Article
Biotechnology & Applied Microbiology
Paul L. Reiter, Michael L. Pennell, Glenn A. Martinez, Mira L. Katz
Summary: This study found that healthcare provider recommendation is crucial for HPV vaccination among Hispanic/Latinx adolescents, but there are differences in how parents receive provider recommendations across different Hispanic/Latinx subgroups. Efforts are needed to improve communication and recommendations for HPV vaccination among the Hispanic/Latinx population, as well as to ensure language assistance services are available for individuals with limited English proficiency.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
Abraham Aragones, Francesca Gany, Andrea Kaplan, Denise Bruno
Summary: This study evaluated potential opportunities for discussing the HPV vaccine during a recent primary care provider visit for Latino parents of 9-10-year-old children in New York City. The majority of parents reported not discussing or receiving a recommendation for the vaccine during that visit. Lowering the recommended age for routine HPV vaccination to 9-10 years old could be an important strategy to increase vaccination rates among Latino populations.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Immunology
Katarzyna Smolarczyk, Anna Duszewska, Slawomir Drozd, Slawomir Majewski
Summary: The study reveals that parents in Poland have low knowledge about HPV and HPV vaccines, with only 49.4% providing correct answers. Parents' attitudes are influenced solely by knowledge and education.
Article
Immunology
Lauri E. Markowitz, John T. Schiller
Summary: HPV vaccines are highly effective in preventing HPV-attributable cancers and have been introduced into national immunization programs in over 100 countries. The success of these vaccines has sparked interest in ambitious disease reduction goals.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Medicine, General & Internal
Bettina Huber, Joshua Weiyuan Wang, Richard B. S. Roden, Reinhard Kirnbauer
Summary: Current HPV vaccines have limitations and there is a need for next generation vaccines. Vaccine candidates based on the L2 minor structural protein show promise in inducing broad cross-neutralizing effects. Several promising candidates have entered or will soon enter clinical studies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Psychology, Multidisciplinary
Sara E. Fleszar-Pavlovic, Linda D. Cameron
Summary: This meta-analysis examined the efficacy of HPV vaccination interventions for adults and found that these interventions can effectively increase vaccine intentions and completion rates, but not vaccine initiation rates. The study highlights the need for more effective interventions to increase HPV vaccine initiation in adults.
ANNALS OF BEHAVIORAL MEDICINE
(2023)
Review
Immunology
Lauri E. Markowitz, Melanie Drolet, Rayleen M. Lewis, Philippe Lemieux-Mellouki, Norma Perez, Mark Jit, Julia M. Brotherton, Gina Ogilvie, Aimee R. Kreimer, Marc Brisson
Summary: This study provides a systematic literature review on the effectiveness of HPV vaccines. It highlights the biases in observational studies and the need for further research to obtain valid effectiveness estimates.
Review
Biochemistry & Molecular Biology
Raphael P. P. Viscidi, Treva Rowley, Ioannis Bossis
Summary: Recent research has highlighted the important role of tissue-resident memory T cells (T-RM cells) and a subset of dendritic cells in inducing strong protective immune responses. However, effective vaccine technologies that can induce robust CD8+ T cell responses through cross-priming are lacking. Here, we developed a platform technology using genetically engineered bovine papillomavirus virus-like particles (VLPs) that possess self-adjuvant properties. These polyionic VLP vaccines were able to induce robust CD8+ T cell responses in peripheral blood and tumor tissues, and outperformed other vaccines and immunotherapies for the treatment of prostate cancer in a relevant murine model. The immunogenicity of polyionic VLP vaccines depended on particle size, reversible antigen-VLP linkage, and a mechanism involving type 1 interferon and Toll-like receptor (TLR)3/7.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Cecilia Losada, Hady Samaha, Erin M. Scherer, Bahaa Kazzi, Lana Khalil, Ighovwerha Ofotokun, Nadine Rouphael
Summary: People living with HIV (PLH) have a higher risk of HPV infection and HPV-related diseases. However, there is limited data on the long-term effectiveness of HPV vaccines in this population. PLH have lower seroconversion rates and lower antibody levels compared to HIV-negative individuals, especially those with a low CD4 count and detectable viral load. It is uncertain whether these differences affect protection. Few studies have focused on vaccine efficacy in PLH, with varied results depending on age at vaccination and baseline seropositivity. Further research is needed to understand the differences between vaccine formulations and the impact of additional doses on immune protection durability.
