Neural progenitor cell pyroptosis contributes to Zika virus-induced brain atrophy and represents a therapeutic target

The association between Zika virus infection and microcephaly in Brazil 2015–2017: An observational analysis of over 4 million births

(2019) Oliver J. Brady et al.   PLOS MEDICINE

NLRP3 Inflammasome Activation Mediates Zika Virus–Associated Inflammation

(2018) Zhenjian He et al.   JOURNAL OF INFECTIOUS DISEASES

Acute and chronic neurological consequences of early-life Zika virus infection in mice

(2018) Isis Nem de Oliveira Souza et al.   Science Translational Medicine

Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1β secretion

(2018) Wenbiao Wang et al.   Nature Communications

In situ inflammasome activation results in severe damage to the central nervous system in fatal Zika virus microcephaly cases

(2018) Jorge Rodrigues de Sousa et al.   CYTOKINE

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

(2018) Joseph Flores et al.   Nature Communications

How does Zika virus cause microcephaly?

(2017) Zhexing Wen et al.   GENES & DEVELOPMENT

Zika Virus Targeting in the Developing Brain

(2017) Anthony N. van den Pol et al.   JOURNAL OF NEUROSCIENCE

Zika Virus Infection and Associated Neurologic Disorders in Brazil

(2017) Wanderson K. de Oliveira et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Characterizing the Pattern of Anomalies in Congenital Zika Syndrome for Pediatric Clinicians

(2017) Cynthia A. Moore et al.   JAMA Pediatrics

Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation

(2016) Hongda Li et al.   Cell Stem Cell

Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice

(2016) Cui Li et al.   Cell Stem Cell

Fatal encephalitis associated with Zika virus infection in an adult

(2016) Cristiane N. Soares et al.   JOURNAL OF CLINICAL VIROLOGY

Pathology of congenital Zika syndrome in Brazil: a case series

(2016) Roosecelis Brasil Martines et al.   LANCET

Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study

(2016) Guilherme Calvet et al.   LANCET INFECTIOUS DISEASES

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

The Brazilian Zika virus strain causes birth defects in experimental models

(2016) Fernanda R. Cugola et al.   NATURE

Zika Virus and the Guillain–Barré Syndrome — Case Series from Seven Countries

(2016) Thais dos Santos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zika Virus Associated with Meningoencephalitis

(2016) Guillaume Carteaux et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zika Virus Associated with Microcephaly

(2016) Jernej Mlakar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zika Virus and Birth Defects — Reviewing the Evidence for Causality

(2016) Sonja A. Rasmussen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy

(2016) Fares Bassil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for the Inflammasome in Spontaneous Labor at Term with Acute Histologic Chorioamnionitis

(2016) Nardhy Gomez-Lopez et al.   Reproductive Sciences

Zika virus impairs growth in human neurospheres and brain organoids

(2016) P. P. Garcez et al.   SCIENCE

Characterization of Lethal Zika Virus Infection in AG129 Mice

(2016) Matthew T. Aliota et al.   PLoS Neglected Tropical Diseases

Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise

(2016) Manoel Sarno et al.   PLoS Neglected Tropical Diseases

Congenital Zika Virus Infection

(2016) Adriana Suely de Oliveira Melo et al.   JAMA Neurology

ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in Macrophages

(2016) Qing-Bing Zha et al.   Frontiers in Immunology

Notes from the Field: Evidence of Zika Virus Infection in Brain and Placental Tissues from Two Congenitally Infected Newborns and Two Fetal Losses — Brazil, 2015

(2016) Roosecelis Brasil Martines et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Staying Alive: Cell Death in Antiviral Immunity

(2014) Jason W. Upton et al.   MOLECULAR CELL

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species

(2013) Bridgette D. Semple et al.   PROGRESS IN NEUROBIOLOGY

Progress report on new antiepileptic drugs: A summary of the Eleventh Eilat Conference (EILAT XI)

(2012) Meir Bialer et al.   EPILEPSY RESEARCH

NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells

(2012) Seth L. Masters et al.   IMMUNITY

NLRP1-Dependent Pyroptosis Leads to Acute Lung Injury and Morbidity in Mice

(2012) M. Kovarova et al.   JOURNAL OF IMMUNOLOGY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Genetic causes of microcephaly and lessons for neuronal development

(2012) Edward C. Gilmore et al.   Wiley Interdisciplinary Reviews-Developmental Biology