Review
Cell Biology
Danhua Ruan, Jirui Wen, Fei Fang, Yuqin Lei, Zhiwei Zhao, Yali Miao
Summary: This study firstly proposes the important role of ferroptosis in the treatment of epithelial ovarian cancer, including its functions in tumorigenesis and progression, chemotherapy resistance and therapeutic strategies. The article also discusses the construction of related prognostic prediction systems and mechanisms of resistance to ferroptosis.
CELL DEATH DISCOVERY
(2023)
Article
Oncology
Nina Lapke, Chien-Hung Chen, Ting-Chang Chang, Angel Chao, Yen-Jung Lu, Chyong-Huey Lai, Kien Thiam Tan, Hua-Chien Chen, Hsiao-Yun Lu, Shu-Jen Chen
Summary: Genetic alterations in epithelial ovarian carcinoma are complex and vary among histologies, with characteristic mutations such as BRCA1/2 alterations and PTEN loss in high-grade serous carcinoma, and ARID1A, PIK3CA, and KRAS mutations more common in other histologies. Drug target downstream alterations impact the actionability for all histologies, with many patients having multiple actionable drug targets.
Article
Medicine, General & Internal
Jiyan Zhang, Jie Xi, Ping Huang, Saitian Zeng
Summary: This study identified two molecular subtypes (C1 and C2) based on the ferroptosis mRNA expression profile, showing distinct clinical outcomes. The C1 subtype exhibited higher stromal score, immune cell score, immune function, and mRNA expression levels of immune checkpoints compared to C2. Potential small molecular drugs and chemotherapy drug sensitivity were also identified. Furthermore, a 15-ferroptosis-related mRNA signature and a nomogram model were developed for predicting outcomes and overall survival probability in ovarian cancer patients.
FRONTIERS IN MEDICINE
(2021)
Review
Oncology
Lanyu Li, Cheng Qiu, Min Hou, Xinyu Wang, Changzhen Huang, Jialin Zou, Tianyi Liu, Jinfeng Qu
Summary: Ovarian cancer, as one of the deadliest malignancies, requires more effective treatment options beyond traditional methods. The potential connection between ferroptosis and ovarian cancer has raised interest in exploring new therapeutic approaches. Further research is needed to understand the role of ferroptosis in ovarian cancer treatment and to identify potential pathways for intervention.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Man-Ning Wu, Dong-Mei Zhou, Chun-Yan Jiang, Wei-Wen Chen, Jia-Chi Chen, Yue-Min Zou, Tao Han, Li-Jia-Ming Zhou
Summary: In this study, the Ferroptosis Database and the gene expression omnibus (GEO) database were used to identify ferroptosis-related genes (FRGs) and psoriasis-associated data. A total of 199 psoriasis-associated DE-FRGs were identified, and they were closely associated with immune and autophagy modulation. Functional annotation revealed that these marker genes may have important effects on psoriasis through involvement in various psoriasis pathogenesis-related pathways. Moreover, 37 drugs targeting these marker genes were identified. Furthermore, alterations in the immune microenvironment in psoriasis cases were potentially associated with certain marker genes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Jung-A Choi, Hyosun Kim, Hyunja Kwon, Elizabeth Hyeji Lee, Hanbyoul Cho, Joon-Yong Chung, Jae-Hoon Kim
Summary: This study examined the clinical value and therapeutic potential of ascitic autotaxin (ATX) in epithelial ovarian cancer (EOC). The results showed that elevated levels of ascitic ATX were associated with advanced stage, high grade, and a short disease-free period in EOC patients. Combining ascitic ATX and serum CA-125 levels improved the diagnostic accuracy for EOC, and functional studies revealed that ascitic ATX played a role in maintaining cancer stem cell-like characteristics and invadopodia formation in EOC.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Na Xu, Baohong Li, Yong Liu, Cui Yang, Siqi Tang, William C. Cho, Zunnan Huang
Summary: This study identified biomarkers and potential targets for triple-negative breast cancer (TNBC) related to ferroptosis. A prognostic model composed of 12 ferroptosis-related genes was constructed and validated. Seven genes were identified as potential therapeutic targets, and two drugs were found to have potential for treating TNBC.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Yunhan Wang, Zongying Zhang, Weichen Sun, Jie Zhang, Qiuyun Xu, Xiaorong Zhou, Liming Mao
