Article
Cardiac & Cardiovascular Systems
Takahiko Kiyooka, Vahagn Ohanyan, Liya Yin, Yuh Fen Pung, Yeong-Renn Chen, Chwen-Lih Chen, Patrick T. Kang, James P. Hardwick, June Yun, Danielle Janota, Joanna Peng, Christopher Kolz, Giacinta Guarini, Glenn Wilson, Inna Shokolenko, Donte A. Stevens, William M. Chilian
Summary: Endothelial dysfunction in diabetes is mainly attributed to impaired mitochondrial function, not just the result of oxidative stress. Restoring mitochondrial function can reverse endothelial dysfunction, indicating the critical role of mitochondrial function in endothelium-dependent vasodilation.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Emmanuel Makinde, Linlin Ma, George D. Mellick, Yunjiang Feng
Summary: Mitochondria are essential for energy metabolism and play key roles in calcium homeostasis, ROS balance, cell apoptosis, and biosynthetic pathways. Disruption of mitochondrial function is associated with various diseases. This review discusses the physiological and pathological functions of mitochondria, as well as bioactive compounds that protect mitochondria and their mechanisms of action. The article provides insights into promising compounds, challenges in therapeutic use, and future research directions on mitochondrial modulators.
Review
Food Science & Technology
Jing Yang, Huayi Suo, Jiajia Song
Summary: MitoQ reduces mitochondrial oxidative stress and promotes autophagy and mitochondrial biogenesis to alleviate MetS symptoms such as obesity, insulin resistance, hypertension, and cardiovascular disease. Its regulatory effect on mitochondrial homeostasis is mediated through AMPK and its downstream signaling pathways.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Geriatrics & Gerontology
Dongye Guo, Andi Zhang, Tianyuan Zou, Rui Ding, Kaili Chen, Yi Pan, Peilin Ji, Bin Ye, Mingliang Xiang
Summary: With the increase in life expectancy worldwide, elderly populations are growing, including in China. Age-related hearing loss and metabolic syndrome are common chronic diseases, and many people suffer from both simultaneously. Recent studies have found that mitochondrial dysfunction is present in both conditions, highlighting the importance of studying the impact of metabolic syndrome on age-related hearing loss from the perspective of mitochondrial dysfunction.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Nutrition & Dietetics
Mohamad Khalil, Harshitha Shanmugam, Hala Abdallah, Jerlin Stephy John Britto, Ilaria Galerati, Javier Gomez-Ambrosi, Gema Fruhbeck, Piero Portincasa
Summary: Abnormal expansion of body fat leads to metabolic abnormalities and increases the risk of cardiovascular disease. Adopting a healthy diet, such as the Mediterranean diet, can improve mitochondrial function and metabolism.
Article
Biochemistry & Molecular Biology
Elisa Martino, Amalia Luce, Anna Balestrieri, Luigi Mele, Camilla Anastasio, Nunzia D'Onofrio, Maria Luisa Balestrieri, Giuseppe Campanile
Summary: Endothelial dysfunction plays a critical role in the progression of type 2 diabetes mellitus (T2DM), leading to cardiovascular complications. Whey (WH), a dairy by-product with a considerable content of bioactive compounds, showed protective effects on human endothelial cell function under diabetic conditions mimicked in vitro.
Article
Cardiac & Cardiovascular Systems
Rahele A. Farahani, Shasha Yu, Christopher M. Ferguson, Xiang-Yang Zhu, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, Sandra M. Herrmann, Alejandro R. Chade, Amir Lerman, Lilach O. Lerman, Alfonso Eirin
Summary: The study showed that PTRA treatment improved myocardial mitochondrial damage, enhanced microvascular maturity, reduced oxidative stress and fibrosis, and mitigated left ventricular remodeling and diastolic dysfunction in pigs with MetS and RVH, indicating the therapeutic potential of PTRA in these conditions.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Wembley Rodrigues Vilela, Paula Maria Quaglio Bellozi, Victor Luna Picolo, Bruna Neves Cavadas, Keila Valentina Silva Marques, Louise Tavares Garcia Pereira, Ainhoa Rodriguez de Yurre Guirao, Angelica Amorim Amato, Kelly Grace Magalhaes, Marcia Renata Mortari, Emiliano Horacio Medei, Jair Trape Goulart, Andreza Fabro de Bem
Summary: The study aimed to evaluate the relationship between metabolic and bioenergetic changes induced by a two-hit protocol and cognitive function in mice. The results showed that the two-hit protocol, involving a high-fat diet and low doses of streptozotocin, impaired cognitive function and affected the energy metabolism in brain tissues. These findings highlight the detrimental impact of early overnutrition on cognitive function.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Jian-Kang Mu, Lei Zi, Yan-Qin Li, Li-Ping Yu, Zheng-Guo Cui, Ting-Ting Shi, Fan Zhang, Wen Gu, Jun-Jie Hao, Jie Yu, Xing-Xin Yang
Summary: JHP alleviates HFD-induced MAFLD through the protection of mitochondrial function, as shown by the results of decreased levels of total cholesterol, triglyceride, LDL-C, ALT, and AST, and increased HDL-C, as well as regulation of oxidative stress and fatty acid metabolism.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biology
I. -Fan Liu, Tzu-Chieh Lin, Shu-Chi Wang, Chia-Hung Yen, Chia-Yang Li, Hsuan-Fu Kuo, Chong-Chao Hsieh, Chia-Yuan Chang, Chuang-Rung Chang, Yung-Hsiang Chen, Yu-Ru Liu, Tsung-Ying Lee, Chi-Yuan Huang, Chih-Hsin Hsu, Shing-Jong Lin, Po-Len Liu
Summary: Long-term consumption of excessive fat and sucrose diet can lead to metabolic syndrome and cardiovascular disease. The study found that CAV-1 and caveolae proteins are related to abnormal lipid accumulation in the endothelium and myocardium, as well as dysfunction in microvascular endothelial cells and mitochondrial remodeling.
