Article
Polymer Science
Ting He, Die Hu, Qian Ren, Zhongcheng Li, Sili Han, Longjiang Ding, Ziqian Lu, Linglin Zhang
Summary: Biomimetic mineralization is a promising strategy for dentin repair. However, the degradation of collagen fibrils and the lack of sustained supply of calcium and phosphorus ions are two main limitations. In this study, a novel nanoscale platform called PA-ACP/NPs was proposed to address these limitations. PA-ACP/NPs effectively protected collagen and induced complete intrafibrillar mineralization, facilitating remineralization of demineralized dentin. The nanoscale delivery of PA-ACP/NPs exhibited excellent effects in stabilizing collagen and providing long-term mineral ions supply.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Biotechnology & Applied Microbiology
Abhishek Indurkar, Rajan Choudhary, Kristaps Rubenis, Janis Locs
Summary: Bone is a composite material consisting of inorganic calcium phosphate and organic collagen. The mineralization of collagen plays a crucial role in the formation of bone and tooth. It has been found that synthetic calcium phosphate undergoes a transformation to apatite nanocrystals before entering the collagen gap zone. However, this transformation is hindered by a nucleation catalyst. Organic macromolecules and low-molecular-weight carboxylic compounds present in bone and tooth can interact with both apatite and collagen, controlling nucleation, crystal growth, and particle size. These compounds also prevent the transformation of calcium phosphate into apatite before entering the collagen gap zone. Therefore, understanding the role of these organic compounds is important in regulating collagen mineralization.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Songzhe Shan, Zhenhang Tang, Kaida Sun, Wenjing Jin, Haihua Pan, Ruikang Tang, Wei Yin, Zhijian Xie, Zhuo Chen, Changyu Shao
Summary: This study proposes a new pathway for collagen fibril mineralization via particle-mediated phase transformation, deepens the understanding of its mechanism, and offers a new strategy for hard tissue repair.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Marc Robin, Camila B. Tovani, Jean-Marc Krafft, Guylene Costentin, Thierry Azais, Nadine Nassif
Summary: This study investigates the impact of organic additives concentration on apatite formation, finding that different concentrations of additives significantly alter the formation sequence of apatite precursors. Polyaspartate and citrate are identified as inhibitors or activators in calcium phosphate formation, and collagen has different roles at various concentrations.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Chemistry, Multidisciplinary
Kohei Okuda, Ryosuke Shigemasa, Ken Hirota, Tadashi Mizutani
Summary: Nanohydroxyapatite (HAP) was crystallized in an aqueous solution of carboxymethyl cellulose (CMC) to prepare composites with a stable interface between them. The mechanical properties of the composites were optimized by adjusting the temperature and CMC concentration. The optimized composite exhibited high flexural strength and elastic modulus, making it a potential replacement for petroleum-derived engineering plastics.
Article
Chemistry, Multidisciplinary
Alejandro B. Rodriguez Navarro, Sergio Madero, Martina Greiner, Pablo A. Rodriguez-Jimenez, Wolfgang W. Schmahl, Concepcion Jimenez-Lopez
Summary: This study examines the changes in avian bone during heating, finding that the transformation is influenced by bone architecture, organic matrix composition, and mineral-organic integration. The type of bone (cortical or medullary) also affects the transformation process, with different materials and structures involved.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Materials Science, Multidisciplinary
Xing Fu, Qian-cheng Zhao, Dong Uk Ahn, Mei-hu Ma, Xi Huang
Summary: This study developed biomineralization scaffolds using eggshell membranes as the bio-template, which showed better mineralization potential and cell adhesion ability after enzyme treatment.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Weijing Kong, Qiaolin Du, Yinan Qu, Changyu Shao, Chaoqun Chen, Jian Sun, Caiyun Mao, Ruikang Tang, Xinhua Gu
Summary: It is known that crosslinking agents can improve the mechanical properties of dentin by crosslinking collagen. This study focused on the influence of tannic acid (TA) crosslinking on the collagen-mineral interface and found that TA crosslinked collagen fibers can induce dentin biomineralization and improve the mechanical and anti-enzyme properties of dentin.
Article
Chemistry, Multidisciplinary
Yu Seob Shin, Min-kyung Jo, Young Shin Cho, Sung Ho Yang
Summary: This study successfully synthesized homogeneous and integrated octacalcium phosphate/hydrogel composites by optimizing diffusion-controlled systems. The ion flux and local pH play an important role in determining the crystal morphology, density, and phase.
Article
Polymer Science
Jeremy Elias, Bobbi-Ann Matheson, Laurie Gower
Summary: To achieve ideal bone regeneration scaffolds for bone defect repair, this study compares four different collagen crosslinking methods and combines them with biomimetic mineralization to obtain bone-like collagen-hydroxyapatite composites. The mechanical properties of the mineralized scaffolds are analyzed and compared. Results show that the EDC-NHS and riboflavin crosslinking methods improve modulus and tensile strength, while quercetin and methacrylated collagen have little effect on mechanical properties. Optimizing the mineral content below a percolation threshold is necessary for retaining tensile strength in these interpenetrating nanocomposites. This study highlights the potential of combining collagen crosslinking and biomimetic mineralization methods for developing robust bone-like composites on a larger scale.
Article
Chemistry, Multidisciplinary
Jimin Jung, Sung Ho Yang
Summary: Mesocrystals are superstructural crystals formed by the assembly and attachment of primary crystals. In this study, fluorapatite crystals were synthesized using a hydrogel to mimic the slow and controlled ion transport in biomineralization.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Engineering, Biomedical
Yan Han, Joel Gomez, Rui Hua, Pengwei Xiao, Wei Gao, Jean X. Jiang, Xiaodu Wang
Summary: Research shows that removal of GAGs from bone tissues increases the elastic modulus and reduces plastic energy dissipation, particularly in wet conditions. GAGs not only affect the capacity of EFM, but may also impact the elastic modulus of MCFs.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Engineering, Multidisciplinary
Jeremy Elias, Thomas Angelini, Mark Q. Martindale, Laurie Gower
Summary: Cellular strategies and regulation are crucial for the formation of biominerals. By studying the interaction between organic matrices and mineral precursors under different temperatures and seawater compositions, we identified suitable conditions for calcium carbonate infiltration. These findings are valuable for the development of novel biosynthetic materials.
Article
Chemistry, Physical
Jing Zhang, Wenjun Zhang, Lijun Wang
Summary: Calcium orthophosphates are important minerals in biomineralization and biomedicine. The recently discovered dicalcium phosphate monohydrate (DCPM) has higher metastability than other phases, making it potentially useful in biomaterial development. This study proposes a method to prepare micrometer-sized DCPM and investigates its crystallization process. The results show that DCPM can quickly transform into more stable octacalcium phosphate in physiological conditions.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Multidisciplinary Sciences
Susrut Akkineni, Cheng Zhu, Jiajun Chen, Miao Song, Samuel E. Hoff, Johan Bonde, Jinhui Tao, Hendrik Heinz, Stefan Habelitz, James J. De Yoreo
Summary: Protein scaffolds and nanoribbons play a crucial role in the nucleation of amorphous calcium phosphate, which is important for the biomineralization of bones and teeth.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)