Carrageenans as Broad-Spectrum Microbicides: Current Status and Challenges

Antiviral bioactivity of renewable polysaccharides against Varicella Zoster

(2019) Eiman Abu-Galiyun et al.   CELL CYCLE

Efficacy of a Carrageenan gel Against Transmission of Cervical HPV (CATCH): interim analysis of a randomized, double-blind, placebo-controlled, phase 2B trial

(2018) S. Magnan et al.   CLINICAL MICROBIOLOGY AND INFECTION

Heparan sulfate is an important mediator of Ebola virus infection in polarized epithelial cells

(2018) Manasi Tamhankar et al.   Virology Journal

Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo

(2018) Nina Derby et al.   Nature Communications

A VP1 mutation acquired during an enterovirus 71 disseminated infection confers heparan sulfate binding ability and modulates ex vivo tropism

(2018) Eirini D. Tseligka et al.   PLoS Pathogens

Environmentally Friendly Valorization of Solieria filiformis (Gigartinales, Rhodophyta) from IMTA Using a Biorefinery Concept

(2018) Ana Peñuela et al.   Marine Drugs

In VitroExposure to PC-1005 and Cervicovaginal Lavage Fluid from Women Vaginally Administered PC-1005 Inhibits HIV-1 and HSV-2 Infection in Human Cervical Mucosa

(2016) Guillermo Villegas et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vitro inhibition of human papillomavirus following use of a carrageenan-containing vaginal gel

(2016) Akiva P. Novetsky et al.   GYNECOLOGIC ONCOLOGY

First-in-Human Trial of MIV-150 and Zinc Acetate Coformulated in a Carrageenan Gel

(2016) Barbara A. Friedland et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Characterization of in vitro dengue virus resistance to carrageenan

(2016) Laura B. Talarico et al.   JOURNAL OF MEDICAL VIROLOGY

Inhibition of Human Metapneumovirus Binding to Heparan Sulfate Blocks Infection in Human Lung Cells and Airway Tissues

(2016) Edita M. Klimyte et al.   JOURNAL OF VIROLOGY

The Experimental Research (In Vitro) of Carrageenans and Fucoidans to Decrease Activity of Hantavirus

(2016) Stanislav N. Pavliga et al.   Food and Environmental Virology

MIV-150/Zinc Acetate Gel Inhibits Cell-Associated Simian-Human Immunodeficiency Virus Reverse Transcriptase Infection in a Macaque Vaginal Explant Model

(2015) Patrick Barnable et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multipurpose Prevention Approaches with Antiretroviral-Based Formulations

(2015) Ninochka Jean-Pierre et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Griffithsin and Carrageenan Combination To Target Herpes Simplex Virus 2 and Human Papillomavirus

(2015) Keith Levendosky et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Partial and total C-6 oxidation of gelling carrageenans. Modulation of the antiviral activity with the anionic character

(2015) Vanina A. Cosenza et al.   CARBOHYDRATE POLYMERS

Human papillomavirus capsids preferentially bind and infect tumor cells

(2015) Rhonda C. Kines et al.   INTERNATIONAL JOURNAL OF CANCER

λ-Carrageenan P32 Is a Potent Inhibitor of Rabies Virus Infection

(2015) Zhaochen Luo et al.   PLoS One

Antiviral activity of lambda-carrageenan prepared from red seaweed (Gigartina skottsbergii) against BoHV-1 and SuHV-1

(2015) Jésica V. Diogo et al.   RESEARCH IN VETERINARY SCIENCE

Antiviral Potential of Algae Polysaccharides Isolated from Marine Sources: A Review

(2015) Azin Ahmadi et al.   Biomed Research International

Non-Clinical Safety Evaluation of Intranasal Iota-Carrageenan

(2015) Alexandra Hebar et al.   PLoS One

The Intranasal Application of Zanamivir and Carrageenan Is Synergistically Active against Influenza A Virus in the Murine Model

(2015) Martina Morokutti-Kurz et al.   PLoS One

In vitro and in vivo evaluation of two carrageenan-based formulations to prevent HPV acquisition