Article
Biochemistry & Molecular Biology
Wenjun Jiang, Nan Jia, Chaowan Guo, Juan Wen, Lingqian Wu, Tomoo Ogi, Huiwen Zhang
Summary: The study investigated a Bloom-like syndrome caused by TOP3A mutations, showing that the defects affect both genome stability and mitochondrial metabolism, suggesting the importance of impaired mitochondrial metabolism in disease pathogenesis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Aoxue Li, Ningning Zheng, Xudong Ding
Summary: Metabolic syndrome is a collection of cardiovascular risk factors, and oxidative stress plays a crucial role in it; oxidative stress can disrupt cardiac function through various pathways, leading to heart diseases and apoptosis of cardiomyocytes.
HEART FAILURE REVIEWS
(2022)
Article
Oncology
Jin-Young Yoon, Nastaran Daneshgar, Yi Chu, Biyi Chen, Marco Hefti, Ajit Vikram, Kaikobad Irani, Long-Sheng Song, Charles Brenner, E. Dale Abel, Barry London, Dao-Fu Dai
Summary: This study reveals the mechanistic explanations for cardiac bradyarrhythmia, diastolic dysfunction, and neuronal apoptosis observed in models of Leigh syndrome (LS).
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Natalia Todosenko, Olga Khaziakhmatova, Vladimir Malashchenko, Kristina Yurova, Maria Bograya, Maria Beletskaya, Maria Vulf, Natalia Gazatova, Larisa Litvinova
Summary: Metabolic syndrome acts as a precursor to major health diseases such as cardiovascular disease and diabetes, which have high mortality rates in industrialized countries. Mitochondrial dysfunction plays a crucial role in the pathogenesis of metabolic syndrome, leading to tissue hypoxia, disruption of mitochondrial integrity, increased production of reactive oxygen species, and decreased ATP levels, resulting in chronic inflammation affecting tissues and organs. The mitochondrial protease Lon (Lonp1) shows potential as a molecular target for the development of targeted therapy for metabolic syndrome and its components due to its broad spectrum of activities, including protein degradation, chaperone activity, and mitochondrial DNA binding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Tapan Behl, Rashita Makkar, Md. Khalid Anwer, Rym Hassani, Gulrana Khuwaja, Asaad Khalid, Syam Mohan, Hassan A. Alhazmi, Monika Sachdeva, Mahesh Rachamalla
Summary: Mitochondria are semiautonomous intracellular components involved in metabolism and energy production. Defects in mitochondria lead to chronic cellular diseases. Dysfunctional mitochondria play a critical role in cancer, diabetes, infections, and obesity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Gemma Ferrer-Curriu, Mariona Guitart-Mampel, Celia Ruperez, Monica Zamora, Fatima Crispi, Francesc Villarroya, Joaquim Fernandez-Sola, Gloria Garrabou, Anna Planavila
Summary: Alcoholic cardiomyopathy (ACM) is a major cause of heart failure and cardiovascular mortality due to chronic alcohol misuse. Fibroblast growth factor 21 (FGF21) has been identified as a cardioprotective factor. The study showed that FGF21 levels in the blood and heart tissue increased in subjects with chronic alcohol consumption, playing a role in protecting against alcohol-induced cardiomyopathy.
