Article
Microbiology
Subhayan Sur, Robert Steele, T. Scott Isbell, Ranjit Ray, Ratna B. Ray
Summary: This study demonstrates that exosomes from severe COVID-19 patients can enhance inflammasome activity in distant endothelial cells, leading to the secretion of IL-1 beta and inflammatory response.
Article
Immunology
Tamara S. Rodrigues, Camila C. S. Caetano, Keyla S. G. de Sa, Leticia Almeida, Amanda Becerra, Augusto Goncalves, Leticia de Sousa Lopes, Samuel Oliveira, Danielle P. A. Mascarenhas, Sabrina S. Batah, Bruna M. Silva, Giovanni F. Gomes, Ricardo Castro, Ronaldo B. Martins, Jonathan Avila, Fabiani G. Frantz, Thiago M. Cunha, Eurico Arruda, Fernando Q. Cunha, Helder Nakaya, Larissa D. Cunha, Alexandre T. Fabro, Paulo Louzada-Junior, Rene D. R. de Oliveira, Dario S. Zamboni
Summary: SARS-CoV-2 infection activates the NLRP3 inflammasome and leads to inflammation and severe COVID-19. Human caspase-4 (mouse caspase-11) is upregulated and activated by SARS-CoV-2, contributing to NLRP3 activation. In vivo studies using transgenic hACE2 humanized mice show that hACE2 Casp11(-/-) mice are protected from disease development, with reduced lung damage, clinical symptoms, and mortality. Analysis of human samples from fatal COVID-19 cases reveals the expression of CASP4 in patient lungs, which correlates with inflammasome components and inflammatory mediators. These findings suggest CASP4/11 as a potential target for therapeutic interventions in COVID-19.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Immunology
Yuan-Yuan Yong, Li Zhang, Yu-Jiao Hu, Jian-Ming Wu, Lu Yan, Yi-Ru Pan, Yong Tang, Lu Yu, Betty Yuen-Kwan Law, Chong-Lin Yu, Jie Zhou, Mao Li, Da-Lian Qin, Xiao-Gang Zhou, An-Guo Wu
Summary: This article discusses autophagy regulation at different stages of COVID-19 and highlights the therapeutic potential of autophagy activators in inhibiting cytokine storms.
CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Pan Pan, Miaomiao Shen, Zhenyang Yu, Weiwei Ge, Keli Chen, Mingfu Tian, Feng Xiao, Zhenwei Wang, Jun Wang, Yaling Jia, Wenbiao Wang, Pin Wan, Jing Zhang, Weijie Chen, Zhiwei Lei, Xin Chen, Zhen Luo, Qiwei Zhang, Meng Xu, Geng Li, Yongkui Li, Jianguo Wu
Summary: This study reveals a unique mechanism by which SARS-CoV-2 N protein promotes NLRP3 inflammasome activation, leading to excessive inflammatory responses. The interaction between N protein and NLRP3 enhances the assembly of the NLRP3 inflammasome by facilitating binding with ASC.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Jianxiong Zeng, Xiaochun Xie, Xiao-Li Feng, Ling Xu, Jian-Bao Han, Dandan Yu, Qing-Cui Zou, Qianjin Liu, Xiaohong Li, Guanqin Ma, Ming-Hua Li, Yong-Gang Yao
Summary: The study found that the NLRP3 inflammasome plays a crucial role in the lungs during SARS-CoV-2 infection, and inhibiting this inflammasome can reduce the release of pro-inflammatory cytokines related to COVID-19 in cells and mice. Therefore, targeting the NLRP3 inflammasome could be a promising immune intervention against severe COVID-19 disease.
Review
Immunology
Leila Mohamed Khosroshahi, Mohsen Rokni, Tahmineh Mokhtari, Farshid Noorbakhsh
Summary: COVID-19 infection, caused by SARS-CoV-2, is highly contagious and involves pulmonary inflammation and systemic immune dysregulation. Immune dysregulation may be the core pathogenic element, highlighting the importance of precise immune response management for successful treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Jiayu Zhang, Xuejing Ma, Fuwei Liu, Deju Zhang, Jitao Ling, Zicheng Zhu, Yixuan Chen, Pingping Yang, Yanlin Yang, Xiao Liu, Jing Zhang, Jianping Liu, Peng Yu
Summary: 2019 Coronavirus Disease (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Severe cases of COVID-19 are associated with a cytokine storm, characterized by elevated levels of pro-inflammatory cytokines in the bloodstream. Recent studies have shown a higher severity of necrobiosis infection in diabetic patients, as well as higher morbidity and mortality in people with chronic metabolic diseases such as diabetes. Additionally, COVID-19 may result in hyperglycemia in infected individuals. This review explores the potential relationship between NLRP3 inflammatory vesicles in diabetes and COVID-19, and discusses the cellular/molecular mechanisms by which SARS-CoV-2 infection activates NLRP3 inflammatory vesicles. Finally, several promising targeted NLRP3 inflammatory vesicle inhibitors are proposed as a basis for clinical management of patients with diabetes combined with noncoronary pneumonia.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Geraldine Blanchard-Rohner, Arnaud Didierlaurent, Anne Tilmanne, Pierre Smeesters, Arnaud Marchant
Summary: Children exhibit unique characteristics in the context of the COVID-19 pandemic, showing lower medical impact compared to adults but developing a severe and unique complication known as multisystem inflammatory syndrome. Their contribution to the transmission of SARS-CoV-2 appears lower than that of adults, which must be considered when vaccinating them.
