Emerging role of bacterial extracellular vesicles in cancer

Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

(2020) Cayetano Pleguezuelos-Manzano et al.   NATURE

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

The Uptake, Trafficking, and Biodistribution of Bacteroides thetaiotaomicron Generated Outer Membrane Vesicles

(2020) Emily J. Jones et al.   Frontiers in Microbiology

Microbiome analyses of blood and tissues suggest cancer diagnostic approach

(2020) Gregory D. Poore et al.   NATURE

The human gut bacterial genotoxin colibactin alkylates DNA

(2019) Matthew R. Wilson et al.   SCIENCE

Modulating the microbiome to improve therapeutic response in cancer

(2019) Jennifer L McQuade et al.   LANCET ONCOLOGY

The Healthy Human Blood Microbiome: Fact or Fiction?

(2019) Diego J. Castillo et al.   Frontiers in Cellular and Infection Microbiology

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Exploitation of Neisseria meningitidis Group B OMV Vaccines Against N. gonorrhoeae to Inform the Development and Deployment of Effective Gonorrhea Vaccines

(2019) Helen Petousis-Harris et al.   Frontiers in Immunology

Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

(2019) Golnaz Morad et al.   ACS Nano

Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

(2019) Erick Riquelme et al.   CELL

The Landscape of Genetic Content in the Gut and Oral Human Microbiome

(2019) Braden T. Tierney et al.   Cell Host & Microbe

The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL

(2019) Berk Aykut et al.   NATURE

Analyzing bacterial extracellular vesicles in human body fluids by orthogonal biophysical separation and biochemical characterization

(2019) Joeri Tulkens et al.   Nature Protocols

Host- and Microbiota-Derived Extracellular Vesicles, Immune Function, and Disease Development

(2019) Laurence Macia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy

(2018) Vancheswaran Gopalakrishnan et al.   CANCER CELL

Membrane vesicles from Pseudomonas aeruginosa activate the non-canonical inflammasome through caspase-5 in human monocytes

(2018) Natalie J Bitto et al.   IMMUNOLOGY AND CELL BIOLOGY

Current understanding of the human microbiome

(2018) Jack A Gilbert et al.   NATURE MEDICINE

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

(2018) Vyara Matson et al.   SCIENCE

The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies

(2018) Laurence Zitvogel et al.   SCIENCE

Toll Like Receptor 4 Signaling Licenses the Cytosolic Transport of Lipopolysaccharide from Bacterial Outer Membrane Vesicles

(2018) Lan Gu et al.   SHOCK

Extracellular Vesicle RNA: A Universal Mediator of Microbial Communication?

(2018) James A. Tsatsaronis et al.   TRENDS IN MICROBIOLOGY

The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression

(2018) Smruti Pushalkar et al.   Cancer Discovery

Outer Membrane Vesicles From Probiotic and Commensal Escherichia coli Activate NOD1-Mediated Immune Responses in Intestinal Epithelial Cells

(2018) María-Alexandra Cañas et al.   Frontiers in Microbiology

Fantastic voyage: the journey of intestinal microbiota-derived microvesicles through the body

(2018) Régis Stentz et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction

(2018) Joeri Tulkens et al.   GUT

Types and origins of bacterial membrane vesicles

(2018) Masanori Toyofuku et al.   NATURE REVIEWS MICROBIOLOGY

Effectiveness of a group B outer membrane vesicle meningococcal vaccine against gonorrhoea in New Zealand: a retrospective case-control study

(2017) Helen Petousis-Harris et al.   LANCET

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

(2017) Vinod P. Balachandran et al.   NATURE

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

(2017) Leore T. Geller et al.   SCIENCE

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response

(2017) Oh Youn Kim et al.   Nature Communications

The role of the microbiome in human health and disease: an introduction for clinicians

(2017) Vincent B Young   BMJ-British Medical Journal

16S rRNA Next Generation Sequencing Analysis Shows Bacteria in Alzheimer’s Post-Mortem Brain

(2017) David C. Emery et al.   Frontiers in Aging Neuroscience

The role of the microbiome in human health and disease: an introduction for clinicians

(2017) Vincent B Young   BMJ-British Medical Journal

Outer Membrane Vesicles Prime and Activate Macrophage Inflammasomes and Cytokine Secretion In Vitro and In Vivo

(2017) Jessica D. Cecil et al.   Frontiers in Immunology

Metagenome Analysis of Bodily Microbiota in a Mouse Model of Alzheimer Disease Using Bacteria-derived Membrane Vesicles in Blood

