Review
Chemistry, Physical
Vignesh Kumaravel, John Bartlett, Suresh C. Pillai
Summary: Recent fire accidents in the electronics and electric vehicles industries have highlighted the importance of addressing thermal runaway reactions, where solid electrolytes play a crucial role in mitigating these issues and prolonging the lifecycle of energy storage devices. Solid electrolytes, such as ceramic polymer nanocomposites, hydrogels, and ionogels, offer solutions for high-temperature stability and flexibility, making them suitable for various applications in next-generation EVs, space devices, aviation gadgets, defense tools, and mobile electronics.
ADVANCED ENERGY MATERIALS
(2021)
Article
Chemistry, Physical
Bazilah Awang Abd Manaf, Shyang Pei Hong, Mohammad Rizwan, Fareeha Arshad, Christopher Gwenin, Minhaz Uddin Ahmed
Summary: Carcinoembryonic antigen (CEA) is a prominent cancer biomarker that allows for early diagnosis of various cancers. Nanomaterial-based immunosensors have gained attention for their high specificity and low detection limit in detecting CEA biomarkers. Various nanomaterials like platinum, gold, silver, and carbon have shown promising results in the detection and diagnostics of CEA. This review explores the significance and recent developments of nanomaterial-based biosensors for detecting CEA biomarkers with high sensitivity, selectivity, and specificity.
SURFACES AND INTERFACES
(2023)
Review
Chemistry, Analytical
Shreanshi Agrahari, Ravindra Kumar Gautam, Ankit Kumar Singh, Ida Tiwari
Summary: Various modern techniques for early cancer detection have pros and cons, with nanotechnologies proving highly advantageous in detecting cancer biomarkers at their lower limits.
MICROCHEMICAL JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Sona Jain, Wanessa Santana, Silvio S. Dolabella, Andre L. S. Santos, Eliana B. Souto, Patricia Severino
Summary: This article highlights the importance of diagnosing leishmaniasis accurately and the limitations of current diagnostic techniques. It explores new methods based on biosensors and nanotechnology as potential improvements for the diagnosis of Leishmania. Future research opportunities to overcome the current limitations on available diagnostic approaches are also discussed.
Review
Nanoscience & Nanotechnology
Weiqi Qian, Suwen Xu, Xiaoming Zhang, Chuanbo Li, Weiyou Yang, Chris R. Bowen, Ya Yang
Summary: The review provides a comprehensive overview of the differences and similarities in photocatalysis and electrocatalysis in the latest 2D nanomaterials, highlighting strategies and traps for enhancing performance, as well as issues related to the differences and similarities between photocatalysis and electrocatalysis.
NANO-MICRO LETTERS
(2021)
Article
Chemistry, Physical
Paolo Cignoni, Niclas Blanc, Kristina Tschulik
Summary: The advancement of electrocatalysis from fundamental research to application requires seamless collaboration between researchers from different fields. This mini review highlights the common problems faced when evaluating the performance of complex electrode assemblies made of nanostructured materials. Applying classical kinetic descriptors to these assemblies often makes it challenging to distinguish and attribute material properties to electrode performance. Recent advancements in discerning and analyzing electrocatalysis on composite or nanostructured electrodes are discussed, with emphasis on detecting and addressing inhomogeneities in the electrocatalytic activity of three-dimensional electrodes.
CURRENT OPINION IN ELECTROCHEMISTRY
(2023)
Review
Chemistry, Analytical
Hoang Vinh Tran, Benoit Piro
Summary: The discovery of microRNAs (miRNAs) in the late twentieth century has revealed their crucial roles in regulating translation and degradation of messenger RNAs, as well as in various biological processes. The presence of miRNAs in body fluids has potential implications for cancer and disease diagnosis, leading to the development of sensitive electrochemical biosensors for miRNA detection. The advantages of these biosensors, including sensitivity, mass fabrication, low-cost, and potential decentralized analysis, make them promising tools for miRNA sensing.
Article
Biophysics
Jia Chen, Zhifang Zhou, Siheng Luo, Guokun Liu, Juan Xiang, Zhongqun Tian
Summary: This review outlines the application of advanced nanomaterials in the early and staged diagnosis of neurodegenerative diseases. In vivo research utilizes magnetic resonance, fluorescence, and Raman imaging techniques to study brain tissue, cerebral vessel structures, and biomarker distributions. In vitro research focuses on detecting fluid biomarkers in cerebrospinal fluid and peripheral blood using fluorescence, electrochemical, Raman, and surface plasmon resonance techniques.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Biotechnology & Applied Microbiology
Tahir Raza, Lijun Qu, Waquar Ahmed Khokhar, Boakye Andrews, Afzal Ali, Mingwei Tian
Summary: Conductive nanostructured materials are currently being used in the fabrication of modern chemical and biological sensors, with carbon, metals, and conductive polymers playing key roles. The combination of conductive polymer nanocomposites with carbon and metal nanoparticles is highlighted as a way to enhance sensor performance, with future challenges and opportunities in this field also discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Riccardo Goldoni, Carolina Dolci, Elisa Boccalari, Francesco Inchingolo, Alessandro Paghi, Lucanos Strambini, Daniela Galimberti, Gianluca Martino Tartaglia
Summary: Salivary analysis is a novel and promising field of research for the diagnosis of neurodegenerative and demyelinating diseases related to aging. Collection of saliva is noninvasive, stress-free, and repeatable, offering advantages for early diagnosis and timely treatment. Advanced biosensors have been proposed for detecting salivary biomarkers associated with various neurodegenerative diseases.
