Zerumbone-Induced Analgesia Modulated via Potassium Channels and Opioid Receptors in Chronic Constriction Injury-Induced Neuropathic Pain

Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

(2020) Miriam Stoeber et al.   eLife

Zerumbone Modulates α2A-Adrenergic, TRPV1, and NMDA NR2B Receptors Plasticity in CCI-Induced Neuropathic Pain In Vivo and LPS-Induced SH-SY5Y Neuroblastoma In Vitro Models

(2020) Jasmine Siew Min Chia et al.   Frontiers in Pharmacology

Biological and Computational Studies for Dual Cholinesterases Inhibitory Effect of Zerumbone

(2020) Jayeong Hwang et al.   Nutrients

Experimental Characterization of the Chronic Constriction Injury-Induced Neuropathic Pain Model in Mice

(2019) Banulata Gopalsamy et al.   NEUROCHEMICAL RESEARCH

Antinociceptive Activity of Petroleum Ether Fraction of Clinacanthus nutans Leaves Methanolic Extract: Roles of Nonopioid Pain Modulatory Systems and Potassium Channels

(2019) Zainul Amiruddin Zakaria et al.   Biomed Research International

Overexpression of µ-Opioid Receptors in Peripheral Afferents, but Not in Combination with Enkephalin, Decreases Neuropathic Pain Behavior and Enhances Opioid Analgesia in Mouse

(2018) Amanda H. Klein et al.   ANESTHESIOLOGY

Docking studies reveal zerumbone targets β-catenin of the Wnt-β-catenin pathway in breast cancer

(2018) Ayesha Fatima et al.   JOURNAL OF THE SERBIAN CHEMICAL SOCIETY

Chronic neuropathic pain reduces opioid receptor availability with associated anhedonia in rat

(2018) Scott J. Thompson et al.   PAIN

Zerumbone reduces proliferation of HCT116 colon cancer cells by inhibition of TNF-alpha

(2018) Salam Pradeep Singh et al.   Scientific Reports

Zerumbone Alleviates Neuropathic Pain through the Involvement of l-Arginine-Nitric Oxide-cGMP-K+ ATP Channel Pathways in Chronic Constriction Injury in Mice Model

(2017) Nurul Zulazmi et al.   MOLECULES

Exploring the immunomodulatory and anticancer properties of zerumbone

(2017) Md. Areeful Haque et al.   Food & Function

Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6, and TNF-α in a mouse model of neuropathic pain

(2017) Banulata Gopalsamy et al.   Journal of Pain Research

Zerumbone alleviates chronic constriction injury-induced allodynia and hyperalgesia through serotonin 5-HT receptors

(2016) Jasmine Siew Min Chia et al.   BIOMEDICINE & PHARMACOTHERAPY

Potassium channels in neuropathic pain

(2016) Jérôme Busserolles et al.   PAIN

Several aspects of Zingiber zerumbet: a review

(2016) Adriana Y. Koga et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Several aspects of Zingiber zerumbet: a review

(2016) Adriana Y. Koga et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain

(2015) Nurul Atiqah Zulazmi et al.   FITOTERAPIA

Small-Conductance Calcium-Activated Potassium (SK) Channels in the Amygdala Mediate Pain-Inhibiting Effects of Clinically Available Riluzole in a Rat Model of Arthritis Pain

(2015) Jeremy M. Thompson et al.   Molecular Pain

The role of large-conductance, calcium-activated potassium channels in a rat model of trigeminal neuropathic pain

(2014) Cai-Yue Liu et al.   CEPHALALGIA

Liquiritigenin alleviates mechanical and cold hyperalgesia in a rat neuropathic pain model

(2014) Li Chen et al.   Scientific Reports

Anti-hyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: Participation of the κ-opioid receptor and KATP

(2013) Lee Ming-Tatt et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Measuring Changes in Tactile Sensitivity in the Hind Paw of Mice Using an Electronic von Frey Apparatus

