Aldosterone synthase inhibition in humans

Human aldosterone synthase: Recombinant expression in E. coli and purification enables a detailed biochemical analysis of the protein on the molecular level

(2012) Anna Hobler et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Effects of a Novel Aldosterone Synthase Inhibitor for Treatment of Primary Hypertension

(2011) David A. Calhoun et al.   CIRCULATION

The Role of Aldosterone in the Metabolic Syndrome

(2011) Marie Briet et al.   CURRENT HYPERTENSION REPORTS

Addition of Spironolactone in Patients With Resistant Arterial Hypertension (ASPIRANT)

(2011) Jan Václavík et al.   HYPERTENSION

A double-blind, randomized study comparing the antihypertensive effect of eplerenone and spironolactone in patients with hypertension and evidence of primary aldosteronism

(2011) Hari K Parthasarathy et al.   JOURNAL OF HYPERTENSION

Acute and chronic regulation of aldosterone production

(2011) Namita G. Hattangady et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2)

(2010) Christina Zimmer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Adrenal Cortex Remodeling and Functional Zona Glomerulosa Hyperplasia in Primary Aldosteronism

(2010) Sheerazed Boulkroun et al.   HYPERTENSION

Aldosterone Synthase Inhibition With LCI699

(2010) Laurence Amar et al.   HYPERTENSION

A New Mode of Mineralocorticoid Receptor Antagonism by a Potent and Selective Nonsteroidal Molecule

(2010) Jérôme Fagart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aldosterone Production and Insulin Resistance in Healthy Adults

(2010) Rajesh Garg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

HORMONAL AND ELECTROLYTE RESPONSES TO THE ALDOSTERONE SYNTHASE INHIBITOR LCI699 IN SODIUM DEPLETED HEALTHY SUBJECTS

(2010) Joël Menard et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms

(2010) Faiez Zannad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors

(2009) Daniel LaSala et al.   ANALYTICAL BIOCHEMISTRY

Aldosterone-receptor antagonism in hypertension

(2009) Pieter M Jansen et al.   JOURNAL OF HYPERTENSION

Addition of Angiotensin Receptor Blockade or Mineralocorticoid Antagonism to Maximal Angiotensin-Converting Enzyme Inhibition in Diabetic Nephropathy

(2009) U. F. Mehdi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt

(2009) William B. Lea et al.   KIDNEY INTERNATIONAL

Characterization of Resistant HypertensionAssociation Between Resistant Hypertension, Aldosterone, and Persistent Intravascular Volume Expansion

(2008) Krishna K. Gaddam   ARCHIVES OF INTERNAL MEDICINE

A Lifetime of Aldosterone Excess: Long-Term Consequences of Altered Regulation of Aldosterone Production for Cardiovascular Function

(2008) John M. C. Connell et al.   ENDOCRINE REVIEWS

Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone

(2008) P. Mulder et al.   EUROPEAN HEART JOURNAL

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)

(2008) et al.   EUROPEAN HEART JOURNAL

High plasma aldosterone and low renin predict blood pressure increase and hypertension in middle-aged Caucasian populations

(2008) P Meneton et al.   JOURNAL OF HUMAN HYPERTENSION

Effectiveness of the selective aldosterone blocker, eplerenone, in patients with resistant hypertension

(2008) David A. Calhoun et al.   Journal of the American Society of Hypertension

Aldosterone and mineralocorticoid receptors: Clinical studies and basic biology

(2008) John W. Funder et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY