SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging

Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China

(2020) Aiping Wu et al.   Cell Host & Microbe

α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

(2020) Linlin Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A distinct name is needed for the new coronavirus

(2020) Shibo Jiang et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A novel coronavirus outbreak of global health concern

(2020) Chen Wang et al.   LANCET

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

(2020) Guangdi Li et al.   NATURE REVIEWS DRUG DISCOVERY

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells

(2019) Marcin Poreba et al.   CELL DEATH AND DIFFERENTIATION

Applications of Unnatural Amino Acids in Protease Probes

(2019) Izabela Maluch et al.   Chemistry-An Asian Journal

Selective Substrates and Activity-Based Probes for Imaging of the Human Constitutive 20S Proteasome in Cells and Blood Samples

(2018) Wioletta Rut et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes

(2018) Marcin Poreba et al.   Chemical Science

Toolbox of Fluorescent Probes for Parallel Imaging Reveals Uneven Location of Serine Proteases in Neutrophils

(2017) Paulina Kasperkiewicz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy

(2016) Thanigaimalai Pillaiyar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small Molecule Active Site Directed Tools for Studying Human Caspases

(2015) Marcin Poreba et al.   CHEMICAL REVIEWS

Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus

(2015) Andong Wu et al.   VIRUS RESEARCH

Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates

(2014) M Poreba et al.   CELL DEATH AND DIFFERENTIATION

From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

(2014) Rolf Hilgenfeld   FEBS Journal

Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling

(2014) P. Kasperkiewicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JLigand: a graphical tool for theCCP4 template-restraint library

(2012) Andrey A. Lebedev et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDSAPP: a graphical user interface for the convenient processing of diffraction data usingXDS

(2012) Michael Krug et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Activity, Specificity, and Probe Design for the Smallpox Virus Protease K7L

(2012) Alexander E. Aleshin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An introduction to data reduction: space-group determination, scaling and intensity statistics

(2011) Philip R. Evans   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

(2011) Lili Zhu et al.   ANTIVIRAL RESEARCH

Profiling of Substrate Specificities of 3C-Like Proteases from Group 1, 2a, 2b, and 3 Coronaviruses

(2011) Chi-Pang Chuck et al.   PLoS One

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY