Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intratumoral stromagenesis

An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles

(2019) Angelica Ortiz et al.   CANCER CELL

Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer

(2019) Rongsheng Zhang et al.   Cell Death & Disease

Deletion of Calcineurin Promotes a Protumorigenic Fibroblast Phenotype

(2019) Allyson Lieberman et al.   CANCER RESEARCH

Cancer-Associated Fibroblasts Affect Intratumoral CD8+and FoxP3+T Cells via Interleukin 6 in the Tumor Microenvironment

(2018) Takuya Kato et al.   CLINICAL CANCER RESEARCH

Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy

(2018) Jinyang Li et al.   IMMUNITY

Targeting the tumour stroma to improve cancer therapy

(2018) Kenneth C. Valkenburg et al.   Nature Reviews Clinical Oncology

IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma

(2018) Giulia Biffi et al.   Cancer Discovery

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-β signaling

(2017) Yi Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stromal dynamic reciprocity in cancer: intricacies of fibroblastic-ECM interactions

(2016) Jennifer Alexander et al.   CURRENT OPINION IN CELL BIOLOGY

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

(2016) Philippe Gascard et al.   GENES & DEVELOPMENT

Validation of tumor protein marker quantification by two independent automated immunofluorescence image analysis platforms

(2016) Amy R Peck et al.   MODERN PATHOLOGY

Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression

(2016) Yuliya V. Katlinskaya et al.   Cell Reports

Can Targeting Stroma Pave the Way to Enhanced Antitumor Immunity and Immunotherapy of Solid Tumors?

(2016) E. Pure et al.   Cancer Immunology Research

Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells

(2015) A. Lo et al.   CANCER RESEARCH

Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury

(2014) S. Bhattacharya et al.   EMBO Molecular Medicine

Interferon Receptor Signaling in Malignancy: A Network of Cellular Pathways Defining Biological Outcomes

(2014) E. N. Fish et al.   MOLECULAR CANCER RESEARCH

Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes

(2014) J P Webber et al.   ONCOGENE

TGF-beta in CAF-mediated tumor growth and metastasis

(2014) A. Calon et al.   SEMINARS IN CANCER BIOLOGY

Hope and Fear for Interferon: The Receptor-Centric Outlook on the Future of Interferon Therapy

(2013) Serge Y. Fuchs   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High intratumoral expression of fibroblast activation protein (FAP) in colon cancer is associated with poorer patient prognosis

(2013) Maria L. Wikberg et al.   TUMOR BIOLOGY

Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity

(2013) L.-C. S. Wang et al.   Cancer Immunology Research

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation

(2012) Jacob Piehler et al.   IMMUNOLOGICAL REVIEWS

Vascular endothelial growth factor-induced elimination of the type 1 interferon receptor is required for efficient angiogenesis

(2011) H. Zheng et al.   BLOOD

Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis

(2011) Jacky G. Goetz et al.   CELL

Inflammatory signaling compromises cell responses to interferon alpha

(2011) W-C HuangFu et al.   ONCOGENE

Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation

(2010) J. Webber et al.   CANCER RESEARCH

TGF-β-induced fibroblast activation protein expression, fibroblast activation protein expression increases the proliferation, adhesion, and migration of HO-8910PM

(2009) He Chen et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice

(2009) Angélica M. Santos et al.   JOURNAL OF CLINICAL INVESTIGATION