Article
Polymer Science
Hongwei Li, Martin Fauquignon, Marie Haddou, Christophe Schatz, Jean-Paul Chapel
Summary: The study systematically investigated the surface activity of polyelectrolyte complex (PECs) suspensions as a function of the molar charge ratio Z. It was found that the surface tension of PECs decreases as the system approaches charge stoichiometry. The behavior of complex systems at stoichiometry is informative about the physical nature of the complexes.
Article
Chemistry, Multidisciplinary
Sagun Jonchhe, Wei Pan, Pravin Pokhrel, Hanbin Mao
Summary: This study found that in Tau protein condensates, the halftime of the liquid-to-solid transition is affected by anions' solvation energy according to the Hofmeister series. Charged groups facilitate the transition, similar to the Hofmeister effect, while hydrophobic alkyl chains and aromatic rings inhibit it. These findings not only elucidate the driving force of the liquid-to-solid transition in Tau condensates but also provide guidelines for designing small molecules to modulate this important transition.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Pharmacology & Pharmacy
Adrian Krummnow, Andreas Danzer, Kristin Voges, Stefanie Dohrn, Samuel O. Kyeremateng, Matthias Degenhardt, Gabriele Sadowski
Summary: This study provides a thermodynamic analysis of the release mechanism of amorphous solid dispersions (ASDs) composed of ritonavir and poly(vinylpyrrolidone-co-vinyl acetate). The observed release behavior is explained based on the quantitative thermodynamic phase diagram predicted by PC-SAFT. Liquid-liquid phase separation in the dissolution medium and amorphous phase separation in the ASD are linked back to the same thermodynamic origin, and they occur simultaneously in the investigated system.
Article
Chemistry, Multidisciplinary
Im Kyung Han, Jihoon Han, Youn Soo Kim
Summary: This study compared the responses of two different types of zwitterionic polymers to Hofmeister anions and found significant differences in their aggregation behavior in salt solutions. The results showed that poly(SBVI) exhibited salting-in and salting-out effects depending on the type and concentration of salt, while poly(SBMA) only showed the anti-polyelectrolyte effect.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Jiani Niu, Cindy Qiu, Nicholas L. Abbott, Samuel H. Gellman
Summary: Liquid-liquid phase separation is a phenomenon where distinct liquid phases with different compositions spontaneously form, which has been known in chemical systems for a long time and recently recognized in cell biology as well. By using synthetic peptides and total yeast RNA, researchers have investigated the factors underlying phase separation and discovered the importance of Coulombic complementarity and the specific type of cationic moiety in the peptides.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Cell Biology
Yuxuan Li, Taoyu Chen, Kaiqing You, Tao Peng, Tingting Li
Summary: Life is composed of functional biomolecules, such as proteins and nucleic acids, which can undergo liquid-liquid phase separation to form liquid droplets. These droplets can transition into solid-like biomolecular condensates, which exist in physiological and pathological conditions. The formation of solid-like condensates, also known as detergent-insoluble aggregates, is not fully understood. Recent research has shown that the transition from a liquid to solid phase is crucial for the formation of these condensates. This review summarizes the sequence regions and solution conditions that impact the phase transition, as well as the methods used to study solid phase components.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jun-Chao Liu, Yong Ai, Qin Liu, Yi-Piao Zeng, Xiao-Gang Chen, Hui-Peng Lv, Ren-Gen Xiong, Wei-Qiang Liao
Summary: This article presents a solid-liquid crystal biphasic ferroelectric material, cholestanyl 4-X-benzoate (4X-CB, X = Cl, Br, and I), that exhibits biferroelectricity in both the solid and liquid crystal phases. The liquid crystal phase of 4X-CB is identified as a cholesteric phase with a helical structure, different from the ordinary chiral smectic ferroelectric liquid crystal phase. Furthermore, the spontaneous polarization of 4X-CB in both phases can be regulated by different halogen substitutions. It is suggested that 4X-CB is the first ferroelectric material with tunable biferroelectricity, providing a feasible case for the performance optimization of solid-liquid crystal biphasic ferroelectrics.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Meng Wang, Wenchao Gao, Fengren Cao, Liang Li
Summary: This study reports a new method to obtain highly crystalline perovskite films by adding ethylamine iodide and proposes a novel working mechanism for alkyl amine additives in the perovskite crystallization process. The results indicate that the additive affects the solid-state transition process from the intermediate phase to the final phase.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Physical
