Article
Oncology
Bertha Alejandra Martinez-Cannon, Karen Garcia-Ronquillo, Monica M. Rivera-Franco, Eucario Leon-Rodriguez
Summary: This study evaluated the association between circulating neutrophil extracellular traps (NETs) and clinicopathological characteristics and outcomes in early breast cancer. The results showed no statistically significant associations between circulating NETs levels and clinicopathological characteristics, recurrence, or site of recurrence.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cell Biology
Zhenyu Nie, Mei Chen, Yuanhui Gao, Denggao Huang, Hui Cao, Yanling Peng, Na Guo, Shufang Zhang
Summary: Urinary malignancies such as kidney, bladder, and prostate cancers pose challenges in treatment due to high recurrence and metastasis rates. The regulation of cell death pathways plays a significant role in the pathogenesis of these tumors, with various modes of regulated cell death influencing tumor progression and therapeutic responses. Targeting regulatory cell death pathways shows promise for improving outcomes in urinary system tumor treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Jan Philipp Kolman, Laia Pagerols Raluy, Ingo Mueller, Viacheslav O. Nikolaev, Magdalena Trochimiuk, Birgit Appl, Hannah Wadehn, Charlotte Maria Duecker, Fabian David Stoll, Michael Boettcher, Konrad Reinshagen, Julian Trah
Summary: In this study, the researchers investigated the effect of different culture conditions, including the use of G-CSF, LPS, or TNF-alpha, on the survival and NET formation of neutrophils. They found that untreated neutrophils could form NETs after stimulation with PMA for up to 24 hours. Incubation with LPS or G-CSF extended the ability of neutrophils to form NETs for up to 48 hours, with LPS leading to significantly higher NET release at 48 hours compared to untreated cells. TNF-alpha had no influence on NET release but altered the survival counts of neutrophils.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Oncology
Phei Er Saw, Jianing Chen, Erwei Song
Summary: Neutrophil extracellular traps (NETs) are involved in both infection control and tumor metastasis. The study by Mousset et al. published in Cancer Cell reveals that chemotherapy-induced inflammation promotes NETosis in malignant tumors, leading to chemoresistance. This finding highlights the potential of targeting inflammatory NETs for cancer treatment.
Article
Multidisciplinary Sciences
Hannes A. Baukmann, Justin L. Cope, Colin Bannard, Alexander R. E. C. Schwinges, Margaretha R. J. Lamparter, Sarah Groves, Charles N. J. Ravarani, Borko Amulic, Joern E. Klinger, Marco F. Schmidt
Summary: Despite the availability of vaccines to prevent SARS-CoV-2 infection, treating critically ill COVID-19 patients remains crucial. This study presents an alternative method for identifying drug repurposing targets by screening disease-causing traits, leading to the discovery of potential treatment targets for critical illness.
Article
Oncology
Wei-Wei Wang, Lipei Wu, Wenying Lu, Wei Chen, Wenhui Yan, Chunrun Qi, Shihai Xuan, Anquan Shang
Summary: The study demonstrates that LPS-induced formation of NETs promotes the development and metastasis of colorectal cancer, involving the TLR9 and mitogen-activated protein kinase signaling pathway.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ziyuan Zhao, Zirong Pan, Sen Zhang, Guodong Ma, Wen Zhang, Junke Song, Yuehua Wang, Linglei Kong, Guanhua Du
Summary: Stroke is a cerebrovascular disease caused by thrombus, with high morbidity and mortality rates. Neutrophils are the first cells to be recruited in the brain after stroke, and they aggravate brain injury through multiple mechanisms. Neutrophil extracellular traps (NETs) have been found to play important roles in the pathological process of stroke in recent years.
PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Medicine, Research & Experimental
Erin B. Taylor
Summary: This article discusses the importance of dysregulation of neutrophil extracellular trap formation in viral infections and explores treatment methods targeting NET formation.
Review
Biochemistry & Molecular Biology
Marina Stoimenou, Georgios Tzoros, Panagiotis Skendros, Akrivi Chrysanthopoulou
Summary: Several studies suggest that NETs may play a role in inflammatory and thrombotic disorders, thus serving as potential therapeutic or diagnostic tools. This article compares commonly used techniques for assessing NET formation and discusses the challenges and advantages in evaluating NETs. The review provides insights into the molecular analysis of NETs in translational medicine today.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Edgar Ramos-Martinez, Leticia Hernandez-Gonzalez, Ivan Ramos-Martinez, Laura Perez-Campos Mayoral, Georgina Lopez-Cortes, Eduardo Perez-Campos, Gabriel Mayoral Andrade, Maria Teresa Hernandez-Huerta, Marco Jose
Summary: Extracellular DNA traps (ETs) are evolutionarily conserved antimicrobial mechanisms found in protozoa, plants, and animals. By comparing similarities in ETs across different taxa, it is suggested that ETs may have multiple origins. The presence of a mechanism initiating the formation of ETs in multicellular organisms indicates a relationship between multicellularity and the development of ETs.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Fei Chen, Min Yu, Yonghong Zhong, Lina Wang, Huaqiong Huang
Summary: Asthma is a common chronic respiratory disease with increasing incidence. Neutrophil extracellular traps (NETs) play a significant role in asthma by enriching anti-bacterial substances and limiting pathogen migration, but they may also exacerbate asthma progression.
