The SRG rat, a Sprague-Dawley Rag2/Il2rg double-knockout validated for human tumor oncology studies

NSG mice as hosts for oncological precision medicine

(2019) Claudia Maletzki et al.   LABORATORY INVESTIGATION

A novel immunodeficient rat model supports human lung cancer xenografts

(2018) Di He et al.   FASEB JOURNAL

Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule

(2018) Chiara Marchetti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Generation of immunodeficient rats with Rag1 and Il2rg gene deletions and human tissue grafting models

(2018) Séverine Ménoret et al.   TRANSPLANTATION

Sprague Dawley Rag2 null rats created from engineered spermatogonial stem cells are immunodeficient and permissive to human xenografts

(2018) Fallon K Noto et al.   MOLECULAR CANCER THERAPEUTICS

Patient-derived xenografts undergo mouse-specific tumor evolution

(2017) Uri Ben-David et al.   NATURE GENETICS

Patient-Derived Xenograft Models of Non-Small Cell Lung Cancer and Their Potential Utility in Personalized Medicine

(2017) Katherine M. Morgan et al.   Frontiers in Oncology

Comparative Analysis of piggyBac, CRISPR/Cas9 and TALEN Mediated BAC Transgenesis in the Zygote for the Generation of Humanized SIRPA Rats

(2016) Chris J. Jung et al.   Scientific Reports

Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment

(2013) T. Yamauchi et al.   BLOOD

Cox-2 inhibition enhances the activity of sunitinib in human renal cell carcinoma xenografts

(2013) X Wang et al.   BRITISH JOURNAL OF CANCER

Establishment of patient-derived non-small cell lung cancer xenograft models with genetic aberrations within EGFR, KRAS and FGFR1: useful tools for preclinical studies of targeted therapies

(2013) Xu-chao Zhang et al.   Journal of Translational Medicine

mTORC1 Inhibition Is Required for Sensitivity to PI3K p110  Inhibitors in PIK3CA-Mutant Breast Cancer

(2013) M. Elkabets et al.   Science Translational Medicine

Generation and Characterization of Severe Combined Immunodeficiency Rats

(2012) Tomoji Mashimo et al.   Cell Reports

Establishment of Patient-Derived Non-Small Cell Lung Cancer Xenografts as Models for the Identification of Predictive Biomarkers

(2008) I. Fichtner et al.   CLINICAL CANCER RESEARCH