Aldosterone Production and Signaling Dysregulation in Obesity

Past and present of antiobesity agents: Focus on monoamine modulators

(2015) F. E. Khorassani et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Lack of weight gain after angiotensin AT1receptor blockade in diet-induced obesity is partly mediated by an angiotensin-(1-7)/Mas-dependent pathway

(2015) Johanna Schuchard et al.   BRITISH JOURNAL OF PHARMACOLOGY

New perspectives on the development of antiobesity drugs

(2015) Luca Costantino et al.   Future Medicinal Chemistry

What Is the Role of the Adipocyte Mineralocorticoid Receptor in the Metabolic Syndrome?: Figure.

(2015) Celso E. Gomez-Sanchez   HYPERTENSION

Dynamic regulation of the angiotensinogen gene by DNA methylation, which is influenced by various stimuli experienced in daily life

(2015) Masashi Demura et al.   HYPERTENSION RESEARCH

Cellular mechanisms of MR regulation of adipose tissue physiology and pathophysiology

(2015) Andrea Armani et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Development of CYP11B1 and CYP11B2 assays utilizing homogenates of adrenal glands: Utility of monkey as a surrogate for human

(2015) Matthew A. Cerny et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Crystal structures of the human adiponectin receptors

(2015) Hiroaki Tanabe et al.   NATURE

Epigenetics and arterial hypertension: the challenge of emerging evidence

(2015) Simonetta Friso et al.   Translational Research

Perspective of Small-Molecule AdipoR Agonist for Type 2 Diabetes and Short Life in Obesity

(2015) Miki Okada-Iwabu et al.   Diabetes & Metabolism Journal

Modulation of adiponectin as a potential therapeutic strategy

(2014) Soo Lim et al.   ATHEROSCLEROSIS

Effects of Angiotensin-Converting Enzyme Inhibition on Leptin and Adiponectin Levels in Essential Hypertension

(2014) Vanessa Fontana et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

GPER-1 and Estrogen Receptor-β Ligands Modulate Aldosterone Synthesis

(2014) Brasilina Caroccia et al.   ENDOCRINOLOGY

Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice

(2014) Andrea Armani et al.   FASEB JOURNAL

Primary aldosteronism can alter peripheral levels of transforming growth factor β and tumor necrosis factor α

(2014) C. A. Carvajal et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

20 YEARS OF LEPTIN: Insights into signaling assemblies of the leptin receptor

(2014) Frank Peelman et al.   JOURNAL OF ENDOCRINOLOGY

Angiotensin II-regulated microRNA 483-3p directly targets multiple components of the renin–angiotensin system

(2014) Jacqueline R. Kemp et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Effects of aldosterone on insulin sensitivity and secretion

(2014) James M. Luther   STEROIDS

Narrative Review: The Emerging Clinical Implications of the Role of Aldosterone in the Metabolic Syndrome and Resistant Hypertension

(2013) James R. Sowers   ANNALS OF INTERNAL MEDICINE

Leptin-activity blockers: development and potential use in experimental biology and medicine

(2013) Arieh Gertler et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its α-kinase domain

(2013) Alvaro Yogi et al.   CELLULAR SIGNALLING

Randomized Trial of Perindopril, Enalapril, Losartan and Telmisartan in Overweight or Obese Patients with Hypertension

(2013) Sergey V. Nedogoda et al.   CLINICAL DRUG INVESTIGATION

Immune System Alterations by Aldosterone During Hypertension: From Clinical Observations to Genomic and Non-Genomic Mechanisms Leading to Vascular Damage

(2013) N. Munoz-Durango et al.   CURRENT MOLECULAR MEDICINE

Aldosteroneʼs mechanism of action

(2013) Rene Baudrand et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Effect of mineralocorticoid receptor antagonist on insulin resistance and endothelial function in obese subjects

(2013) R. Garg et al.   DIABETES OBESITY & METABOLISM

Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice

(2013) P. Luo et al.   DIABETOLOGIA

GPER Deficiency in Male Mice Results in Insulin Resistance, Dyslipidemia, and a Proinflammatory State

(2013) Geetanjali Sharma et al.   ENDOCRINOLOGY

GPER mediates the inhibitory actions of estrogen on adipogenesis in 3T3-L1 cells through perturbation of mitotic clonal expansion

(2013) Pei Zhu et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

MicroRNA-24 Is a Novel Regulator of Aldosterone and Cortisol Production in the Human Adrenal Cortex

(2013) Stacy Robertson et al.   HYPERTENSION

Abnormal Aldosterone Physiology and Cardiometabolic Risk Factors

(2013) Anand Vaidya et al.   HYPERTENSION

Dynamic CCAAT/Enhancer Binding Protein–Associated Changes of DNA Methylation in the Angiotensinogen Gene

(2013) Fen Wang et al.   HYPERTENSION

Integrated Analysis of Genome-Wide Methylation and Gene Expression Shows Epigenetic Regulation ofCYP11B2in Aldosteronomas

(2013) Brandi Howard et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Structural Insights into Aldosterone Synthase Substrate Specificity and Targeted Inhibition

(2013) Natallia Strushkevich et al.   MOLECULAR ENDOCRINOLOGY

Are there still healthy obese patients?

(2013) Matthias Blüher   Current Opinion in Endocrinology Diabetes and Obesity

Plasma Aldosterone Is Increased in Class 2 and 3 Obese Essential Hypertensive Patients Despite Drug Treatment

(2012) R. Sarzani et al.   AMERICAN JOURNAL OF HYPERTENSION

Visceral adipose tissue: emerging role of gluco- and mineralocorticoid hormones in the setting of cardiometabolic alterations

(2012) Marco Boscaro et al.   Annals of the New York Academy of Sciences

Contribution of glucocorticoid–mineralocorticoid receptor pathway on the obesity-related adipocyte dysfunction

(2012) Ayumu Hirata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Blood pressure response to angiotensin II is enhanced in obese Zucker rats and is attributed to an aldosterone-dependent mechanism

(2012) Helge Müller-Fielitz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Increased urinary aldosterone excretion is associated with subcutaneous not visceral, adipose tissue area in obese individuals: a possible manifestation of dysfunctional subcutaneous adipose tissue

(2012) Eisaku Harada et al.   CLINICAL ENDOCRINOLOGY

Angiotensin 1-7 as Means to Prevent the Metabolic Syndrome: Lessons From the Fructose-Fed Rat Model

(2012) Y. Marcus et al.   DIABETES

Adipocytes Produce Aldosterone Through Calcineurin-Dependent Signaling Pathways

(2012) Ana M. Briones et al.   HYPERTENSION

High-circulating leptin levels are associated with increased blood pressure in uncontrolled resistant hypertension

(2012) C de Haro Moraes et al.   JOURNAL OF HUMAN HYPERTENSION

Genes implicated in insulin resistance are down-regulated in primary aldosteronism patients

(2012) Tracy Ann Williams et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Role of renin–angiotensin–aldosterone system in adipose tissue dysfunction

(2012) Fei Jing et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Aldosterone synthase inhibition in humans

(2012) Michel Azizi et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Epigenetics: A New Bridge between Nutrition and Health

(2012) Sang-Woon Choi et al.   Advances in Nutrition

The Kidneys and Aldosterone/Mineralocorticoid Receptor System in Salt-Sensitive Hypertension

(2011) Shigeru Shibata et al.   CURRENT HYPERTENSION REPORTS

Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets

(2011) J. M. Luther et al.   DIABETOLOGIA

GPR30 Expression Is Required for the Mineralocorticoid Receptor–Independent Rapid Vascular Effects of Aldosterone

(2011) Robert Gros et al.   HYPERTENSION

Non-genomic actions of aldosterone: From receptors and signals to membrane targets

(2011) Ruth Dooley et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The renin–angiotensin–aldosterone system and glucose homeostasis

(2011) James Matthew Luther et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Insulin-sensitive obesity

(2010) Nora Klöting et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Role of Aldosteronism in Causing Obesity-Related Cardiovascular Risk

(2010) David A. Calhoun et al.   CARDIOLOGY CLINICS

Aldosterone Production and Insulin Resistance in Healthy Adults

(2010) Rajesh Garg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Aldosterone 'escape' vs 'breakthrough'

(2010) Robert W. Schrier   Nature Reviews Nephrology

MicroRNAs miR-124 and miR-135a are potential regulators of the mineralocorticoid receptor gene (NR3C2) expression

(2009) Siim Sõber et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aldosterone and Metabolic Dysfunction

(2009) Eduardo Pimenta et al.   HYPERTENSION

Deletion of Mineralocorticoid Receptors From Macrophages Protects Against Deoxycorticosterone/Salt-Induced Cardiac Fibrosis and Increased Blood Pressure

(2009) Amanda J. Rickard et al.   HYPERTENSION

Aldosterone Promotes Autoimmune Damage by Enhancing Th17-Mediated Immunity

(2009) Andrés A. Herrada et al.   JOURNAL OF IMMUNOLOGY

Corticosteroid receptors, macrophages and cardiovascular disease

(2009) Amanda J Rickard et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Aldosterone and arterial hypertension

(2009) Andreas Tomaschitz et al.   Nature Reviews Endocrinology

Mineralocorticoid Receptor Blockade Reverses Obesity-Related Changes in Expression of Adiponectin, Peroxisome Proliferator-Activated Receptor-γ, and Proinflammatory Adipokines

(2008) Christine Guo et al.   CIRCULATION

The Metabolic Syndrome

(2008) Marc-Andre Cornier et al.   ENDOCRINE REVIEWS

Body Mass Index Predicts Plasma Aldosterone Concentrations in Overweight-Obese Primary Hypertensive Patients

(2008) Gian Paolo Rossi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Silencing of the Mineralocorticoid Receptor by Ribonucleic Acid Interference in Transgenic Rats Disrupts Endocrine Homeostasis

(2008) Hee-Young Lim et al.   MOLECULAR ENDOCRINOLOGY