Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos
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Title
Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos
Authors
Keywords
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Journal
Scientific Reports
Volume 10, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-09-04
DOI
10.1038/s41598-020-71412-0
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- (2020) Georg Michlits et al. NATURE METHODS
- Xenopus tropicalis: Joining the Armada in the Fight Against Blood Cancer
- (2019) Dionysia Dimitrakopoulou et al. Frontiers in Physiology
- Xenbase: Facilitating the Use of Xenopus to Model Human Disease
- (2019) Mardi J. Nenni et al. Frontiers in Physiology
- The Gene Sculpt Suite: a set of tools for genome editing
- (2019) Carla M Mann et al. NUCLEIC ACIDS RESEARCH
- Massively parallel profiling and predictive modeling of the outcomes of CRISPR/Cas9-mediated double-strand break repair
- (2019) Wei Chen et al. NUCLEIC ACIDS RESEARCH
- Predicting CRISPR/Cas9-Induced Mutations for Precise Genome Editing
- (2019) Kutubuddin A. Molla et al. TRENDS IN BIOTECHNOLOGY
- The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy
- (2019) Rik G. H. Lindeboom et al. NATURE GENETICS
- De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens
- (2019) Wei He et al. Nature Communications
- Homozygous Null TBX4 Mutations Lead to Posterior Amelia with Pelvic and Pulmonary Hypoplasia
- (2019) Ariana Kariminejad et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Highly Efficient CRISPR-Cas9-Based Methods for Generating Deletion Mutations and F0 Embryos that Lack Gene Function in Zebrafish
- (2019) Kazuyuki Hoshijima et al. DEVELOPMENTAL CELL
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- (2018) George E. Gentsch et al. DEVELOPMENTAL CELL
- A Rapid Method for Directed Gene Knockout for Screening in G0 Zebrafish
- (2018) Roland S. Wu et al. DEVELOPMENTAL CELL
- Decoding non-random mutational signatures at Cas9 targeted sites
- (2018) Amir Taheri-Ghahfarokhi et al. NUCLEIC ACIDS RESEARCH
- RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6
- (2018) Emmanuelle Szenker-Ravi et al. NATURE
- Robust activation of microhomology-mediated end joining for precision gene editing applications
- (2018) Hirotaka Ata et al. PLoS Genetics
- PAVOOC: designing CRISPR sgRNAs using 3D protein structures and functional domain annotations
- (2018) Moritz Schaefer et al. BIOINFORMATICS
- Predictable and precise template-free CRISPR editing of pathogenic variants
- (2018) Max W. Shen et al. NATURE
- Predicting the mutations generated by repair of Cas9-induced double-strand breaks
- (2018) Felicity Allen et al. NATURE BIOTECHNOLOGY
- TALENs and CRISPR/Cas9 fuel genetically engineered clinically relevantXenopus tropicalistumor models
- (2017) Thomas Naert et al. GENESIS
- Tissue-Specific Gene Inactivation inXenopus laevis: Knockout oflhx1in the Kidney with CRISPR/Cas9
- (2017) Bridget D. DeLay et al. GENETICS
- Tissue-Specific Gene Inactivation inXenopus laevis: Knockout oflhx1in the Kidney with CRISPR/Cas9
- (2017) Bridget D. DeLay et al. GENETICS
- Frameshift indels introduced by genome editing can lead to in-frame exon skipping
- (2017) Simon Lalonde et al. PLoS One
- DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks
- (2016) Megan van Overbeek et al. MOLECULAR CELL
- BATCH-GE: Batch analysis of Next-Generation Sequencing data for genome editing assessment
- (2016) Annekatrien Boel et al. Scientific Reports
- CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis
- (2016) Thomas Naert et al. Scientific Reports
- Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish
- (2015) Fatma O. Kok et al. DEVELOPMENTAL CELL
- Genetic compensation induced by deleterious mutations but not gene knockdowns
- (2015) Andrea Rossi et al. NATURE
- Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
- (2015) Junwei Shi et al. NATURE BIOTECHNOLOGY
- CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo
- (2015) Miguel A Moreno-Mateos et al. NATURE METHODS
- CRISPRdirect: software for designing CRISPR/Cas guide RNA with reduced off-target sites
- (2014) Yuki Naito et al. BIOINFORMATICS
- Biallelic genome modification in F0Xenopus tropicalisembryos using the CRISPR/Cas system
- (2013) Ira L. Blitz et al. GENESIS
- Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis inXenopus tropicalis
- (2013) Takuya Nakayama et al. GENESIS
- Efficient genome editing in zebrafish using a CRISPR-Cas system
- (2013) Woong Y Hwang et al. NATURE BIOTECHNOLOGY
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