Article
Radiology, Nuclear Medicine & Medical Imaging
Justin P. Wright, Jason R. Goodman, Yin-Guo Lin, Brian P. Lieberman, Jennifer Clemens, Luis F. Gomez, Qianwa Liang, Adam T. Hoye, Michael J. Pontecorvo, Kelly A. Conway
Summary: The study aimed to evaluate the binding of [F-18]flortaucipir to MAO-A and MAO-B and its potential impact on PET interpretation. Results showed specific binding of flortaucipir to tau NFT-rich Alzheimer's disease tissue but minimal binding to MAO-A and MAO-B.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Clinical Neurology
Jeffrey S. Phillips, Frederick J. Nitchie, Fulvio Da Re, Christopher A. Olm, Philip A. Cook, Corey T. McMillan, David J. Irwin, James C. Gee, Jacob G. Dubroff, Murray Grossman, Ilya M. Nasrallah
Summary: Longitudinal PET studies in Alzheimer's disease have shown reductions in tau signal, particularly in advanced neurodegeneration. The study investigated this phenomenon in atypical AD and found that F-18-flortaucipir uptake slowed or declined over time in areas with high baseline signal and older, more impaired individuals. ADNI participants also had reduced longitudinal change in early Braak stage regions compared to late-stage areas. Further research is needed to understand if these results apply to other radioligands and if they are related to changes in the radioligand binding site structure or accessibility.
ALZHEIMERS & DEMENTIA
(2022)
Article
Endocrinology & Metabolism
Karine Provost, Renaud La Joie, Amelia Strom, Leonardo Iaccarino, Lauren Edwards, Taylor J. Mellinger, Julie Pham, Suzanne L. Baker, Bruce L. Miller, William J. Jagust, Gil D. Rabinovici
Summary: The study found a high frequency of CCD in patients with neurodegenerative diseases and its association with neuropathology. Cortical asymmetry may contribute to cerebellar metabolic imbalance in some patients, increasing the likelihood of CCD occurrence.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Arenn F. F. Carlos, Nirubol Tosakulwong, Stephen D. D. Weigand, Matthew L. L. Senjem, Christopher G. G. Schwarz, David S. S. Knopman, Bradley F. F. Boeve, Ronald C. C. Petersen, Aivi T. T. Nguyen, R. Ross Reichard, Dennis W. W. Dickson, Clifford R. R. Jack Jr, Val Lowe, Jennifer L. L. Whitwell, Keith A. A. Josephs
Summary: This study investigated the impact of age and TDP-43 pathology on the volume-uptake mismatch in older Alzheimer's disease patients. The results showed that TDP-43 pathology was associated with reduced medial temporal volumes but not with F-18-flortaucipir uptake. The effect size of TDP-43 pathology remained consistent across the age spectrum, but in older age, the mean volumes moved towards those of TDP-43-positive cases, reflecting the increasing frequency of TDP-43 pathology with age.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Michael D. Devous, Adam S. Fleisher, Michael J. Pontecorvo, Ming Lu, Andrew Siderowf, Michael Navitsky, Ian Kennedy, Sudeepti Southekal, Thomas S. Harris, Mark A. Mintun
Summary: The study revealed a significant inverse correlation between flortaucipir SUVr values and cognitive scores in specific domains, supporting the hypothesis that PET imaging may reflect neurodegeneration in AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Clinical Neurology
Ariane G. Bollack, Hugh G. E. Pemberton, Lyduine E. Collij, Pawel M. Markiewicz, David M. Cash, Gill Farrar, Frederik Barkhof
Summary: This review summarizes the current design and methodologies of longitudinal PET studies, utilizing positron emission tomography to quantify amyloid and tau pathology. The intrinsic variability of AD protein load over time and technical factors contributing to PET measurement uncertainty are detailed. Suggestions for mitigating these factors, including leveraging shared information between serial scans, are provided.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Diana I. Bocancea, Anna L. Svenningsson, Anna C. van Loenhoud, Colin Groot, Frederik Barkhof, Olof Strandberg, Ruben Smith, Renaud La Joie, Howard J. Rosen, Michael J. Pontecorvo, Gil D. Rabinovici, Wiesje M. van der Flier, Oskar Hansson, Rik Ossenkoppele
Summary: The mechanisms of resilience against tau pathology in Alzheimer's disease spectrum are not well understood. This longitudinal study investigates the factors that contribute to cognitive and brain resilience against tau pathology and finds that education is the most important determinant of resilience. However, resilience may be depleted in advanced stages of the disease.
