Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration
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Title
Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration
Authors
Keywords
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Journal
Molecular Neurodegeneration
Volume 15, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-10-08
DOI
10.1186/s13024-020-00407-2
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Note: Only part of the references are listed.- Prospective longitudinal atrophy in Alzheimer’s disease correlates with the intensity and topography of baseline tau-PET
- (2020) Renaud La Joie et al. Science Translational Medicine
- Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region
- (2020) Kai Schlepckow et al. EMBO Molecular Medicine
- APOE ε4 and the influence of sex, age, vascular risk factors, and ethnicity on cognitive decline
- (2020) Steve R Makkar et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation
- (2020) Michael Ewers et al. EMBO Molecular Medicine
- Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology
- (2019) Marc Suárez-Calvet et al. Molecular Neurodegeneration
- Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
- (2019) Iris E. Jansen et al. NATURE GENETICS
- Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease
- (2019) Oliver Preische et al. NATURE MEDICINE
- Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model
- (2019) Li Zhong et al. Nature Communications
- A Quarter Century of APOE and Alzheimer’s Disease: Progress to Date and the Path Forward
- (2019) Michaël E. Belloy et al. NEURON
- Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
- (2019) Brian W. Kunkle et al. NATURE GENETICS
- TREM2 function impedes tau seeding in neuritic plaques
- (2019) Cheryl E. G. Leyns et al. NATURE NEUROSCIENCE
- Association of Apolipoprotein E ε4 With Medial Temporal Tau Independent of Amyloid-β
- (2019) Joseph Therriault et al. JAMA Neurology
- Effects of APOE -ε4 allele load on brain morphology in a cohort of middle-aged healthy individuals with enriched genetic risk for Alzheimer's disease
- (2018) Raffaele Cacciaglia et al. Alzheimers & Dementia
- CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts
- (2018) Oskar Hansson et al. Alzheimers & Dementia
- TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response
- (2018) Teng Jiang et al. INFLAMMATION
- Apolipoprotein-E (Apoe) ε4 and cognitive decline over the adult life course
- (2018) Mark James Rawle et al. Translational Psychiatry
- Relationship Between CSF Biomarkers of Alzheimer's Disease and Rates of Regional Cortical Thinning in ADNI Data
- (2018) Duygu Tosun et al. JOURNAL OF ALZHEIMERS DISEASE
- New insights into the role of TREM2 in Alzheimer’s disease
- (2018) Maud Gratuze et al. Molecular Neurodegeneration
- Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
- (2018) Samira Parhizkar et al. NATURE NEUROSCIENCE
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations
- (2017) Ronald Lautner et al. Alzheimers Research & Therapy
- Increase of TREM2 during Aging of an Alzheimer’s Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis
- (2017) Matthias Brendel et al. Frontiers in Aging Neuroscience
- APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts
- (2017) Jing Qian et al. PLOS MEDICINE
- Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status
- (2016) Laura Piccio et al. ACTA NEUROPATHOLOGICA
- Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease
- (2016) Juan Domingo Gispert et al. Alzheimers & Dementia
- Early and protective microglial activation in Alzheimer’s disease: a prospective study using18F-DPA-714 PET imaging
- (2016) Lorraine Hamelin et al. BRAIN
- sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers
- (2016) Marc Suárez‐Calvet et al. EMBO Molecular Medicine
- Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease
- (2016) Amanda Heslegrave et al. Molecular Neurodegeneration
- Relative effect of APOE ε4 on neuroimaging biomarker changes across the lifespan
- (2016) Julie Gonneaud et al. NEUROLOGY
- TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice
- (2016) Teng Jiang et al. NEUROPHARMACOLOGY
- Early changes in CSF sTREM2 in dominantly inherited Alzheimers disease occur after amyloid deposition and neuronal injury
- (2016) M. Suarez-Calvet et al. Science Translational Medicine
- APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern
- (2015) Shannon L. Risacher et al. Alzheimers & Dementia
- Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2
- (2015) Clifford R. Jack et al. Alzheimers & Dementia
- Convergent genetic and expression data implicate immunity in Alzheimer's disease
- (2015) Lesley Jones et al. Alzheimers & Dementia
- TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
- (2015) Yaming Wang et al. CELL
- TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models
- (2015) Taylor R. Jay et al. JOURNAL OF EXPERIMENTAL MEDICINE
- APOE genotype and neuroimaging markers of Alzheimer's disease: systematic review and meta-analysis
- (2014) Y. Liu et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
- (2014) G. Kleinberger et al. Science Translational Medicine
- APOE Genotype and Cognitive Change in Young, Middle-Aged, and Older Adults Living in the Community
- (2013) D. Bunce et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Development and assessment of a composite score for memory in the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
- (2012) Paul K. Crane et al. Brain Imaging and Behavior
- Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease
- (2012) Adam S. Fleisher et al. NEUROBIOLOGY OF AGING
- Variant of TREM2 Associated with the Risk of Alzheimer's Disease
- (2012) Thorlakur Jonsson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Alzheimer's Disease Neuroimaging Initiative (ADNI): Clinical characterization
- (2009) R. C. Petersen et al. NEUROLOGY
- Longitudinal Modeling of Age-Related Memory Decline and theAPOEε4 Effect
- (2009) Richard J. Caselli et al. NEW ENGLAND JOURNAL OF MEDICINE
- The association of APOE genotype and cognitive decline in interaction with risk factors in a 65–69 year old community sample
- (2008) Helen Christensen et al. BMC Geriatrics
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