Review
Public, Environmental & Occupational Health
Veronica N. E. Malange, Gitte Hedermann, Ulrik Lausten-Thomsen, Steen Hoffmann, Marianne Voldstedlund, Anna J. M. Aabakke, Anna K. K. Eltvedt, Jorgen S. Jensen, Morten Breindahl, Lone Krebs, Michael Christiansen, Paula L. L. Hedley
Summary: In the past decade, there have been numerous infectious disease outbreaks worldwide, which have had significant effects on perinatal health, including increased risk of preterm delivery and the delivery of low birth weight or small for gestational age babies. Severe perinatal outcomes, such as perinatal and infant death, have also been observed in relation to various infectious diseases. It is important to monitor perinatal health and collect systematic data to understand the implications of these diseases for pregnant women and their unborn infants.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Public, Environmental & Occupational Health
Seher Topluoglu, Aysegul Taylan-Ozkan, Emine Alp
Summary: Emerging Infectious Diseases (EIDs) and Re-Emerging Infectious Diseases (REIDs) are significant health problems, with up to 75% having zoonotic origin. Factors like destruction of habitats, population migration due to conflicts, and insufficient disease prevention programs contribute to their emergence and distribution. Natural disasters and wars have a major impact on the spread of diseases and worsen health risks.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Xiaowei Ma, Jianyun Lu, Weisi Liu
Summary: This study aims to investigate the knowledge of emerging and reemerging infectious diseases among the public in Guangzhou and provide a scientific basis for health information strategies. The results show that the majority of participants have heard of Middle East respiratory syndrome and Zika, while the knowledge of Ebola and plague is relatively low. Education level and income are key factors that influence knowledge rates.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Medicine, General & Internal
Mariam Abdulmonem Mansouri, Frank Kee, Leandro Garcia, Declan T. Bradley
Summary: This article discusses the complexity of emerging infectious diseases (EIDs) and highlights the role of systems science in understanding and controlling EIDs. The research aims to explore the application of systems methods in controlling EIDs, identify knowledge gaps, and disseminate the results.
Article
Health Care Sciences & Services
Maria Mavrouli, Spyridon Mavroulis, Efthymios Lekkas, Athanassios Tsakris
Summary: On 6 February 2023, two major earthquakes struck Turkey and Syria, causing severe damage to structures and infrastructure in densely populated areas. The authors visited the affected area shortly after the earthquakes to assess the potential impact on public health. Field data revealed that risk factors for infectious diseases were present in the affected residential areas from the early stages of the emergency. Collapsed health facilities, cold winter conditions, destroyed infrastructure, overcrowded shelters, poor sanitation, and adverse socio-economic conditions, along with ongoing crises and disasters, could worsen the public health situation and delay the recovery process. Efficient disease surveillance and other prevention measures are crucial for early warning and management of infectious diseases in earthquake-affected areas.
Article
Multidisciplinary Sciences
Matthew D. Solomon, Gabriel J. Escobar, Yun Lu, David Schlessinger, Jonathan B. Steinman, Lawrence Steinman, Catherine Lee, Vincent X. Liu
Summary: Susceptibility and severity of COVID-19 infection vary widely. Prior exposure to endemic coronaviruses, common in young children, may protect against SARS-CoV-2. In adults, less exposure to young children is associated with more severe COVID-19 illness.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Stacy Hartmann, Zachary Rubin, Heidi Sato, Kelsey O. Yong, Dawn Terashita, Sharon Balter
Summary: Healthcare workers are at greater risk of COVID-19 infection due to the nature of their work. Data collected from Los Angeles County Department of Public Health showed that over 5500 positive cases among healthcare workers were reported, with the highest proportion from long-term care facilities and hospitals. Despite the risk factors, healthcare workers had lower hospitalization and death rates compared to all cases in Los Angeles County.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Veterinary Sciences
David Palma, Lilas Mercuriali, Jordi Figuerola, Tomas Montalvo, Ruben Bueno-Mari, Joan-Pau Millet, Pere Simon, Eva Masdeu, Cristina Rius
Summary: A total of 177 cases of leishmaniasis were reported in Barcelona between 1996 and 2019, with a higher incidence in the foreign-born population. The main types were cutaneous and visceral, with the highest incidence in 0-4 year olds and 25-64 year old males.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biology
Yang Yang, Liping Guo, Hongzhou Lu
Summary: Emerging infectious diseases have always been a part of human society and have caused significant harm. SARS-CoV-2 is just one example from a long list of microbial threats. The spillover of viruses from natural hosts to humans through interspecies transmission is the main source of these diseases. The existence of viruses in animals that can infect human cells indicates the possible outbreak of future viral infections. To combat the potential pandemics of emerging infectious diseases, it is crucial to have extensive international surveillance, stricter wildlife trade legislation, and increased investment in research.