JOURNAL OF PATHOLOGY
(2021)
Article
Immunology
Celia Ruperez, Gemma Ferrer-Curriu, Aina Cervera-Barea, Laura Florit, Mariona Guitart-Mampel, Gloria Garrabou, Monica Zamora, Fatima Crispi, Joaquim Fernandez-Sola, Josep Lupon, Antoni Bayes-Genis, Francesc Villarroya, Anna Planavila
Summary: Meteorin-like/Meteorin-beta, secreted by skeletal muscle and adipose tissue, plays a crucial role in cardiac hypertrophy and dysfunction. It directly inhibits hypertrophy development in cardiomyocytes and acts as a new biomarker for heart failure in patients.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Medical Laboratory Technology
Selena Trifunov, Abraham J. Paredes-Fuentes, Carmen Badosa, Anna Codina, Julio Montoya, Eduardo Ruiz-Pesini, Cristina Jou, Gloria Garrabou, Josep M. Grau-Junyent, Delia Yubero, Raquel Montero, Jordi Muchart, Juan D. Ortigoza-Escobar, Maria M. O'Callaghan, Andres Nascimento, Albert Catala, Angels Garcia-Cazorla, Cecilia Jimenez-Mallebrera, Rafael Artuch
Summary: This study investigated circulating cell-free mitochondrial DNA (ccfmtDNA) levels in the cerebrospinal fluid of patients with mitochondrial diseases (MD). The results showed significantly higher levels of ccfmtDNA in MD patients compared to controls, and a significant positive correlation between ccfmtDNA levels and GDF-15 concentrations. These findings suggest that ccfmtDNA could serve as a novel biomarker for MD research and clinical outcome assessment.
CLINICAL CHEMISTRY
(2021)
Article
Gastroenterology & Hepatology
Erica Lafoz, Genis Camprecios, Hector Garcia-Caldero, Aina Anton, Marina Vilaseca, Maria Ruart, Eduard Guasch, Gloria Garrabou, Teresa C. Delgado, Maria-Luz Martinez-Chantar, Rita Garcia-Martinez, Jordi Gracia-Sancho, Virginia Hernandez-Gea, Juan Carlos Garcia-Pagan
Summary: This study developed two advanced cirrhosis regression experimental models with persistent fibrosis and portal hypertension, mimicking patient conditions. Despite improving metabolism, lifestyle interventions did not enhance the regression process in cirrhotic models. Caloric restriction did not further reduce portal pressure, hepatic fibrosis, or HSC activation. Moderate endurance exercise exhibited a profibrogenic effect in the liver, blunting cirrhosis regression. Potential ammonia accumulation could be one explanation for this worsened effect.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Cell Biology
Sara Ramirez, Roberta Haddad-Tovolli, Marija Radosevic, Miriam Toledo, Adriana Pane, Daniel Alcolea, Vicent Ribas, Maria Mila-Guasch, Macarena Pozo, Arnaud Obri, Elena Eyre, Alicia G. Gomez-Valades, Inigo Chivite, Tomas Van Eeckhout, Ioannis Zalachoras, Jordi Altirriba, Corinna Bauder, Monica Imbernon, Gloria Garrabou, Carmen Garcia-Ruiz, Ruben Nogueiras, David Soto, Xavier Gasull, Carmen Sandi, Jens C. Bruening, Juan Fortea, Amanda Jimenez, Jose C. Fernandez-Checa, Marc Claret
Summary: Obesity and type 2 diabetes are associated with cognitive dysfunction. This study found that specific neurons in the hypothalamus play an important role in the interface of metabolism and cognition. Acute obesogenic diet administration in mice impaired recognition memory due to defective production of the neurosteroid precursor pregnenolone in the hypothalamus. Our data suggest that pregnenolone's effects on cognitive function were mediated via an autocrine mechanism on POMC neurons, influencing hippocampal long-term potentiation. The relevance of central pregnenolone on cognition was also confirmed in metabolically unhealthy patients with obesity.
Article
Genetics & Heredity
Marcello Bellusci, Abraham J. Paredes-Fuentes, Eduardo Ruiz-Pesini, Beatriz Gomez, Miguel A. Martin, Julio Montoya, Rafael Artuch, MITOSPAIN Working Grp
Summary: This study provides nationwide epidemiological data for mitochondrial diseases (MD) in Spain, highlighting the incidence rates and genetic information related to the disease. Among pediatric patients, mutations in nuclear DNA genes were more common than mitochondrial DNA genes.
Review
Medicine, General & Internal
Alba Valiente-Palleja, Juan Tortajada, Bengisu K. Bulduk, Elisabet Vilella, Gloria Garrabou, Gerard Muntane, Lourdes Martorell
Summary: Mitochondrial DNA alterations in human brain tissue can impact brain functioning and are linked to various neurological and psychiatric diseases as well as the aging process. Studies have shown variability in the types of mtDNA alterations across different brain regions and disease categories. More research is needed to fully understand the role of mtDNA in these conditions.