Article
Virology
Ana Gradissimo, Viswanathan Shankar, Fanua Wiek, Lauren St. Peter, Yevgeniy Studentsov, Anne Nucci-Sack, Angela Diaz, Sarah Pickering, Nicolas F. Schlecht, Robert D. Burk
Summary: The study aimed to investigate the serological levels of antibodies against HPV16 prior to incident infections, finding that high-risk controls had higher antibody levels compared to incident cases and randomly selected controls after completing the three doses of the 4vHPV vaccine.
Article
Health Care Sciences & Services
Sunny Jung Kim, Jenna E. Schiffelbein, Inger Imset, Ardis L. Olson
Summary: This study found that evidence-based messages in social media can effectively change parents' attitudes and behavioral intentions towards HPV vaccination. Messages that provide scientific evidence and correct misinformation are particularly effective in promoting positive perceptions of the HPV vaccine.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Lydia Riepler, Laura-Sophie Frommelt, Sarah Wilmschen-Tober, Wilbert Mbuya, Kathrin Held, Andre Volland, Dorothee von Laer, Christof Geldmacher, Janine Kimpel
Summary: Human papilloma virus (HPV) infections are strongly associated with cervical cancers and also with anogenital or oropharyngeal cancers. In this study, a live attenuated cancer vaccine based on the chimeric vesicular stomatitis virus VSV-GP was generated and analyzed for its effectiveness in a mouse tumor model. The vaccine antigen position in the VSV-GP genome was found to impact viral fitness, immunogenicity, and anti-tumoral efficacy, with the first position being more superior. This study suggests that VSV-GP is a promising candidate for a therapeutic HPV vaccine.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Immunology
Gbadebo Collins Adeyanju, Philipp Sprengholz, Cornelia Betsch, Tene-Alima Essoh
Summary: This study explores factors contributing to vaccine hesitancy in different contexts in Malawi, finding that confidence, constraints, belief in rumors, employment status, and trust in healthcare workers are important predictors of vaccination intention. Husband's approval significantly influences childhood vaccination intention, while factors such as education level and trust in healthcare workers affect HPV vaccination intention.
Article
Immunology
Alpamys Issanov, Mohammad Ehsanul Karim, Gulzhanat Aimagambetova, Trevor J. B. Dummer
Summary: This study aimed to evaluate the association between HPV vaccination and HPV-related cancers among US adults. While no statistically significant association was found, the results suggest that vaccinated adults may have lower odds of developing HPV-related cancers.