Review
Environmental Sciences
Johan Bengtsson-Palme, Anna Abramova, Thomas U. Berendonk, Luis Pedro Coelho, Sofia K. Forslund, Remi Gschwind, Annamari Heikinheimo, Victor Hugo Jarquin-Diaz, Ayaz Ali Khan, Uli Kluemper, Ulrike Loeber, Marmar Nekoro, Adriana D. Osinska, Svetlana Ugarcina Perovic, Tarja Pitkanen, Ernst Kristian Rodland, Etienne Ruppe, Yngvild Wasteson, Astrid Louise Wester, Rabaab Zahra
Summary: Antimicrobial resistance (AMR) poses a global threat to human and animal health, and monitoring resistant bacteria and genes is crucial. However, monitoring of AMR in the environment is lacking, hindering our understanding of how resistant microorganisms are disseminated and the human health risks. This lack of knowledge includes the "normal" background levels of environmental AMR, high-risk environments for transmission, antibiotic concentration effects, and detecting non-circulating resistance genes. We need to address these knowledge gaps before implementing large-scale AMR monitoring in the environment.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Maria Laura Calero, Gustavo Monti
Summary: This study used scenario tree modeling to assess the sensitivity of Ecuador's current national surveillance system to leptospirosis. The research found regional variations in sensitivity, with the Coast region having the highest sensitivity and the Andes region having the lowest. The probability of seeking medical attention and the probability of experiencing symptoms were identified as important factors influencing the system's sensitivity.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Kathleen M. O'Reilly, Frank Sandman, David Allen, Christopher Jarvis, Amy Gimma, Amy Douglas, Lesley Larkin, Kerry L. M. Wong, Marc Baguelin, Ralph S. Baric, Lisa C. Lindesmith, Richard A. Goldstein, Judith Breuer, W. John Edmunds
Summary: Research suggests that susceptibility to norovirus infection has likely increased between March 2020 and mid-2021. Depending on assumptions of future contact patterns, norovirus incidence post-restrictions lifting may return to pre-pandemic levels or increase beyond previous reports.
Review
Public, Environmental & Occupational Health
Peng Jia, Shiyong Liu, Shujuan Yang
Summary: Public health surveillance is the ongoing collection, analysis, and interpretation of health data, and plays a central role in modern public health practice. While early identification and prediction of disease trends is possible, more work is needed to improve accuracy. This article reviews the advantages and limitations of current surveillance systems and discusses technological innovations that are expected to enhance the timeliness and accuracy of reporting during outbreaks.
ANNUAL REVIEW OF PUBLIC HEALTH
(2023)
Article
Immunology
Sallee Brandt, Ryan T. Demmer, Sara Walsh, John F. Mulcahy, Evelyn Zepeda, Stephanie Yendell, Craig Hedberg, Angela K. Ulrich, Timothy Beebe
Summary: This cross-sectional study aimed to describe the demographics and behaviors of Minnesota adults who have not received the primary series of the COVID-19 vaccine or the booster shot. The study used data from the Minnesota COVID-19 Antibody Study (MCAS) collected through a web-based survey sent to individuals who responded to a similar survey in 2020 and their adult household members. The study found that a significant proportion of the US population remains unvaccinated, with safety concerns being the most frequently reported reason.
