Titanium dioxide nanoparticle genotoxicity: A review of recent in vivo and in vitro studies

Overview of the toxic effects of titanium dioxide nanoparticles in blood, liver, muscles, and brain of a Neotropical detritivorous fish

(2019) Talita L. L. Carmo et al.   ENVIRONMENTAL TOXICOLOGY

In vitro genotoxic effects of titanium dioxide nanoparticles (n-TiO2 ) in human sperm cells

(2019) Marianna Santonastaso et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Could curcumin ameliorate titanium dioxide nanoparticles effect on the heart? A histopathological, immunohistochemical, and genotoxic study

(2019) Eman Ahmed Alaa El-Din et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Shape-engineered titanium dioxide nanoparticles (TiO2-NPs): cytotoxicity and genotoxicity in bronchial epithelial cells

(2019) Marta Gea et al.   FOOD AND CHEMICAL TOXICOLOGY

The size‐dependent genotoxic potentials of titanium dioxide nanoparticles to endothelial cells

(2019) Fen Liao et al.   ENVIRONMENTAL TOXICOLOGY

Prevalent anatase crystalline phase increases the cytotoxicity of biphasic titanium dioxide nanoparticles in mammalian cells

(2019) Zuzana Skubalova et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Aging-independent and size-dependent genotoxic response induced by titanium dioxide nanoparticles in mammalian cells

(2019) Juan Wang et al.   Journal of Environmental Sciences-China

Exploration of cytotoxic and genotoxic endpoints following sub-chronic oral exposure to titanium dioxide nanoparticles

(2019) Srijita Chakrabarti et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

NPs-TiO2 and Lincomycin Coexposure Induces DNA Damage in Cultured Human Amniotic Cells

(2019) Filomena Mottola et al.   Nanomaterials

Effects of physicochemical properties of TiO2 nanomaterials for pulmonary inflammation, acute phase response and alveolar proteinosis in intratracheally exposed mice

(2019) Pernille Høgh Danielsen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

TiO2 NPs Induce DNA Damage in Lymphocytes from Healthy Individuals and Patients with Respiratory Diseases—An Ex Vivo/In Vitro Study

(2018) Ilham F Osman et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

The effects of a human food additive, titanium dioxide nanoparticles E171, on Drosophila melanogaster - a 20 generation dietary exposure experiment

(2018) Boris Jovanović et al.   Scientific Reports

Genotoxicity evaluation of titanium dioxide nanoparticles using the mouse lymphoma assay and the Ames test

(2018) Xiuming Du et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Impact of anatase titanium dioxide nanoparticles on mutagenic and genotoxic response in Chinese hamster lung fibroblast cells (V-79): The role of cellular uptake

(2017) Abhishek Kumar Jain et al.   FOOD AND CHEMICAL TOXICOLOGY

Titanium Dioxide Nanoparticles Induce DNA Damage in Peripheral Blood Lymphocytes from Polyposis coli, Colon Cancer Patients and Healthy Individuals: An Ex Vivo/In Vitro Study

(2017) Malgorzata Kurzawa-Zegota et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Evaluation of distribution, redox parameters, and genotoxicity in Wistar rats co-exposed to silver and titanium dioxide nanoparticles

(2017) Airton da Cunha Martins et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Cyto-genotoxic and DNA methylation changes induced by different crystal phases of TiO 2 -np in bronchial epithelial (16-HBE) cells

(2017) Manosij Ghosh et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Genotoxic effects of zinc oxide nanoparticles in nasal mucosa cells are antagonized by titanium dioxide nanoparticles

(2017) Stephan Hackenberg et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon

(2017) Sarah Bettini et al.   Scientific Reports

Titanium dioxide nanoparticles induce genotoxicity but not mutagenicity in golden mussel Limnoperna fortunei

(2016) Francine Girardello et al.   AQUATIC TOXICOLOGY

Comparison of the DNA damage response in BEAS-2B and A549 cells exposed to titanium dioxide nanoparticles

(2016) M. Biola-Clier et al.   MUTAGENESIS

Surface modification does not influence the genotoxic and inflammatory effects of TiO2nanoparticles after pulmonary exposure by instillation in mice

(2016) Håkan Wallin et al.   MUTAGENESIS

Genotoxicity of TiO2nanoparticles assessed by mini-gel comet assay and micronucleus scoring with flow cytometry

(2016) Sebastiano Di Bucchianico et al.   MUTAGENESIS

Genotoxicity and gene expression analyses of liver and lung tissues of mice treated with titanium dioxide nanoparticles

(2016) Yan Li et al.   MUTAGENESIS

In vitrogenotoxicity testing of four reference metal nanomaterials, titanium dioxide, zinc oxide, cerium oxide and silver: towards reliable hazard assessment

(2016) Naouale El Yamani et al.   MUTAGENESIS

Titanium dioxide food additive (E171) induces ROS formation and genotoxicity: contribution of micro and nano-sized fractions

(2016) Héloïse Proquin et al.   MUTAGENESIS

Genotoxicity assessment of intravenously injected titanium dioxide nanoparticles in gpt delta transgenic mice

(2016) Tetsuya Suzuki et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Long-term exposure of A549 cells to titanium dioxide nanoparticles induces DNA damage and sensitizes cells towards genotoxic agents

(2016) Lucie Armand et al.   Nanotoxicology

n-TiO2 and CdCl2 co-exposure to titanium dioxide nanoparticles and cadmium: Genomic, DNA and chromosomal damage evaluation in the marine fish European sea bass (Dicentrarchus labrax)