(2014) Aixa Rodríguez et al.   ANTIVIRAL RESEARCH

Assessment of the inhibition of Dengue virus infection by carrageenan via real-time monitoring of cellular oxygen consumption rates within a microfluidic device

(2014) Shih-Hao Huang et al.   Biomicrofluidics

Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1

(2014) M. Carolina Artuso et al.   MICROBIAL PATHOGENESIS

A MIV-150/Zinc Acetate Gel Inhibits SHIV-RT Infection in Macaque Vaginal Explants

(2014) Patrick Barnable et al.   PLoS One

Changes in antiviral susceptibility to entry inhibitors and endocytic uptake of dengue-2 virus serially passaged in Vero or C6/36 cells

(2014) Eliana G. Acosta et al.   VIRUS RESEARCH

Carrageenan nasal spray in virus confirmed common cold: individual patient data analysis of two randomized controlled trials

(2014) Martin Koenighofer et al.   MULTIDISCIPLINARY RESPIRATORY MEDICINE

A Modified Zinc Acetate Gel, a Potential Nonantiretroviral Microbicide, Is Safe and Effective against Simian-Human Immunodeficiency Virus and Herpes Simplex Virus 2 InfectionIn Vivo

(2013) Jessica Kenney et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multipurpose prevention technologies: Products in development

(2013) David R. Friend et al.   ANTIVIRAL RESEARCH

Polyanionic Candidate Microbicides Accelerate the Formation of Semen-Derived Amyloid Fibrils to Enhance HIV-1 Infection

(2013) Suiyi Tan et al.   PLoS One

Efficacy of a Carrageenan nasal spray in patients with common cold: a randomized controlled trial

(2013) Martin Ludwig et al.   RESPIRATORY RESEARCH

Preparation and properties of a papillomavirus infectious intermediate and its utility for neutralization studies

(2013) Joshua W. Wang et al.   VIROLOGY

A Single Dose of a MIV-150/Zinc Acetate Gel Provides 24 h of Protection Against Vaginal Simian Human Immunodeficiency Virus Reverse Transcriptase Infection, with More Limited Protection Rectally 8–24 h After Gel Use

(2012) Jessica Kenney et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Prevention of human enterovirus 71 infection by kappa carrageenan

(2012) Ya-Huang Chiu et al.   ANTIVIRAL RESEARCH

Lessons learned from a double-blind randomised placebo-controlled study with a iota-carrageenan nasal spray as medical device in children with acute symptoms of common cold

(2012) Tamas Fazekas et al.   BMC Complementary and Alternative Medicine

Preparation and potentialin vivoanti-influenza virus activity of low molecular-weight κ-carrageenans and their derivatives

(2012) Fengxiang Tang et al.   JOURNAL OF APPLIED POLYMER SCIENCE

The Antiviral Activities and Mechanisms of Marine Polysaccharides: An Overview

(2012) Wei Wang et al.   Marine Drugs

Risk Factors for HIV and Unprotected Anal Intercourse among Men Who Have Sex with Men (MSM) in Almaty, Kazakhstan

(2012) Mark Berry et al.   PLoS One

Application and removal of polyanionic microbicide compounds enhances subsequent infection by HIV-1

(2012) Vanessa Pirrone et al.   Virology Journal

Structure and anti-influenza A (H1N1) virus activity of three polysaccharides from Eucheuma denticulatum

(2012) Guangli Yu et al.   Journal of Ocean University of China

Zinc Acetate/Carrageenan Gels Exhibit Potent ActivityIn Vivoagainst High-Dose Herpes Simplex Virus 2 Vaginal and Rectal Challenge

(2011) José A. Fernández-Romero et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The rise and fall of polyanionic inhibitors of the human immunodeficiency virus type 1

(2011) Vanessa Pirrone et al.   ANTIVIRAL RESEARCH

In vitro inhibitory effect of carrageenan oligosaccharide on influenza A H1N1 virus

(2011) Wei Wang et al.   ANTIVIRAL RESEARCH

The effectiveness of Carraguard, a vaginal microbicide, in protecting women against high-risk human papillomavirus infection