Article
Cell Biology
Zehua Duan, Tian Xie, Chengnan Chu, Fang Chen, Xinyu Wang, Jieshou Li, Weiwei Ding
Summary: The study suggests that de-escalation therapy can promote NETs formation in sepsis patients, reducing organ injury and inflammatory response in the early stage, and alleviating organ damage and improving survival rates in the late stage. This therapy approach may have significant benefits in managing sepsis.
CELL DEATH DISCOVERY
(2021)
Review
Biochemistry & Molecular Biology
Kritsanawan Sae-khow, Awirut Charoensappakit, Direkrit Chiewchengchol, Asada Leelahavanichkul
Summary: Vitamin C plays an important role in neutrophil function and has been studied in the treatment of sepsis. High-dose intravenous vitamin C (HDIVC) has been shown to improve neutrophil activity and microbial control, but long-term administration may have negative effects. Further studies are needed to determine the proper use of vitamin C in sepsis treatment.
Article
Oncology
Xueping Wang, Hao Huang, Lin Zhang, Yaxian Wu, Yingsheng Wen, Xuezi Weng, Qi Chen, Wanli Liu
Summary: A model incorporating H3Cit, IL-8, and CRP has shown excellent prediction ability for immune checkpoint inhibitor (ICI) response. Patients with a lower risk score are more likely to benefit from ICI treatment, indicating the potential for early detection of ICI response.
CANCER CELL INTERNATIONAL
(2023)
Review
Immunology
Xiu-Qi Chen, Li Tu, Qing Tang, Li Huang, Yuan-Han Qin
Summary: IgA vasculitis is the most common systemic small vessel vasculitis in childhood. Its pathogenesis may be related to various factors such as genetics, infection, environment, and drugs. The presence of neutrophil extracellular traps (NETs) is associated with disease activity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Mikhail Efanov, Diana Salimgereeva, Ruslan Alikhanov, Andrew G. R. Wu, David Geller, Federica Cipriani, Davit L. Aghayan, Asmund Avdem Fretland, Jasper Sijberden, Andrea Belli, Marco V. Marino, Vincenzo Mazzaferro, Adrian K. H. Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung Hoon Choi, Jae Hoon Lee, Mikel Prieto, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee-Chien Yong, Constantino Fondevila, Fernando Rotellar, Gi-Hong Choi, Ricardo Robless Campos, Xiaoying Wang, Robert P. Sutcliffe, Johann Pratschke, Eric Lai, Charing C. Chong, Mathieu D'Hondt, Kazuteru Monden, Santiago Lopez-Ben, Paulo Herman, Fabrizio Di Benedetto, T. Peter Kingham, Rong Liu, Tran Cong Duy Long, Alessandro Ferrero, Giovanni Battista Levi Sandri, Daniel Cherqui, Olivier Scatton, Go Wakabayashi, Roberto I. Troisi, Tan-To Cheung, Atsushi Sugioka, Ho-Seong Han, Mohammad Abu Hilal, Olivier Soubrane, David Fuks, Luca Aldrighetti, Bjorn Edwin, Brian K. P. Goh
Summary: This study compares the outcomes of laparoscopic liver resection of segments 7 and 8 and finds that atypical resection of segment 7 is more difficult than segment 8, while segmentectomy 8 is more difficult than segmentectomy 7.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Yun-Le Linn, Andrew G. Wu, Ho-Seong Han, Rong Liu, Kuo-Hsin Chen, David Fuks, Olivier Soubrane, Daniel Cherqui, David Geller, Tan-To Cheung, Bjorn Edwin, Luca Aldrighetti, Mohammad Abu Hilal, Roberto Troisi, Go Wakabayashi, Brian K. P. Goh
Summary: This study reviewed the literature on difficulty scoring systems (DSS) for minimally invasive liver resection (MILR) and found that existing DSS are effective in predicting the difficulty of the surgery.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Review
Immunology
Christof Kaltenmeier, Hamza O. Yazdani, Sanah Handu, Brandon Popp, David Geller, Samer Tohme
Summary: The innate immune system, particularly neutrophils and Neutrophil Extracellular Traps (NETs), plays a crucial role in liver ischemia and reperfusion injury (IRI) by promoting inflammation, tissue damage, and tumor progression. Understanding the role of innate immune cells and targeting neutrophils and NETs can contribute to the prevention and treatment of IRI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Epameinondas Dogeas, David A. A. Geller, Samer Tohme, Jennifer Steel, Winifred Lo, Brittany Morocco, Amit Tevar, Michele Molinari, Christopher Hughes, Abhinav Humar
Summary: This study compared textbook outcomes (TO) of open live donor right hepatectomy (RH) versus open right hepatic lobectomy for cancer in a single Western center and identified clinical factors associated with failure to achieve a TO. The results showed that the TO rate after RH for live donor purposes was 92.2% and for RH for cancer cases was 53.7%.