Review
Public, Environmental & Occupational Health
Ahmed S. Keshta, Saad Mallah, Khaled Al Zubaidi, Omar K. Ghorab, Mohamed S. Keshta, Dalal Alarabi, Mohammad A. Abousaleh, Mustafa Thaer Salman, Omer E. Taha, Anas A. Zeidan, Mahmoud F. Elsaid, Patrick Tang
Summary: Two genetically similar coronaviruses, SARS-CoV-1 and SARS-CoV-2, have caused global epidemics of different scales due to differences in transmission dynamics and clinical presentations. Comprehensive understanding of the clinical pathogenesis of each virus is essential due to potential involvement of multiple organ systems during infection. The management of COVID-19 has evolved as more knowledge and experience are accumulated, and new therapeutics and vaccines are developed, impacting healthcare and public health systems profoundly.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Biology
Jaspreet Toor, Susy Echeverria-Londono, Xiang Li, Kaja Abbas, Emily D. Carter, Hannah E. Clapham, Andrew Clark, Margaret J. de Villiers, Kirsten Eilertson, Matthew Ferrari, Ivane Gamkrelidze, Timothy B. Hallett, Wes R. Hinsley, Daniel Hogan, John H. Huber, Michael L. Jackson, Kevin Jean, Mark Jit, Andromachi Karachaliou, Petra Klepac, Alicia Kraay, Justin Lessler, Xi Li, Benjamin A. Lopman, Tewodaj Mengistu, C. Jessica E. Metcalf, Sean M. Moore, Shevanthi Nayagam, Timos Papadopoulos, T. Alex Perkins, Allison Portnoy, Homie Razavi, Devin Razavi-Shearer, Stephen Resch, Colin Sanderson, Steven Sweet, Yvonne Tam, Hira Tanvir, Quan Tran Minh, Caroline L. Trotter, Shaun A. Truelove, Emilia Vynnycky, Neff Walker, Amy Winter, Kim Woodruff, Neil M. Ferguson, Katy A. M. Gaythorpe
Summary: Vaccination activities from 2000 to 2030 are estimated to prevent 97 million deaths, with additional benefits for children under 5. This study motivates the sustaining and improvement of global vaccination coverage in the future.
Article
Microbiology
Gebbiena M. Bron, Kathryn Strimbu, Helene Cecilia, Anita Lerch, Sean M. Moore, Quan Tran, T. Alex Perkins, Quirine A. ten Bosch
Summary: Over the past 100 years, Rift Valley fever virus (RVFV) has caused potentially lethal diseases in both animals and humans in various countries, indicating an increased risk of transmission. The study found that in 24 countries, detection of RVFV antibodies in animals or humans was common, suggesting that the transmission of RVFV may go unnoticed.
Article
Public, Environmental & Occupational Health
Sean Cavany, Aaron Bivins, Zhenyu Wu, Devin North, Kyle Bibby, T. Alex Perkins
Summary: A study suggests that RNA shedding of SARS-CoV-2 into wastewater peaks around 6 days after infection, and wastewater surveillance has limited utility in predicting transmission trends. It may be most useful as an early warning in areas with low transmission or delayed/limited clinical testing.
EPIDEMIOLOGY AND INFECTION
(2022)
Article
Microbiology
T. Alex Perkins, Melissa Stephens, Wendy Alvarez Barrios, Sean Cavany, Liz Rulli, Michael E. Pfrender
Summary: Accurate testing for SARS-CoV-2 is crucial in controlling its spread. This study used Bayesian latent class modeling to assess the accuracy of three different testing methods and found that RT-PCR testing of saliva samples at a campus facility showed higher sensitivity and specificity, making it an effective surveillance screening method in a university setting.