Review
Biochemistry & Molecular Biology
Hongliang Zhang, Yujie Tang, Jinhui Tao
Summary: The COVID-19 pandemic caused by SARS-CoV-2 infection poses a significant threat to human life and economic well-being globally, with male patients showing a higher probability of severe symptoms and mortality. The NLRP3 inflammasome likely plays a critical role in this process.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Immunology
Dan Lv, Jing Peng, Rui Long, Xingguang Lin, Renjie Wang, Di Wu, Mengzhou He, Shujie Liao, Yun Zhao, Dongrui Deng
Summary: This review analyzes the unique immunological characteristics of pregnant women and reviews their known outcomes at different trimesters from the perspective of underlying mechanisms that have been studied and speculated so far.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Arinna Bertoni, Federica Penco, Hilaria Mollica, Paola Bocca, Ignazia Prigione, Anna Corcione, Davide Cangelosi, Francesca Schena, Genny Del Zotto, Adriana Amaro, Noemi Paladino, Emanuele Pontali, Marcello Feasi, Sara Signa, Marta Bustaffa, Roberta Caorsi, Serena Palmeri, Paola Contini, Raffaele De Palma, Ulrich Pfeffer, Paolo Uva, Anna Rubartelli, Marco Gattorno, Stefano Volpi
Summary: This study reveals the crucial role of IL-1 beta in driving inflammatory phenotypes in severe COVID-19 patients, whose maturation and secretion are regulated by inflammasomes. The findings suggest that targeting IL-1 beta could be an effective strategy for treating COVID-19 and provide a mechanistic explanation for the strong inflammatory manifestations associated with the disease.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Cell Biology
Aldo Bonaventura, Alessandra Vecchie, Lorenzo Dagna, Flavio Tangianu, Antonio Abbate, Francesco Dentali
Summary: SARS-CoV-2 can activate NLRP3 inflammasome, leading to an inflammatory response. Colchicine, as an anti-inflammatory drug, can block the activation of NLRP3 inflammasome and reduce the release of inflammatory cytokines. Some studies have shown that colchicine may have therapeutic effects on COVID-19. However, more research is needed to confirm these findings.
INFLAMMATION RESEARCH
(2022)
Article
Immunology
Deborah Lecuyer, Roberta Nardacci, Desiree Tannous, Emie Gutierrez-Mateyron, Aurelia Deva Nathan, Frederic Subra, Cristina Di Primio, Paola Quaranta, Vanessa Petit, Clemence Richetta, Ali Mostefa-Kara, Franca Del Nonno, Laura Falasca, Romain Marlin, Pauline Maisonnasse, Julia Delahousse, Juliette Pascaud, Eric Deprez, Marie Naigeon, Nathalie Chaput, Angelo Paci, Veronique Saada, David Ghez, Xavier Mariette, Mario Costa, Mauro Pistello, Awatef Allouch, Olivier Delelis, Mauro Piacentini, Roger Le Grand, Jean-Luc Perfettini
Summary: The purinergic receptor P2X7 and NLRP3 inflammasome are found to be cellular host factors required for SARS-CoV-2 infection, and their activation promotes viral replication and inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Nicola Potere, Marco Giuseppe Del Buono, Roberto Caricchio, Paul C. Cremer, Alessandra Vecchie, Ettore Porreca, Daniela Dalla Gasperina, Francesco Dentali, Antonio Abbate, Aldo Bonaventura
Summary: A hyperinflammatory response during SARS-CoV-2 infection worsens the clinical progression of COVID-19. Activation of the NLRP3 inflammasome and release of IL-1 beta aggravate pulmonary injury, induce hypercoagulability, and contribute to respiratory failure and multiorgan failure. Inhibition of IL-1 has shown promising results in clinical trials.
