Novel Acetylcholinesterase Inhibitors Based on Uracil Moiety for Possible Treatment of Alzheimer Disease

The Role of Macrophage Migration Inhibitory Factor in Alzheimer′s Disease: Conventionally Pathogenetic or Unconventionally Protective?

(2020) Maria Cristina Petralia et al.   MOLECULES

The cytokine network in the pathogenesis of major depressive disorder. Close to translation?

(2020) Maria Cristina Petralia et al.   AUTOIMMUNITY REVIEWS

Present Algorithms and Future Treatments for Alzheimer’s Disease

(2019) George T. Grossberg et al.   JOURNAL OF ALZHEIMERS DISEASE

New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease

(2019) Irina Zueva et al.   NEUROPHARMACOLOGY

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease: A General Introduction and Pathomechanism

(2017) Verena H. Finder   JOURNAL OF ALZHEIMERS DISEASE

Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors

(2015) Chaolei Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

6-Methyluracil Derivatives as Bifunctional Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease

(2015) Vyacheslav E. Semenov et al.   ChemMedChem

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer’s Disease

(2014) Angel Agis-Torres et al.   Current Neuropharmacology

Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents

(2014) Elisabet Viayna et al.   JOURNAL OF MEDICINAL CHEMISTRY

Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease

(2013) Masha G. Savelieff et al.   ACS Chemical Biology

Effects of viscosity and osmotic stress on the reaction of human butyrylcholinesterase with cresyl saligenin phosphate, a toxicant related to aerotoxic syndrome: kinetic and molecular dynamics studies

(2013) Patrick Masson et al.   BIOCHEMICAL JOURNAL

Importance of Accurate Charges in Binding Affinity Calculations: A Case of Neuraminidase Series

(2013) Kichul Park et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Target- and Mechanism-Based Therapeutics for Neurodegenerative Diseases: Strength in Numbers

(2013) Paul C. Trippier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands

(2012) Jonah Cheung et al.   JOURNAL OF MEDICINAL CHEMISTRY

1,3-dipolar cycloaddition reactions in the series of N-alkynyl-substituted uracils

(2012) V. E. Semenov et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Discovery of dual binding site acetylcholinesterase inhibitors identified by pharmacophore modeling and sequential virtual screening techniques

(2011) Shikhar Gupta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Unusual Reaction of Macrocyclic Uracils with Paraformaldehyde

(2011) Vyacheslav E. Semenov et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Robust Scoring Functions for Protein–Ligand Interactions with Quantum Chemical Charge Models

(2011) Jui-Chih Wang et al.   Journal of Chemical Information and Modeling

Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

(2010) Fraser F. Fleming et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and structure of pyrimidinophanes with a sulfur atom in the spacer

(2010) Anton E. Nikolaev et al.   MENDELEEV COMMUNICATIONS

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Alzheimer Disease and the Role of Free Radicals in the Pathogenesis of the Disease

(2008) George Perry et al.   CNS & Neurological Disorders-Drug Targets

Amyloid-cholinesterase interactions

(2008) Nibaldo C. Inestrosa et al.   FEBS Journal

An efficient and accurate molecular alignment and docking technique using ab initio quality scoring

(2008) László Füsti-Molnár et al.   JOURNAL OF CHEMICAL PHYSICS

Potent β-Amyloid Modulators

(2008) E. García-Palomero et al.   Neurodegenerative Diseases