MICROBIOLOGY SPECTRUM
(2022)
Article
Multidisciplinary Sciences
Estee Y. Cramer, Evan L. Ray, Velma K. Lopez, Johannes Bracher, Andrea Brennen, Alvaro J. Castro Rivadeneira, Aaron Gerding, Tilmann Gneiting, Katie H. House, Yuxin Huang, Dasuni Jayawardena, Abdul H. Kanji, Ayush Khandelwal, Khoa Le, Anja Muhlemann, Jarad Niemi, Apurv Shah, Ariane Stark, Yijin Wang, Nutcha Wattanachit, Martha W. Zorn, Youyang Gu, Sansiddh Jain, Nayana Bannur, Ayush Deva, Mihir Kulkarni, Srujana Merugu, Alpan Raval, Siddhant Shingi, Avtansh Tiwari, Jerome White, Neil F. Abernethy, Spencer Woody, Maytal Dahan, Spencer Fox, Kelly Gaither, Michael Lachmann, Lauren Ancel Meyers, James G. Scott, Mauricio Tec, Ajitesh Srivastava, Glover E. George, Jeffrey C. Cegan, Ian D. Dettwiller, William P. England, Matthew W. Farthing, Robert H. Hunter, Brandon Lafferty, Igor Linkov, Michael L. Mayo, Matthew D. Parno, Michael A. Rowland, Benjamin D. Trump, Yanli Zhang-James, Samuel Chen, Stephen Faraone, Jonathan Hess, Christopher P. Morley, Asif Salekin, Dongliang Wang, Sabrina M. Corsetti, Thomas M. Baer, Marisa C. Eisenberg, Karl Falb, Yitao Huang, Emily T. Martin, Ella McCauley, Robert L. Myers, Tom Schwarz, Daniel Sheldon, Graham Casey Gibson, Rose Yu, Liyao Gao, Yian Ma, Dongxia Wu, Xifeng Yan, Xiaoyong Jin, Yu-Xiang Wang, YangQuan Chen, Lihong Guo, Yanting Zhao, Quanquan Gu, Jinghui Chen, Lingxiao Wang, Pan Xu, Weitong Zhang, Difan Zou, Hannah Biegel, Joceline Lega, Steve McConnell, V. P. Nagraj, Stephanie L. Guertin, Christopher Hulme-Lowe, Stephen D. Turner, Yunfeng Shi, Xuegang Ban, Robert Walraven, Qi-Jun Hong, Stanley Kong, Axel van de Walle, James A. Turtle, Michal Ben-Nun, Steven Riley, Pete Riley, Ugur Koyluoglu, David DesRoches, Pedro Forli, Bruce Hamory, Christina Kyriakides, Helen Leis, John Milliken, Michael Moloney, James Morgan, Ninad Nirgudkar, Gokce Ozcan, Noah Piwonka, Matt Ravi, Chris Schrader, Elizabeth Shakhnovich, Daniel Siegel, Ryan Spatz, Chris Stiefeling, Barrie Wilkinson, Alexander Wong, Sean Cavany, Guido Espana, Sean Moore, Rachel Oidtman, Alex Perkins, David Kraus, Andrea Kraus, Zhifeng Gao, Jiang Bian, Wei Cao, Juan Lavista Ferres, Chaozhuo Li, Tie-Yan Liu, Xing Xie, Shun Zhang, Shun Zheng, Alessandro Vespignani, Matteo Chinazzi, Jessica T. Davis, Kunpeng Mu, Ana Pastore Y. Piontti, Xinyue Xiong, Andrew Zheng, Jackie Baek, Vivek Farias, Andreea Georgescu, Retsef Levi, Deeksha Sinha, Joshua Wilde, Georgia Perakis, Mohammed Amine Bennouna, David Nze-Ndong, Divya Singhvi, Ioannis Spantidakis, Leann Thayaparan, Asterios Tsiourvas, Arnab Sarker, Ali Jadbabaie, Devavrat Shah, Nicolas Della Penna, Leo A. Celi, Saketh Sundar, Russ Wolfinger, Dave Osthus, Lauren Castro, Geoffrey Fairchild, Isaac Michaud, Dean Karlen, Matt Kinsey, Luke C. Mullany, Kaitlin Rainwater-Lovett, Lauren Shin, Katharine Tallaksen, Shelby Wilson, Elizabeth C. Lee, Juan Dent, Kyra H. Grantz, Alison L. Hill, Joshua Kaminsky, Kathryn Kaminsky, Lindsay T. Keegan, Stephen A. Lauer, Joseph C. Lemaitre, Justin Lessler, Hannah R. Meredith, Javier Perez-Saez, Sam Shah, Claire P. Smith, Shaun A. Truelove, Josh Wills, Maximilian Marshall, Lauren Gardner, Kristen Nixon, John C. Burant, Lily Wang, Lei Gao, Zhiling Gu, Myungjin Kim, Xinyi Li, Guannan Wang, Yueying Wang, Shan Yu, Robert C. Reiner, Ryan Barber, Emmanuela Gakidou, Simon Hay, Steve Lim, Chris Murray, David Pigott, Heidi L. Gurung, Prasith Baccam, Steven A. Stage, Bradley T. Suchoski, B. Aditya Prakash, Bijaya Adhikari, Jiaming Cui, Alexander Rodriguez, Anika Tabassum, Jiajia Xie, Pinar Keskinocak, John Asplund, Arden Baxter, Buse Eylul Oruc, Nicoleta Serban, Sercan O. Arik, Mike Dusenberry, Arkady Epshteyn, Elli Kanal, Long T. Le, Chun-Liang Li, Tomas Pfister, Dario Sava, Rajarishi Sinha, Thomas Tsai, Nate Yoder, Jinsung Yoon, Leyou Zhang, Sam Abbott, Nikos Bosse, Sebastian Funk, Joel Hellewell, Sophie R. Meakin, Katharine Sherratt, Mingyuan Zhou, Rahi Kalantari, Teresa K. Yamana, Sen Pei, Jeffrey Shaman, Michael L. Li, Dimitris Bertsimas, Omar Skali Lami, Saksham Soni, Hamza Tazi Bouardi, Turgay Ayer, Madeline Adee, Jagpreet Chhatwal, Ozden O. Dalgic, Mary A. Ladd, Benjamin P. Linas, Peter Mueller, Jade Xiao, Yuanjia Wang, Qinxia Wang, Shanghong Xie, Donglin Zeng, Alden Green, Jacob Bien, Logan Brooks, Addison J. Hu, Maria Jahja, Daniel McDonald, Balasubramanian Narasimhan, Collin Politsch, Samyak Rajanala, Aaron Rumack, Noah Simon, Ryan J. Tibshirani, Rob Tibshirani, Valerie Ventura, Larry Wasserman, Eamon B. O'Dea, John M. Drake, Robert Pagano, Quoc T. Tran, Lam Si Tung Ho, Huong Huynh, Jo W. Walker, Rachel B. Slayton, Michael A. Johansson, Matthew Biggerstaff, Nicholas G. Reich