AGEING RESEARCH REVIEWS
(2022)
Review
Chemistry, Analytical
Chunmei Li, Bo Che, Linhong Deng
Summary: Respiratory diseases, especially due to the COVID-19 outbreak, have gained significant global attention in recent years. Electrochemical biosensors based on carbon nanomaterials have shown great potential in efficient and non-invasive diagnosis of these diseases. This paper reviews the latest research and development of these biosensors for diagnosing various respiratory diseases and discusses their advantages, challenges, and future prospects.
Review
Chemistry, Analytical
Norah Salem Alsaiari, Khadijah Mohammedsaleh M. Katubi, Fatimah Mohammed Alzahrani, Saifeldin M. Siddeeg, Mohamed A. Tahoon
Summary: This study discusses the latest developments in the identification of antibiotics by nanomaterial-constructed biosensors, which utilize various types of nanomaterials for electrochemical signal-transducing mechanisms. The review provides an in-depth assessment of the nanostructured electrochemical sensing method for residues of antibiotics in different systems, while also outlining existing problems and future opportunities in this area.
Review
Chemistry, Analytical
Lais Canniatti Brazaca, Pamyla Layene dos Santos, Paulo Roberto de Oliveira, Diego Pessoa Rocha, Jessica Santos Stefano, Cristiane Kalinke, Rodrigo Alejandro Abarza Munoz, Juliano Alves Bonacin, Bruno Campos Janegitz, Emanuel Carrilho
Summary: This critical review article discusses the advancements in electrochemical biosensors for diagnosing viral infections, focusing on genosensors, aptasensors, and immunosensors. The article also addresses the advantages of biosensors in viral disease diagnosis and potential future trends in the field, such as lab-on-a-chip and flexible sensors.
ANALYTICA CHIMICA ACTA
(2021)
Review
Chemistry, Analytical
Xuechi Yin, Sijie Liu, Deepak Kukkar, Jianlong Wang, Daohong Zhang, Ki-Hyun Kim
Summary: The lateral flow immunoassay strip is a classic and dominant tool in point-of-care detection, known for its portability and simplicity. However, current colored nanomaterials used as signal labels in LFIA have limited sensing potential, leading to the recognition of composite nanoparticles as alternatives to enhance sensitivity, signal readout diversity, anti-matrix interference, and cost-effectiveness.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Nanoscience & Nanotechnology
Min Wei, Zhaofei Yang, Song Li, Weidong Le
Summary: Neurodegeneration is a progressive and incurable neurological disorder characterized by the loss of specific neurons. Stem cell therapy shows promise in treating neurodegenerative diseases through various mechanisms, but its clinical use is limited by poor survival and differentiation rates of transplanted cells. The rapid development of nanotechnology offers potential solutions to these limitations and allows for improved therapeutic efficacy when combined with stem cell therapy. This review summarizes recent advancements in stem cell therapeutics and nanotherapeutic strategies and explores their potential in treating neurodegenerative diseases.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Analytical
Alba Iglesias-Mayor, Olaya Amor-Gutierrez, Antonello Novelli, Maria-Teresa Fernandez-Sanchez, Agustin Costa-Garcia, Alfredo de la Escosura-Muniz
ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Analytical
Olaya Amor-Gutierrez, Giulia Selvolini, M. Teresa Fernandez-Abedul, Alfredo de la Escosura-Muniz, Giovanna Marrazza
Review
Chemistry, Multidisciplinary
Maria Diaz-Gonzalez, Alfredo de la Escosura-Muniz, Maria Teresa Fernandez-Arguelles, Francisco Javier Garcia Alonso, Jose Manuel Costa-Fernandez
TOPICS IN CURRENT CHEMISTRY
(2020)
Article
Biochemical Research Methods
Maria Diaz-Gonzalez, Alfredo de la Escosura-Muniz
Summary: Nanoparticle (NP)-based lateral flow assay (LFA) technology has ideal characteristics for point-of-care bioanalytical applications, but sensitivity remains a significant limitation. Current research efforts are focused on nanoparticle labels and alternative optical detection modes, while modification of strip pads for improved sensitivity is a promising area for future study.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biophysics
Celia Toyos-Rodriguez, Alaa Adawy, Francisco Javier Garcia-Alonso, Alfredo de la Escosura-Muniz
Summary: This work explores the role of slight changes in the Pd/Au proportion in the electrocatalytic activity of bimetallic Pd-AuNPs for the oxygen reduction reaction (ORR). The study finds that the synergy between Pd and Au is maximized when the amount of gold is controlled and occupies the more reactive positions of the cluster. The optimal Pd-AuNPs with 30% gold exhibit the highest catalytic activity.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
C. Toyos-Rodriguez, A. Llamedo-Gonzalez, D. Pando, S. Garcia, J. A. Garcia, F. J. Garcia-Alonso, A. De la Escosura-Muniz
Summary: Magnetic beads (MBs) are widely used in biosensing platforms due to their magnetic behavior, simplifying sample purification and separation. In this study, novel, reliable, and low-cost MBs were synthesized and used as electrochemical immunosensing platforms, showing improved performance.