Article
Clinical Neurology
Rosaleena Mohanty, Daniel Ferreira, Agneta Nordberg, Eric Westman
Summary: This study investigated the relationship between tau pathology and atrophy in Alzheimer's disease (AD) using tau-PET and structural MRI. The results showed that tau-PET patterns were associated with longitudinal atrophy in the AD continuum. Heterogeneity was also characterized as a continuous phenomenon, offering new insights into disease progression.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mei Tian, A. Cahid Civelek, Ignasi Carrio, Yasuyoshi Watanabe, Keon Wook Kang, Koji Murakami, Valentina Garibotto, John O. Prior, Henryk Barthel, Rui Zhou, Haifeng Hou, Xiaofeng Dou, Chentao Jin, Chuantao Zuo, Hong Zhang
Summary: This international consensus aims to help nuclear medicine practitioners perform F-18-flortaucipir PET imaging in patients with cognitive impairment. It will promote the standardized use of F-18-flortaucipir PET and become an international standard in clinical practice.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Giulia Quattrini, Clarissa Ferrari, Michela Pievani, Andrea Geviti, Federica Ribaldi, Max Scheffler, Giovanni B. Frisoni, Valentina Garibotto, Moira Marizzoni
Summary: This study aimed to establish and validate unsupervised T+ cutoffs in Alzheimer's disease (AD) using Gaussian mixture models (GMM). The GMM-based cutoffs showed reliability in clinical applications and may be useful in selecting participants for clinical and research studies.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Yang Shi, Bernardino Ghetti, Michel Goedert, Sjors H. W. Scheres
Summary: Positron emission tomography (PET) imaging is used to monitor the progression of amyloid aggregation in the living brain. [18F]-Flortaucipir is the only approved PET tracer for visualizing tau aggregation. Cryo-EM experiments were conducted on tau filaments from individuals with Alzheimer's disease (AD) and primary age-related tauopathy (PART) with chronic traumatic encephalopathy (CTE) co-pathology. Flortaucipir was observed binding to CTE Type I filaments from the PART case, but no additional cryo-EM density was observed for AD paired helical or straight filaments (PHFs or SFs).
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Yuying Li, Tianqing Liu, Mengchao Cui
Summary: This review summarizes the latest development of Tau tracers and analyzes their chemical structures and biological properties. The limitations of current tracers and considerations for the development of new tracers are also discussed.
CHINESE CHEMICAL LETTERS
(2022)
Review
Clinical Neurology
Gabriel Cassinelli Petersen, Michelle Roytman, Gloria C. Chiang, Yi Li, Marc L. Gordon, Ana M. Franceschi
Summary: This article provides an overview of tau PET imaging in neurodegenerative disorders, focusing on first-generation and second-generation radiotracers. Tau PET has emerged as a valuable tool for diagnosis and staging of tauopathies such as Alzheimer's disease and non-Alzheimer's disease tauopathies.
CURRENT OPINION IN NEUROLOGY
(2022)
Article
Clinical Neurology
Julien Lagarde, Pauline Olivieri, Matteo Tonietto, Sebastian Rodrigo, Philippe Gervais, Fabien Caille, Martin Moussion, Michel Bottlaender, Marie Sarazin
Summary: Monitoring the progression of Tau pathology can help study the clinical diversity of Alzheimer's disease. This 2-year longitudinal PET study found that [F-18]-flortaucipir binding and cortical atrophy progression are related to cognitive decline. Despite a relatively small sample size, tau-PET imaging could identify patients with potentially more aggressive clinical courses.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
William Charles Kreisl, Patrick J. Lao, Aubrey Johnson, Zeljko Tomljanovic, Julia Klein, Krista Polly, Benjamin Maas, Krystal K. Laing, Anthony G. Chesebro, Kay Igwe, Qolamreza R. Razlighi, Lawrence S. Honig, Xinyu Yan, Seonjoo Lee, Akiva Mintz, Jose A. Luchsinger, Yaakov Stern, D. P. Devanand, Adam M. Brickman
Summary: F-18-MK-6240 showed good correlation with CSF tau and p-tau levels, as well as age, cognition, and amyloid-based AD biomarkers. The study also found that F-18-MK-6240 binding patterns were associated with specific cognitive impairments in amyloid-positive participants, reflecting the progression of AD pathology.
