontal long-term potentiation in mGluR4 knockout mice

(2013) E. Iscru et al.   GENES BRAIN AND BEHAVIOR

Memory, navigation and theta rhythm in the hippocampal-entorhinal system

(2013) György Buzsáki et al.   NATURE NEUROSCIENCE

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Animal Models of Alzheimer Disease

(2013) F. M. LaFerla et al.   Cold Spring Harbor Perspectives in Medicine

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

(2012) Justin M. Nussbaum et al.   NATURE

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Synapses and Alzheimer's Disease

(2012) M. Sheng et al.   Cold Spring Harbor Perspectives in Biology

Plasticity of spontaneous excitatory and inhibitory synaptic activity in morphologically defined vestibular nuclei neurons during early vestibular compensation

(2011) Mei Shao et al.   JOURNAL OF NEUROPHYSIOLOGY

An N-methyl-d-aspartate-receptor dependent, late-phase long-term depression in middle-aged mice identifies no GluN2-subunit bias

(2011) T. Ahmed et al.   NEUROSCIENCE

Hippocampal synaptic plasticity in Alzheimer’s disease: what have we learned so far from transgenic models?

(2011) Cristina Marchetti et al.   REVIEWS IN THE NEUROSCIENCES

Control of CA3 Output by Feedforward Inhibition Despite Developmental Changes in the Excitation-Inhibition Balance

(2010) C. L. Torborg et al.   JOURNAL OF NEUROSCIENCE

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Long-term depression in the CNS

(2010) Graham L. Collingridge et al.   NATURE REVIEWS NEUROSCIENCE

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

(2010) Raik Rönicke et al.   NEUROBIOLOGY OF AGING

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Spred1 Is Required for Synaptic Plasticity and Hippocampus-Dependent Learning

(2009) E. Denayer et al.   JOURNAL OF NEUROSCIENCE

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Amyloid β-protein fragments 25-35 and 31-35 potentiate long-term depression in hippocampal CA1 region of rats in vivo

(2008) Li Cheng et al.   SYNAPSE