Exploiting attractive non-covalent interactions for the enantioselective catalysis of reactions involving radical intermediates

Engineering new catalytic activities in enzymes

(2020) Kai Chen et al.   Nature Catalysis

Photoenzymatic Hydrogenation of Heteroaromatic Olefins using ‘Ene’‐Reductases with Photoredox Catalysts

(2020) Todd Hyster et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Emerging strategies for expanding the toolbox of enzymes in biocatalysis

(2020) Braddock A. Sandoval et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Enantioselective Hydroamination of Alkenes with Sulfonamides Enabled by Proton-Coupled Electron Transfer

(2020) Casey B. Roos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic enantioselective desymmetrizing functionalization of alkyl radicals via Cu(i)/CPA cooperative catalysis

(2020) Yong-Feng Cheng et al.   Nature Catalysis

Enantioselective Visible Light-mediated Formation of 3-Cyclopropylquinolones via Triplet-sensitized Deracemization

(2019) Andreas Tröster et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Addition of Prochiral Radicals to Vinylpyridines

(2019) Kangning Cao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photoenzymatic Catalysis Enables Radical-Mediated Ketone Reduction in Ene-Reductases

(2019) Braddock A. Sandoval et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and Optimization of Catalysts Based on Mechanistic Insights Derived from Quantum Chemical Reaction Modeling

(2019) Seihwan Ahn et al.   CHEMICAL REVIEWS

Lactam Hydrogen Bonds as Control Elements in Enantioselective Transition-Metal-Catalyzed and Photochemical Reactions

(2019) Finn Burg et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Induction and Enantiodivergence in Catalytic Radical C–H Amination via Enantiodifferentiative H-Atom Abstraction and Stereoretentive Radical Substitution

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Photoexcitation of flavoenzymes enables a stereoselective radical cyclization

(2019) Kyle F. Biegasiewicz et al.   SCIENCE

Enantioselective Intermolecular Excited-State Photoreactions Using a Chiral Ir Triplet Sensitizer: Separating Association from Energy Transfer in Asymmetric Photocatalysis

(2019) Jian Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalysis of Organic Reactions through Halogen Bonding

(2019) Revannath L. Sutar et al.   ACS Catalysis

Copper(I)-Catalyzed Asymmetric Reactions Involving Radicals

(2019) Qiang-Shuai Gu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Asymmetric Synthesis of Heterocyclic γ-Amino-Acid and Diamine Derivatives by Three-Component Radical Cascade Reactions

(2019) Danqing Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Copper(I)/Chiral Phosphoric Acid Catalyzed Intramolecular Amination of Allylic and Benzylic C−H Bonds

(2019) Liu Ye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Predictive Multivariate Linear Regression Analysis Guides Successful Catalytic Enantioselective Minisci Reactions of Diazines

(2019) Jolene P. Reid et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Light-driven deracemization enabled by excited-state electron transfer

(2019) Nick Y. Shin et al.   SCIENCE

The importance of catalytic promiscuity for enzyme design and evolution

(2019) Reuben B. Leveson-Gower et al.   Nature Reviews Chemistry

Asymmetric redox-neutral radical cyclization catalysed by flavin-dependent ‘ene’-reductases

(2019) Michael J. Black et al.   Nature Chemistry

Site- and Enantioselective C−H Oxygenation Catalyzed by a Chiral Manganese Porphyrin Complex with a Remote Binding Site

(2018) Finn Burg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diastereo- and Enantioselective Formal [3 + 2] Cycloaddition of Cyclopropyl Ketones and Alkenes via Ti-Catalyzed Radical Redox Relay

(2018) Wei Hao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Radical Cyclization for Construction of 5-Membered Ring Structures by Metalloradical C–H Alkylation

(2018) Yong Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conjugate Addition–Enantioselective Protonation of N-Aryl Glycines to α-Branched 2-Vinylazaarenes via Cooperative Photoredox and Asymmetric Catalysis

(2018) Yanli Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of Pyrroloindolines via Noncovalent Stabilization of Indole Radical Cations and Applications to the Synthesis of Alkaloid Natural Products

(2018) Emily C. Gentry et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic promiscuity enabled by photoredox catalysis in nicotinamide-dependent oxidoreductases

(2018) Kyle F. Biegasiewicz et al.   Nature Chemistry

Catalytic enantioselective Minisci-type addition to heteroarenes

(2018) Rupert S. J. Proctor et al.   SCIENCE

Enantioselective counter-anions in photoredox catalysis: The asymmetric cation radical Diels-Alder reaction

