Journal
SCIENTIFIC REPORTS
Volume 10, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-020-69163-z
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Funding
- European Research Council (ERC) [677697]
- UCL Leonard Wolfson Experimental Neurology Centre [PR/ylr/18575]
- Wellcome Trust through a Sir Henry Wellcome Postdoctoral Fellowship
- Multiple System Atrophy Trust
- Multiple System Atrophy Coalition
- Fund Sophia by the King Baudouin Foundation
- Karin & Sten Mortstedt CBD Solutions
- Reta Lila Weston Institute for Neurological Studies
- Medical Research Council UK
- National Institute for Health Research University College London Hospitals Biomedical Research Centre
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Ex vivo imaging enables analysis of the human brain at a level of detail that is not possible in vivo with MRI. In particular, histology can be used to study brain tissue at the microscopic level, using a wide array of different stains that highlight different microanatomical features. Complementing MRI with histology has important applications in ex vivo atlas building and in modeling the link between microstructure and macroscopic MR signal. However, histology requires sectioning tissue, hence distorting its 3D structure, particularly in larger human samples. Here, we present an open-source computational pipeline to produce 3D consistent histology reconstructions of the human brain. The pipeline relies on a volumetric MRI scan that serves as undistorted reference, and on an intermediate imaging modality (blockface photography) that bridges the gap between MRI and histology. We present results on 3D histology reconstruction of whole human hemispheres from two donors.
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