Review
Cell Biology
Tess A. Leathers, Crystal D. Rogers
Summary: Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the activity of cyclooxygenase isoenzymes, which drive tissue inflammation pathways, making them a class of analgesics. However, caution should be exercised during pregnancy as these drugs increase the risk of developmental defects. In this review, the roles of cyclooxygenase signaling pathway components throughout pregnancy are characterized, and the effects of perturbation of this pathway on embryonic development are discussed.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jan Haas, Karen S. Frese, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Rewati Tappu, Rouven Nietsch, Oguz Firat Tugrul, Michael Wisdom, Carsten Dietrich, Ali Amr, Tanja Weis, Torsten Niederdraenk, Michael P. Murphy, Thomas Krieg, Marcus Doerr, Uwe Voelker, Jens Fielitz, Norbert Frey, Stephan B. Felix, Andreas Keller, Hugo A. Katus, Benjamin Meder
Summary: This study identified a new set of metabolomic biomarkers for heart failure (HF) through a multi-OMICS approach, revealing underlying biological cascades that potentially represent suitable intervention targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Wang Shao-Mei, Ye Li-Fang, Wang Li-Hong
Summary: Heart failure often stems from various cardiovascular diseases, with an energy metabolism disorder of cardiomyocytes serving as a molecular basis. Current drugs like ARNi and SGLT-2 inhibitors target myocardial metabolism to treat HF. Traditional Chinese medicine, including Danshen yin and Fufang Danshen dripping pill, has gained acceptance for HF treatment, potentially serving as a complementary approach for prevention.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Medicine, General & Internal
Haider Al-Waeli, Ana Paula Reboucas, Alaa Mansour, Martin Morris, Faleh Tamimi, Belinda Nicolau
Summary: This study conducted a systematic review and meta-analysis on the effects of NSAID administration after bone fracture in animal models. The results indicate that NSAIDs can decrease the biomechanical properties of healing bones, with variations observed in different sites, sex, and assessment times.
SYSTEMATIC REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Ying-Chang Tung, Mei-Ling Cheng, Lung-Sheng Wu, Hsiang-Yu Tang, Cheng-Yu Huang, Gwo-Jyh Chang, Chi-Jen Chang
Summary: This study investigates the changes and reversibility of cardiac energetics in a rat model of cardiac volume overload (VO) using transcriptomics and metabolomics analyses. The findings suggest that glycolysis is downregulated and redirected towards the hexosamine biosynthetic pathway (HBP) and O-linked-N-acetylglucosaminylation in the compensated hypertrophy (CH) phase, and further suppressed in the progression to heart failure (HF). Derangements in fatty acid oxidation become prominent only in HF. Correction of VO can reverse the differential expression of genes involved in glycolysis, HBP, and fatty acid oxidation in CH but not in HF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Qian Xu, Yi-meng Zhao, Nai-qi He, Rong Gao, Wen-xin Xu, Xiu-juan Zhuo, Zhong Ren, Chun-yan Wu, Lu-shan Liu
Summary: Heart failure is a complex clinical syndrome caused by various cardiovascular diseases, with pathogenesis involving cardiomyocyte loss, myocardial energy metabolism disorder, and activation of cardiac inflammation. The increased level of PCSK9 in heart failure patients suggests a potential involvement of PCSK9 in the disease, although the specific mechanism is yet to be explored.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cardiac & Cardiovascular Systems
Qutuba G. Karwi, Kim L. Ho, Simran Pherwani, Ezra B. Ketema, Qiuyu Sun, Gary D. Lopaschuk
Summary: Diabetes increases the risk of heart failure, with both diseases exacerbating cardiovascular outcomes and progression. Factors contributing to diabetic cardiomyopathies are not fully understood.