ALZHEIMERS & DEMENTIA
(2022)
Review
Psychology, Clinical
Anneke Terneusen, Ieke Winkens, Caroline van Heugten, Sven Stapert, Heidi I. L. Jacobs, Rudolf Ponds, Conny Quaedflieg
Summary: Self-awareness is crucial for rehabilitation after acquired brain injury (ABI), however, ABI often affects self-awareness. This systematic review aimed to identify the neural correlates of self-awareness after ABI. The results showed that different levels of self-awareness are associated with variations in brain activation and connectivity, and further research is needed to confirm these findings.
NEUROPSYCHOLOGY REVIEW
(2023)
Article
Clinical Neurology
Heidi I. L. Jacobs, John Alex Becker, Kenneth Kwong, Diana Munera, Liliana Ramirez-Gomez, Nina Engels-Dominguez, Justin S. Sanchez, Clara Vila-Castelar, Ana Baena, Reisa A. Sperling, Keith A. Johnson, Francisco Lopera, Yakeel T. Quiroz
Summary: LC integrity is a marker of disease progression in preclinical ADAD.
ALZHEIMERS & DEMENTIA
(2023)
Article
Multidisciplinary Sciences
R. A. I. Bethlehem, J. Seidlitz, S. R. White, J. W. Vogel, K. M. Anderson, C. Adamson, S. Adler, G. S. Alexopoulos, E. Anagnostou, A. Areces-Gonzalez, D. E. Astle, B. Auyeung, M. Ayub, J. Bae, G. Ball, S. Baron-Cohen, R. Beare, S. A. Bedford, V. Benegal, F. Beyer, J. Blangero, M. Blesa Cabez, J. P. Boardman, M. Borzage, J. F. Bosch-Bayard, N. Bourke, V. D. Calhoun, M. M. Chakravarty, C. Chen, C. Chertavian, G. Chetelat, Y. S. Chong, J. H. Cole, A. Corvin, M. Costantino, E. Courchesne, F. Crivello, V. L. Cropley, J. Crosbie, N. Crossley, M. Delarue, R. Delorme, S. Desrivieres, G. A. Devenyi, M. A. Di Biase, R. Dolan, K. A. Donald, G. Donohoe, K. Dunlop, A. D. Edwards, J. T. Elison, C. T. Ellis, J. A. Elman, L. Eyler, D. A. Fair, E. Feczko, P. C. Fletcher, P. Fonagy, C. E. Franz, L. Galan-Garcia, A. Gholipour, J. Giedd, J. H. Gilmore, D. C. Glahn, I. M. Goodyer, P. E. Grant, N. A. Groenewold, F. M. Gunning, R. E. Gur, R. C. Gur, C. F. Hammill, O. Hansson, T. Hedden, A. Heinz, R. N. Henson, K. Heuer, J. Hoare, B. Holla, A. J. Holmes, R. Holt, H. Huang, K. Im, J. Ipser, C. R. Jack, A. P. Jackowski, T. Jia, K. A. Johnson, P. B. Jones, D. T. Jones, R. S. Kahn, H. Karlsson, L. Karlsson, R. Kawashima, E. A. Kelley, S. Kern, K. W. Kim, M. G. Kitzbichler, W. S. Kremen, F. Lalonde, B. Landeau, S. Lee, J. Lerch, J. D. Lewis, J. Li, W. Liao, C. Liston, M. V. Lombardo, J. Lv, C. Lynch, T. T. Mallard, M. Marcelis, R. D. Markello, S. R. Mathias, B. Mazoyer, P. McGuire, M. J. Meaney, A. Mechelli, N. Medic, B. Misic, S. E. Morgan, D. Mothersill, J. Nigg, M. Q. W. Ong, C. Ortinau, R. Ossenkoppele, M. Ouyang, L. Palaniyappan, L. Paly, P. M. Pan, C. Pantelis, M. M. Park, T. Paus, Z. Pausova, D. Paz-Linares, A. Pichet