Comprehensive review of epidemiological and animal studies on the potential carcinogenic effects of nicotineper se

Nicotinic acetylcholine receptor expression in human airway correlates with lung function

(2016) David Chi-Leung Lam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Characterization of potential impurities and degradation products in electronic cigarette formulations and aerosols

(2016) Jason W. Flora et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

 -Arrestin-1 Mediates Nicotine-Induced Metastasis through E2F1 Target Genes That Modulate Epithelial-Mesenchymal Transition

(2015) S. Pillai et al.   CANCER RESEARCH

Nuciferine, extracted from Nelumbo nucifera Gaertn, inhibits tumor-promoting effect of nicotine involving Wnt/β-catenin signaling in non-small cell lung cancer

(2015) Wei Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Nicotine induces resistance to erlotinib via cross-talk between α 1 nAChR and EGFR in the non-small cell lung cancer xenograft model

(2015) Heyan Li et al.   LUNG CANCER

Nicotine Induces Tumor Growth and Chemoresistance through Activation of the PI3K/Akt/mTOR Pathway in Bladder Cancer

(2015) K. Yuge et al.   MOLECULAR CANCER THERAPEUTICS

Nicotine: Carcinogenicity and Effects on Response to Cancer Treatment – A Review

(2015) Tore Sanner et al.   Frontiers in Oncology

Nicotine and oxidative stress induced exomic variations are concordant and overrepresented in cancer-associated genes

(2015) Jasmin H. Bavarva et al.   Oncotarget

Nicotine Induces Inhibitor of Differentiation-1 in a Src-dependent Pathway Promoting Metastasis and Chemoresistance in Pancreatic Adenocarcinoma

(2015) Jose G. Trevino et al.   NEOPLASIA

Nicotine suppresses acute colitis and colonic tumorigenesis associated with chronic colitis in mice

(2014) Shusaku Hayashi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Differential modulation of nicotine-induced gemcitabine resistance by GABA receptor agonists in pancreatic cancer cell xenografts and in vitro

(2014) Jheelam Banerjee et al.   BMC CANCER

Chronic nicotine pretreatment is sufficient to upregulate α4* nicotinic receptors and increase oral nicotine self-administration in mice

(2014) Anthony Renda et al.   BMC NEUROSCIENCE

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

(2014) Calvin C. Willhite et al.   CRITICAL REVIEWS IN TOXICOLOGY

Weight-of-evidence evaluation of long-term ozone exposure and cardiovascular effects

(2014) Robyn L. Prueitt et al.   CRITICAL REVIEWS IN TOXICOLOGY

Weight-of-evidence evaluation of short-term ozone exposure and cardiovascular effects

(2014) Julie E. Goodman et al.   CRITICAL REVIEWS IN TOXICOLOGY

Nicotine Promotes Initiation and Progression of KRAS-Induced Pancreatic Cancer via Gata6-Dependent Dedifferentiation of Acinar Cells in Mice

(2014) Patrick C. Hermann et al.   GASTROENTEROLOGY

Toxicological evaluation of aerosols of a tobacco extract formulation and nicotine formulation in acute and short-term inhalation studies

(2014) Michael S. Werley et al.   INHALATION TOXICOLOGY

Nicotine-Mediated Cell Proliferation and Tumor Progression in Smoking-Related Cancers

(2014) Courtney Schaal et al.   MOLECULAR CANCER RESEARCH

Addressing the Evidence for FDA Nicotine Replacement Therapy Label Changes: A Policy Statement of the Association for the Treatment of Tobacco Use and Dependence and the Society for Research on Nicotine and Tobacco

(2014) L. M. Fucito et al.   NICOTINE & TOBACCO RESEARCH

Influenza Virus-Induced Lung Inflammation Was Modulated by Cigarette Smoke Exposure in Mice

(2014) Yan Han et al.   PLoS One

Nicotine derived genotoxic effects in human primary parotid gland cells as assessed in vitro by comet assay, cytokinesis-block micronucleus test and chromosome aberrations test

(2014) Christian Ginzkey et al.   TOXICOLOGY IN VITRO

Nicotine causes genotoxic damage but is not metabolized during long-term exposure of human nasal miniorgan cultures

(2014) Christian Ginzkey et al.   TOXICOLOGY LETTERS

Impact of Neuro-Psychological Factors on Smoking-Associated Lung Cancer

(2014) Hildegard Schuller   Cancers

Novel Delivery Systems for Nicotine Replacement Therapy as an Aid to Smoking Cessation and for Harm Reduction: Rationale, and Evidence for Advantages over Existing Systems