(2013) Tijana Martinov et al.   Jove-Journal of Visualized Experiments

Measuring Motor Coordination in Mice

(2013) Robert M.J. Deacon   Jove-Journal of Visualized Experiments

Neuroprotective role of ATP-sensitive potassium channels in cerebral ischemia

(2012) Hong-shuo Sun et al.   ACTA PHARMACOLOGICA SINICA

Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model

(2012) Qin Zheng et al.   PAIN

Molecular Mechanisms of Opioid Receptor-dependent Signaling and Behavior

(2011) Ream Al-Hasani et al.   ANESTHESIOLOGY

The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions

(2011) Akiyoshi Saitoh et al.   BEHAVIOURAL BRAIN RESEARCH

The peripheral L-arginine–nitric oxide–cyclic GMP pathway and ATP-sensitive K+ channels are involved in the antinociceptive effect of crotalphine on neuropathic pain in rats

(2011) Vanessa P. Gutierrez et al.   BEHAVIOURAL PHARMACOLOGY

Ginger and its Health Claims: Molecular Aspects

(2011) Masood Sadiq Butt et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury

(2011) Kirstin Rose et al.   PAIN

Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease

(2011) Amirhossein Sahebkar   WORLD JOURNAL OF GASTROENTEROLOGY

Zerumbone-Induced Antinociception: Involvement of the l-Arginine-Nitric Oxide-cGMP -PKC-K+ATP Channel Pathways

(2010) Enoch Kumar Perimal et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Large conductance, Ca2+ -activated K+ channels (BKCa ) and arteriolar myogenic signaling

(2010) Michael A. Hill et al.   FEBS LETTERS

Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice

(2010) M.R. Sulaiman et al.   FITOTERAPIA

The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl– channels

(2010) Boyi Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Recommendations for the Pharmacological Management of Neuropathic Pain: An Overview and Literature Update

(2010) Robert H. Dworkin et al.   MAYO CLINIC PROCEEDINGS

The Therapeutic Potential of κ-Opioids for Treatment of Pain and Addiction

(2010) Charles Chavkin   NEUROPSYCHOPHARMACOLOGY

The Effect of κ-Opioid Receptor Agonists on Tetrodotoxin-Resistant Sodium Channels in Primary Sensory Neurons

(2009) Xin Su et al.   ANESTHESIA AND ANALGESIA

N,N-Diethyl-4-[(3-hydroxyphenyl)(piperidin-4-yl)amino] benzamide derivatives: The development of diaryl amino piperidines as potent δ opioid receptor agonists with in vivo anti-nociceptive activity in rodent models

(2009) Paul Jones et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Expression of BKCa channels and the modulatory β-subunits in the rat and porcine trigeminal ganglion

(2009) Helle Wulf-Johansson et al.   BRAIN RESEARCH

Delta and Kappa Opioid Receptors as Suitable Drug Targets for Pain

(2009) Todd W. Vanderah   CLINICAL JOURNAL OF PAIN

Preliminary analysis of the antinociceptive activity of zerumbone

(2009) M.R. Sulaiman et al.   FITOTERAPIA

High content of zerumbone in volatile oils ofZingiber zerumbetfrom southern India and Malaysia

(2009) Sabulal Baby et al.   FLAVOUR AND FRAGRANCE JOURNAL

Plasticity and emerging role of BKCachannels in nociceptive control in neuropathic pain

(2009) Shao-Rui Chen et al.   JOURNAL OF NEUROCHEMISTRY

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

Reward Processing by the Opioid System in the Brain

(2009) Julie Le Merrer et al.   PHYSIOLOGICAL REVIEWS

Opioid Tolerance Development: A Pharmacokinetic/Pharmacodynamic Perspective

(2008) Emily O. Dumas et al.   AAPS Journal

Disruption of Kv1.1 N-type inactivation by novel small molecule inhibitors (disinactivators)

(2008) Qiang Lu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular mechanisms of BK channel activation

(2008) J. Cui et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inflammatory pain is enhanced in delta opioid receptor-knockout mice

(2008) Claire Gavériaux-Ruff et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery ofN,N-Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859)

(2008) Bertrand Le Bourdonnec et al.   JOURNAL OF MEDICINAL CHEMISTRY

Surface expression and distribution of voltage-gated potassium channels in neurons (Review)

(2008) Lynn McKeown et al.   MOLECULAR MEMBRANE BIOLOGY

Presynaptic large-conductance calcium-activated potassium channels control synaptic transmission in the superficial dorsal horn of the mouse

(2008) Naoki Furukawa et al.   NEUROSCIENCE LETTERS