Binette, K. Pierce, X. Qian, J. Qiu, A. Qiu, A. Raznahan, T. Rittman, A. Rodrigue, C. K. Rollins, R. Romero-Garcia, L. Ronan, M. D. Rosenberg, D. H. Rowitch, G. A. Salum, T. D. Satterthwaite, H. L. Schaare, R. J. Schachar, A. P. Schultz, G. Schumann, M. Scholl, D. Sharp, R. T. Shinohara, I. Skoog, C. D. Smyser, R. A. Sperling, D. J. Stein, A. Stolicyn, J. Suckling, G. Sullivan, Y. Taki, B. Thyreau, R. Toro, N. Traut, K. A. Tsvetanov, N. B. Turk-Browne, J. J. Tuulari, C. Tzourio, E. Vachon-Presseau, M. J. Valdes-Sosa, P. A. Valdes-Sosa, S. L. Valk, T. van Amelsvoort, S. N. Vandekar, L. Vasung, L. W. Victoria, S. Villeneuve, A. Villringer, P. E. Vertes, K. Wagstyl, Y. S. Wang, S. K. Warfield, V. Warrier, E. Westman, M. L. Westwater, H. C. Whalley, A. V. Witte, N. Yang, B. Yeo, H. Yun, A. Zalesky, H. J. Zar, A. Zettergren, J. H. Zhou, H. Ziauddeen, A. Zugman, X. N. Zuo, E. T. Bullmore, A. F. Alexander-Bloch
Summary: Neuroimaging has become a widely used tool in brain research, but there is currently a lack of reference standards to quantify individual differences over time. In this study, researchers created an open resource that benchmarks brain morphology using a large dataset of MRI scans. The brain charts identified neurodevelopmental milestones and showed high individual stability and robustness to technical and methodological differences.
Editorial Material
Clinical Neurology
Arman Eshaghi, Rachel F. Buckley
Summary: There is an urgent need to develop individualized preventive approaches for those likely to develop Alzheimer's disease. Machine learning can help recognize high-risk individuals and provide personalized treatment before symptoms appear.
Article
Clinical Neurology
Jennifer S. Rabin, Jeremy Pruzin, Matthew Scott, Hyun-Sik Yang, Olivia Hampton, Stephanie Hsieh, Aaron P. Schultz, Rachel F. Buckley, Trey Hedden, Dorene Rentz, Keith A. Johnson, Reisa A. Sperling, Jasmeer P. Chhatwal
Summary: This study examines the interaction between vascular risk factors and beta-amyloid burden on gray matter atrophy and cognitive decline in older adults. The results suggest that managing vascular risk factors may be an intervention to slow neurodegeneration and cognitive decline in preclinical Alzheimer's disease.
Article
Psychology, Clinical
Olivia L. Hampton, Shubhabrata Mukherjee, Michael J. Properzi, Aaron P. Schultz, Paul K. Crane, Laura E. Gibbons, Timothy J. Hohman, Paul Maruff, Yen Ying Lim, Rebecca E. Amariglio, Kathryn V. Papp, Keith A. Johnson, Dorene M. Rentz, Reisa A. Sperling, Rachel F. Buckley
Summary: This study proposes a harmonized preclinical Alzheimer cognitive composite (PACC) using modern psychometric approaches. By performing confirmatory factor analysis (CFA) on longitudinal data, parameters were determined to generate latent PACC (lPACC) scores. The study found that lPACC slightly outperformed the standardized PACC (zPACC) in predicting progression to dementia.