Summary: Colorectal cancer is a common malignant tumor with unsatisfactory prognosis. Ferroptosis, a novel form of cell death, has shown success in eliminating cancer cells resistant to other forms of cell death. Therefore, ferroptosis may become a new direction for designing therapies for colorectal cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Chuchu Xu, Yian Chen, Qinghong Yu, Jiaqing Song, Ying Jin, Xiufei Gao
Summary: This comprehensive review examines the compounds that target ferroptosis in breast cancer and elucidates their potential mechanisms of action. It also discusses the challenges associated with the clinical application of ferroptosis-inducing drugs, providing valuable insights for the development of novel treatment strategies for breast cancer.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Carmen Alarcon-Veleiro, Rocio Mato-Basalo, Sergio Lucio-Gallego, Andrea Vidal-Pampin, Maria Quindos-Varela, Thamer Al-Qatarneh, German Berrecoso, Angel Vizoso-Vazquez, Maria C. Arufe, Juan Fafian-Labora
Summary: Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer, and current treatment methods are not satisfactory due to the development of chemo-resistance. Recently, ferroptosis, a new form of regulated cell death, has been found to be a promising anti-tumor strategy for EOC treatment.
Article
Oncology
Iris S. Brummelhuis, Stephen J. Fiascone, Kathleen T. Hasselblatt, Gyorgy Frendl, Kevin M. Elias
Summary: The study examines the expression of voltage-gated sodium channels in ovarian cancer cells, finding lower levels compared to normal cells and identifying two channels, SCN8A and SCN1B, as prognostic biomarkers for overall survival. In vitro studies suggest that blocking these channels may sensitize ovarian cancer cells to chemotherapy. Furthermore, VGSC blockade using anti-epileptic drugs or local anesthetics decreased cancer cell proliferation and increased sensitivity to platinum and taxane chemotherapies, suggesting VGSC as potential prognostic biomarkers and therapeutic targets in EOC.
Article
Biochemistry & Molecular Biology
Minghai Zhang, Yingjie Wang, Shilin Xu, Shan Huang, Meixuan Wu, Guangquan Chen, Yu Wang
Summary: In this study, a risk classifier based on 10 differentially expressed genes related to endoplasmic reticulum stress was established to evaluate the prognosis of ovarian cancer patients and assist in medical decision-making. The prediction ability of the classifier was tested and confirmed, and TRPM2 was identified as a potential therapeutic target for ovarian cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Yasaman Setayeshpour, Yunji Lee, Jen-Tsan Chi
Summary: The environment can significantly affect the growth, progression, and metastasis of cancer cells. Ferroptosis, an iron-dependent form of cell death caused by oxidative stress, can influence the metastasis of cancer cells. Understanding both intrinsic and extrinsic factors that modulate ferroptosis can optimize therapeutic sensitivity to prevent tumor growth and metastasis.
Review
Pharmacology & Pharmacy
Hanshu Yuan, Justin Pratte, Charles Giardina
Summary: Ferroptosis is a recently defined form of programmed cell death that is distinct due to its iron dependency and accumulation of lipid hydroperoxides. It can be regulated by various cellular variables and is potentially linked to degenerative diseases and acute injury scenarios. Additionally, ferroptosis may have significance in tumor-suppression and cancer therapy as a proposed target.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jiayu Zou, Li Wang, Hailin Tang, Xiuxiu Liu, Fu Peng, Cheng Peng
Summary: Ferroptosis plays a significant role in inhibiting tumor progression in non-small cell lung cancer by regulating the GPX4 signaling pathway and also has a GSH-independent preventive mechanism. It has the potential to become a novel strategy for overcoming therapy resistance in NSCLC, highlighting its therapeutic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