Article
Oncology
Qiang Du, Silvia Liu, Kun Dong, Xiao Cui, Jing Luo, David A. Geller
Summary: Metastasis is the main cause of death in patients with colorectal cancer. The study found that iNOS downregulation induces the EMT program and promotes metastasis in colorectal cancer. The reduced expression of iNOS may serve as a potential therapeutic target for patients with colorectal cancer.
MOLECULAR CANCER RESEARCH
(2023)
Article
Oncology
Ning-Ning Zhang, Jian Zheng, Ying Wu, Jia-Yu Lv, Shu-Wen Zhang, Ya-Min Zhang, Wen-Tao Jiang, Tian-Qiang Song, Victoria Kim, Samer Tohme, Tian Liu, Wei Zhang, Jie Gu, Ze-Yu Wang, Yu-Hong Suo, Shuai Wang, Wang Li, Li Zhang, Yan Xie, Yong-He Zhou, Jian-Yong Liu, Yi-Bo Qiu, Zhong-Yang Shen, Ji-Hui Hao, David Geller, Wei Lu
Summary: This study aimed to develop a prognostic calculator to compare the long-term outcomes of liver transplantation (LT), resection (LR), and ablation (LA) as treatment options for early hepatocellular carcinoma (HCC) patients. The study found that LT resulted in significantly higher recurrence-free survival (RFS) and HCC-specific survival (HSS) rates compared to LR and LA, and LR had significantly better outcomes than LA. For multinodular HCC with a diameter ≤3 cm, LR and LA showed similar effectiveness. A prognostic calculator was developed based on preoperative clinical factors to evaluate RFS, recurrence within the Milan criteria (RWM), and HSS at different time intervals for all three treatment options.
Article
Gastroenterology & Hepatology
Giada Aizza, Nadia Russolillo, Alessandro Ferrero, Nicholas L. Syn, Federica Cipriani, Davit Aghayan, Marco Marino, Riccardo Memeo, Vincenzo Mazzaferro, Adrian K. H. Chiow, Iswanto Sucandy, Arpad Ivanecz, Marco Vivarelli, Fabrizio Di Benedetto, Sung-Hoon Choi, Jae Hoon Lee, James O. Park, Mikel Gastaca, Constantino Fondevila, Mikhail Efanov, Fernando Rotellar, Gi-Hong Choi, Ricardo Robles-Campos, Xiaoying Wang, Robert P. Sutcliffe, Johann Pratschke, Chung Ngai Tang, Charing C. Chong, Mathieu D'Hondt, Chee Chien Yong, Andrea Ruzzenente, Paolo Herman, T. Peter Kingham, Olivier Scatton, Rong Liu, Giovanni Battista Levi Sandri, Olivier Soubrane, Alejandro Mejia, Santiago Lopez-Ben, Kazateru Monden, Go Wakabayashi, Daniel Cherqui, Roberto Troisi, Mengqiu Yin, Felice Giuliante, David Geller, Atsushi Sugioka, Bjorn Edwin, Tan-To Cheung, Tran Cong Duy Long, Mohammad Abu Hilal, David Fuks, Kuo-Hsin Chen, Luca Aldrighetti, Ho-Seong Han, Brian K. P. Goh
Summary: This study aimed to investigate the relationship between tumor size and the difficulty of laparoscopic left lateral sectionectomy (L-LLS). Three optimal tumor size cutoffs (40-, 70-, and 100-mm) were identified. As tumor size increased, there was a stepwise increase in the rates of open conversion, operative time, blood loss, intraoperative blood transfusion, Pringle maneuver use, major morbidity, and 30-day readmission.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Surgery
Victor Lopez-Lopez, Jaime Arthur Pirola Krurger, Christopher Kuemmerli, Samer Tohme, Concepcion Gomez-Gavara, Maria Iniesta, Asuncion Lopez-Conesa, Epameinondas Dogeas, Mar Dalmau, Roberto Brusadin, Ignacio Sanchez-Esquer, David A. Geller, Paulo Herman, Ricardo Robles-Campos
Summary: This study compared the short-term and long-term outcomes of hand-assisted laparoscopic (HALS)/Hybrid and pure laparoscopic (PLS) resection for colorectal cancer liver metastasis. The results showed no differences in long-term oncologic outcomes between the two techniques. However, the PLS group had longer operative time, higher rates of intraoperative ablation, positive resection margins, and longer time to control bleeding. HALS/Hybrid may have a shorter learning curve and better hemorrhage control.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Guido P. Fiorentini, Yasmin Essaji, David A. Geller, David A. Iannitti, Erin H. Baker, Susanne G. Warner, Iswanto Sucandy, Pablo E. Serrano, Edwin Onkendi, William S. Helton, Adnan Alseidi, Sean P. Cleary