Article
Clinical Neurology
Alexander J. Ehrenberg, Michael A. Kelberman, Kathy Y. Liu, Martin J. Dahl, David Weinshenker, Neus Falgas, Shubir Dutt, Mara Mather, Mareike Ludwig, Matthew J. Betts, Joseph R. Winer, Stefan Teipel, Alexandra J. Weigand, Oxana Eschenko, Dorothea Haemmerer, Marina Leiman, Scott E. Counts, James M. Shine, Ian H. Robertson, Allan I. Levey, Elisa Lancini, Gowoon Son, Chrisoph Schneider, Maxime Van Egroo, Claudio Liguori, Qin Wang, Elena M. Vazey, Federico Rodriguez-Porcel, Lena Haag, Mark W. Bondi, Sven Vanneste, Whitney M. Freeze, Yeo-Jin Yi, Mihovil Maldinov, Jennifer Gatchel, Abhijit Satpati, Claudio Babiloni, William S. Kremen, Robert Howard, Heidi I. L. Jacobs, Lea T. Grinberg
Summary: The nuclei in the neuromodulatory subcortical system (NSS) play critical roles in survival, hedonic tone, and homeostasis. Degeneration of NSS occurs early in the pathogenesis of Alzheimer's disease (AD), even before the emergence of memory dysfunction and cortical lesions. NSS dysfunction and degeneration are associated with the behavioral and neuropsychiatric symptoms observed in early AD stages. Experimental studies suggest that NSS degeneration contributes to the neuroinflammatory status and disease progression in AD. It is important to understand the mechanisms underlying NSS vulnerability and the clinical progression of NSS changes in AD.
ALZHEIMERS & DEMENTIA
(2023)
Editorial Material
Clinical Neurology
Elouise A. Koops, Heidi I. L. Jacobs
Article
Behavioral Sciences
Nina Engels-Dominguez, Elouise A. Koops, Prokopis C. Prokopiou, Maxime Van Egroo, Christoph Schneider, Joost M. Riphagen, Tarun Singhal, Heidi I. L. Jacobs
Summary: Primary prevention trials are now focusing on the earliest stages of Alzheimer's disease (AD). Autopsy data suggests that the nuclei of the neuromodulatory subcortical systems (NSS) are particularly susceptible to initial tau pathology, making them promising targets for early detection of AD in the aging brain. Recent advancements in imaging methods, such as ultra-high field scanners and new radioligands, have enabled more NSS neuroimaging studies on aging and neurodegeneration. This review highlights the findings of current imaging studies on the structure, function, and molecular changes of these nuclei and identifies challenges and future directions for improving in vivo imaging of the NSS in AD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Maxime Van Egroo, Joost M. Riphagen, Nicholas J. Ashton, Shorena Janelidze, Reisa A. Sperling, Keith A. Johnson, Hyun-Sik Yang, David A. Bennett, Kaj Blennow, Oskar Hansson, Henrik Zetterberg, Heidi I. L. Jacobs
Summary: Autopsy data suggests that the locus coeruleus (LC) is one of the first areas in the brain to accumulate tau pathology. Using advanced imaging technology, researchers investigated the relationship between LC imaging measures and tau pathology, and whether this relationship can be detected in early adulthood and associated with cognitive decline. They also validated these findings using autopsy data from the Rush Memory and Aging Project (MAP). The results showed a specific correlation between plasma measures of phosphorylated tau and LC integrity, highlighting the potential of LC imaging as an early marker of AD-related processes.
MOLECULAR PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Julian Dronse, Anna Ohndorf, Nils Richter, Gerard N. Bischof, Ronja Fassbender, Qumars Behfar, Hannes Gramespacher, Kim Dillen, Heidi I. L. Jacobs, Juraj Kukolja, Gereon R. Fink, Oezguer A. Onur
Summary: A study found that elevated cortisol levels are associated with memory decline in Alzheimer's disease patients, as well as hippocampal atrophy and memory impairment in healthy seniors.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Prokopis C. Prokopiou, Nina Engels-Dominguez, Aaron P. Schultz, Jorge Sepulcre, Elouise A. Koops, Kathryn V. Papp, Gad A. Marshall, Marc D. Normandin, Georges El Fakhri, Dorene Rentz, Reisa A. Sperling, Keith A. Johnson, Heidi I. L. Jacobs
Summary: The study found an association between LC activity and cortical tau deposition, specifically in the medial-lateral temporal cortex, as well as with memory decline. The relationship between LC activity and memory decline was partially mediated by EC tau, particularly in individuals with elevated beta-amyloid deposition.
Meeting Abstract
Clinical Neurology
M. Van Egroo, H. Jacobs
JOURNAL OF SLEEP RESEARCH
(2022)
Meeting Abstract
Clinical Neurology
E. Beckers, I. Campbell, I. Paparella, R. Sharifpour, E. Koshmanova, A. Berger, J. F. Balda Aizpurua, N. Mortazavi, P. Talwar, S. Sherif, H. Jacobs, G. Vandewalle
JOURNAL OF SLEEP RESEARCH
(2022)