(2015) M. Nigro et al.   AQUATIC TOXICOLOGY

Genotoxicity, potential cytotoxicity and cell uptake of titanium dioxide nanoparticles in the marine fish Trachinotus carolinus (Linnaeus, 1766)

(2015) Caroline P. Vignardi et al.   AQUATIC TOXICOLOGY

Genotoxicity assessment of TiO2 nanoparticles in the teleost Danio rerio

(2015) Lucia Rocco et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Genotoxic and cell-transforming effects of titanium dioxide nanoparticles

(2015) Eşref Demir et al.   ENVIRONMENTAL RESEARCH

Cytotoxicity, cell uptake and microscopic analysis of titanium dioxide and silver nanoparticles in vitro

(2015) Katerina Tomankova et al.   FOOD AND CHEMICAL TOXICOLOGY

Anemia and genotoxicity induced by sub-chronic intragastric treatment of rats with titanium dioxide nanoparticles

(2015) Intissar Grissa et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Genotoxic testing of titanium dioxide anatase nanoparticles using the wing-spot test and the comet assay in Drosophila

(2015) Erico R. Carmona et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Genotoxicity and gene expression modulation of silver and titanium dioxide nanoparticles in mice

(2015) Nana Asare et al.   Nanotoxicology

Oxidative Stress and Nano-Toxicity Induced by TiO2 and ZnO on WAG Cell Line

(2015) Akhilesh Dubey et al.   PLoS One

Cyto- and genotoxic effects of metallic nanoparticles in untransformed human fibroblast

(2015) Leonardo P. Franchi et al.   TOXICOLOGY IN VITRO

Different mechanisms are involved in oxidative DNA damage and genotoxicity induction by ZnO and TiO2 nanoparticles in human colon carcinoma cells

(2015) Andrea Zijno et al.   TOXICOLOGY IN VITRO

TiO2nanoparticles induce DNA double strand breaks and cell cycle arrest in human alveolar cells

(2014) Krupa Kansara et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Cytotoxicity, DNA damage, and apoptosis induced by titanium dioxide nanoparticles in human non-small cell lung cancer A549 cells

(2014) Yurong Wang et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Th2 Factors May Be Involved in TiO2 NP-Induced Hepatic Inflammation

(2014) Jie Hong et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Genotoxicity of titanium dioxide nanoparticles

(2014) Tao Chen et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Long-term exposures to low doses of titanium dioxide nanoparticles induce cell transformation, but not genotoxic damage in BEAS-2B cells

(2014) Gerard Vales et al.   Nanotoxicology

Large Uptake of Titania and Iron Oxide Nanoparticles in the Nucleus of Lung Epithelial Cells as Measured by Raman Imaging and Multivariate Classification

(2013) Linnea Ahlinder et al.   BIOPHYSICAL JOURNAL

Mechanisms of genotoxicity. A review ofin vitroandin vivostudies with engineered nanoparticles

(2013) Zuzana Magdolenova et al.   Nanotoxicology

Nano-titanium dioxide induces genotoxicity and apoptosis in human lung cancer cell line, A549

(2012) RK Srivastava et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Gene Expression in Liver Injury Caused by Long-term Exposure to Titanium Dioxide Nanoparticles in Mice

(2012) Yaling Cui et al.   TOXICOLOGICAL SCIENCES

Phototoxicity of nano titanium dioxides in HaCaT keratinocytes—Generation of reactive oxygen species and cell damage

(2012) Jun-Jie Yin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Titanium dioxide particles phosphorylate histone H2AX independent of ROS production

(2011) Tatsushi Toyooka et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Titanium dioxide nanoparticles exhibit genotoxicity and impair DNA repair activity in A549 cells

(2011) Mary-Line Jugan et al.   Nanotoxicology

TiO2nanoparticles induce oxidative DNA damage and apoptosis in human liver cells

(2011) Ritesh K Shukla et al.   Nanotoxicology

Nitric oxide and ABA in the control of plant function

(2011) J.T. Hancock et al.   PLANT SCIENCE

Titanium dioxide in our everyday life; is it safe?

(2011) Matej Skocaj et al.   Radiology and Oncology

Titanium dioxide nanoparticles induced cytotoxicity, oxidative stress and DNA damage in human amnion epithelial (WISH) cells

(2011) Quaiser Saquib et al.   TOXICOLOGY IN VITRO

Nanosized titanium dioxide particles do not induce DNA damage in human peripheral blood lymphocytes

(2010) Stephan Hackenberg et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

DNA damage and alterations in expression of DNA damage responsive genes induced by TiO2nanoparticles in human hepatoma HepG2 cells

(2010) Jana PetkoviĆ et al.   Nanotoxicology

ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells

(2010) Ritesh K. Shukla et al.   TOXICOLOGY IN VITRO

Interaction Between Nano-Anatase TiO2 and Liver DNA from Mice In Vivo

(2009) Na Li et al.   Nanoscale Research Letters

Hydroxyl radicals (OH) are associated with titanium dioxide (TiO2) nanoparticle-induced cytotoxicity and oxidative DNA damage in fish cells

(2008) James F. Reeves et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Potential neurological lesion after nasal instillation of TiO2 nanoparticles in the anatase and rutile crystal phases

(2008) J WANG et al.   TOXICOLOGY LETTERS