Bhaskar Chandra Khan, Prabir K. Mukherjee
Summary: In this study, the isotropic to smectic-A phase transition in taper-shaped liquid crystal was described using Landau theory. Experimental observations showed electro-optical switching and a polarization peak similar to ferroelectric behavior in the smectic phase of taper-shaped liquid crystal. Phenomenological theory was used to explain this behavior, and the switched polarization behavior with respect to temperature, electric field, and frequency was described for both isotropic and smectic-A phases. Additionally, the temperature dependence of the switching time was discussed, showing qualitative agreement between theoretical and experimental results.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Yu Su, Xiao-Dong Wang, Qingmei Su, Gaohui Du, Yang Ren, Kenny Stahl, Qingping Cao, Dongxian Zhang, Jian-Zhong Jiang
Summary: Experimental evidence reveals the existence of an intermediate liquid during solid-solid phase transitions, attributed to the melting of low-melting-point crystalline phases rather than elastic stress energy. This phenomenon could be a general feature in multicomponent alloys and triggers more studies on the microscopic mechanism of solid-solid phase transitions via an intermediate liquid.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Review
Biochemistry & Molecular Biology
Beata Szala-Mendyk, Tien Minh Phan, Priyesh Mohanty, Jeetain Mittal
Summary: Membraneless organelles, or biomolecular condensates, have important cellular functions and their dysfunction is related to cancer and neurodegeneration. Liquid-liquid phase separation is a possible mechanism for the formation of biomolecular condensates. Liquid-like condensates can undergo liquid-to-solid phase transitions, leading to the formation of amyloid structures. Experimental studies on the microscopic details of these transitions present a challenge, but computational models can provide valuable insights. This review highlights recent biophysical studies on the phase transitions of proteins and summarizes the range of computational models used to study protein aggregation and phase separation.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Abraham Garcia-Jimenez, Angelica Roman-Guerrero, Cesar Perez-Alonso, Benoit Fouconnier
Summary: This study investigates the effect of pH and ionic strength on the association interactions and phase separations in polyelectrolyte systems. The results show that the structure and phase transitions can be controlled by modifying the ionization degree, pKa, and charge screening. The findings provide insights into the functional properties of complexed polysaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Guangfei Duan, Yanqin Li, Meimei Ye, Hexin Liu, Ning Wang, Shizhong Luo
Summary: Transthyretin (TTR) aggregation and amyloid formation in ATTR diseases involve liquid-liquid phase separation (LLPS) and subsequent liquid-to-solid phase transition. Electrostatic interactions mediate LLPS of TTR, and pathogenic mutations and heparin promote the process of phase transition and aggregate formation. Post-translational modifications of TTR, such as S-cysteinylation and S-sulfonation, affect the stability and aggregation propensity of TTR. These findings provide molecular insights into the mechanism of TTR aggregation and suggest potential therapeutic targets for ATTR diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physics, Multidisciplinary
Md. S. Hossain, M. K. Ma, K. A. Villegas-Rosales, Y. J. Chung, L. N. Pfeiffer, K. W. West, K. W. Baldwin, M. Shayegan
Summary: The interplay between the Fermi sea anisotropy, electron-electron interaction, and localization phenomena can give rise to exotic many-body phases. This study reports the observation of an ordered anisotropic Wigner solid in a clean two-dimensional electron system with anisotropic effective mass and Fermi sea.
PHYSICAL REVIEW LETTERS
(2022)
Article
Chemistry, Physical
Prabir K. Mukherjee
Summary: The experimental results demonstrated the significant impact of ferromagnetic nanoparticles on the smectic-A to chiral smectic-C phase transition, with discussions on various properties near the transition. Both qualitative and quantitative agreement between experiments and theory were observed, based on the thermodynamic description presented in this study.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Polymer Science
Hao Wu, Jeffrey M. Ting, Matthew V. Tirrell
Article
Chemistry, Multidisciplinary
Jeffrey M. Ting
Summary: Chemical safety education is crucial for creating a culture of safety in academic research settings. Safety moments, which raise awareness about routine safety issues in research laboratories, serve as a proactive way to foster open communication among students and faculty across science and engineering disciplines. By designing effective safety moments and tailoring them to practical safety needs, institutions can combat complacency and encourage local dialogue on safety, ultimately leading to long-term improvements in lab safety culture.