(2013) Lion Shahab et al.   CNS DRUGS

Evaluation of the causal framework used for setting National Ambient Air Quality Standards

(2013) Julie E. Goodman et al.   CRITICAL REVIEWS IN TOXICOLOGY

A survey of frameworks for best practices in weight-of-evidence analyses

(2013) Lorenz R. Rhomberg et al.   CRITICAL REVIEWS IN TOXICOLOGY

Regulatory Role of the ?7nAChR in Cancer

(2013) Hildegard M. Schuller   CURRENT DRUG TARGETS

Nicotine Induces the Up-regulation of the α7-Nicotinic Receptor (α7-nAChR) in Human Squamous Cell Lung Cancer Cells via the Sp1/GATA Protein Pathway

(2013) Kathleen C. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinic Receptor β2 Determines NK Cell-Dependent Metastasis in a Murine Model of Metastatic Lung Cancer

(2013) Junwei Hao et al.   PLoS One

Towards the validation of a lung tumorigenesis model with mainstream cigarette smoke inhalation using the A/J mouse

(2013) Walter Stinn et al.   TOXICOLOGY

Nicotinic acetylcholine receptors mediate lung cancer growth

(2013) Ma. Reina Improgo et al.   Frontiers in Physiology

Nicotine enhances proliferation, migration, and radioresistance of human malignant glioma cells through EGFR activation

(2012) Ashraf A. Khalil et al.   Brain Tumor Pathology

 -Cryptoxanthin Restores Nicotine-Reduced Lung SIRT1 to Normal Levels and Inhibits Nicotine-Promoted Lung Tumorigenesis and Emphysema in A/J Mice

(2012) A. R. Iskandar et al.   Cancer Prevention Research

Gamma-Amino Butyric Acid Inhibits the Nicotine-Imposed Stimulatory Challenge in Xenograft Models of Non-Small Cell Lung Carcinoma

(2012) H. A.N. Al-Wadei et al.   CURRENT CANCER DRUG TARGETS

Chronic nicotine inhibits the therapeutic effects of gemcitabine on pancreatic cancer in vitro and in mouse xenografts

(2012) Jheelam Banerjee et al.   EUROPEAN JOURNAL OF CANCER

Nicotinic modulation of therapeutic responsein vitroandin vivo

(2012) Graham W. Warren et al.   INTERNATIONAL JOURNAL OF CANCER

Lung carcinogenesis by tobacco smoke

(2012) Stephen S. Hecht   INTERNATIONAL JOURNAL OF CANCER

Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway

(2012) Tomohisa Nakada et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Muscle sarcomas and alopecia in A/J mice chronically treated with nicotine

(2012) Valentin Galitovskiy et al.   LIFE SCIENCES

Nicotinic receptor and tobacco-related cancer

(2012) Patrizia Russo et al.   LIFE SCIENCES

Nicotine and pathological angiogenesis

(2012) Jieun Lee et al.   LIFE SCIENCES

Assessment of nicotine-induced DNA damage in a genotoxicological test battery

(2012) Christian Ginzkey et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Nicotine Promotes Acquisition of Stem Cell and Epithelial-to-Mesenchymal Properties in Head and Neck Squamous Cell Carcinoma

(2012) Michael Andrew Yu et al.   PLoS One

Enhancement of cancer stem-like and epithelial−mesenchymal transdifferentiation property in oral epithelial cells with long-term nicotine exposure: Reversal by targeting SNAIL

(2012) Cheng-Chia Yu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Toxicity of Nicotine by Repeated Intratracheal Instillation to F344 Rats

(2012) Masanao Yokohira et al.   Journal of Toxicologic Pathology

Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer

(2011) Ma. Reina Improgo et al.   BIOCHEMICAL PHARMACOLOGY

Nicotine Does Not Enhance Tumorigenesis in Mutant K-Ras-Driven Mouse Models of Lung Cancer

(2011) C. R. Maier et al.   Cancer Prevention Research

Chronic Nicotine Consumption Does Not Influence 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone-Induced Lung Tumorigenesis

(2011) S. E. Murphy et al.   Cancer Prevention Research

Long-term Nicotine Replacement Therapy: Cancer Risk in Context

(2011) P. G. Shields   Cancer Prevention Research

Avitalized bacteria mediate tumor growth control via activation of innate immunity

(2011) Ulrike Klier et al.   CELLULAR IMMUNOLOGY

Smokeless Tobacco as a Nicotine Delivery Device: Harm or Harm Reduction?