(2011) Dianne Marais et al.   ANTIVIRAL THERAPY

Differential inhibition of dengue virus infection in mammalian and mosquito cells by iota-carrageenan

(2011) L. B. Talarico et al.   JOURNAL OF GENERAL VIROLOGY

Effect of Pap Smear Collection and Carrageenan on Cervicovaginal Human Papillomavirus-16 Infection in a Rhesus Macaque Model

(2011) Jeffrey N. Roberts et al.   JNCI-Journal of the National Cancer Institute

The Nonnucleoside Reverse Transcriptase Inhibitor MIV-150 in Carrageenan Gel Prevents Rectal Transmission of Simian/Human Immunodeficiency Virus Infection in Macaques

(2011) R. Singer et al.   JOURNAL OF VIROLOGY

An Antiretroviral/Zinc Combination Gel Provides 24 Hours of Complete Protection against Vaginal SHIV Infection in Macaques

(2011) Jessica Kenney et al.   PLoS One

Acceptability of Carraguard Vaginal Microbicide Gel among HIV-Infected Women in Chiang Rai, Thailand

(2011) Sara J. Whitehead et al.   PLoS One

Emergence of Herpes Simplex Virus-1 Syncytial Variants With Altered Virulence for Mice After Selection With a Natural Carrageenan

(2011) Cecilia G. Mateu et al.   SEXUALLY TRANSMITTED DISEASES

HIV genital shedding and safety of Carraguard use by HIV-infected women: a crossover trial in Thailand

(2010) Catherine A McLean et al.   AIDS

Expanded safety and acceptability of the candidate vaginal microbicide Carraguard® in South Africa

(2010)   CONTRACEPTION

Red microalgal cell-wall polysaccharides: biotechnological aspects

(2010) Shoshana (Malis) Arad et al.   CURRENT OPINION IN BIOTECHNOLOGY

Mucosal Human Defensins 5 and 6 Antagonize the Anti-HIV Activity of Candidate Polyanion Microbicides

(2010) Jian Ding et al.   Journal of Innate Immunity

Iota-Carrageenan Is a Potent Inhibitor of Influenza A Virus Infection

(2010) Andreas Leibbrandt et al.   PLoS One

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

(2010) Q. Abdool Karim et al.   SCIENCE

No Increase in Cervicovaginal Proinflammatory Cytokines After Carraguard Use in a Placebo-Controlled Randomized Clinical Trial

(2009) Liesbeth JM Bollen et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

A Randomized, Placebo-Controlled Trial to Assess the Safety and Acceptability of Use of Carraguard Vaginal Gel by Heterosexual Couples in Thailand

(2009) PETER H. KILMARX et al.   SEXUALLY TRANSMITTED DISEASES

Short Communication: Enhancement of HIV Infection by Cellulose Sulfate

(2008) Wang Tao et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Focus on antivirally active sulfated polysaccharides: From structure–activity analysis to clinical evaluation

(2008) Tuhin Ghosh et al.   GLYCOBIOLOGY

The Cationic Properties of SEVI Underlie Its Ability To Enhance Human Immunodeficiency Virus Infection

(2008) N. R. Roan et al.   JOURNAL OF VIROLOGY

Efficacy of Carraguard for prevention of HIV infection in women in South Africa: a randomised, double-blind, placebo-controlled trial

(2008) Stephanie Skoler-Karpoff et al.   LANCET

Lack of Effectiveness of Cellulose Sulfate Gel for the Prevention of Vaginal HIV Transmission

(2008) Lut Van Damme et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of Carraguard®-Based Microbicides In Vivo Despite Variable In Vitro Activity

(2008) Stuart G. Turville et al.   PLoS One

Effectiveness of Cellulose Sulfate Vaginal Gel for the Prevention of HIV Infection: Results of a Phase III Trial in Nigeria

(2008) Vera Halpern et al.   PLoS One

Iota-Carrageenan is a potent inhibitor of rhinovirus infection

(2008) Andreas Grassauer et al.   Virology Journal