(2018) Peter D. Morse et al.   TETRAHEDRON

The Emergence of Anion−π Catalysis

(2018) Yingjie Zhao et al.   ACCOUNTS OF CHEMICAL RESEARCH

Enhancing the potential of enantioselective organocatalysis with light

(2018) Mattia Silvi et al.   NATURE

Organocatalytic Enantioselective Addition of α-Aminoalkyl Radicals to Isoquinolines

(2018) Xiangyuan Liu et al.   ORGANIC LETTERS

Catalytic enantioselective radical coupling of activated ketones with N-aryl glycines

(2018) Yang Liu et al.   Chemical Science

Catalytic enantioconvergent coupling of secondary and tertiary electrophiles with olefins

(2018) Zhaobin Wang et al.   NATURE

Catalytic deracemization of chiral allenes by sensitized excitation with visible light

(2018) Alena Hölzl-Hobmeier et al.   NATURE

Origin of Stereoselectivity of the Photoinduced Asymmetric Phase-Transfer-Catalyzed Perfluoroalkylation of β-Ketoesters

(2017) Chen Yang et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Excited-State Photoreactions Controlled by a Chiral Hydrogen-Bonding Iridium Sensitizer

(2017) Kazimer L. Skubi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Hydrogen Atom Transfer: Discovery of Catalytic Promiscuity in Flavin-Dependent ‘Ene’-Reductases

(2017) Braddock A. Sandoval et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exploiting non-covalent π interactions for catalyst design

(2017) Andrew J. Neel et al.   NATURE

Enantioselective cyclizations and cyclization cascades of samarium ketyl radicals

(2017) Nicolas Kern et al.   Nature Chemistry

Catalytic Asymmetric Radical Diamination of Alkenes

(2017) Fu-Li Wang et al.   Chem

The merger of transition metal and photocatalysis

(2017) Jack Twilton et al.   Nature Reviews Chemistry

The Development of Multidimensional Analysis Tools for Asymmetric Catalysis and Beyond

(2016) Matthew S. Sigman et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Practical Guide for Predicting the Stereochemistry of Bifunctional Phosphoric Acid Catalyzed Reactions of Imines

(2016) Jolene P. Reid et al.   ACCOUNTS OF CHEMICAL RESEARCH

Noncovalent Interactions in Organocatalysis and the Prospect of Computational Catalyst Design

(2016) Steven E. Wheeler et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Cation-π Interaction in Small-Molecule Catalysis

(2016) C. Rose Kennedy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organic Photoredox Catalysis

(2016) Nathan A. Romero et al.   CHEMICAL REVIEWS

Enantioselective Visible-Light-Induced Radical-Addition Reactions to 3-Alkylidene Indolin-2-ones

(2016) Dominik Lenhart et al.   CHEMISTRY-A EUROPEAN JOURNAL

Beyond ferryl-mediated hydroxylation: 40 years of the rebound mechanism and C–H activation

(2016) Xiongyi Huang et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Independence from the Sequence of Single-Electron Transfer of Photoredox Process in Redox-Neutral Asymmetric Bond-Forming Reaction

(2016) Tomohito Kizu et al.   JOURNAL OF ORGANIC CHEMISTRY

Photoredox Catalysis in Organic Chemistry

(2016) Megan H. Shaw et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Intermolecular [2 + 2] Photocycloaddition Reactions of 2(1H)-Quinolones Induced by Visible Light Irradiation

(2016) Andreas Tröster et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Dual-Catalytic Strategy To Direct Asymmetric Radical Aminotrifluoromethylation of Alkenes

(2016) Jin-Shun Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Decarboxylative Arylation of α-Amino Acids via the Merger of Photoredox and Nickel Catalysis

(2016) Zhiwei Zuo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light

(2016) Megan A. Emmanuel et al.   NATURE

Asymmetric catalytic formation of quaternary carbons by iminium ion trapping of radicals

(2016) John J. Murphy et al.   NATURE

Asymmetric copper-catalyzed C-N cross-couplings induced by visible light

(2016) Q. M. Kainz et al.   SCIENCE

Enantioselective cyanation of benzylic C–H bonds via copper-catalyzed radical relay

(2016) Wen Zhang et al.   SCIENCE

London Dispersion in Molecular Chemistry-Reconsidering Steric Effects

(2015) J. Philipp Wagner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Catalysis of Photochemical Reactions

