Intracellular sodium elevation reprograms cardiac metabolism

Is there a causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy?

(2018) Dunja Aksentijevic et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

(2017) Timothy S. Luongo et al.   NATURE

Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart

(2016) Anja Karlstaedt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is rate-pressure product of any use in the isolated rat heart? Assessing cardiac ‘effort’ and oxygen consumption in the Langendorff-perfused heart

(2015) Dunja Aksentijević et al.   EXPERIMENTAL PHYSIOLOGY

Multiple quantum filtered 23Na NMR in the Langendorff perfused mouse heart: Ratio of triple/double quantum filtered signals correlates with [Na]i

(2015) Thomas R. Eykyn et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation

(2015) Latt S. Mansor et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cardiac hypertrophy in mice expressing unphosphorylatable phospholemman

(2014) Andrii Boguslavskyi et al.   CARDIOVASCULAR RESEARCH

Inhibiting Mitochondrial Na + /Ca 2+ Exchange Prevents Sudden Death in a Guinea Pig Model of Heart Failure

(2014) Ting Liu et al.   CIRCULATION RESEARCH

Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity

(2014) Dunja Aksentijević et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation

(2013) Waleed G.T. Masoud et al.   CARDIOVASCULAR RESEARCH

Novel regulation of cardiac Na pump via phospholemman

(2013) Davor Pavlovic et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

CardioNet: A human metabolic network suited for the study of cardiomyocyte metabolism

(2012) Anja Karlstädt et al.   BMC Systems Biology

The mitochondrial Na+/Ca2+ exchanger

(2012) Raz Palty et al.   CELL CALCIUM

Regulation of the cardiac sodium pump

(2012) W. Fuller et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Properties of blebbistatin for cardiac optical mapping and other imaging applications

(2012) Luther M. Swift et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Return to the fetal gene program

(2010) Heinrich Taegtmeyer et al.   Annals of the New York Academy of Sciences

Elevated Cytosolic Na + Increases Mitochondrial Formation of Reactive Oxygen Species in Failing Cardiac Myocytes

(2010) Michael Kohlhaas et al.   CIRCULATION

Role of mitochondrial dysfunction in cardiac glycoside toxicity

(2010) Ting Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Digitalis and Na/Ca exchange: Old dog learns new mitochondrial tricks

(2010) Donald M. Bers   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

CGP-37157 Inhibits the Sarcoplasmic Reticulum Ca2+ ATPase and Activates Ryanodine Receptor Channels in Striated Muscle

(2010) J. T. Neumann et al.   MOLECULAR PHARMACOLOGY

The Randle cycle revisited: a new head for an old hat

(2009) Louis Hue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Phospholemman: its role in normal cardiac physiology and potential as a drugable target in disease

(2009) Michael J Shattock   CURRENT OPINION IN PHARMACOLOGY

Insulin resistance and altered glucose transporter 4 expression in experimental uremia

(2009) Dunja Aksentijević et al.   KIDNEY INTERNATIONAL

Enhancing Mitochondrial Ca 2+ Uptake in Myocytes From Failing Hearts Restores Energy Supply and Demand Matching

(2008) Ting Liu et al.   CIRCULATION RESEARCH