Review
Biochemistry & Molecular Biology
Ali Hosseinpour, Elnaz Daneshzad, Ramin Abdi Dezfouli, Shokoofeh Zamani, Mostafa Qorbani
Summary: It is proven that blood antioxidant concentration is associated with the severity of viral infections, including COVID-19. However, there is a lack of comprehensive studies on COVID-19 data. This systematic review analyzed the association between blood antioxidant concentration and the overall health condition of COVID-19 patients. The review found that lower serum antioxidants were associated with worse outcomes, while higher levels of antioxidants may be beneficial in preventing disease progression.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Majid Mounir, Amal Ibijbijen, Kawtar Farih, Holy N. Rabetafika, Hary L. Razafindralambo
Summary: Antioxidants play a vital role in maintaining the longevity and health of humans and animals. Microbial-based products, such as probiotics and their derivatives, have been recognized for their antioxidant properties. Synbiotics combining probiotics with prebiotics can generate superior antioxidant compounds that have positive effects on human and animal health.
Review
Biochemistry & Molecular Biology
Edirisinghe Dewage Nalaka Sandun Abeyrathne, Kichang Nam, Xi Huang, Dong Uk Ahn
Summary: Antioxidants are compounds that prevent lipid and protein oxidation, playing a major role in preventing adverse conditions in the human body. While synthetic antioxidants are commonly used in the food industry, plant- and animal-based antioxidants are more preferred by consumers. Plant-based antioxidants mainly consist of phenolic compounds, carotenoids, and vitamins, while animal-based antioxidants are mainly proteins or peptides from meat, fish, eggs, milk, and plants. The structure and efficacy of plant- and animal-based antioxidants differ, with plant-based compounds being more practical in the food industry.
Review
Biochemistry & Molecular Biology
Zhen Zeng, Christoph Centner, Albert Gollhofer, Daniel Koenig
Summary: Whole dietary strategies rich in antioxidants have gained attention for their potential to alleviate exercise-induced oxidative stress, with most studies showing favorable effects. However, research on the effects of such strategies on oxidative stress is still limited, and further systematically designed studies are needed to strengthen the evidence.
Review
Computer Science, Information Systems
Yi Guo, Yahan Zhang, Tianchen Lyu, Mattia Prosperi, Fei Wang, Hua Xu, Jiang Bian
Summary: The study identified 7 key areas where AI was applied in COVID-19 research but found a lack of heterogeneous data integration in these applications. Most AI applications adopted a single-sourced approach, potentially leading to biased algorithms.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Review
Food Science & Technology
Mohammad Yassin Zamanian, Mehraveh Sadeghi Ivraghi, Lusine G. Khachatryan, Diana E. Vadiyan, Hanie Yavarpour Bali, Maryam Golmohammadi
Summary: Non-alcoholic fatty liver disease (NAFLD) is often associated with metabolic disorders and is prevalent in obese and diabetic patients. Pomegranate polyphenols have antioxidant capabilities that can help reduce oxidative stress and inflammation associated with NAFLD. Therefore, research has found that pomegranate can attenuate oxidative stress, inflammation, and other risk factors associated with NAFLD, ultimately preventing the disease's development.
FOOD SCIENCE & NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Ana Alvarez-Barrios, Lydia Alvarez, Montserrat Garcia, Enol Artime, Rosario Pereiro, Hector Gonzalez-Iglesias
Summary: The human eye is greatly affected by both internal and external oxidants, leading to oxidative stress and potential eye diseases. Metallothioneins (MTs) are a family of proteins with antioxidant properties and cell-mediated functions that play a crucial role in capturing and neutralizing free radicals in the eye.
Review
Biochemistry & Molecular Biology
Hendrik Nieraad, Nina Pannwitz, Natasja de Bruin, Gerd Geisslinger, Uwe Till
Summary: Disturbances in one-carbon metabolism can lead to altered levels of homocysteine, potentially contributing to various pathologies. Animal studies suggest a significant impact of high homocysteine on cognitive performance. Despite controversy, preclinical evidence points to a causal link between high homocysteine and cognition-related disorders.
Review
Veterinary Sciences
Izabela Michalak, Ruchi Tiwari, Manish Dhawan, Mahmoud Alagawany, Mayada R. Farag, Khan Sharun, Talha Bin Emran, Kuldeep Dhama
Summary: Natural antioxidants applied as feed additives can improve animals' health and resistance to environmental stress. Seaweeds, rich in antioxidant compounds, can enhance antioxidant activity, immunity, and meat quality in animals. However, excessive consumption of seaweeds should be avoided.