(2011) N L Benowitz   CLINICAL PHARMACOLOGY & THERAPEUTICS

Is exposure to formaldehyde in air causally associated with leukemia?—A hypothesis-based weight-of-evidence analysis

(2011) Lorenz R. Rhomberg et al.   CRITICAL REVIEWS IN TOXICOLOGY

Nicotine: specific role in angiogenesis, proliferation and apoptosis

(2011) Alessio Cardinale et al.   CRITICAL REVIEWS IN TOXICOLOGY

The genotoxic effect of nicotine on chromosomes of human fetal cells: The first report described as an important study

(2011) Osman Demirhan et al.   INHALATION TOXICOLOGY

Intervention of nicotine on MNU-induced bladder cancer in rats

(2011) Di Liu et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

DNA Alkylating Therapy Induces Tumor Regression through an HMGB1-Mediated Activation of Innate Immunity

(2011) J. L. Guerriero et al.   JOURNAL OF IMMUNOLOGY

CpG Oligodeoxynucleotide Stimulates Protective Innate Immunity Against Human Renal Cell Carcinoma Xenografted in Nude Mice

(2011) Pei-jun Zhou et al.   JOURNAL OF IMMUNOTHERAPY

Research Opportunities Related to Establishing Standards for Tobacco Products Under the Family Smoking Prevention and Tobacco Control Act

(2011) S. S. Hecht   NICOTINE & TOBACCO RESEARCH

Stimulation of the Nicotine Antiinflammatory Pathway Improves Food Intake and Body Composition in Tumor-Bearing Rats

(2011) Alessio Molfino et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Analysis of nicotine-induced DNA damage in cells of the human respiratory tract

(2011) Christian Ginzkey et al.   TOXICOLOGY LETTERS

Nicotinic Acetylcholine Receptor Signaling in Tumor Growth and Metastasis

(2011) Sandeep Singh et al.   Journal of Oncology

Toxicological evaluation of smokeless tobacco: 90-Day rodent feeding studies

(2010) Eugenia H. Theophilus et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Overexpression and Activation of the α9-Nicotinic Receptor During Tumorigenesis in Human Breast Epithelial Cells

(2010) Chia-Hwa Lee et al.   JNCI-Journal of the National Cancer Institute

Comparison of NTP Historical Control Tumor Incidence Rates in Female Harlan Sprague Dawley and Fischer 344/N Rats

(2010) Gregg E. Dinse et al.   TOXICOLOGIC PATHOLOGY

Nicotine stimulates pancreatic cancer xenografts by systemic increase in stress neurotransmitters and suppression of the inhibitory neurotransmitter  -aminobutyric acid

(2009) H. A. N. Al-Wadei et al.   CARCINOGENESIS

Chemically induced pheochromocytomas in rats: mechanisms and relevance for human risk assessment

(2009) Helmut Greim et al.   CRITICAL REVIEWS IN TOXICOLOGY

Does nicotine replacement therapy cause cancer? Evidence from the Lung Health Study

(2009) R. P. Murray et al.   NICOTINE & TOBACCO RESEARCH

Nicotine Promotes Tumor Growth and Metastasis in Mouse Models of Lung Cancer

(2009) Rebecca Davis et al.   PLoS One

Retracted : Role of α7-nicotinic acetylcholine receptor in human non-small cell lung cancer proliferation

(2008) L. Paleari et al.   CELL PROLIFERATION

Association of Inhalation Toxicologists (AIT) Working Party Recommendation for Standard Delivered Dose Calculation and Expression in Non-Clinical Aerosol Inhalation Toxicology Studies with Pharmaceuticals

(2008) David J. Alexander et al.   INHALATION TOXICOLOGY

Effect of Nicotine and Cigarette Smoke on an Experimental Model of Intraepithelial Lesions and Pancreatic Adenocarcinoma Induced by 7,12-Dimethylbenzanthracene in Mice

(2008) Vivian P. Bersch et al.   PANCREAS

Toxicological evaluation of potassium sorbate added to cigarette tobacco

(2007) C.L. Gaworski et al.   FOOD AND CHEMICAL TOXICOLOGY