Uncovering the Molecular Mechanism of the Qiang-Xin 1 Formula on Sepsis-Induced Cardiac Dysfunction Based on Systems Pharmacology

CTRP1 prevents sepsis-induced cardiomyopathy via Sirt1-dependent pathways

(2020) Wanli Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Taxifolin protects rat against myocardial ischemia/reperfusion injury by modulating the mitochondrial apoptosis pathway

(2019) Zhenqiu Tang et al.   PeerJ

The inhibitor of interleukin-3 receptor protects against sepsis in a rat model of cecal ligation and puncture

(2019) Juntao Hu et al.   MOLECULAR IMMUNOLOGY

Dihydrotanshinone exhibits an anti-inflammatory effect in vitro and in vivo through blocking TLR4 dimerization

(2019) Renyikun Yuan et al.   PHARMACOLOGICAL RESEARCH

Heart failure and sepsis: practical recommendations for the optimal management

(2019) Angelos Arfaras-Melainis et al.   HEART FAILURE REVIEWS

Systems Pharmacology and Microbiome Dissection of Shen Ling Bai Zhu San Reveal Multiscale Treatment Strategy for IBD

(2019) Wei-jie Lv et al.   Oxidative Medicine and Cellular Longevity

Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug Discovery

(2019) Wenjuan Zhang et al.   Frontiers in Pharmacology

Uncovering the pharmacological mechanism of Carthamus tinctorius L. on cardiovascular disease by a systems pharmacology approach

(2019) Guohua Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology

(2019) Won-Yung Lee et al.   Biomolecules

Protective effects of astragalus polysaccharide nanoparticles on septic cardiac dysfunction through inhibition of TLR4/NF-κB signaling pathway

(2019) Xiaoying Xu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Physiological and unappreciated roles of CaMKII in the heart

(2018) Jan Beckendorf et al.   BASIC RESEARCH IN CARDIOLOGY

Enhancing Recovery From Sepsis

(2018) Hallie C. Prescott et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Quercetin exerts cardiovascular protective effects in LPS-induced dysfunction in vivo by regulating inflammatory cytokine expression, NF-κB phosphorylation, and caspase activity

(2018) Xiqing Wei et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Knockout of Toll-like receptor 4 improves survival and cardiac function in a murine model of severe sepsis

(2018) Dan Zhou et al.   Molecular Medicine Reports

Qiang-Xin 1 Formula Prevents Sepsis-Induced Apoptosis in Murine Cardiomyocytes by Suppressing Endoplasmic Reticulum- and Mitochondria-Associated Pathways

(2018) Xiaolong Xu et al.   Frontiers in Pharmacology

Systems pharmacology uncover the mechanism of anti-non-small cell lung cancer for Hedyotis diffusa Willd

(2018) Xing Su et al.   BIOMEDICINE & PHARMACOTHERAPY

Dendrobium huoshanense polysaccharide regionally regulates intestinal mucosal barrier function and intestinal microbiota in mice

(2018) Song-Zi Xie et al.   CARBOHYDRATE POLYMERS

Enhanced Glycolytic Metabolism Contributes to Cardiac Dysfunction in Polymicrobial Sepsis

(2017) Zhibo Zheng et al.   JOURNAL OF INFECTIOUS DISEASES

Sepsis-Induced Cardiomyopathy: Mechanisms and Treatments

(2017) Yan-Cun Liu et al.   Frontiers in Immunology

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations

(2016) Carolin Fleischmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Immunotherapeutic implications of IL-6 blockade for cytokine storm

(2016) Toshio Tanaka et al.   Immunotherapy

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

IκB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD

(2016) Jianmin Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Plant Natural Product Formononetin Protects Rat Cardiomyocyte H9c2 Cells against Oxygen Glucose Deprivation and Reoxygenation via Inhibiting ROS Formation and Promoting GSK-3βPhosphorylation

(2016) Yuanyuan Cheng et al.   Oxidative Medicine and Cellular Longevity

Kaempferol Attenuates Myocardial Ischemic InjuryviaInhibition of MAPK Signaling Pathway in Experimental Model of Myocardial Ischemia-Reperfusion Injury

(2016) Kapil Suchal et al.   Oxidative Medicine and Cellular Longevity

Melatonin attenuates sepsis-induced cardiac dysfunction via a PI3K/Akt-dependent mechanism

(2015) Rui An et al.   BASIC RESEARCH IN CARDIOLOGY

Effect of Carvedilol on Serum Heart-type Fatty Acid-binding Protein, Brain Natriuretic Peptide, and Cardiac Function in Patients With Chronic Heart Failure

(2015) Yu-ping Sun et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Quantitative proteomic analysis reveals heat stress-induced injury in rat small intestine via activation of the MAPK and NF-κB signaling pathways

(2015) Shasha He et al.   Molecular BioSystems

Calcium-sensing receptor in the T lymphocyte enhanced the apoptosis and cytokine secretion in sepsis

(2015) Chun-li Wu et al.   MOLECULAR IMMUNOLOGY

Large-scale Direct Targeting for Drug Repositioning and Discovery

(2015) Chunli Zheng et al.   Scientific Reports

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

(2014) Jinlong Ru et al.   Journal of Cheminformatics

Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway

(2013) Y. Wang et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Tanshinone IIA and Cryptotanshinone Prevent Mitochondrial Dysfunction in Hypoxia-Induced H9c2 Cells: Association to Mitochondrial ROS, Intracellular Nitric Oxide, and Calcium Levels

(2013) Hyou-Ju Jin et al.   Evidence-based Complementary and Alternative Medicine

Systems approaches and polypharmacology for drug discovery from herbal medicines: An example using licorice

(2013) Hui Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

(2013) Richard S Hotchkiss et al.   LANCET INFECTIOUS DISEASES

Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: an insight into oestrogen receptor activation and PI3K/Akt signalling

(2012) Bing Sun et al.   BRITISH JOURNAL OF PHARMACOLOGY

Characterization of the Role of Nitric Oxide and Its Clinical Applications

(2012) Arlene Bradley Levine et al.   CARDIOLOGY

Clinical Spectrum, Frequency, and Significance of Myocardial Dysfunction in Severe Sepsis and Septic Shock

(2012) Juan N. Pulido et al.   MAYO CLINIC PROCEEDINGS

CaMKII determines mitochondrial stress responses in heart

(2012) Mei-ling A. Joiner et al.   NATURE

Activation of Myocardial Phosphoinositide-3-Kinase p110α Ameliorates Cardiac Dysfunction and Improves Survival in Polymicrobial Sepsis

(2012) Chuanfu Li et al.   PLoS One

Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase*

(2011) Nazima Pathan et al.   CRITICAL CARE MEDICINE

Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?

(2011) Lien Dejager et al.   TRENDS IN MICROBIOLOGY

Therapeutic targeting of innate immunity in the failing heart

(2010) Veli K. Topkara et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Immunodesign of experimental sepsis by cecal ligation and puncture

(2009) Daniel Rittirsch et al.   Nature Protocols