VETERINARY QUARTERLY
(2022)
Review
Pharmacology & Pharmacy
Mohammad Reza Kalhori, Fatemeh Saadatpour, Ehsan Arefian, Masoud Soleimani, Mohammad Hosien Farzaei, Ina Yosifova Aneva, Javier Echeverria
Summary: The study introduces the genetic and morphological structure of the SARS-CoV-2 virus and explores the roles of miRNAs, siRNAs, chemical drugs, and natural compounds in preventing or treating coronavirus infection.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Juan D. Rios-Mera, Erick Saldana, Iliani Patinho, Miriam M. Selani, Carmen J. Contreras-Castillo
Summary: Brazilian researchers have explored various alternatives for reformulating meat products, such as reducing salt and animal fat and using natural antioxidants. However, Brazilian regulations are restrictive regarding the use of natural antioxidants and salt substitutes, prompting researchers to propose alternatives that are more compliant with regulations.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sarah Temmam, Xavier Montagutelli, Cecile Herate, Flora Donati, Beatrice Regnault, Mikael Attia, Eduard Baquero Salazar, Delphine Chretien, Laurine Conquet, Gregory Jouvion, Juliana Pipoli Da Fonseca, Thomas Cokelaer, Faustine Amara, Francis Relouzat, Thibaut Naninck, Julien Lemaitre, Nathalie Derreudre-Bosquet, Quentin Pascal, Massimiliano Bonomi, Thomas Bigot, Sandie Munier, Felix A. Rey, Roger Le Grand, Sylvie van Der Werf, Marc Eloit
Summary: The highly related Bat sarbecovirus BANAL-236 infects human cells like SARS-CoV-2 but lacks the furin cleavage site. It replicates efficiently and with mild symptoms in humanized mice and macaques, showing a different tissue tropism compared to SARS-CoV-2. BANAL-236 infection provides protection against superinfection by a virulent strain, and no antibodies recognizing bat sarbecoviruses were found in populations in close contact with bats where the virus was identified, suggesting rare spillover infections.
Review
Food Science & Technology
Md Yousuf Ali, Abu Ali Ibn Sina, Shahad Saif Khandker, Lutfun Neesa, E. M. Tanvir, Alamgir Kabir, Md Ibrahim Khalil, Siew Hua Gan
Summary: Tomatoes are consumed worldwide for their high nutrient content and antioxidants, providing protection against oxidative stress-related diseases. The main dietary carotenoid in tomatoes, lycopene, has been reported to have various health benefits, including protecting against cancer, cardiovascular diseases, cognitive function, and osteoporosis.
Review
Biochemistry & Molecular Biology
Ricardo Teixo, Ana Salome Pires, Eurico Pereira, Beatriz Serambeque, Ines Alexandra Marques, Mafalda Laranjo, Slavko Mojsilovic, Roberto Gramignoli, Peter Ponsaerts, Andreina Schoeberlein, Maria Filomena Botelho
Summary: The increasing cancer incidence has made oncological management one of the most critical challenges for the coming decades. Recent research suggests that human perinatal derivatives (PnD) may offer promising anticancer effects and support for chemotherapy and radiation therapy. However, the paradoxical and dichotomous roles of PnD products need further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Water Resources
Fabian Mendez, Jenny Ordonez-Betancourth, Nathalie Abrahams
Summary: This study summarized the research on the impact of glyphosate on human reproductive health, showing strong toxic effects in animal models and in vitro studies. Significant health consequences were found for mothers, fetuses, and offspring, even several generations after exposure. Human studies are scarce and controversial.
