Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into Cells
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Title
Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into Cells
Authors
Keywords
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Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 66, Issue 7, Pages -
Publisher
American Society for Microbiology
Online
2022-06-15
DOI
10.1128/aac.00439-22
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Note: Only part of the references are listed.- Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity
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- SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development
- (2021) Nicholas Murgolo et al. PLoS Pathogens
- Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity
- (2021) Markus Hoffmann et al. EBioMedicine
- Clofazimine broadly inhibits coronaviruses including SARS-CoV-2
- (2021) Shuofeng Yuan et al. NATURE
- COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
- (2021) Toni M. Delorey et al. NATURE
- Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7
- (2021) Nicholas G. Davies et al. NATURE
- Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization
- (2021) Delphine Planas et al. NATURE
- Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2
- (2021) Tia A. Tummino et al. SCIENCE
- The TMPRSS2 Inhibitor Nafamostat Reduces SARS-CoV-2 Pulmonary Infection in Mouse Models of COVID-19
- (2021) Kun Li et al. mBio
- Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers
- (2021) Edurne Rujas et al. Nature Communications
- Strategies to target SARS-CoV-2 entry and infection using dual mechanisms of inhibition by acidification inhibitors
- (2021) Chaitra Prabhakara et al. PLoS Pathogens
- Current status of therapeutic monoclonal antibodies against SARS-CoV-2
- (2021) Sanjeev Kumar et al. PLoS Pathogens
- Characterization of the Modulatory Effect of Hydroxychloroquine on ACE2 Activity: New Insights in relation to COVID-19
- (2021) Juan E. Tichauer et al. Biomed Research International
- COVID antiviral pills: what scientists still want to know
- (2021) Heidi Ledford NATURE
- Dual inhibition of TMPRSS2 and Cathepsin B prevents SARS-CoV-2 infection in iPS cells
- (2021) Rina Hashimoto et al. Molecular Therapy-Nucleic Acids
- A new coronavirus associated with human respiratory disease in China
- (2020) Fan Wu et al. NATURE
- A pneumonia outbreak associated with a new coronavirus of probable bat origin
- (2020) Peng Zhou et al. NATURE
- A Novel Coronavirus from Patients with Pneumonia in China, 2019
- (2020) Na Zhu et al. NEW ENGLAND JOURNAL OF MEDICINE
- The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2
- (2020) Nature Microbiology
- Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2
- (2020) Qihui Wang et al. CELL
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
- (2020) Markus Hoffmann et al. CELL
- Structural basis of receptor recognition by SARS-CoV-2
- (2020) Jian Shang et al. NATURE
- SynergyFinder 2.0: visual analytics of multi-drug combination synergies
- (2020) Aleksandr Ianevski et al. NUCLEIC ACIDS RESEARCH
- Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells
- (2020) Shutoku Matsuyama et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays
- (2020) Katharine H. D. Crawford et al. Viruses-Basel
- Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
- (2020) Xiuyuan Ou et al. Nature Communications
- Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro
- (2020) Jia Liu et al. Cell Discovery
- Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus
- (2020) Bette Korber et al. CELL
- Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2
- (2020) Markus Hoffmann et al. NATURE
- Distinct conformational states of SARS-CoV-2 spike protein
- (2020) Yongfei Cai et al. SCIENCE
- Is hydroxychloroquine beneficial for COVID-19 patients?
- (2020) Xing Li et al. Cell Death & Disease
- Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant
- (2020) Leonid Yurkovetskiy et al. CELL
- Identification of required host factors for SARS-CoV-2 infection in human cells
- (2020) Zharko Daniloski et al. CELL
- Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19
- (2020) Wesley H. Self et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Cysteine Cathepsins and their Extracellular Roles: Shaping the Microenvironment
- (2019) Eva Vidak et al. Cells
- Consensus and variations in cell line specificity among human metapneumovirus strains
- (2019) Naganori Nao et al. PLoS One
- Host-directed therapies for bacterial and viral infections
- (2017) Stefan H. E. Kaufmann et al. NATURE REVIEWS DRUG DISCOVERY
- Protease inhibitors targeting coronavirus and filovirus entry
- (2015) Yanchen Zhou et al. ANTIVIRAL RESEARCH
- Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research
- (2013) Graham Simmons et al. ANTIVIRAL RESEARCH
- Different host cell proteases activate the SARS-coronavirus spike-protein for cell–cell and virus–cell fusion
- (2011) Graham Simmons et al. VIROLOGY
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