Review
Biotechnology & Applied Microbiology
Meiqi Jin, Shuxia Zhang, Mengchen Wang, Qiaoyu Li, Jiahui Ren, Yun Luo, Xiaobo Sun
Summary: Ischemic stroke is a major cause of death and disability globally, and there is a need for early brain tissue perfusion therapies and functional recovery enhancement in stroke survivors. Exosomes, as natural mediators, have the potential to explore cellular communication and organ homeostasis mechanisms, and may play a crucial role in ischemic stroke.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Engineering, Biomedical
Xing Tian, Taojian Fan, Wentian Zhao, Ghulam Abbas, Bo Han, Ke Zhang, Nan Li, Ning Liu, Weiyuan Liang, Hao Huang, Wen Chen, Bing Wang, Zhongjian Xie
Summary: This review focuses on the potential applications of nanotechnology in stroke treatment. It discusses the main molecular pathological mechanisms of ischemic stroke, the role of the blood-brain barrier, and summarizes the challenges and future prospects of nanomedicine-based stroke treatments.
BIOACTIVE MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Jianglong Kong, Runxuan Chu, Yi Wang
Summary: Stroke is a major cause of death and disability worldwide. Neuroprotective therapy, combined with thrombolytic therapy, is an important treatment for stroke.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Hui-min Gao, Hao Chen, Gui-Yun Cui, Jin-Xia Hu
Summary: This article briefly describes the role and mechanism of action of the blood-brain barrier (BBB), as well as the functional proteins involved. Additionally, it discusses the mechanisms of BBB damage following an ischemic stroke and presents several therapeutic strategies addressing these impairments. The article aims to provide innovative ideas for drug delivery research via the BBB.
CELL AND BIOSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Marina S. Hernandes, Qian Xu, Kathy K. Griendling
Summary: In this review, recent findings on the role of NADPH oxidases in BBB disruption induced by ischemic stroke were highlighted, emphasizing the impact of ROS on the function of the blood-brain barrier in neurological disorders.
Article
Neurosciences
Wenxuan Han, Yang Song, Marcelo Rocha, Yejie Shi
Summary: Brain edema is a devastating consequence of ischemic stroke, with malignant cerebral edema being the main cause of high mortality in large hemispheric strokes. Despite efforts to understand the mechanisms and find therapeutic targets, current treatments for ischemic brain edema focus on relieving symptoms rather than stopping its formation and progression. Recent research has revealed novel cellular mechanisms and advancements in neuroimaging techniques that offer opportunities for early diagnosis and intervention in stroke patients. Understanding how therapeutic reperfusion affects cerebral edema formation post-stroke is critical for decision-making and management. This review summarizes these research advances in ischemic brain edema, aiming to provide insight for future research on diagnosis and treatment.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Cell Biology
Haroon Khan, Jia-Ji Pan, Yongfang Li, Zhijun Zhang, Guo-Yuan Yang
Summary: Exosomes are natural cells-derived vesicles that are considered as a leading option for treating various diseases, including cerebral ischemia. Despite the potential for ischemic stroke therapy, native exosomes face challenges due to undesirable features. Bioengineering exosomes may enhance their effectiveness in stroke treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Maria Luz Alonso-Alonso, Ana Sampedro-Viana, Sabela Fernandez-Rodicio, Marcos Bazarra-Barreiros, Alberto Ouro, Tomas Sobrino, Francisco Campos, Jose Castillo, Pablo Hervella, Ramon Iglesias-Rey
Summary: Blood-brain barrier dysfunction is closely associated with cerebrovascular disease, but its detrimental or reparative effects depend on the stage of stroke. Understanding the structure, function, and chronic alterations of the BBB related to ischemic stroke is important for new drug development and clinical translation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Wenxiu He, Qiyong Mei, Jie Li, Yuting Zhai, Yiting Chen, Rui Wang, Enhao Lu, Xiao-Yong Zhang, Zhiwen Zhang, Xianyi Sha
Summary: The study presents a novel biomimetic nanoplatform designed to enhance drug delivery to cerebral ischemic lesions, demonstrating superior neuroprotective effects.
Article
Peripheral Vascular Disease
Jose Leon, Jesenia Acurio, Lina Bergman, Juan Lopez, Anna Karin Wikstrom, Pablo Torres-Vergara, Felipe Troncoso, Fidel Ovidio Castro, Manu Vatish, Carlos Escudero
Summary: The study found that circulating small extracellular vesicles in plasma from women with preeclampsia or from hypoxic placentae disrupt the blood-brain barrier, which can be prevented using magnesium sulfate.
Review
Medicine, General & Internal
Min Zhou, Samuel X. Shi, Ning Liu, Yinghua Jiang, Mardeen S. Karim, Samuel J. Vodovoz, Xiaoying Wang, Boli Zhang, Aaron S. Dumont
Summary: Disruption of the blood-brain barrier following ischemic stroke can lead to various complications, with recent studies showing a stepwise impairment of the transcellular barrier followed by the paracellular barrier as a potential cause. Increased endothelial transcytosis, which is caveolae-mediated, has been identified as a factor independent of tight junction disintegration, challenging previous beliefs and providing new insights for future research and treatment strategies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Min Zhou, Dongna Li, Qian Shen, Lei Gao, Pengwei Zhuang, Yanjun Zhang, Hong Guo
Summary: The study showed that treatment with Storax can inhibit the caveolae-mediated transcytosis at the blood-brain barrier (BBB) in rats with ischemic stroke. This treatment also attenuated the ultrastructural disruption of BBB and regulated the expressions of key proteins involved in BBB function.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Morteza Heidarzadeh, Yasemin Gursoy-Ozdemir, Mehmet Kaya, Aysan Eslami Abriz, Amir Zarebkohan, Reza Rahbarghazi, Emel Sokullu
Summary: Current drug delivery strategies for neurological disorders face challenges due to the blood-brain barrier (BBB) limiting transport to the brain parenchyma. Stem cell byproducts such as exosomes are proposed as natural nano-drug carriers, but the intact BBB may hinder their delivery. Understanding the molecular mechanisms behind exosomal trafficking through the BBB remains unclear despite some preliminary studies showing potential.
CELL AND BIOSCIENCE
(2021)
Review
Psychiatry
Jie Dai, Min-zhe Zhang, Qi-qiang He, Rui Chen
Summary: Schizophrenia is a serious mental disorder and a leading cause of disease burden worldwide. Exosomes, as natural nanocarriers, have the ability to cross the blood-brain barrier and play a crucial role in central nervous system communication. This article reviews the current research on exosomes and schizophrenia, discussing their roles as biomarkers and therapeutic targets, as well as the challenges faced in this field.
PSYCHIATRY RESEARCH
(2023)
Review
Biotechnology & Applied Microbiology
Wei Lv, Yijiao Liu, Shengnan Li, Lingyan Lv, Hongdan Lu, Hongliang Xin
Summary: This article reviews the recent advances and challenges in the diagnosis and treatment of ischemic stroke, specifically focusing on the application of nanotechnology and the impact of the blood-brain barrier.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.