Article
Engineering, Multidisciplinary
Muhammad Asif Rasheed, Sohail Raza, Ali Zohaib, Muhammad Ilyas Riaz, Amina Amin, Muhammad Awais, Sami Ullah Khan, M. Ijaz Khan, Yu-Ming Chu
Summary: The emergence of SARS-CoV-2 in December 2019 in Wuhan has led to a global pandemic. Developing therapeutic agents and vaccines to combat this virus is crucial. This study utilizes bioinformatics to predict B and T cell epitopes of the SARS-CoV-2 spike glycoprotein, potentially leading to a candidate vaccine after further confirmation through immunological assays.
ALEXANDRIA ENGINEERING JOURNAL
(2021)
Article
Environmental Sciences
M. Petala, D. Dafou, M. Kostoglou, Th Karapantsios, E. Kanata, A. Chatziefstathiou, F. Sakaveli, K. Kotoulas, M. Arsenakis, E. Roilides, T. Sklaviadis, S. Metallidis, A. Papa, E. Stylianidis, A. Papadopoulos, N. Papaioannou
Summary: Detection of SARS-CoV-2 in sewage is used as an early warning indicator of virus spreading in communities, but the accuracy of quantitative measurements may be affected by the adsorption of virus fragments onto suspended solids in wastewater. Factors such as the presence of other dissolved chemicals can influence the capacity of adsorption. The research develops a physicochemical model to rationalize the quantitative measurements of viral fragments in sewage, with the ratio of specific absorption over dissolved oxygen showing the highest correlation with viral copies.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Mohammed Hakim Jafferali, Kasra Khatami, Merve Atasoy, Madeleine Birgersson, Cecilia Williams, Zeynep Cetecioglu
Summary: Wastewater-based epidemiology provides a cost-effective approach for testing SARS-CoV-2 virus in large populations and can serve as an early warning system for pandemic spread. Efficient concentration methods and suitable reference viruses are essential for reliable detection in municipal wastewater. Studies show that the modified ultrafiltration-based method has higher recovery rates and efficiency for detecting SARS-CoV-2, with ultracentrifugation being the most effective method for detecting the virus in wastewater.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Multidisciplinary Sciences
Syed Hani Abidi, Nahlah Makki Almansour, Daulet Amerzhanov, Khaled S. Allemailem, Wardah Rafaqat, Mahmoud A. A. Ibrahim, Philip la Fleur, Martin Lukac, Syed Ali
Summary: Researchers have identified 12 drugs that show strong interactions with the helicase protein of SARS-CoV-2 through in silico approaches. Among these drugs, posaconazole and grazoprevir exhibit the most favorable binding energy. The potent interactions of posaconazole and grazoprevir with conserved amino acids across human coronaviruses suggest their potential effectiveness against SARS-CoV-2.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Weizheng Liang, Xiushen Li, Hao Wang, Kechao Nie, Qingxue Meng, Junli He, Chunfu Zheng
Summary: This study investigates the mechanism of puerarin in the treatment of patients with EHF/SARS-CoV-2 using network pharmacology and bioinformatics. The results suggest that puerarin may reduce excessive immune responses and inflammation through the regulation of NF-B, TNF, and HIF-1 signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Seham S. El-hawary, Taha F. S. Ali, Sara O. Abo El-Ela, Ahlam Elwekeel, Usama Ramadan Abdelmohsen, Asmaa Owis
Summary: This study identifies tricin from Livistona decipiens as a potential lead compound for inhibiting the COVID-19 virus main protease. In vitro experiments show that the alcoholic extract of the plant inhibits SARS-CoV-2, indicating its potential as an anti-COVID-19 agent with low toxicity. The study provides scientific basis for further in vivo testing and highlights the importance of finding affordable, safe, and natural sources for treating COVID-19.
Article
Biochemistry & Molecular Biology
Priyashi Rao, Arpit Shukla, Paritosh Parmar, Rakesh M. Rawal, Baldev V. Patel, Meenu Saraf, Dweipayan Goswami
Summary: This article introduces the viral protein structure of SARS-CoV-2 and the research on finding potential drugs. Among them, 3CL(pro) is considered an attractive antiviral drug, and Flaviolin is proposed as a potential effective inhibitor.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Medicine, Research & Experimental
Augusto Amici, Daniela Pozzi, Cristina Marchini, Giulio Caracciolo
Summary: The integration of the lipid nanoparticle (LNP)-protein corona represents a groundbreaking approach in vaccine development against current and future SARS-CoV-2 variants. It offers a universal platform that can be adapted to combat unknown viruses and has the potential to address viral threats, cancer, and genetic diseases. Collaborative efforts and safety assessments are key in translating this transformative workflow from the laboratory to clinical reality.
