期刊
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
卷 31, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.pdpdt.2020.101920
关键词
Porphyrins; Pd(II) porphyrins; ROS generation; Antimicrobial activity; Antimicrobial Photodynamic Therapy
类别
资金
- CNPq
- CAPES
- FAPERGS
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq - Brazil) [409150/2018-5, 304711/2018-7]
- CAPES/PROEX [001]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq -Brazil) [310360/2019-6]
In this work, we report the antimicrobial photoinactivation using tetra-cationic porphyrins with peripheral palladium(II) complexes against bacterial strains. Two different isomeric Pd(II)-porphyrins were used and applied in PDI experiments in the strains Gram negative bacilli Escherichia coil , Klebsiella pneumoniae and Pseudomonas aeruginosa and a Gram positive cocci Staphylococcus aureus. All experiments are conducted with adequate concentration (without aggregation) of photosensitizer under white-light irradiation over 2 h . We showed that the most effective PS caused a significative reduction in the concentration of viable bacteria. The present results show that porphyrin with positively charge at meta position (3-PtTPyP) are more efficient photosensitizer against bacteria strains. In this way, tetra-cationic porphyrins might be promising antibacterial PDI agents with potential applications in clinical cases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据