Article
Biotechnology & Applied Microbiology
Amal Khan, Sylvia Abonyi, Cory Neudorf, Sandro Galea, Shahid Ahmed
Summary: Disparities in HPVV uptake among immigrants and refugees are primarily due to barriers such as lack of information, awareness, education, and vaccine logistics. A multi-component intervention involving educating parents, vaccinating children, and training staff in school-based programs is crucial for improving HPV immunization rates in these subgroups.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Wangheng Hou, Chu Fang, Jiayan Liu, Hai Yu, Jialong Qi, Zhiqing Zhang, Ruixue Yuan, Dan Xiong, Shuangquan Gao, Y. Adam Yuan, Shaowei Li, Ying Gu, Ningshao Xia
ANTIVIRAL RESEARCH
(2015)
Article
Immunology
Cunbao Liu, Bin Shan, Jialong Qi, Yanbing Ma
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2017)
Article
Microbiology
Cunbao Liu, Jialong Qi, Bin Shan, Yanbing Ma
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Immunology
Cunbao Liu, Jialong Qi, Bin Shan, Ruiyu Gao, Fulan Gao, Hanghang Xie, Mingcui Yuan, Hongxian Liu, Shumei Jin, Fei Wu, Yanbing Ma
INTERNATIONAL IMMUNOPHARMACOLOGY
(2018)
Article
Pharmacology & Pharmacy
Cunbao Liu, Xiaojie Chu, Mengmeng Yan, Jialong Qi, Hongxian Liu, Fulan Gao, Ruiyu Gao, Guilei Ma, Yanbing Ma
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2018)
Article
Immunology
Zhiqing Zhang, Xiang Wei, Yanling Lin, Fang Huang, Jia Shao, Jialong Qi, Tingting Deng, Zizhen Li, Shuangquan Gao, Shaoyong Li, Hai Yu, Qinjian Zhao, Shaowei Le, Ying Gu, Ningshao Xia
IMMUNOLOGY LETTERS
(2019)
Article
Infectious Diseases
Jialong Qi, Ruiyu Gao, Cunbao Liu, Bin Shan, Fulan Gao, Jinrong He, Mingcui Yuan, Hanghang Xie, Shumei Jin, Yanbing Ma
INFECTION AND DRUG RESISTANCE
(2019)
Article
Engineering, Biomedical
Weiwei Huang, Congyan Shu, Liangqun Hua, Yilin Zhao, Hanghang Xie, Jialong Qi, Fulan Gao, Ruiyu Gao, Yongjun Chen, Qishu Zhang, Weiran Li, Mingcui Yuan, Chao Ye, Yanbing Ma
ACTA BIOMATERIALIA
(2020)
Article
Nanoscience & Nanotechnology
Congyan Shu, Pengyan Sun, Hanghang Xie, Weiwei Huang, Jialong Qi, Yanbing Ma
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Virology
Yunfei Wang, Jialong Qi, Han Cao, Cunbao Liu
Summary: The study demonstrates that the use of PLGA delivery system combined with immune-stimulating nucleic acids shows promise as a safe and economical candidate for varicella and zoster vaccine.
Article
Oncology
Jia-long Qi, Jin-rong He, Shu-mei Jin, Xu Yang, Hong-mei Bai, Cun-bao Liu, Yan-bing Ma
Summary: The study found that Pseudomonas aeruginosa can inhibit tumor growth by inducing immunogenic cell death, triggering a long-lasting anti-tumor response and reshaping the tumor microenvironment through promoting DC maturation and modulating immune responses.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Chao Ye, Weiran Li, Ying Yang, Qingwen Liu, Sijing Li, Peng Zheng, Xiao Zheng, Ye Zhang, Jinrong He, Yongjun Chen, Liangqun Hua, Zhongqian Yang, Duo Li, Zhaoling Ren, Jialong Qi, Weiwei Huang, Yanbing Ma
Summary: Research shows that inappropriate use of antibiotics can lead to exacerbated inflammatory responses in MDR bacterial infections, even affecting the function of the immune system.
Article
Biochemistry & Molecular Biology
Jia-Long Qi, Jin-Rong He, Cun-Bao Liu, Shu-Mei Jin, Xu Yang, Hong-Mei Bai, Yan-Bing Ma
Summary: This study reveals that overexpression of SQSTM1/p62 in breast cancer is correlated with poor prognosis. Silencing SQSTM1/p62 expression inhibits breast cancer progression by regulating cell proliferation and reshaping the tumor microenvironment. This finding provides a novel molecular therapeutic strategy for breast cancer treatment.
Article
Medicine, Research & Experimental
Jia-Long Qi, Jin-Rong He, Cun-Bao Liu, Shu-Mei Jin, Rui-Yu Gao, Xu Yang, Hong-Mei Bai, Yan-Bing Ma
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