MOLECULAR PHARMACEUTICS
(2023)
Article
Microbiology
Simoun Icho, Edurne Rujas, Krithika Muthuraman, John Tam, Huazhu Liang, Shelby Landreth, Mingmin Liao, Darryl Falzarano, Jean-Philippe Julien, Roman A. Melnyk
Summary: This study highlights the importance of the endosomal route of entry for SARS-CoV-2 and provides a rationale for the generation of successful intervention strategies against this virus that combine inhibitors of both entry pathways.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Public, Environmental & Occupational Health
Itay Bar-Or, Karin Yaniv, Marilou Shagan, Eden Ozer, Merav Weil, Victoria Indenbaum, Michal Elul, Oran Erster, Ella Mendelson, Batya Mannasse, Rachel Shirazi, Esti Kramarsky-Winter, Oded Nir, Hala Abu-Ali, Zeev Ronen, Ehud Rinott, Yair E. Lewis, Eran Friedler, Eden Bitkover, Yossi Paitan, Yakir Berchenko, Ariel Kushmaro
Summary: SARS-CoV-2, an RNA virus, has had a significant impact on affected countries' healthcare systems, economies, and societies in the past 8 months. Wastewater monitoring may serve as an efficient tool for epidemiological surveillance of the virus in large populations.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Engineering, Environmental
Atikah Mohd Nasir, Nuha Awang, Siti Khadijah Hubadillah, Juhana Jaafar, Mohd Hafiz Dzarfan Othman, Wan Norhayati Wan Salleh, Ahmad Fauzi Ismail
Summary: This review paper discusses the powerful virus disinfection capability of photocatalytic technology in wastewater and its potential as a solution in combating the transmission of viruses like SARS-CoV-2. Along with examining the advantages and limitations of existing oxidation processes, a wide spectrum of virus degradation by various photocatalysts is considered to understand the potential mechanism for deactivating deadly viruses, with comprehensive discussions on challenges and future perspectives.
JOURNAL OF WATER PROCESS ENGINEERING
(2021)
Review
Biochemistry & Molecular Biology
Dharmendra Kumar Yadav, Desh Deepak Singh, Ihn Han, Yogesh Kumar, Eun-Ha Choi
Summary: The ongoing SARS-CoV-2 pandemic poses a serious threat to global public health with no effective treatment available yet. Various pharmaceutical approaches have been proposed to prevent and treat SARS-CoV-2 infection, including inhibitors of TMPRSS2 and ACE2, as well as antiviral drugs like remdesivir, lopinavir, ritonavir, arbidol, and favipiravir. These treatments have shown to reduce the spread of SARS-CoV-2 and mortality associated with COVID-19.
Article
Biophysics
Santheraleka Ramanathan, Subash C. B. Gopinath, Zool Hilmi Ismail, M. K. Md Arshad, Prabakaran Poopalan
Summary: The strategy using a 10 μm gap-sized gold interdigitated electrode (AuIDE) with silane-modified diamond has shown enhanced detection of SARS-CoV-2 nucleocapsid protein (NCP). Structural analyses confirmed the cubic crystalline nature of the chemically modified diamond, with XPS analysis showing a strong interaction of carbon element. FTIR analysis revealed major intrinsic bondings between elements, making the aptasensing platform highly recommended for early diagnosis of SARS-CoV-2 infection.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Nutrition & Dietetics
Fang-Ju Cheng, Thanh-Kieu Huynh, Chia-Shin Yang, Dai-Wei Hu, Yi-Cheng Shen, Chih-Yen Tu, Yang-Chang Wu, Chih-Hsin Tang, Wei-Chien Huang, Yeh Chen, Chien-Yi Ho
Summary: The study demonstrates that hesperetin and hesperidin have the potential to inhibit SARS-CoV-2 infection by blocking the cellular entry process. They can reduce the binding of the S protein to the cellular receptor and decrease the expression of related proteins, thereby inhibiting the viral infection.
Review
Pharmacology & Pharmacy
Mohana Das, Manish Kumar, Abhishek Jha, D. R. Madhukiran, Kanchan Bharti, Shomedeep Mondal, Brahmeshwar Mishra
Summary: Coronaviruses are a group of RNA viruses that primarily infect the respiratory system. Recent outbreaks of Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome Coronaviruses have highlighted the urgent need for new screening models to identify potential drugs against COVID-19. The global spread of the SARS-CoV-2 virus has led to a massive pandemic with no successful treatment currently available.