EXPOSURE AND HEALTH
(2022)
Article
Chemistry, Medicinal
Pablo Rayff da Silva, Natalia Diniz NunesPazos, Thallita Karla Silva do Nascimento Gonzaga, Jessica Cabral de Andrade, Alefe Brito Monteiro, Anne Caroline Ribeiro Portela, Hugo Fernandes Oliveira Pires, Mayara Dos Santos Maia, Diogo Vilar da Fonseca, Marcus T. Scotti, Jose Maria Barbosa Filho, Damiao Pergentino de Sousa, Cicero Francisco Bezerra Felipe, Reinaldo Nobrega de Almeida, Luciana Scotti
Summary: This study evaluated the potential of the monoterpene tetrahydrolinalool as an anxiolytic and antidepressant through in vivo animal models and molecular docking. Results showed that tetrahydrolinalool at appropriate doses effectively reduced anxiety and depression symptoms without compromising locomotor activity or motor coordination in animals. It demonstrated promising energy values for potential pharmacological targets, indicating its potential as a drug candidate.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Virology
Kathleen Subramoney, Nkhensani Mtileni, Avani Bharuthram, Ashlyn Davis, Beauty Kalenga, Mikateko Rikhotso, Mpho Maphahlele, Jennifer Giandhari, Yeshnee Naidoo, Sureshnee Pillay, Upasana Ramphal, Yajna Ramphal, Houriiyah Tegally, Eduan Wilkinson, Thabo Mohale, Arshad Ismail, Bonolo Mashishi, Nonhlanhla Mbenenge, Tulio de Oliveira, Zinhle Makatini, Burtram C. Fielding, Florette K. Treurnicht
Summary: This study evaluated the ability to detect Omicron BA.1 using genotyping assays in the Gauteng province of South Africa. The results showed that genotyping assays for the detection of del69/70 and K417N mutations coupled with spike gene target failure (SGTF) can efficiently exclude Alpha and Beta variants and rapidly detect Omicron BA.1. However, there is still a need for assays to detect unique mutations for differentiation between other Omicron sublineages.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Thaissa Q. Machado, Anna C. C. da Fonseca, Allana B. S. Duarte, Bruno K. Robbs, Damiao P. de Sousa
Summary: This review discusses the antitumor activity of monoterpenes found in essential oils and their pharmacological mechanisms. Carvacrol and linalool are the most investigated monoterpenes, showing significant antitumor effects in various types of cancers. These natural products inhibit tumor growth through multiple mechanisms, including apoptosis, cell cycle impairment, ROS production, and autophagy. The findings from this study are important for advancing the understanding of the mechanisms of monoterpenes and developing synthetic drugs with better anticancer effects.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Biology
Lucas Solyano Almeida de Oliveira, Sara Raquel de Moura Bandeira, Rodrigo Lopes Gomes Goncalves, Benedito Pereira de Sousa Neto, Diana Carvalho de Rezende, Antonio Carlos dos Reis-Filho, Ian Jhemes Oliveira Sousa, Flaviano Ribeiro Pinheiro-Neto, Boris Timah Acha, Gabriela do Nascimento Caldas Trindade, Lazaro Gomes do Nascimento, Damiao Pergentino de Sousa, Fernanda Regina de Castro Almeida, Massimo Lucarini, Alessandra Durazzo, Daniel Dias Rufino Arcanjo, Francisco de Assis Oliveira
Summary: The study found that isopropyl gallate (IPG) can alleviate ifosfamide (IFOS)-induced hemorrhagic cystitis by enhancing antioxidant activity and anti-inflammatory mechanisms. This suggests that IPG may be a promising adjuvant therapy for oxazaphosphorine-based chemotherapy treatments.
Article
Virology
Dewald Schoeman, Ruben Cloete, Burtram C. Fielding
Summary: This study models and analyzes the E proteins of different virulent levels of human coronaviruses and finds that the E proteins of more virulent viruses have more stable interactions with host proteins, which may contribute to the severity of the disease. The study provides new insights for drug and vaccine development.
Review
Chemistry, Medicinal
Luxuan Zhang, Hua Yu, Haifang Chen, Yinghong Huang, Irina Bakunina, Damia Pregentino de Sousa, Mingna Sun, Jianye Zhang
Summary: The molecular imprinting technique is an attractive and prominent method for synthesizing materials used for target recognition and rapid separation. It has been successfully applied in the separation of active compounds from various plants, such as flavonoids, organic acids, alkaloids, phenylpropanoids, anthraquinones, phenolics, terpenes, steroids, and diketones. This review provides a brief introduction of molecularly imprinted polymers and their efficient application in the separation of active components from plants, offering valuable insights for stimulating further research in this fascinating and useful field.
Article
Chemistry, Physical
Francisco Valmor Macedo Cunha, Arthur Sergio Avelino de Medeiros, Alaine Maria dos Santos Silva, Mayara Castro de Morais, Damiao Pergentino de Sousa, Francisco de Assis Oliveira, Arnobio Antonio da Silva Jr, Livio Cesar Cunha Nunes
Summary: Different nanoemulsion (NE) formulations were prepared to achieve a stable and efficient aqueous colloidal dispersion of ethyl ferulate (EF), which is immiscible with water. The NE samples, selected from a pseudo-ternary phase diagram, exhibited physical stability and controlled drug release. In vivo experiments with rats showed the biocompatibility and anti-inflammatory effect of the EF nanoemulsion. This study suggests the potential of EF nanoemulsion as a novel drug delivery system for topical anti-inflammatory application.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Rayanne H. N. Silva, Thaissa Q. Machado, Anna Carolina C. da Fonseca, Eduardo Tejera, Yunierkis Perez-Castillo, Bruno K. Robbs, Damiao P. de Sousa
Summary: Cancer is a major cause of death worldwide and effective pharmacological treatment to improve quality of life and reduce mortality remains a challenge. Piplartine, an alkamide found in certain species of the Piper genus, has shown antitumor activity. In this study, the cytotoxic potential of a collection of piplartine analogs against human oral SCC9 carcinoma cells was evaluated.
