Of mitogens and morphogens: modelling Sonic Hedgehog mechanisms in vertebrate development

Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback

(2019) Denis Menshykau et al.   Nature Communications

Opposite regulation of Wnt/β-catenin and Shh signaling pathways by Rack1 controls mammalian cerebellar development

(2019) Haihong Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of the basal hypothalamus through anisotropic growth

(2019) Travis Fu et al.   JOURNAL OF NEUROENDOCRINOLOGY

Influence of SHH/GLI1 axis on EMT mediated migration and invasion of breast cancer cells

(2019) Syeda Kiran Riaz et al.   Scientific Reports

An autoregulatory cell cycle timer integrates growth and specification in chick wing digit development

(2019) Joseph Pickering et al.   eLife

Neuronal differentiation influences progenitor arrangement in the vertebrate neuroepithelium

(2019) Pilar Guerrero et al.   DEVELOPMENT

A highlight on Sonic hedgehog pathway

(2018) Gabriela Basile Carballo et al.   Cell Communication and Signaling

Gli3 in fetal thymic epithelial cells promotes thymocyte positive selection and differentiation by repression of Shh

(2018) Anisha Solanki et al.   DEVELOPMENT

Sonic hedgehog in vertebrate neural tube development

(2018) Marysia Placzek et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

The Elegance of Sonic Hedgehog: Emerging Novel Functions for a Classic Morphogen

(2018) A. Denise R. Garcia et al.   JOURNAL OF NEUROSCIENCE

Patched Receptors Sense, Interpret, and Establish an Epidermal Hedgehog Signaling Gradient

(2017) Christelle Adolphe et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Mathematical Model of Granule Cell Generation During Mouse Cerebellum Development

(2016) Shoshana R. Leffler et al.   BULLETIN OF MATHEMATICAL BIOLOGY

An updated view of hypothalamic–vascular–pituitary unit function and plasticity

(2016) Paul Le Tissier et al.   Nature Reviews Endocrinology

The reverse control of irreversible biological processes

(2016) Kwang-Hyun Cho et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Physical and Mathematical Modeling in Experimental Papers

(2015) Wolfram Möbius et al.   CELL

Morphogen rules: design principles of gradient-mediated embryo patterning

(2015) J. Briscoe et al.   DEVELOPMENT

Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms

(2015) Michael Cohen et al.   Nature Communications

Orientation of Turing-like Patterns by Morphogen Gradients and Tissue Anisotropies

(2015) Tom W. Hiscock et al.   Cell Systems

Vertex Models of Epithelial Morphogenesis

(2014) Alexander G. Fletcher et al.   BIOPHYSICAL JOURNAL

The Role of Mathematical Models in Understanding Pattern Formation in Developmental Biology

(2014) David M. Umulis et al.   BULLETIN OF MATHEMATICAL BIOLOGY

An interplay of geometry and signaling enables robust lung branching morphogenesis

(2014) D. Menshykau et al.   DEVELOPMENT

A theoretical framework for the regulation of Shh morphogen-controlled gene expression

(2014) M. Cohen et al.   DEVELOPMENT

Coordination of progenitor specification and growth in mouse and chick spinal cord

(2014) A. Kicheva et al.   SCIENCE

Sonic hedgehog signaling in the postnatal brain

(2014) Arturo Álvarez-Buylla et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Sonic hedgehog-expressing cells in the developing limb measure time by an intrinsic cell cycle clock

(2014) Kavitha Chinnaiya et al.   Nature Communications

Specified Neural Progenitors Sort to Form Sharp Domains after Noisy Shh Signaling

(2013) Fengzhu Xiong et al.   CELL

Mathematical modelling of digit specification by a sonic hedgehog gradient

(2013) Thomas E. Woolley et al.   DEVELOPMENTAL DYNAMICS

Quantitative model analysis with diverse biological data: Applications in developmental pattern formation

(2013) Michael Pargett et al.   METHODS

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube

(2012) Nikolaos Balaskas et al.   CELL

The importance of geometry in mathematical models of developing systems

(2012) David M Umulis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Periodic stripe formation by a Turing mechanism operating at growth zones in the mammalian palate

(2012) Andrew D Economou et al.   NATURE GENETICS

Digit patterning during limb development as a result of the BMP-receptor interaction

(2012) Amarendra Badugu et al.   Scientific Reports

Branch Mode Selection during Early Lung Development

(2012) Denis Menshykau et al.   PLoS Computational Biology

Analysis of mutants with altered shh activity and posterior digit loss supports a biphasic model for shh function as a morphogen and mitogen

(2011) Jianjian Zhu et al.   DEVELOPMENTAL DYNAMICS

Primary cilia and Gli3 activity regulate cerebral cortical size

(2011) Sandra L. Wilson et al.   Developmental Neurobiology

The Role of Spatially Controlled Cell Proliferation in Limb Bud Morphogenesis

(2010) Bernd Boehm et al.   PLOS BIOLOGY

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

(2008) E. Dessaud et al.   DEVELOPMENT

Integration of growth and specification in chick wing digit-patterning

(2008) Matthew Towers et al.   NATURE