Review
Clinical Neurology
Shamila D. Alipoor, Esmaeil Mortaz, Mohammad Varahram, Johan Garssen, Ian M. Adcock
Summary: COVID-19 may enter the central nervous system through the olfactory nerve, causing neurological dysregulation and potentially cell death. The virus may promote the development or progression of neurodegenerative diseases by inducing inflammation and hypercoagulation.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biophysics
Paulo Anastacio Furtado Pacheco, Leonardo Braga Gomes Ferreira, Leonardo Mendonca, Dinarte Neto M. Ferreira, Juliana Pimenta Salles, Robson Xavier Faria, Pedro Celso Nogueira Teixeira, Luiz Anastacio Alves
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2016)
Article
Chemistry, Medicinal
Daniel Tadeu Gomes Gonzaga, Leonardo Braga Gomes Ferreira, Thadeu Estevam Moreira Maramaldo Costa, Natalia Lidmar von Ranke, Paulo Anastacio Furtado Pacheco, Ana Paula Sposito Simoes, Juliana Carvalho Arruda, Luiza Pereira Dantas, Hercules Rezende de Freitas, Ricardo Augusto de Melo Reis, Carmen Penido, Murilo Lamim Bello, Helena Carla Castro, Carlos Rangel Rodrigues, Vitor Francisco Ferreira, Robson Xavier Faria, Fernando de Carvalho da Silva
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Biophysics
Robson Xavier Faria, Daniel Tadeu Gomes Gonzaga, Paulo Anastacio Furtado Pacheco, Andre Luis Almeida Souza, Vitor Francisco Ferreira, Fernando de Carvalho da Silva
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2018)
Review
Biophysics
P. A. F. Pacheco, L. P. Dantas, L. G. B. Ferreira, Robson Xavier Faria
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2018)
Article
Biochemistry & Molecular Biology
P. A. F. Pacheco, R. M. S. Galvao, A. F. M. Faria, N. L. Von Ranke, M. S. Rangel, T. M. Ribeiro, M. L. Bello, C. R. Rodrigues, V. F. Ferreira, D. R. da Rocha, R. X. Faria
BIOORGANIC & MEDICINAL CHEMISTRY
(2019)
Article
Biophysics
Paulo Anastacio Furtado Pacheco, Thais de Menezes Ribeiro, Raissa Maria dos Santos Galvao, Eldio Goncalves dos Santos, Ana Flavia Martins Faria, Natalia Lidmar von Ranke, Murilo Lamim Bello, Carlos Rangel Rodrigues, Vitor Francisco Ferreira, Andre Luis Almeida Souza, Daiana de Jesus Hardoim, Katia da Silva Calabreses, Robson Xavier Faria, David Rodrigues da Rocha
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2020)
Review
Chemistry, Medicinal
Paulo Anastacio Furtado Pacheco, Roberta Tosta Diogo, Betina Quintanilha Magalhaes, Robson Xavier Faria
Review
Chemistry, Medicinal
Caroline dos S. Moreira, Thais B. Santos, Rosana H. C. N. Freitas, Paulo A. F. Pacheco, David R. da Rocha
Summary: Juglone, a metabolite produced by certain plants, is a 1,4-naphthoquinone with various biological actions. Its derivatives show potent pharmacological effects, making it a valuable structure for the design and development of new drugs.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Paulo A. F. Pacheco, Daniel T. Gonzaga, Claudio C. Cirne-Santos, Caroline S. Barros, Max W. L. Gomes, Rafaela S. P. Gomes, Mariana C. Goncalves, Vitor F. Ferreira, Vitor W. Rabelo, Paula A. Abreu, Robson X. Faria, Gabriel O. de Resende, David R. da Rocha, Izabel C. N. P. Paixao, Fernando C. da Silva
Summary: Chikungunya virus is a re-emerging disease and there is an urgent need to develop new antiviral drugs. In this study, 19 derivatives were synthesized and evaluated, and 5 compounds showed potent activity. Compound 11a exhibited a high antiviral effect.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2022)
Review
Biochemistry & Molecular Biology
Paulo A. F. Pacheco, Maria M. M. Santos
Summary: Protozoan diseases pose a significant global health problem, particularly for socially and economically vulnerable populations. Due to limited investment in drug discovery, the available therapeutic options are limited. The emergence of drug-resistant parasite strains further emphasizes the need for safe and effective antiparasitic agents. Indole-based compounds have shown promise as drug candidates for treating important parasitic diseases such as malaria, trypanosomiasis, and leishmaniasis, with recent advancements in the design, optimization, and synthesis of synthetic indole scaffolds.