CURRENT DRUG TARGETS
(2021)
Review
Dentistry, Oral Surgery & Medicine
Thodur Madapusi Balaji, Saranya Varadarajan, Raghunathan Jagannathan, Archana A. Gupta, A. Thirumal Raj, Shankargouda Patil, Hammam Ibrahim Fageeh, Hytham N. Fageeh
Summary: The study aimed to compare melatonin levels in periodontitis and healthy states, finding lower levels in periodontitis patients but with caution due to overall low quality of the included studies.
Article
Biology
Pradeep Kumar Yadalam, Indhu Krishnamurthi, R. Srimathi, Khalid J. Alzahrani, Maryam H. Mugri, Mohammed Sayed, Khalid H. Almadi, Mazen F. Alkahtany, Mohammad Almagbol, Shilpa Bhandi, Hosam Ali Baeshen, A. Thirumal Raj, Shankargouda Patil
Summary: This study identified a hub protein and gene involved in the epithelial-mesenchymal transition of Hertwig's Epithelial Root Sheath (HERS) using an in-silico systems biology approach. The ligand isoetharine was found to be a potential drug for periodontal regeneration.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biology
Shankargouda Patil, Hytham N. Fageeh, Hammam Ibrahim Fageeh, Wael Ibraheem, Abdulrahman Saleh Alshehri, Ashraf Al-Brakati, Salem Almoammar, Mohammad Almagbol, Harisha Dewan, Samar Saeed Khan, Hosam Ali Baeshen, Vikrant R. Patil, A. Thirumal Raj, Shilpa Bhandi
Summary: Gingival mesenchymal stem cells (GMSCs) have significant regenerative potential. Preconditioning them with hypoxia can enhance the secretion of neurotrophic factors, leading to neuronal lineage differentiation.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Shekhar Gupta, Bharti Gupta, Bhagwandas K. Motwani, Sultan Binalrimal, Waseem Radwan, Ali Robaian, Bassam Zidane, Mohammed Hussain Dafer Al Wadei, Vishnu Priya Veeraraghavan, Shilpa Bhandi, A. Thirumal Raj, Shankargouda Patil
Summary: This study compares different etching techniques and finds that hydrofluoric acid etching can create larger irregular roughness, resulting in the highest bond strength and improvement for dental implants.
Review
Medicine, General & Internal
A. Thirumal Raj, Kamran Habib Awan, Shankargouda Patil, Peter Morgan, Saman Warnakulasuriya
Summary: Oral warty dyskeratoma is a rare benign lesion that can be misdiagnosed as carcinoma due to its clinical and histopathological resemblance. The most common site of occurrence is the alveolar ridge, and tobacco is the most commonly associated risk factor. Lack of molecular data hinders the understanding of the etiopathogenesis of this lesion.
Article
Medicine, General & Internal
Samar Saeed Khan, Manisha Tijare, Sowmya Kasetty, Megha Jain, Ahmed Alamoudi, Hammam Ahmed Bahammam, Sarah Ahmed Bahammam, Maha A. Bahammam, Saranya Varadarajan, A. Thirumal Raj, Shankargouda Patil
Summary: The study compares different deparaffinization methods and DNA isolation techniques, and evaluates the effectiveness of different storing methods for archived OSCC samples in terms of DNA quantity, quality, and PCR amplification of the P53 gene. It finds that xylene deparaffinization and the conventional phenol-chloroform DNA isolation method are effective for obtaining suitable DNA, and samples fixed in formalin overnight and embedded in wax yield better quality and quantity DNA.