Summary: Short-term probabilistic forecasts of the COVID-19 pandemic in the United States have been crucial in communication between scientists and the public and decision-makers. The US COVID-19 Forecast Hub collected millions of predictions from various academic, industry, and independent research groups, providing accurate forecasts for short-term decision-making. Collaboration between government agencies, academic modeling teams, and industry partners plays a significant role in developing modeling capabilities to support outbreak response at different levels.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, General & Internal
Anita Lerch, Quirine A. Ten Bosch, Maina L'Azou Jackson, Alison A. Bettis, Mauro Bernuzzi, Georgina A. Murphy, Quan M. Tran, John H. Huber, Amir S. Siraj, Gebbiena M. Bron, Margaret Elliott, Carson S. Hartlage, Sojung Koh, Kathyrn Strimbu, Magdalene Walters, T. Alex Perkins, Sean M. Moore
Summary: In order to respond effectively to potential outbreaks of emerging zoonotic diseases, vaccines are being developed for prioritized pathogens. Vaccination strategies targeting healthcare workers have shown to have a higher impact compared to population-wide vaccination. The current estimates are based on the epidemiology of each pathogen, but uncertainties and evolution of pathogens may alter vaccine stockpile requirements in the future.
Article
Biochemical Research Methods
Guido Espana, T. Alex Perkins, Simon D. Pollett, Morgan E. Smith, Sean M. Moore, Paul O. Kwon, Tara L. Hall, Milford H. Beagle, Clinton K. Murray, Shilpa Hakre, Sheila A. Peel, Kayvon Modjarrad, Paul T. Scott
Summary: This study presents a simulation model of COVID-19 outbreaks in a U.S. Army basic training setting and provides practical approaches to improve prevention. The findings suggest that virus introductions from trainers pose a greater risk than the number of trainees, and the risk of outbreaks is highly influenced by false-positive results during entry testing. These findings offer practical recommendations to prevent COVID-19 outbreaks in basic training and ensure a continuous flow of new soldiers. The study highlights the importance of bespoke modeling to inform prevention in diverse institutional settings.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Marya L. Poterek, Chantal B. F. Vogels, Nathan D. Grubaugh, Gregory D. Ebel, T. Alex Perkins, Sean M. Cavany
Summary: The overall incidence and drivers of arbovirus co-infection are not well understood. This study developed a mathematical model to investigate the co-circulation of two arboviruses and found that temporal synchrony of the co-infecting viruses and average temperature were the most influential factors. The study suggests that significant co-infections are unlikely to occur except in tropical climates when the viruses co-occur in time and space.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Immunology
Tran Quan Minh, James Soda, Amir Siraj, Sean Moore, Hannah Clapham, T. Alex Perkins
Summary: There has been an increased interest in developing a vaccine for chikungunya in recent decades due to its unpredictable transmission. To inform decision making on vaccine trials, a new framework was developed to project the expected number of endpoint events at a given site using serological data and an SIR transmission model. The results suggest that some sites may have sufficient transmission potential and susceptibility to support future vaccine trials.