(2017) Jin-Young Park et al.   Experimental Neurobiology

Bacterial membrane vesicles transport their DNA cargo into host cells

(2017) Natalie J. Bitto et al.   Scientific Reports

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

(2016) Ron Sender et al.   CELL

Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

(2016) Claire C. Chen et al.   Cellular and Molecular Bioengineering

Environmentally controlled bacterial vesicle-mediated export

(2016) Nichole Orench-Rivera et al.   CELLULAR MICROBIOLOGY

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

(2016) H. Chu et al.   SCIENCE

Acute-on-Chronic Liver Failure: Definition, Diagnosis, and Clinical Characteristics

(2016) Rajiv Jalan et al.   SEMINARS IN LIVER DISEASE

Comparison of placenta samples with contamination controls does not provide evidence for a distinct placenta microbiota

(2016) Abigail P. Lauder et al.   Microbiome

Differential Responses of Pattern Recognition Receptors to Outer Membrane Vesicles of Three Periodontal Pathogens

(2016) Jessica D. Cecil et al.   PLoS One

Fusobacterium nucleatumin colorectal carcinoma tissue and patient prognosis

(2015) Kosuke Mima et al.   GUT

Bacterial Membrane Vesicles Mediate the Release ofMycobacterium tuberculosisLipoglycans and Lipoproteins from Infected Macrophages

(2015) Jaffre J. Athman et al.   JOURNAL OF IMMUNOLOGY

Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions

(2015) Carmen Schwechheimer et al.   NATURE REVIEWS MICROBIOLOGY

Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi

(2015) Lisa Brown et al.   NATURE REVIEWS MICROBIOLOGY

Reagent and laboratory contamination can critically impact sequence-based microbiome analyses

(2014) Susannah J Salter et al.   BMC BIOLOGY

Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles Are Internalized in Human Host Cells and Trigger NOD1- and NOD2-Dependent NF-κB Activation

(2014) Bernard Thay et al.   INFECTION AND IMMUNITY

Pseudomonas aeruginosa Outer Membrane Vesicles Modulate Host Immune Responses by Targeting the Toll-Like Receptor 4 Signaling Pathway

(2013) Kelei Zhao et al.   INFECTION AND IMMUNITY

Immunogenicity and safety of an investigational multicomponent, recombinant, meningococcal serogroup B vaccine (4CMenB) administered concomitantly with routine infant and child vaccinations: results of two randomised trials

(2013) Timo Vesikari et al.   LANCET

Extracellular Vesicles Derived from Gut Microbiota, Especially Akkermansia muciniphila, Protect the Progression of Dextran Sulfate Sodium-Induced Colitis

(2013) Chil-sung Kang et al.   PLoS One

Bacteria-Human Somatic Cell Lateral Gene Transfer Is Enriched in Cancer Samples

(2013) David R. Riley et al.   PLoS Computational Biology

Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection

(2012) Yue Shen et al.   Cell Host & Microbe

Membrane Vesicle Release in Bacteria, Eukaryotes, and Archaea: a Conserved yet Underappreciated Aspect of Microbial Life

(2012) Brooke L. Deatherage et al.   INFECTION AND IMMUNITY

Vibrio choleraeO395 Outer Membrane Vesicles Modulate Intestinal Epithelial Cells in a NOD1 Protein-dependent Manner and Induce Dendritic Cell-mediated Th2/Th17 Cell Responses

(2012) Debashree Chatterjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

(2012) Jeremiah R. McDole et al.   NATURE

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Defining the human microbiome

(2012) Luke K Ursell et al.   NUTRITION REVIEWS

Circulating Bacterial Membrane Vesicles Cause Sepsis in Rats

(2012) Bhairav Shah et al.   SHOCK

Peyer's Patch Dendritic Cells Sample Antigens by Extending Dendrites Through M Cell-Specific Transcellular Pores

(2011) Hugues Lelouard et al.   GASTROENTEROLOGY

Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice

(2011) Rafael Prados-Rosales et al.   JOURNAL OF CLINICAL INVESTIGATION

Virulence and Immunomodulatory Roles of Bacterial Outer Membrane Vesicles

(2010) T. N. Ellis et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Organismal, genetic, and transcriptional variation in the deeply sequenced gut microbiomes of identical twins

(2010) P. J. Turnbaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B Cell Activation by Outer Membrane Vesicles—A Novel Virulence Mechanism

(2010) Maria Laura A. Perez Vidakovics et al.   PLoS Pathogens

Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells

(2009) Maria Kaparakis et al.   CELLULAR MICROBIOLOGY

The NIH Human Microbiome Project

(2009) et al.   GENOME RESEARCH

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Inter-kingdom signalling: communication between bacteria and their hosts

(2008) David T. Hughes et al.   NATURE REVIEWS MICROBIOLOGY

Exosomes Derived from M. Bovis BCG Infected Macrophages Activate Antigen-Specific CD4+ and CD8+ T Cells In Vitro and In Vivo

(2008) Pramod K. Giri et al.   PLoS One