(2015) Richard Brimioulle et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular architectures and functions of radical enzymes and their (re)activating proteins

(2015) Naoki Shibata et al.   JOURNAL OF BIOCHEMISTRY

Enantioselective Cross-Coupling of meso-Epoxides with Aryl Halides

(2015) Yang Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photo-organocatalytic Enantioselective Perfluoroalkylation of β-Ketoesters

(2015) Łukasz Woźniak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synergistic Catalysis of Ionic Brønsted Acid and Photosensitizer for a Redox Neutral Asymmetric α-Coupling of N-Arylaminomethanes with Aldimines

(2015) Daisuke Uraguchi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Cross-Coupling of Photoredox-Generated Radicals: Uncovering a General Manifold for Stereoconvergence in Nickel-Catalyzed Cross-Couplings

(2015) Osvaldo Gutierrez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Organo-Photocatalysis Mediated by Atropisomeric Thiourea Derivatives

(2014) Nandini Vallavoju et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Chiral Thioxanthone as an Organocatalyst for Enantioselective [2+2] Photocycloaddition Reactions Induced by Visible Light

(2014) Rafael Alonso et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Radical S-Adenosylmethionine Enzymes

(2014) Joan B. Broderick et al.   CHEMICAL REVIEWS

Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates

(2014) Dixit Parmar et al.   CHEMICAL REVIEWS

Asymmetric photoredox transition-metal catalysis activated by visible light

(2014) Haohua Huo et al.   NATURE

An organic thiyl radical catalyst for enantioselective cyclization

(2014) Takuya Hashimoto et al.   Nature Chemistry

Solar Synthesis: Prospects in Visible Light Photocatalysis

(2014) D. M. Schultz et al.   SCIENCE

A Dual-Catalysis Approach to Enantioselective [2 + 2] Photocycloadditions Using Visible Light

(2014) J. Du et al.   SCIENCE

Enantioselective Functionalization of Radical Intermediates in Redox Catalysis: Copper-Catalyzed Asymmetric Oxytrifluoromethylation of Alkenes

(2013) Rong Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Developments in Asymmetric Phase-Transfer Reactions

(2013) Seiji Shirakawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biocatalysis in Organic Chemistry and Biotechnology: Past, Present, and Future

(2013) Manfred T. Reetz   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Catalysis with an Inert Chiral-at-Metal Iridium Complex

(2013) Liang-An Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Photoredox Catalysis Enabled by Proton-Coupled Electron Transfer: Development of an Asymmetric Aza-Pinacol Cyclization

(2013) Lydia J. Rono et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Lewis Acid Catalysis of Intramolecular Enone [2+2] Photocycloaddition Reactions

(2013) R. Brimioulle et al.   SCIENCE

Photoredox activation and anion binding catalysis in the dual catalytic enantioselective synthesis of β-amino esters

(2013) Giulia Bergonzini et al.   Chemical Science

Asymmetric Ion-Pairing Catalysis

(2012) Katrien Brak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Counteranion-Directed Catalysis: Concept, Definition, and Applications

(2012) Manuel Mahlau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Enantioselective Intramolecular Alkene Amination/Intermolecular Heck-Type Coupling Cascade

(2012) Timothy W. Liwosz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The progression of chiral anions from concepts to applications in asymmetric catalysis

(2012) Robert J. Phipps et al.   Nature Chemistry

Enantioselective Intramolecular [2 + 2]-Photocycloaddition Reactions of 4-Substituted Quinolones Catalyzed by a Chiral Sensitizer with a Hydrogen-Bonding Motif

(2011) Christiane Müller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective radical cyclisation reactions of 4-substituted quinolones mediated by a chiral template

(2011) Aline Bakowski et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Visible light photoredox catalysis: applications in organic synthesis

(2010) Jagan M. R. Narayanam et al.   CHEMICAL SOCIETY REVIEWS

Attractive noncovalent interactions in asymmetric catalysis: Links between enzymes and small molecule catalysts

(2010) R. R. Knowles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Light-Driven Enantioselective Organocatalysis

(2009) Christiane Müller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective radical addition reactions to imines using binaphthol-derived chiral N-triflyl phosphoramides

(2009) Sunggi Lee et al.   TETRAHEDRON LETTERS

Merging Photoredox Catalysis with Organocatalysis: The Direct Asymmetric Alkylation of Aldehydes

(2008) D. A. Nicewicz et al.   SCIENCE