Article
Multidisciplinary Sciences
Aurel Holzschuh, Anita Lerch, Inna Gerlovina, Bakar S. Fakih, Abdul-wahid H. Al-mafazy, Erik J. Reaves, Abdullah Ali, Faiza Abbas, Mohamed Haji Ali, Mohamed Ali Ali, Manuel W. Hetzel, Joshua Yukich, Cristian Koepfli
Summary: A highly multiplexed PCR sequencing method was developed to investigate the genetic structure of malaria parasites in Zanzibar, providing actionable insights for malaria elimination efforts.
NATURE COMMUNICATIONS
(2023)
Article
Health Care Sciences & Services
Rebecca K. Borchering, Luke C. Mullany, Emily Howerton, Matteo Chinazzi, Claire P. Smith, Michelle Qin, Nicholas G. Reich, Lucie Contamin, John Levander, Jessica Kerr, J. Espino, Harry Hochheiser, Kaitlin Lovett, Matt Kinsey, Kate Tallaksen, Shelby Wilson, Lauren Shin, Joseph C. Lemaitre, Juan Dent Hulse, Joshua Kaminsky, Elizabeth C. Lee, Alison L. Hill, Jessica T. Davis, Kunpeng Mu, Xinyue Xiong, Ana Pastore Y. Piontti, Alessandro Vespignani, Ajitesh Srivastava, Przemyslaw Porebski, Srini Venkatramanan, Aniruddha Adiga, Bryan Lewis, Brian Klahn, Joseph Outten, Benjamin Hurt, Jiangzhuo Chen, Henning Mortveit, Amanda Wilson, Madhav Marathe, Stefan Hoops, Parantapa Bhattacharya, Dustin Machi, Shi Chen, Rajib Paul, Daniel Janies, Jean-Claude Thill, Marta Galanti, Teresa Yamana, Sen Pei, Jeffrey Shaman, Guido Espana, Sean Cavany, Sean Moore, Alex Perkins, Jessica M. Healy, Rachel B. Slayton, Michael A. Johansson, Matthew Biggerstaff, Katriona Shea, Shaun A. Truelove, Michael C. Runge, Cecile Viboud, Justin Lessler
Summary: This study examined the impact of expanding COVID-19 vaccination to children aged 5-11 years on disease burden and resilience against variant strains. The results showed that vaccinating children can significantly reduce cases, hospitalizations, and deaths, with greater benefits for children in particular.
LANCET REGIONAL HEALTH-AMERICAS
(2023)
Article
Infectious Diseases
Alexander D. Meyer, Sandra Mendoza Guerrero, Natalie E. Dean, Kathryn B. Anderson, Steven T. Stoddard, T. Alex Perkins
Summary: Assessing the factors responsible for differences in outbreak severity for the same pathogen is challenging. This study proposes a method to directly compare outbreaks described with varied data types by estimating a common set of epidemiological parameters. The model and inference method developed in this study can improve the understanding of CHIKV and other pathogens for which outbreaks are described with varied data types.
Article
Multidisciplinary Sciences
Gonzalo M. Vazquez-Prokopec, Amy C. Morrison, Valerie Paz-Soldan, Steven T. Stoddard, William Koval, Lance A. Waller, T. Alex Perkins, Alun L. Lloyd, Helvio Astete, John Elder, Thomas W. Scott, Uriel Kitron
Summary: Transmission heterogeneity is a common feature in infectious disease systems. This study examined the distribution of dengue virus infections in the human activity spaces of individuals in Iquitos, Peru. The results showed marked heterogeneity in dengue case distribution, with a small number of locations contributing to the majority of infections.