CARDIOVASCULAR RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Aya Shiraki, Jun-ichi Oyama, Takahiko Shimizu, Takayuki Nakajima, Takashi Yokota, Koichi Node
Summary: This study found that empagliflozin can improve cardiac mitochondrial function, enhance energy metabolism, and improve the survival rate and cardiac fibrosis in HF mice. The findings provide novel mechanisms for the beneficial effects of SGLT2 inhibitors on HF.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Frank Yu, Bianca McLean, Mitesh Badiwala, Filio Billia
Summary: Cardiovascular disease is the leading cause of mortality globally, with heart failure affecting millions of people. The use of metabolomics and lipidomics has improved our understanding of heart failure and revealed new pathways and potential interventions. The discovery of metabolic effects of heart failure drugs, particularly sodium-glucose transport protein 2 inhibitors, has revolutionized the treatment of heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Julia Ritterhoff, Timothy S. McMillen, Outi Villet, Sara Young, Stephen C. Kolwicz, Taurence Senn, Arianne Caudal, Rong Tian
Summary: The study revealed a sex-dependent regulation of PPAR alpha signaling pathway in heart failure, which accounted for the differential response to ACC2 deletion. Male mice showed downregulation in mitochondrial oxidative function under pressure overload, and the improvement in cardiac function with ACC2 deletion was limited. In contrast, mitochondrial oxidative capacity was sustained in female mice under pressure overload, and ACC2 deletion improved myocardial energetics.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ninghui Cheng, Qianxing Mo, Jimmonique Donelson, Lingfei Wang, Ghislain Breton, George G. Rodney, Jin Wang, Kendal D. Hirschi, Xander H. T. Wehrens, Paul A. Nakata
Summary: The lack of Grx3 protein in diet-induced obese mice was found to result in left ventricular systolic dysfunction and heart failure. Compared to the control group, mice lacking Grx3 showed decreased gene expression levels associated with fatty acid uptake and increased levels associated with glucose uptake.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Hao Chen, Rui Jiang, Wentao Huang, Kequan Chen, Ruijie Zeng, Huihuan Wu, Qi Yang, Kehang Guo, Jingwei Li, Rui Wei, Songyan Liao, Hung-Fat Tse, Weihong Sha, Zewei Zhuo
Summary: This study identified ten diagnostic markers for predicting the risk of heart failure due to myocardial infarction using random forest algorithm. The proposed nomogram showed good predictive performance and clinical usefulness. Moreover, the study predicted drugs and potential molecular mechanisms related to energy metabolism, providing further information for clinical treatment of heart failure.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Patrick B. Ampomah, Bishuang Cai, Santosh R. Sukka, Brennan D. Gerlach, Arif Yurdagul, Xiaobo Wang, George Kuriakose, Lancia N. F. Darville, Yan Sun, Simone Sidoli, John M. Koomen, Alan R. Tall, Ira Tabas
Summary: This study demonstrates that methionine derived from apoptotic cells taken up by macrophages during efferocytosis plays a role in mediating tissue resolution by providing a substrate for DNA methylation and repressing the expression of the ERK1/2 phosphatase Dusp4, leading to activation of ERK1/2 and the expression of pro-resolving mediators.
Review
Pharmacology & Pharmacy
Yanan He, Wei Huang, Chen Zhang, Lumeng Chen, Runchun Xu, Nan Li, Fang Wang, Li Han, Ming Yang, Dingkun Zhang
Summary: Heart failure is a global public health issue caused by severe energy metabolism disorders leading to insufficient heart energy supply. Current therapies focus on symptomatic treatment by reducing heart rate and cardiac load, but there are no drugs targeting cardiac energy metabolism.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Cardiac & Cardiovascular Systems
Lingfang Zhuang, Kangni Jia, Chen Chen, Zhigang Li, Jiaxin Zhao, Jian Hu, Hang Zhang, Qin Fan, Chunkai Huang, Hongyang Xie, Lin Lu, Weifeng Shen, Guang Ning, Jiqiu Wang, Ruiyan Zhang, Kang Chen, Xiaoxiang Yan
Summary: This study reveals the significant role of DYRK1B in mitochondrial bioenergetics and the progression of cardiac hypertrophy and heart failure. DYRK1B promotes impaired mitochondrial bioenergetics by directly binding with STAT3, leading to the downregulation of PGC-1 alpha. Inhibition of DYRK1B or STAT3 activity restores cardiac performance by rejuvenating mitochondrial bioenergetics. These findings may offer new therapeutic options for heart failure patients.
Article
Cell Biology
Cheng Yan, Jingqi Liu, Jiamei Gao, Ying Sun, Lei Zhang, Haiyun Song, Lei Xue, Lixing Zhan, Guanjun Gao, Zunji Ke, Yong Liu, Jingnan Liu
CELL DEATH & DISEASE
(2019)
Correction
Cell Biology
Cheng Yan, Jingqi Liu, Jiamei Gao, Ying Sun, Lei Zhang, Haiyun Song, Lei Xue, Lixing Zhan, Guanjun Gao, Zunji Ke, Yong Liu, Jingnan Liu
CELL DEATH & DISEASE
(2020)
Article
Chemistry, Multidisciplinary
Man Li, Shi-chun Li, Bao-kai Dou, Ying-xiang Zou, Hao-zhen Han, Dong-xiang Liu, Zun-ji Ke, Zhi-fei Wang
ACTA PHARMACOLOGICA SINICA
(2020)
Article
Multidisciplinary Sciences
Da Song, Deheng Wang, Qinghu Yang, Tianyi Yan, Zhe Wang, Yan Yan, Juan Zhao, Zhen Xie, Yuchen Liu, Zunji Ke, Talal Jamil Qazi, Yanhui Li, Yili Wu, Qing Shi, Yiran Lang, Heao Zhang, Tao Huang, Chunjian Wang, Zhenzhen Quan, Hong Qing
NATURE COMMUNICATIONS
(2020)
Article
Oncology
Baokai Dou, Shichun Li, Luyao Wei, Lixin Wang, Shiguo Zhu, Zhengtao Wang, Zunji Ke, Kaixian Chen, Zhifei Wang
Summary: Astragaloside IV (ASIV) has been shown to inhibit post-ischemic NK cell brain infiltration and activation, as well as reverse NK cell deficiency in the periphery, contributing to its beneficial effects against brain ischemia. Additionally, ASIV's effects on suppressing NK cell brain infiltration and activation may involve HDAC inhibition.