Article
Medicine, General & Internal
Sandra Casas-Recasens, Nuria Mendoza, Alejandra Lopez-Giraldo, Tamara Garcia, Borja G. Cosio, Sergi Pascual-Guardia, Ady Acosta-Castro, Alicia Borras-Santos, Joaquim Gea, Gloria Garrabou, Alvar Agusti, Rosa Faner
Summary: The study suggests a link between respiratory diseases such as COPD and accelerated ageing. Telomere length may be associated with lung function impairment, and there are differences in mitochondrial function in COPD patients of different age groups.
FRONTIERS IN MEDICINE
(2021)
Editorial Material
Biochemistry & Molecular Biology
Gloria Garrabou, Ana Sandra Hernandez, Mariona Guitart-Mampel, Elena Escalada-Casellas, Gemma Malats-Revelles, Sara Castro-Barquero, Ana Maria Ruiz-Leon, Kilian Vellve, Rosa Casas, Francesc Cardellach, Fatima Crispi, Francesc Josep Garcia-Garcia
Summary: This study found that dietary interventions, including supplementation with hydroxytyrosol, can improve complications of IUGR. Additionally, early biomarkers combined with dietary interventions may help predict IUGR diagnosis, aiding in avoiding risks of newborn mortality and morbidity.
Article
Biochemistry & Molecular Biology
Nuria Bujan, Constanza Moren, Francesc J. Garcia-Garcia, Alberto Blazquez, Clara Carnicer, Ana Belen Cortes, Cristina Gonzalez, Ester Lopez-Gallardo, Ester Lozano, Sonia Moliner, Laura Gort, Ester Tobias, Aitor Delmiro, Miguel Angel Martin, Miguel Angel Fernandez-Moreno, Eduardo Ruiz-Pesini, Elena Garcia-Arumi, Juan Carlos Rodriguez-Aguilera, Gloria Garrabou
Summary: The quantification of mitochondrial respiratory chain (MRC) enzymatic activities is crucial for diagnosing mitochondrial diseases. However, the high variability in measuring MRC enzymatic activities and the methodological challenges have hindered comparative analysis. To address this issue, seven Spanish centers collaborated to standardize spectrophotometric MRC enzymatic measurements using minimum sample amounts.
Review
Health Care Sciences & Services
Teresa Torres Moral, Albert Sanchez-Niubo, Anna Monistrol-Mula, Chiara Gerardi, Rita Banzi, Paula Garcia, Jacques Demotes-Mainard, Josep Maria Haro
Summary: Personalized medicine requires large cohorts for patient stratification and validation, but there is a lack of defined standards and practices for designing and managing cohorts in this field. This study aims to describe the current state-of-the-art in personalized medicine cohorts through a scoping review. The review found information on data generation and tools for data management and analysis, but scarce information on data quality and monitoring associated clinical data.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Adriana Pane, Camila Milad, Marta Santana-Dominguez, Nuria Banos, Cristina Borras-Novell, Gerard Espinosa, Laura Magnano, Meritxell Nomdedeu, Pedro Juan Moreno-Lozano, Frederic Cofan, Merce Placeres, Rosa Maria Fernandez, Judit Garcia-Villoria, Gloria Garrabou, Irene Vinagre, Laura M. Tanner, Cristina Montserrat-Carbonell, Maria de Tallo Forga-Visa
Summary: Lysinuric protein intolerance (LPI) is a rare metabolic disorder that presents challenges during pregnancy and delivery. This case report highlights the successful natural birth of a woman with LPI, despite various challenges and risks. Collaboration between interdisciplinary teams and careful consideration of risks are crucial in achieving a successful pregnancy and delivery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Maria Isabel Alvarez-Mora, Gloria Garrabou, Laura Molina-Porcel, Ruben Grillo-Risco, Francisco Garcia-Garcia, Tamara Barcos, Judith Canto-Santos, Laia Rodriguez-Revenga
Summary: This study investigated the expression levels of SUMO2/3 and the autophagy process in samples from FXTAS patients. The results showed that SUMO2/3 accumulation is involved in inclusion formation, and the autophagy process is downregulated in FXTAS. These findings provide new evidence for the role of SUMOylation and autophagic processes in the pathogenic mechanisms underlying FXTAS.
Review
Oncology
Masaya Hattori, Diego Novick, Kana Takaura, Yoshinori Tanizawa, Tsutomu Kawaguchi, Josep Maria Haro, Anna Monistrol-Mula, Akira Onishi, Hiroji Iwata
Summary: The study found that disease-free interval, the number of metastatic organs, and liver metastasis are independent prognostic factors for overall survival in patients with HR+/HER2- advanced and metastatic breast cancer in Japan. These findings could aid clinical decision-making and improve patient outcomes.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2021)