Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation

Coming together to define membrane contact sites

(2019) Luca Scorrano et al.   Nature Communications

Roles of protrudin at interorganelle membrane contact sites

(2019) Michiko SHIRANE   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

NeurodegenERation: The Central Role for ER Contacts in Neuronal Function and Axonopathy, Lessons From Hereditary Spastic Paraplegias and Related Diseases

(2019) Philippa C. Fowler et al.   Frontiers in Neuroscience

Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

(2018) Yvette C. Wong et al.   NATURE

Visualizing multiple inter-organelle contact sites using the organelle-targeted split-GFP system

(2018) Yuriko Kakimoto et al.   Scientific Reports

Roles for ER : endosome membrane contact sites in ligand-stimulated intraluminal vesicle formation

(2018) Louise H. Wong et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission

(2018) Melissa J. Hoyer et al.   CELL

Here, there, and everywhere: The importance of ER membrane contact sites

(2018) Haoxi Wu et al.   SCIENCE

Defects in ER–endosome contacts impact lysosome function in hereditary spastic paraplegia

(2017) Rachel Allison et al.   JOURNAL OF CELL BIOLOGY

PtdIns3P controls mTORC1 signaling through lysosomal positioning

(2017) Zhi Hong et al.   JOURNAL OF CELL BIOLOGY

Reconstitution of the tubular endoplasmic reticulum network with purified components

(2017) Robert E. Powers et al.   NATURE

Lipid transport by TMEM24 at ER–plasma membrane contacts regulates pulsatile insulin secretion

(2017) Joshua A. Lees et al.   SCIENCE

ER-mitochondria tethering by PDZD8 regulates Ca2+dynamics in mammalian neurons

(2017) Yusuke Hirabayashi et al.   SCIENCE

SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth

(2017) Takafumi Ohnishi et al.   Scientific Reports

The TULIP superfamily of eukaryotic lipid-binding proteins as a mediator of lipid sensing and transport

(2016) Vikram Alva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Genetic risk mechanisms of posttraumatic stress disorder in the human brain

(2016) Rahul A. Bharadwaj et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Control of plasma membrane lipid homeostasis by the extended synaptotagmins

(2016) Yasunori Saheki et al.   NATURE CELL BIOLOGY

ER-endosome contact sites: molecular compositions and functions

(2015) C. Raiborg et al.   EMBO JOURNAL

Repeated ER–endosome contacts promote endosome translocation and neurite outgrowth

(2015) Camilla Raiborg et al.   NATURE

Structure and function of ER membrane contact sites with other organelles

(2015) Melissa J. Phillips et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Conserved SMP domains of the ERMES complex bind phospholipids and mediate tether assembly

(2015) Andrew P. AhYoung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient human immunodeficiency virus (HIV-1) infection of cells lacking PDZD8

(2015) Shijian Zhang et al.   VIROLOGY

Membrane-shaping disorders: a common pathway in axon degeneration

(2014) Christian A. Hübner et al.   BRAIN

ER Contact Sites Define the Position and Timing of Endosome Fission

(2014) Ashley A. Rowland et al.   CELL

Protrudin Regulates Endoplasmic Reticulum Morphology and Function Associated with the Pathogenesis of Hereditary Spastic Paraplegia

(2014) Yutaka Hashimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small regulators, major consequences - Ca2+ and cholesterol at the endosome-ER interface

(2014) R. van der Kant et al.   JOURNAL OF CELL SCIENCE

Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer

(2014) Curtis M. Schauder et al.   NATURE

Organization and function of membrane contact sites

(2013) Sebastian C.J. Helle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PI(4,5)P2-Dependent and Ca2+-Regulated ER-PM Interactions Mediated by the Extended Synaptotagmins

(2013) Francesca Giordano et al.   CELL

Identification and characterization of a neuron-specific isoform of protrudin

(2013) Takafumi Ohnishi et al.   GENES TO CELLS

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation

(2013) J. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Pathways of Hereditary Spastic Paraplegia

(2012) Craig Blackstone   Annual Review of Neuroscience

Role of spastin and protrudin in neurite outgrowth

(2012) Chuanling Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation

(2011) Fumiko Matsuzaki et al.   MOLECULAR BIOLOGY OF THE CELL

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

PDZD8 is a novel moesin-interacting cytoskeletal regulatory protein that suppresses infection by herpes simplex virus type 1

(2011) Matthew S. Henning et al.   VIROLOGY

Homology of SMP domains to the TULIP superfamily of lipid-binding proteins provides a structural basis for lipid exchange between ER and mitochondria

(2010) Klaus O. Kopec et al.   BIOINFORMATICS

Promotion of Neurite Extension by Protrudin Requires Its Interaction with Vesicle-associated Membrane Protein-associated Protein

(2009) Shotaro Saita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

The Amyotrophic Lateral Sclerosis 8 Protein VAPB Is Cleaved, Secreted, and Acts as a Ligand for Eph Receptors

(2008) Hiroshi Tsuda et al.   CELL