Summary: The aim of this study was to determine the benchmark performance of MILLS throughout the AMILES database. Results showed that among 1665 minimally invasive liver resections, 49% of MILLS cases met all textbook outcomes. Benchmark performance metrics for MILLS included conversion rate, blood loss, OR time, transfusion rate, complication rate, and length of stay.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Oncology
Winifred M. M. Lo, Samer T. T. Tohme, David A. A. Geller
Summary: Minimally invasive surgery, including laparoscopic and robotic approaches, is a safe and effective option for treating liver metastases from colorectal cancer. Laparoscopic liver resection (LLR) is associated with shorter hospital stays and similar post-operative complications compared to open techniques. LLR allows for early initiation of chemotherapy and simultaneous resection of colorectal and liver tumors can be safe in selected patients. Robotic liver resection (RLR) has comparable safety and may improve resection rates. It is important to carefully select patients and ensure surgeon experience when considering minimally invasive liver surgery for colorectal liver metastases.
Review
Gastroenterology & Hepatology
Ioannis A. Ziogas, Christos D. Kakos, Dimitrios P. Moris, Christof Kaltenmeier, Georgios Tsoulfas, Martin I. Montenovo, Sophoclis P. Alexopoulos, David A. Geller, Elizabeth A. Pomfret
Summary: The value of minimally invasive approaches for living donor hepatectomy remains unclear. This study compared donor outcomes after different surgical approaches and found that pure laparoscopic and robotic living donor hepatectomy were associated with decreased blood loss and length of stay compared to open hepatectomy, but had longer operative time. Robotic living donor hepatectomy was also associated with decreased length of stay compared to laparoscopy-assisted hepatectomy.
LIVER TRANSPLANTATION
(2023)
Review
Oncology
Jurgis Alvikas, Winifred Lo, Samer Tohme, David A. Geller
Summary: Surgically removing part of the liver is an essential method of treating liver cancers, particularly hepatocellular carcinoma (HCC) and colorectal liver metastasis (CRLM). Laparoscopic liver resection (LLR) has been developed as a minimally invasive technique, offering better short-term outcomes compared to open liver resection (OLR). LLR patients have fewer complications, reduced blood loss, and shorter hospital stays, while maintaining similar long-term survival as OLR. The article also discusses patient selection for LLR and the emerging robotic-assisted liver resection technique.
Article
Oncology
Xicai Li, Jingquan Huang, Qiulin Wu, Qiang Du, Yingyu Wang, Yubin Huang, Xiaoyong Cai, David A. Geller, Yihe Yan
Summary: This study reveals the relationship between CHK1 expression and the tumor microenvironment in hepatocellular carcinoma (HCC). High CHK1 expression is associated with advanced tumor stage and poor prognosis. CHK1 inhibition and cisplatin induce DNA damage and apoptosis in HCC cells. CHK1 directly interacts with IRF1 to regulate MICA expression, which is correlated with NK cell and CD8+T cell infiltration in HCC.
Meeting Abstract
Psychology, Multidisciplinary
Jingting Yan, David A. Geller, Michael H. Antoni, Jonas T. Johnson, Vincent Reyes, Gauri J. Kiefer, Christopher R. Marsh, Jason Bierenbaum, Nishant Tageja, Michal Krauze, Robert A. VanderWeele, Gaurav Goel, Gopala A. Ramineni, Bhanu Pappu, Dan P. Zandberg, Marci Nilsen, Jennifer L. Steel
ANNALS OF BEHAVIORAL MEDICINE
(2022)
Meeting Abstract
Psychology, Multidisciplinary
Carly A. Flaig, Peter J. Gianaros, Scott Beach, Yoram Vodovotz, Vincent Reyes, Michael H. Antoni, Jonas T. Johnson, Gauri J. Kiefer, Christopher R. Marsh, Jason Bierenbaum, Nishant Tageja, Michal Krauze, Robert A. VanderWeele, Gaurav Goel, Gopala A. Ramineni, Bhanu Pappu, Dan P. Zandberg, Marci Nilsen, David A. Geller, Jennifer L. Steel
ANNALS OF BEHAVIORAL MEDICINE
(2022)