Article
Health Care Sciences & Services
Pradeep Kumar Yadalam, V Kalaivani, Hammam Ibrahim Fageeh, Wael Ibraheem, Manea Musa Al-Ahmari, Samar Saeed Khan, Zeeshan Heera Ahmed, Hesham H. Abdulkarim, Hosam Ali Baeshen, Thodur Madapusi Balaji, Shilpa Bhandi, A. Thirumal Raj, Shankargouda Patil
Summary: Periodontal disease is an inflammatory disease caused by infection, leading to destruction of tooth-supporting tissues. Effective management involves controlling plaque and using non-surgical interventions. Recent studies have explored novel approaches for treatment.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Shilpa Bhandi, Shankargouda Patil, Nezar Boreak, Hitesh Chohan, Abdulaziz S. AbuMelha, Mazen F. Alkahtany, Khalid H. Almadi, Thilla Sekar Vinothkumar, A. Thirumal Raj, Luca Testarelli
Summary: Different intracanal medicaments have varying effects on the viability and survival of dental pulp stem cells at different doses and exposure times. Calcium hydroxide and triamcinolone promote cell viability, while doxycycline, potassium iodide, and glutaraldehyde increase cell death.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sivasankari Thilagar, Ramakrishnan Theyagarajan, Maryam H. Mugri, Hammam Ahmed Bahammamd, Sarah Ahmed Bahammam, Maha A. Bahammam, Pradeep Kumar Yadalam, A. Thirumal Raj, Shilpa Bhandi, Shankargouda Patil
Summary: Periodontal therapy can improve periodontal conditions and have a significant impact on the clinical Disease Activity Score and C-reactive protein levels in patients with rheumatoid arthritis. However, its effect on anti-citrullinated protein antibody and rheumatoid factor levels is not significant.
INTERNATIONAL DENTAL JOURNAL
(2022)
Article
Medicine, Research & Experimental
Santosh Kumar Goje, Bhavna Dave, Ali Abdel-Halim Abdel-Azim Hassan, Sarah Ahmed Bahammam, Hammam Ahmed Bahammam, Bassam Zidane, Abdulrahman Alshehri, Wael Awadh, Shilpa Bhandi, A. Thirumal Raj, Shankargouda Patil
Summary: This study evaluated the mesiodistal root angulation of permanent lateral incisors, canines, and first molars in 296 children aged 6-14 years and found a moderate correlation between the movements of these teeth in boys and girls aged 6-12 years.
MEDICAL SCIENCE MONITOR
(2022)
Article
Health Care Sciences & Services
Shankargouda Patil, Ahmed Alamoudi, Bassam Zidane, Khalid J. Alzahrani, Fuad M. Alzahrani, Hamsa Jameel Banjer, Rodolfo Reda, Thodur Madapusi Balaji, Shilpa Bhandi, A. Thirumal Raj, Luca Testarelli
Summary: This study investigated the effects of melatonin on the proliferation and differentiation of dental pulp stem cells (DPSCs). The results showed that melatonin at concentrations of 1 μM and 25 μM stimulated the differentiation of DPSCs into osteocytes, but had little influence on adipogenic and chondrogenic differentiation.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Letter
Oncology
Arthisri Anandhi Sekar, Vishnu Priya Veeraraghavan, A. Thirumal Raj, Shankargouda Patil
Review
Medicine, General & Internal
G. B. Protyusha, B. Kavitha, B. Sivapathasundharam, P. Manodh, A. Thirumal Raj, Snehashish Ghosh, Safal Dhungel
Summary: This article presents a case of COVID-associated mucormycosis in a patient with toothache in the maxilla, possibly with mild COVID-19 symptoms. Mucormycosis, especially the rhinocerebral type, is strongly associated with COVID-19, especially in immunocompromised patients. This report highlights the importance of awareness and appropriate management of mucormycosis in the maxillofacial region.
CLINICAL CASE REPORTS
(2023)
Article
Health Care Sciences & Services
Prishita Mehta, Rashmi Bhavasar, Namratha A. Ajith, Rahul P. Bhavsar, Maha A. Bahammam, Mohammed Mousa H. Bakri, Khalid J. Alzahrani, Ahmad A. Alghamdi, Ibrahim F. Halawani, Shilpa Bhandi, A. Thirumal Raj, Shankargouda Patil
Summary: Curcumin gel intervention resulted in significant changes in cytomorphometric analysis and Candida colonization in tobacco users.
Article
Medicine, General & Internal
Preethi Shankar, Burnice Nalina Kumari Chellathurai, S. Ashok Kumar, Jaideep Mahendra, Maryam H. Mugri, Mohammed Sayed, Mohammad Almagbol, Mohammed Hussain Dafer Al Wadei, Rajaram Vijayalakshmi, Namasivayam Ambalavanan, A. Thirumal Raj, Shankargouda Patil
Summary: This study assessed the level of comfort and anxiety in patients during the administration of local anesthesia using needleless jet anesthesia (JA) compared to a conventional syringe (CS) in periodontal surgery. The results showed that patients reported greater comfort and less anxiety with JA. Jet injectors have potential importance in providing local anesthesia in periodontal surgery.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)