Article
Biochemistry & Molecular Biology
Mayara Castro de Morais, Edeltrudes de Oliveira Lima, Yunierkis Perez-Castillo, Damiao Pergentino de Sousa
Summary: In this study, nineteen synthetic cinnamides and cinnamates were prepared and evaluated for their antimicrobial activity against pathogenic fungi and bacteria. Derivative 6 showed the best antifungal profile, while derivative 18 exhibited the best antibacterial profile. These compounds could serve as prototypes for the development of new antimicrobial drugs.
Article
Biochemistry & Molecular Biology
Carlos S. M. B. Filho, Ramon R. P. P. B. de Menezes, Emanuel P. Magalhaes, Yunierkis P. Castillo, Alice M. C. Martins, Damiao P. de Sousa
Summary: This study evaluated the trypanocidal activity of 13 ester compounds analogous to Piplartine and found that compound 11 showed good activity against Trypanosoma cruzi through the induction of oxidative stress and mitochondrial damage. The study suggests that compound 11 has potential for the development of new trypanocidal prototypes for researching drugs against Chagas disease.
Article
Multidisciplinary Sciences
Kathleen Subramoney, Nkhensani Mtileni, Ashlyn Davis, Jennifer Giandhari, Houriiyah Tegally, Eduan Wilkinson, Yeshnee Naidoo, Yajna Ramphal, Sureshnee Pillay, Upasana Ramphal, Andiswa Simane, Bhaveshan Reddy, Bonolo Mashishi, Nonhlanhla Mbenenge, Tulio de Oliveira, Burtram C. Fielding, Florette K. Treurnicht
Summary: This study investigated the frequency and diversity of spike protein mutations within SARS-CoV-2 infected individuals in South Africa. SNP assays and whole genome sequencing were performed to identify the mutations. The study found that mutations at positions E484Q and delY144 in the spike protein were confirmed by sequencing.
Article
Virology
Kathleen Subramoney, Nkhensani Mtileni, Jennifer Giandhari, Yeshnee Naidoo, Yajna Ramphal, Sureshnee Pillay, Upasana Ramphal, Akhil Maharaj, Derek Tshiabuila, Houriiyah Tegally, Eduan Wilkinson, Tulio de Oliveira, Burtram C. Fielding, Florette K. Treurnicht
Summary: SARS-CoV-2 lineages and variants of concern have evolved with increased transmission efficiency and immune evasion capabilities. The study analyzes the circulation of these variants in South Africa and the potential impact of low-frequency lineages on the emergence of future variants.
Review
Biochemistry & Molecular Biology
Lucio Ricardo Leite Diniz, Leonardo Luiz Calado, Allana Brunna Sucupira Duarte, Damiao Pergentino de Sousa
Summary: Studies have shown that Centella asiatica extracts (CAE) display activity in tissue regeneration, cell migration, and wound repair process. Its active component, asiatic acid, is directly associated with its healing activity. This study discusses the effects of Centella asiatica and asiatic acid in different stages of the healing process of cutaneous wounds, including phytochemical and antimicrobial aspects.
Review
Biochemistry & Molecular Biology
Damiao P. de Sousa, Renan Oliveira S. Damasceno, Riccardo Amorati, Hatem A. Elshabrawy, Ricardo D. de Castro, Daniel P. Bezerra, Vitoria Regina V. Nunes, Rebeca C. Gomes, Tamires C. Lima
Summary: In this review, the authors provide an overview of the mechanisms of pharmacological action of essential oils and their components in various biological systems. They discuss the antioxidant, anti-inflammatory, antitumor, antimicrobial activities, as well as the mechanisms of action against various types of viruses. The data indicate that the chemical diversity in the composition of essential oils allows them to interfere with biological processes at different levels, making them a promising source for the development of new drugs.
Review
Chemistry, Medicinal
Allana Brunna S. Duarte, Rebeca C. Gomes, Vitoria Regina V. Nunes, Juan Carlos R. Goncalves, Camylla A. Correia, Ana Zulmira G. dos Santos, Damiao P. de Sousa
Summary: This review summarizes the research on the antitumor activity of piplartine, confirming its potential as an anticancer agent against various types of tumors. The evidence found in this study serves as a reference for advancing mechanistic research on this metabolite and developing new drug candidates.
