Cryo-EM reveals the transition of Arp2/3 complex from inactive to nucleation-competent state

Cryo-EM structure of NPF-bound human Arp2/3 complex and activation mechanism

(2020) Austin Zimmet et al.   Science Advances

Mechanism of actin polymerization revealed by cryo-EM structures of actin filaments with three different bound nucleotides

(2019) Steven Z. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Turnover Activation of Arp2/3 Complex by Dip1 May Balance Nucleation of Linear versus Branched Actin Filaments

(2019) Connor J. Balzer et al.   CURRENT BIOLOGY

Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo-EM

(2018) Felipe Merino et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of Wiskott-Aldrich syndrome protein (WASP) binding sites on the branched actin filament nucleator Arp2/3 complex

(2018) Qing Luan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo-EM

(2018) Felipe Merino et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational changes in Arp2/3 complex induced by ATP, WASp-VCA, and actin filaments

(2018) Sofia Espinoza-Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dip1 Co-opts Features of Branching Nucleation to Create Linear Actin Filaments that Activate WASP-Bound Arp2/3 Complex

(2018) Connor J. Balzer et al.   CURRENT BIOLOGY

A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis

(2018) Jasenko Zivanov et al.   IUCrJ

Cellular functions of WASP family proteins at a glance

(2017) Olga Alekhina et al.   JOURNAL OF CELL SCIENCE

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Addressing preferred specimen orientation in single-particle cryo-EM through tilting

(2017) Yong Zi Tan et al.   NATURE METHODS

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Role and structural mechanism of WASP-triggered conformational changes in branched actin filament nucleation by Arp2/3 complex

(2016) Max Rodnick-Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex

(2016) Max Rodnick-Smith et al.   Nature Communications

Sampling the conformational space of the catalytic subunit of human γ-secretase

(2015) Xiao-chen Bai et al.   eLife

Crystals of the Arp2/3 complex in two new space groups with structural information about actin-related protein 2 and potential WASP binding sites

(2015) Christopher T. Jurgenson et al.   Acta Crystallographica Section F-Structural Biology Communications

Structural analysis of the transitional state of Arp2/3 complex activation by two actin-bound WCAs

(2014) Malgorzata Boczkowska et al.   Nature Communications

Small Molecules CK-666 and CK-869 Inhibit Actin-Related Protein 2/3 Complex by Blocking an Activating Conformational Change

(2013) Byron Hetrick et al.   CHEMISTRY & BIOLOGY

Dip1 Defines a Class of Arp2/3 Complex Activators that Function without Preformed Actin Filaments

(2013) Andrew R. Wagner et al.   CURRENT BIOLOGY

Arp2/3 complex ATP hydrolysis promotes lamellipodial actin network disassembly but is dispensable for assembly

(2013) Elena Ingerman et al.   JOURNAL OF CELL BIOLOGY

Structural basis for regulation of Arp2/3 complex by GMF

(2013) Qing Luan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation

(2013) Benjamin A Smith et al.   eLife

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Characterization of Dip1p Reveals a Switch in Arp2/3-Dependent Actin Assembly for Fission Yeast Endocytosis

(2011) Roshni Basu et al.   CURRENT BIOLOGY

Three-dimensional reconstructions of Arp2/3 complex with bound nucleation promoting factors

(2011) Xiao-Ping Xu et al.   EMBO JOURNAL

Structural and biochemical characterization of two binding sites for nucleation-promoting factor WASp-VCA on Arp2/3 complex

(2011) S.-C. Ti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arp2/3 complex is bound and activated by two WASP proteins

(2011) S. B. Padrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Molecular Dynamics Simulations of Arp2/3 Complex Activation

(2010) Paul Dalhaimer et al.   BIOPHYSICAL JOURNAL

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Characterization of two classes of small molecule inhibitors of Arp2/3 complex

(2009) B. J. Nolen et al.   NATURE

The nature of the globular- to fibrous-actin transition

(2009) Toshiro Oda et al.   NATURE

Structure and Biochemical Properties of Fission Yeast Arp2/3 Complex Lacking the Arp2 Subunit

(2008) Brad J. Nolen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis of actin filament branching by the Arp2/3 complex

(2008) Isabelle Rouiller et al.   JOURNAL OF CELL BIOLOGY