MICROCHEMICAL JOURNAL
(2022)
Article
Biophysics
Alba Iglesias-Mayor, Olaya Amor-Gutierrez, Celia Toyos-Rodriguez, Arnau Bassegoda, Tzanko Tzanov, Alfredo de la Escosura-Muniz
Summary: Chronic wounds and their associated infections are a significant challenge in developed countries. A lack of methods for early diagnosis and treatment decision-making exists. This study proposes a novel methodology for electrically monitoring infection biomarkers in chronic wound exudates using nanoporous alumina membranes. By immobilizing peptidoglycan, a bacterial layer component, on the inner walls of nanochannels, specific degradation by lysozyme allows for the detection of infection biomarkers. This methodology offers advantages such as no need for bioreceptors, low matrix effects, and quick analysis at the point-of-care.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Biochemical Research Methods
Celia Toyos-Rodriguez, David Valero-Calvo, Alfredo de la Escosura-muniz
Summary: The abusive use of antimicrobial compounds and the associated appearance of antimicrobial resistant strains pose a major threat to human health. Improved antimicrobial administration requires faster diagnosis and detection of resistances. Electrochemical methods used in antimicrobial susceptibility testing (AST), particularly for evaluating new drug candidates, have shown significant potential. The role of nanomaterials in these biosensing platforms is relatively minor compared to other applications.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
David Valero-Calvo, Celia Toyos-Rodriguez, Francisco Javier Garcia-Alonso, Alfredo de la Escosura-Muniz
Summary: For the first time, nanoparticles are suggested as carriers of an immobilized enzymatic substrate in nanoporous alumina membranes to enhance nanochannel blocking and improve enzyme determination efficiency. Polystyrene nanoparticles modified with streptavidin are proposed as carrier agents, providing steric and electrostatic blockage due to their charge at different pH values. The effect of using negatively charged and positively charged redox indicator ions on electrostatic blockage is studied for the first time. The approach shows great potential in point-of-care diagnostics with cheap and fast sensing methodology, allowing detection of clinically relevant levels of matrix-metalloproteinase 9 with good reproducibility and selectivity.
Article
Food Science & Technology
Beatriz Perez-Fernandez, Britt Marianna Maestroni, Shuichi Nakaya, Sofia Bussalino, Christina Vlachou, Alfredo de la Escosura-Muniz
Summary: Aflatoxins (AFs) can be produced by fungi in nuts, and their levels in food are strictly regulated due to their adverse effects on humans. Electrochemical immunosensing is a sensitive and cost-effective alternative to standard AFs analysis, and has been used for the detection of AFB1. However, the determination of total AFs is not widely reported with electrochemical immunosensors.
Article
Chemistry, Analytical
Ana M. Villa-Manso, Tamara Guerrero-Esteban, Felix Pariente, Celia Toyos-Rodriguez, Alfredo de la Escosura-Muniz, Monica Revenga-Parra, Cristina Gutierrez-Sanchez, Encarnacion Lorenzeo
Summary: A novel immunosensor based on electrochemiluminescence resonance energy transfer (ECL-RET) has been developed for the sensitive determination of N protein of the SARS-CoV-2 coronavirus. The immunosensor utilizes bifunctional core@shell nanoparticles as ECL acceptor and [Ru(bpy)(3)](2+) as ECL donor. It demonstrates a wide linear response to the concentration of N protein with a detection limit of 1.27 pg/mL, high stability, and specificity. The immunosensor has been successfully applied for quantification of N protein in saliva samples and showed consistent results with a commercial colorimetric ELISA kit.
Article
Clinical Neurology
Sara Garcia, Olaya Amor-Gutierrez, Maria Palomares-Albarran, Celia Toyos-Rodriguez, Fernando Cuetos, Carmen Martinez, Agustin Costa-Garcia, Maria Teresa Fernandez-Sanchez, Alfredo De la Escosura-Muniz, Antonello Novelli
Summary: The study aimed to investigate whether plasma concentration of unfolded p53 could differentiate among neurodegenerative processes in Mild Cognitive Impairment, Alzheimer's disease, and Parkinson's disease. Results showed significantly higher levels of unfolded p53 in the plasma of patients with each condition compared to controls, with Alzheimer's disease patients having the highest levels. The findings suggest that unfolded p53 concentration in plasma may serve as a useful biomarker for common neuropathological processes in these diseases.
CURRENT ALZHEIMER RESEARCH
(2021)
