Sirtuin 3 Inhibits Airway Epithelial Mitochondrial Oxidative Stress in Cigarette Smoke-Induced COPD

Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis

(2020) Wei Rao et al.   CELL

Nix/BNIP3L-dependent mitophagy accounts for airway epithelial cell injury induced by cigarette smoke

(2019) Ming Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inactivation of MTOR promotes autophagy-mediated epithelial injury in particulate matter-induced airway inflammation

(2019) Yin-Fang Wu et al.   Autophagy

Mitochondrial biology in airway pathogenesis and the role of NRF2

(2019) Hye-Youn Cho et al.   ARCHIVES OF PHARMACAL RESEARCH

Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease

(2019) Mahyar Aghapour et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke

(2019) Mari Hikichi et al.   Journal of Thoracic Disease

The Role of Sirtuins in Antioxidant and Redox Signaling

(2018) Chandra K. Singh et al.   ANTIOXIDANTS & REDOX SIGNALING

Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study

(2018) Chen Wang et al.   LANCET

p66Shc Mediates Mitochondrial Dysfunction Dependent on PKC Activation in Airway Epithelial Cells Induced by Cigarette Smoke

(2018) Ming Zhang et al.   Oxidative Medicine and Cellular Longevity

Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases

(2018) Jie Wu et al.   FREE RADICAL RESEARCH

Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress

(2017) Han Shi et al.   HUMAN MOLECULAR GENETICS

SIRT3 protects hepatocytes from oxidative injury by enhancing ROS scavenging and mitochondrial integrity

(2017) Jingxin Liu et al.   Cell Death & Disease

Effect of simvastatin on MMPs and TIMPs in cigarette smoke-induced rat COPD model

(2017) Jiawei Sun et al.   International Journal of Chronic Obstructive Pulmonary Disease

Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease

(2016) Aneesa Ansari et al.   AGING CELL

The Substrate Specificity of Sirtuins

(2016) Poonam Bheda et al.   Annual Review of Biochemistry

Curcumin ameliorates alveolar epithelial injury in a rat model of chronic obstructive pulmonary disease

(2016) Ming Zhang et al.   LIFE SCIENCES

Sirtuin 3 Protects against Urban Particulate Matter-Induced Autophagy in Human Bronchial Epithelial Cells

(2016) I.-Chieh Chen et al.   TOXICOLOGICAL SCIENCES

The innate immune function of airway epithelial cells in inflammatory lung disease

(2015) Pieter S. Hiemstra et al.   EUROPEAN RESPIRATORY JOURNAL

SIRT3 protects cells from hypoxia via PGC-1α- and MnSOD-dependent pathways

(2015) Q. Wang et al.   NEUROSCIENCE

Bronchial epithelial cells: The key effector cells in the pathogenesis of chronic obstructive pulmonary disease?

(2015) Wei Gao et al.   RESPIROLOGY

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

(2014) Kenji Mizumura et al.   JOURNAL OF CLINICAL INVESTIGATION

SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1

(2014) S M Jeong et al.   ONCOGENE

Oxidative Stress in COPD

(2013) Paul A. Kirkham et al.   CHEST

Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells

(2013) Roland F Hoffmann et al.   RESPIRATORY RESEARCH

The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals

(2012) Anna-Maria Joseph et al.   AGING CELL

SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging

(2012) Albert Giralt et al.   BIOCHEMICAL JOURNAL

SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

(2012) Kristi Muldoon Jacobs et al.   International Journal of Biological Sciences

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

(2010) Xingxing Kong et al.   PLoS One