JOURNAL OF CHEMICAL EDUCATION
(2021)
Article
Biochemistry & Molecular Biology
Jeffrey M. Ting, Alexander E. Marras, Joseph D. Mitchell, Trinity R. Campagna, Matthew Tirrell
Article
Polymer Science
Lu Li, Samanvaya Srivastava, Siqi Meng, Jeffrey M. Ting, Matthew Tirrell
Article
Polymer Science
Lu Li, Artem M. Rumyantsev, Samanvaya Srivastava, Siqi Meng, Juan J. de Pablo, Matthew Tirrell
Summary: The study provides insights into the thermodynamics and kinetics of polyelectrolyte complexation by systematically comparing experimental and theoretical phase diagrams of PECs with different backbone-solvent interactions. Results show the influence of backbone chemistry on the compositions and salt resistance of complexes, with predictions aligning well with experimental observations.
Article
Chemistry, Physical
Alexander E. Marras, Jeffrey M. Ting, Kaden C. Stevens, Matthew Tirrell
Summary: PCMs are unique self-assembled nanoparticles with great potential for delivery and fundamental polymer physics research. Controlled block copolymer design allows precise tuning of size, morphology, and stability of PCMs for tailored nanocarriers. Recent advances focus on predictive PCM design and dynamics characterization using time-resolved scattering techniques.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Electrochemistry
Xiaoqin Wang, Kaden C. Stevens, Jeffrey M. Ting, Alexander E. Marras, Gelareh Rezvan, Xiaojun Wei, Nader Taheri-Qazvini, Matthew Tirrell, Chang Liu
Summary: In this study, the potential of diblock synthetic polyelectrolytes as nanopore sensing probes was explored by investigating their translocation behaviors through alpha-hemolysin and MspA nanopores. The results indicate efficient translocations of PEO-b-PSS through alpha-HL and PEO-b-PVBTMA through MspA, suggesting that synthetic polyelectrolytes can offer more flexibility and cost-effectiveness for nanopore sensing.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Jeffrey M. Ting, Corinne E. Lipscomb
Summary: The advent of materials informatics has provided opportunities for transforming traditional scientific research workflows. This article highlights a MI initiative at 3M Corporate Research Laboratories, showcasing the strategic application of MI tools and data-driven methodologies for industrial materials research and product development.
PURE AND APPLIED CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jeffrey M. Ting, Teresa Tamayo-Mendoza, Shannon R. Petersen, Jared Van Reet, Usman Ali Ahmed, Nathaniel J. Snell, John D. Fisher, Mitchell Stern, Felipe Oviedo
Summary: Materials informatics (MI) has the potential to accelerate innovation and new product development in biotechnology, but the scarcity of large and standardized materials data is a major obstacle. Advances in polymer-based therapeutic delivery platforms provide ideal use-cases for machine learning to understand molecular interactions involved in drug protection and delivery.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Ludwig Schneider, Marcus Schwarting, Joshua Mysona, Heyi Liang, Ming Han, Phillip M. Rauscher, Jeffrey M. Ting, Shruti Venkatram, Richard B. Ross, K. J. Schmidt, Ben Blaiszik, Ian Foster, Juan J. de Pablo
Summary: Machine learning is a promising technology for accelerating materials discovery. By providing a reliable, reproducible, and automated simulation pipeline, users with different backgrounds can easily generate thermodynamic data and further drive chemical exploration through active learning methods.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2022)
Article
Chemistry, Physical
Boyuan Yu, Artem M. Rumyantsev, Nicholas E. Jackson, Heyi Liang, Jeffrey M. Ting, Siqi Meng, Matthew Tirrell, Juan J. de Pablo
Summary: Advances in synthetic chemistry have allowed for greater control over the sequence of polymeric materials, creating patterns reminiscent of biological macromolecules. Charged monomers enhance the tendency towards complex coacervation and increase the stability of coacervates with the addition of salt. High charge blockiness leads to the formation of microphase separated coacervates, resulting in a non-monotonic dependence of density on charge blockiness.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2021)
Article
Polymer Science
Hao Wu, Jeffrey M. Ting, Boyuan Yu, Nicholas E. Jackson, Siqi Meng, Juan J. de Pablo, Matthew Tirrell