FRONTIERS OF MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Shichun Li, Baokai Dou, Shi Shu, Luyao Wei, Shiguo Zhu, Zunji Ke, Zhifei Wang
Summary: Astragaloside IV (ASIV) inhibits the infiltration and activation of natural killer (NK) cells through STAT3 suppression, thereby protecting against ischemic brain injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Anesthesiology
Zhengyu Cui, Zhongzhao Guo, Luyao Wei, Xiang Zou, Zilu Zhu, Yuchen Liu, Jie Wang, Liang Chen, Deheng Wang, Zunji Ke
Summary: Research indicates that abnormal pain sensitivity in Alzheimer's disease modeling mice is closely related to changes in neuronal activity and dendritic spine loss in ACC pyramidal neurons, highlighting the crucial role of dendritic spine density in pain processing.
Article
Biochemistry & Molecular Biology
Luyao Wei, Wantao Wang, Junxia Yao, Zhengyu Cui, Zihang Xu, Hanqing Ding, Xiaojun Wu, Deheng Wang, Jia Luo, Zun-Ji Ke
Summary: This study identifies protein activator of the interferon-induced protein kinase (PACT) as a key player in basal-like breast cancer (BLBC) metastasis. High expression of PACT is associated with poor prognosis in BLBC patients. It is found that PACT regulates BLBC metastasis by interacting with SUMO-conjugating enzyme Ubc9.
Article
Medicine, General & Internal
Xiang Zou, Zilu Zhu, Yu Guo, Hongmiao Zhang, Yuchen Liu, Zhengyu Cui, Zunji Ke, Shize Jiang, Yusheng Tong, Zehan Wu, Ying Mao, Liang Chen, Deheng Wang
Summary: This study demonstrates that inadequate control of seizures by VPA monotherapy may be associated with neural excitatory rebounds, which can be predicted by intraoperative electrocorticogram (ECoG) analysis. Animal experiments and computational modeling further support this finding.
Article
Medicine, Research & Experimental
Yan Zhao, Yi Lei, Huying Ning, Yaqiang Zhang, Guilin Chen, Chenchen Wang, Qiangyou Wan, Shumin Guo, Qian Liu, Ruotian Xie, Yujuan Zhuo, Shuai Yan, Jing Zhao, Fengjiang Wei, Lu Wang, Xiaohong Wang, Weidong Li, Hua Yan, Ying Yu
Summary: Pathological retinal angiogenesis can lead to blindness. Prostaglandin F-2 alpha (PGF-2a) and its receptor (Ptgfr) play a role in the pathogenesis of retinopathy. Inhibition of PTGFR can attenuate retinopathy and reduce neovascularization. PTGFR may be a potential therapeutic target for retinal neovascularization.
EMBO MOLECULAR MEDICINE
(2023)
Article
Geriatrics & Gerontology
Huying Ning, Huiwen Ren, Yan Zhao, HaiFang Yin, Zhenji Gan, Yujun Shen, Ying Yu
Summary: This study found that PGD(2) inhibits muscle fiber transition from glycolytic to oxidative type via the RhoA/ROCK2/NFATc1 signaling pathway, thereby suppressing muscle wasting and obesity. Inhibition of DP2 may be a potential therapeutic approach against obesity and muscle disorders.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Endocrinology & Metabolism
Bohao Cui, Xu Guo, Wei Zhou, Xiaodan Zhang, Kai He, Tinghui Bai, Dongxue Lin, Selena Wei-Zhang, Yan Zhao, Shengnan Liu, Hui Zhou, Qing Wang, Xueming Yao, Ying Shi, Ruotian Xie, Xue Dong, Yi Lei, Mei Du, Yongsheng Chang, Heping Xu, Dongming Zhou, Ying Yu, Xiaohong Wang, Hua Yan
Summary: Exercise reduces the occurrence of neovascular age-related macular degeneration (nvAMD) and enhances the efficacy of anti-angiogenic therapy by inhibiting AIM2 inflammasome activation. It promotes the release of adiponectin, an anti-inflammatory adipokine, reducing DNA damage and suppressing AIM2 inflammasome activation in myeloid cells of CNV eyes. Simultaneous targeting of AIM2 inflammasome product IL-1 beta and VEGF has a synergistic effect in treating choroidal neovascularization.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Neurosciences
Zhongzhao Guo, Hong Ni, Zhengyu Cui, Zilu Zhu, Jiansheng Kang, Deheng Wang, Zunji Ke
Summary: Cytoplasmic dynein is crucial for neuronal growth and development. Knocking out the Dync1i1 gene in mice results in impaired pain sensation and dysfunctional gamma oscillations. Optogenetic activation of PV neurons rescues this dysfunction, while chemogenetic suppression of PV neurons mimics it. This study highlights the association between impaired pain sensation and the cytoplasmic dynein complex.
NEUROBIOLOGY OF DISEASE
(2023)