Article
Biochemistry & Molecular Biology
Fernanda Guilhon-Simplicio, Carlos Klinger Rodrigues Serrao, Ana Cristina da Silva Pinto, Paulo Anastacio Furtado Pacheco, Robson Xavier Faria, David Rodrigues Rocha, Vitor Francisco Ferreira, Raimundo Carlos Pereira-Junior, An Matheeussen, Adrienn Baan, Filip Kiekens, Maria de Meneses Pereira, Emerson Silva Lima, Hans De Winter, Paul Cos
Summary: Triterpene derivatives were synthesized and their antimicrobial activity was evaluated in this study. It was found that five derivatives exhibited activity against various pathogens, with derivatives 14a/14b showing potent activity against Trypanosoma cruzi without cytotoxicity. The results suggest that triterpene derivatives with antitrypanosomal activity can be synthesized using an inexpensive and rapid method.
CHEMICAL BIOLOGY & DRUG DESIGN
(2022)
Article
Cell Biology
Nathalia Gugick Pinheiro, Daniel Tadeu Gomes Gonzaga, Aldo Rodrigues da Silva, Andre Lopes Fuly, Natalia Lidmar von Ranke, Carlos Rangel Rodrigues, Betina Quintanilha Magalhaes, Julianne Soares Pereira, Paulo Anastacio F. Pacheco, Ana Claudia Silva, Vitor Francisco Ferreira, Fernando de Carvalho da Silva, Robson Xavier Faria
Summary: The present study aimed to investigate five triazole compounds as P2X7R inhibitors and evaluate their ability to reduce acute inflammation in vivo. The tested compounds showed significant reduction in paw edema and inhibited carrageenan-induced peritonitis. These molecules have potential as antagonist drugs of P2X7R with anti-inflammatory action.
INFLAMMATION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Paulo Anastacio Purtado Pacheco, Juliana Vieira Faria, Ana Claudia Silva, Natalia Lidmar von Ranke, Robson Coutinho Silva, Carlos Rangel Rodrigues, David Rodrigues da Rocha, Robson Xavier Faria
Summary: This study evaluated the pharmacological effects of eleven N, S-acetal juglone derivatives as P2x7R inhibitors. Through in vitro and in vivo experiments, we identified one derivative with promising inhibitory activity and low toxicity. Our in silico studies suggest that the 1,4-naphthoquinone moiety might be a valuable molecular scaffold for the development of novel P2x7R antagonists, consistent with our previous research.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Paulo A. F. Pacheco, Daniel T. Gonzaga, Claudio C. Cirne-Santos, Caroline S. Barros, Max W. L. Gomes, Rafaela S. P. Gomes, Mariana C. Goncalves, Vitor F. Ferreira, Vitor W. Rabelo, Paula A. Abreu, Robson X. Faria, Gabriel O. de Resende, David R. da Rocha, Izabel C. N. P. Paixao, Fernando C. da Silva
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2022)
Article
Immunology
Hilal Uensal, Canan Caka, Hacer Neslihan Bildik, Saliha Esenboga, Alphan Kupesiz, Baris Kuskonmaz, Duygu Uckan Cetinkaya, Mirjam van Der Burg, Ilhan Tezcan, Deniz Cagdas
Summary: The study investigated the demographic, clinical, laboratory, follow-up, and treatment characteristics of 21 patients with Major Histocompatibility Complex Class II (MHC-II) deficiency. It was found that patients with Bare Lymphocyte Syndrome (BLS) exhibited clinical findings similar to severe combined immunodeficiency (SCID), and the flow cytometric MHC-II expression study played a crucial role in the diagnosis, differential diagnosis, early hematopoietic stem cell transplantation (HSCT), and post-HSCT follow-up.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Axel Rosell, Cecilia Karlstrom, Joakim S. Dahlin, Daryl Boey, Monika Klimkowska, Kajsa Ax, Charlotte Thalin, Johanna Ungerstedt
Summary: There is no evidence of global increase in neutrophil extracellular trap release in patients with systemic mastocytosis.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Charles W. Armitage, Connor P. O'Meara, Emily R. Bryan, Avinash Kollipara, Logan K. Trim, Danica Hickey, Alison J. Carey, Wilhelmina M. Huston, Gavin Donnelly, Anusch Yazdani, Richard S. Blumberg, Kenneth W. Beagley
Summary: This study demonstrates that IgG seroconversion during male infection can amplify female immunopathology and infertility. IgG transcytosis through the FcRn receptor allows Chlamydia to cross the epithelial barrier and be phagocytosed by antigen-presenting cells. This leads to increased pro-inflammatory signaling and T cell proliferation, resulting in more severe pathology and infertility in female mice.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Fatma Gonca Kocanci, Azize Yasemin Goksu Erol, Fatma Yildiz, Hamiyet Eciroglu
Summary: Calcineurin inhibitors, such as pimecrolimus, have been found to have preventive effects against neuroinflammation and apoptotic pathways, which are underlying mechanisms in neurodegenerative diseases. This study demonstrated that pimecrolimus exerts neuroprotective effects by inhibiting inflammation and oxidative stress, making it a potential treatment option for neurodegenerative diseases.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
