Network pharmacology based virtual screening of active constituents of Prunella vulgaris L. and the molecular mechanism against breast cancer

Prediction of potential cancer-related molecular targets of North African plants constituents using network pharmacology-based analysis

(2019) Eman Shawky   JOURNAL OF ETHNOPHARMACOLOGY

Network pharmacology‐based research on the active component and mechanism of the antihepatoma effect of Rubia cordifolia L.

(2019) Yiyi Xiong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Prunella vulgaris: A comprehensive review of chemical constituents, pharmacological effects and clinical applications

(2019) Su-Juan Wang et al.   CURRENT PHARMACEUTICAL DESIGN

A bioinformatics investigation into the pharmacological mechanisms of the effect of Fufang Danshen on pain based on methodologies of network pharmacology

(2019) Yantao Sun et al.   Scientific Reports

Yinchenhao decoction suppresses rat liver fibrosis involved in an apoptosis regulation mechanism based on network pharmacology and transcriptomic analysis

(2019) Fei-Fei Cai et al.   BIOMEDICINE & PHARMACOTHERAPY

Utilising network pharmacology to explore the underlying mechanism of Wumei Pill in treating pancreatic neoplasms

(2019) Yuxiang Wan et al.   BMC Complementary and Alternative Medicine

Network pharmacology-based identifcation of potential targets of the flower of Trollius chinensis Bunge acting on anti-inflammatory effectss

(2019) Jing-wei Liang et al.   Scientific Reports

Uncovering the pharmacological mechanism of Carthamus tinctorius L. on cardiovascular disease by a systems pharmacology approach

(2019) Guohua Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR

(2018) Verena Hiebl et al.   BIOTECHNOLOGY ADVANCES

Challenging the Drug-Likeness Dogma for New Drug Discovery in Tuberculosis

(2018) Diana Machado et al.   Frontiers in Microbiology

Oral Administration of Prunella vulgaris L Improves the Effect of Taxane on Preventing the Progression of Breast Cancer and Reduces Its Side Effects

(2018) Jixue Zhao et al.   Frontiers in Pharmacology

Investigate the mechanisms of Chinese medicine Fuzhengkangai towards EGFR mutation-positive lung adenocarcinomas by network pharmacology

(2018) Zhitong Bing et al.   BMC Complementary and Alternative Medicine

ADME-Space: a new tool for medicinal chemists to explore ADME properties

(2017) Giovanni Bocci et al.   Scientific Reports

Modulation of the Tumor Metastatic Microenvironment and Multiple Signal Pathways byPrunella vulgarisin Human Hepatocellular Carcinoma

(2016) Yu-Chieh Su et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Pushing estrogen receptor around in breast cancer

(2016) Elgene Lim et al.   ENDOCRINE-RELATED CANCER

Phytochemistry and pharmacological activities of the genus Prunella

(2016) Yubing Bai et al.   FOOD CHEMISTRY

Computer-aided drug discovery research at a global contract research organization

(2016) Douglas B. Kitchen   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Treatment with kaempferol suppresses breast cancer cell growth caused by estrogen and triclosan in cellular and xenograft breast cancer models

(2016) Seung-Hee Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors

(2016) L A Jung et al.   ONCOGENE

Luteolin suppresses the metastasis of triple-negative breast cancer by reversing epithelial-to-mesenchymal transition via downregulation of β-catenin expression

(2016) Dan Lin et al.   ONCOLOGY REPORTS

Herb-target interaction network analysis helps to disclose molecular mechanism of traditional Chinese medicine

(2016) Hao Liang et al.   Scientific Reports

Molecular Docking and Structure-Based Drug Design Strategies

(2015) Leonardo Ferreira et al.   MOLECULES

Morin, a flavonoid from Moraceae, suppresses growth and invasion of the highly metastatic breast cancer cell line MDA-MB-231 partly through suppression of the Akt pathway

(2014) HANA JIN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

ModuleRole: A Tool for Modulization, Role Determination and Visualization in Protein-Protein Interaction Networks

(2014) GuiPeng Li et al.   PLoS One

Biochemical and Cellular Evidence Demonstrating AKT-1 as a Binding Partner for Resveratrol Targeting Protein NQO2

(2014) Tze-chen Hsieh et al.   PLoS One

In vitro antioxidant and anticancer effects of solvent fractions from prunella vulgaris var. lilacina

(2013) Yu-Jin Hwang et al.   BMC Complementary and Alternative Medicine

A review on plant-based rutin extraction methods and its pharmacological activities

(2013) Lee Suan Chua   JOURNAL OF ETHNOPHARMACOLOGY

Pharmacokinetic Properties and In Silico ADME Modeling in Drug Discovery

(2013) Kathia M. Honorio et al.   Medicinal Chemistry

Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain

(2012) Jin H. Park et al.   BIOCHEMICAL JOURNAL

Combination of Active Components Enhances the Efficacy of Prunella in Prevention and Treatment of Lung Cancer

(2010) Liang Feng et al.   MOLECULES

Antioxidant Activities of Total Phenols of Prunella vulgaris L. in Vitro and in Tumor-bearing Mice

(2010) Liang Feng et al.   MOLECULES

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

(2010) Wen-I Wu et al.   PLoS One

Network analyses in systems pharmacology

(2009) S. I. Berger et al.   BIOINFORMATICS

Assessing drug-likeness – what are we missing?

(2008) Giulio Vistoli et al.   DRUG DISCOVERY TODAY

Prunella vulgaris extract and rosmarinic acid suppress lipopolysaccharide-induced alteration in human gingival fibroblasts

(2008) A. Zdařilová et al.   TOXICOLOGY IN VITRO

Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell linesin vitroand in nude mice xenografts

(2007) Heekyoung Chung et al.   INTERNATIONAL JOURNAL OF CANCER